El transcriptoma es el conjunto de moléculas de ARN -codificantes y no codificantes- presentes en una célula o grupo de células en un momento determinado. Partiendo de muestras de tejido tiroideo sin infiltrar (NIT), con pequeñas infiltraciones focales (SFI) y con infiltraciones extensivas (ELI), pretendemos comparar sus transcriptomas e identificar aquellos genes que están diferencialmente expresados en cada una de las posibles comparaciones (NIT-SFI, NIT-ELI, SFI-ELI). Con este objetivo en mente, se analizarán datos provenientes de RNAseq, una técnica de secuenciación que, en contraste con los microarrays, permite detectar hasta un 25% más de DEG entre condiciones. El procesado de los datos y la búsqueda de DEG se realizará mediante el software estadístico R (versión 3.6.2) y de paquetes del proyecto BioConductor (versión 3.10). Los datos y el código relacionados con el análisis pueden ser consultados en el siguiente repositorio GitHub.
El objetivo del estudio es aportar nueva información y mejorar el conocimiento del efecto que tiene la presencia -en diferente grado- de infiltraciones en el tejido tiroideo. En esta dirección, se pretende identificar -a partir de los counts obtenidos mediante RNAseq- que genes y que vías metabólicas están diferencialmente expresados en cada una de las posibles comparaciones entre las tres condiciones experimentales (NIT, SFI, ELI).
Aunque se ha propuesto el uso del software Galaxy (Afgan et al. 2016) como alternativa para este análisis, nosotros nos hemos decantado por la combinación de R (versión 3.6.2) y BioConductor (versión 3.10). Además, para facilitar el procesado y hacerlo más cómodo visualmente, hemos utilizado la interfaz R-Studio (RStudio Team 2015). En la Tabla 1 se muestra un listado con los paquetes implementados durante el análisis.
| Package | Repository | Description | Version |
|---|---|---|---|
| knitr | CRAN | Provides a general-purpose tool for dynamic report generation in R using Literate Programming techniques. | 1.28 |
| kableExtra | CRAN | Build complex HTML or ‘LaTeX’ tables using ‘kable()’ from ‘knitr’ and the piping syntax from ‘magrittr’. | 1.1.0 |
| readxl | CRAN | Import excel files into R. Supports ‘.xls’ via the embedded ‘libxls’ C library and ‘.xlsx’ via the embedded ‘RapidXML’ C++ library . | 1.3.1 |
| ggplot2 | CRAN | A system for ‘declaratively’ creating graphics, based on “The Grammar of Graphics”. | 3.3.0 |
| citr | CRAN | Functions and an ‘RStudio’ add-in that search ‘Bib(La)TeX’-files or ‘Zotero’ libraries to insert formatted Markdown citations into the current document. | 0.3.2 |
| ggrepel | CRAN | Provides text and label geoms for ‘ggplot2’ that help to avoid overlapping text labels. Labels repel away from each other and away from the data points. | 0.8.2 |
| gplots | CRAN | Various R programming tools for plotting data. | 3.0.3 |
| viridis | CRAN | Implementation of the ‘viridis’ - the default -, ‘magma’, ‘plasma’, ‘inferno’, and ‘cividis’ color maps for ‘R’. | 0.5.1 |
| cowplot | CRAN | Provides various features that help with creating publication-quality figures with ‘ggplot2’. | 1.0.0 |
| RColorBrewer | CRAN | Creates nice looking color palettes especially for thematic maps. | 1.1.2 |
| magritrr | CRAN | The magrittr is a package with two aims: to decrease development time and to improve readability and maintainability of code. | 1.5 |
| factoextra | CRAN | Provides some easy-to-use functions to extract and visualize the output of multivariate data analyses. | 1.07 |
| cluster | CRAN | Methods for Cluster analysis. | 3.14 |
| Biobase | BioConductor | Functions that are needed by many other packages or which replace R functions. | 2.46.0 |
| EnhancedVolcano | BioConductor | Here, we present a highly-configurable function that produces publication-ready volcano plots. | 1.4.0 |
| ReactomePA | BioConductor | This package provides functions for pathway analysis based on REACTOME pathway database. | 1.30.0 |
| org.Hs.eg.db | BioConductor | Genome wide annotation for Human, primarily based on mapping using Entrez Gene identifiers. | 3.1 |
| DESeq2 | BioConductor | Estimate variance-mean dependence in count data from high-throughput sequencing assays and test for differential expression using the negative binomial distribution. | 1.26 |
| AnnotationDbi | BioConductor | Implements a user-friendly interface for querying SQLite-based annotation data packages. | 1.48 |
| clusterProfiler | BioConductor | This package implements methods to analyze and visualize functional profiles (GO and KEGG) of gene and gene clusters. | 3.14 |
| enrichplot | BioConductor | The ‘enrichplot’ package implements several visualization methods for interpreting functional enrichment results obtained from ORA or GSEA analysis. | 1.61 |
Tabla 1: lista de paquetes utilizados durante el análisis.
Los datos utilizados para el análisis provienen del portal GTEx (Carithers et al. 2015), un servidor web que subministra datos asociados a estudios relacionados con la expresión de hasta 54 tejidos diferentes. En contraste con lo que vimos en la PEC 1, no tenemos que descargar los datos desde ningún portal o servidor. De hecho, se nos han subministrado un par de archivos (counts.csv, targets.csv) que incluyen -respectivamente- los counts crudos de cada uno de los genes estudiados e información acerca de cada una de las muestras (metadata).
Vamos a centrarnos un poco más en el contenido. Como ya se ha comentado anteriormente, los datos corresponden a un estudio que pretendía identificar que genes están diferencialmente expresados en la tiroides en función de la presencia y el grado de infilitraciones en este tejido. En consecuencia, nos encontramos frente a un diseño factorial de un factor (Grado de infiltración) con 3 niveles (NIT, SFI, ELI). Como veremos posteriormente, antes del preprocesado dispondremos de una matriz cruda con un total de 292 muestras (236 NIT, 42 SFI y 14 ELI) y 5.620210^{4} genes. Sin embargo, una vez seleccionadas -aleatoriamente- las muestras para el análisis, cada nivel conformará un único grupo experimental compuesto de 10 réplicas biológicas y, por lo tanto, el tamaño muestral del experimento será de 30 muestras.
El análisis de datos provenientes de RNAseq se puede realizar siguiendo protocolos muy variables. En esta sección del informe se intenta resumir un workflow que gira entorno al paquete DESeq2 (Love, Huber, and Anders 2014) y que está bastante extendido entre la comunidad científica.
Para facilitar el análisis, intentaremos almacenar todos los datos de origen, resultados y ficheros intermedios utilizando una estructura ramificada y jerarquizada de directorios comprendida en el interior de nuestro directorio de trabajo (C:/Users/USER/Documents/Màster Bioestadística i Bioinfo/Análisis de datos Ómicos/PECS/ADO_PEC2_Marc_Garcia). Principalmente, este subconjunto estará formado por los cuatro directorios siguientes:
data: contendrá -entre otros- las matrices con los counts (original, subset y subset normalizado) y los ficheros con la información de las muestras (original y subset).
results: contendrá los resultados generados durante el análisis.
figures: aquí guardaremos las figuras generadas durante el análisis.
other: incluirá otro tipo de contenido como la tabla con la información sobre los paquetes utilizados.
El primer paso del pipeline de análisis consiste en un breve análisis exploratorio para identificar que estructura tienen los datos y cual es su contenido. En esta dirección, hemos utilizado una batería de funciones clásicas de R. Entre estas destacan las funciones View(), str(), head(), colnames() o dim(). Todas estas funciones pertenecen a los paquetes base y utils (R Core Team 2019).
Para simplificar el análisis a la vez que garantizamos que los resultados obtenidos sean significativos, queremos que la representación de cada grupo se reduzca y sea idéntica. Además, para que los resultados de cada alumno sean ligeramente diferentes, queremos que la selección de estas muestras se haga de forma aleatoria. Consecuentemente, el objetivo de este apartado consiste en seleccionar -del total de muestras y de forma aleatoria- un subset de 30 compuesto por 10 muestras de cada uno de los grupos. Con este objetivo, utilizaremos la sintaxis de los corchetes y las funciones as.character(), set.seed() y sample() del paquete base (R Core Team 2019).
Adicionalmente, esta sección incluye el cambio de nombre de las muestras y el guardado del contenido en un nuevo archivo .csv. Con este objetivo en mente, utilizaremos la sintaxis de corchetes combinada con las funciones colnames(), rownames(), paste0() y write.csv() del paquete base (R Core Team 2019).
Antes de proseguir con el análisis, si queremos utilizar el paquete DESeq2 (Love, Huber, and Anders 2014) para el análisis, debemos generar un objeto de tipo DESeqDataSet. Como veremos más adelante, estos objetos presentan similitudes con la estructura de los ExpressionSet que vimos en la PEC 1. Con este objetivo en mente utilizaremos la función DESeqDataSetFromMatrix(). Como argumentos especificaremos la matriz de counts cruda (countData), los metadatos (colData) y el diseño factorial (design).
Aunque este paso no es estrictamente necesario, con el objetivo de dinamizar el análisis, una de las primeras etapas consiste en eliminar -de los datos crudos- aquellos genes que no están expresados. Dicho de otro modo, pretendemos descartar aquellos genes que tienen -para todas las muestras- un número de counts igual a 0. Alternativamente, podemos decir que nos queremos quedar únicamente con aquellas filas que tengan como mínimo un count (rowSums >= 1). En esta dirección utilizaremos la sintaxis de los corchetes combinada con las funciones rowSums() del paquete base (R Core Team 2019) y counts() del paquete BiocGenerics (Huber et al. 2015).
Algunas de la pruebas gráficas -que utilizaremos a continuación para el control de calidad- funcionan mejor con datos homocedáticos. Es decir, con muestras que -independientemente de su media de counts- tienen varianzas o desviaciones estándar parecidas. Ya que la media del número de counts y su varianza siguen -generalmente- una relación positiva, antes de proseguir con el control de calidad, debemos realizar lo que se conoce como estabilización de la varianza. El objetivo de este proceso es -precisamente- transformar los datos para que las muestras tengan varianzas similares. Es importante mencionar que, a parte de permitir el control de calidad, este proceso normaliza los datos. Principalmente, existen dos transformaciones ámpliamente utilizadas: la transformación vst y la transformación rlog. La primera se utiliza para datasets que tienen más de 30 muestras, mientras que la segunda se aplica para aquellos con n < 30. Además, la primera es más rápida y menos sensible a outliers. En consecuencia, nosotros utilizaremos esta transformación. Para implementarla usaremos la función vst() del paquete DESeq2 (Love, Huber, and Anders 2014).
Una vez eliminados los genes que no están expresados en ninguna de las muestras y transformados/normalizados los datos, es necesario realizar un control para determinar si estos tienen la calidad suficiente para ser posteriormente analizados y si hay alguna muestra problemática. En esta dirección, existe una gran variedad de pruebas que podemos realizar, siendo la gran mayoría pruebas gráficas. Como veremos a continuación, entre las más típicas se encuentran los boxplots, los PCAplots o los dendrogramas.
Una de las alternativas más clásicas y ámpliamente utilizadas para valorar la calidad de las muestras consiste en construir un boxplot que muestre la distribución del número de pseudocounts para cada una de las muestras. De este modo podemos comparar las distribuciones entre muestras, identificando cuales de ellas presentan distribuciones que se alejan de lo esperado. En este informe, para construir los boxplots, utilizaremos la sintaxis del paquete ggplot2 (Wickham 2016).
Otra opción muy interesante consiste en construir un PCA plot. Este tipo de gráficos se basan en aquellas componentes de los datos que son responsables de la mayor parte de la variabilidad observada entre muestras (PCs o componentes principales). Son una muy buena opción para determinar si las muestras de un mismo grupo se agrupan conjuntamente e independientemente del resto de grupos. También permiten detectar que muestras se alejan demasiado de su grupo (outliers) y, consecuentemente, puede ser que deban ser eliminadas. En contraste con lo comentado para el boxplot, para el PCA plot crearemos nuestra propia función (plotPCA3()). Esta función ha sido rescatada de la PEC 1 y ligeramente modificada para que se adapte a nuestras necesidades. Su código se muestra en el annexo.
La tercera y última prueba gráfica que utilizaremos para el control de calidad se basa en el clustering jerárquico y la posterior construcción de un dendrograma. Este tipo de gráficos son especialmente potentes para identificar si existen diferencias entre las muestras de los grupos experimentales y si existe alguna muestra que podamos catalogar como outlier. En realidad, este gráfico aporta información que es complementaria a la del PCA plot. Para la construcción del dendrograma utilizaremos las funciones dist() del paquete stats (R Core Team 2019) y las funciones hcut() y fviz_dend() del paquete factoextra (Kassambara and Mundt 2020).
Con la intención de identificar que genes estan diferencialmente expresados entre cada una de las dietas y el control, podemos utilizar diferentes enfoques. Aunque existen algunas alternativas que pasan por la utilización de los paquetes limma (Ritchie et al. 2015) o edgeR (Robinson, McCarthy, and Smyth 2009), nosotros hemos preferido utilizar la librería DESeq2 (Love, Huber, and Anders 2014). A continuación se describen brevemente todos los psos necesarios para generar el modelo lineal e identificar y visualizar aquellos genes que presentan una expresión diferencial entre comparaciones.
Realizar un análisis de expresión diferencial con el paquete DESeq2 (Love, Huber, and Anders 2014) es tremendamente fácil. Simplemente debemos aplicar la función DESeq() sobre un objeto de tipo DESeqDataSet, DESeqDataSetFromMatrix o DESeqDataSetFromHTSeqCount. Consecuentemente, esta función realizará un análisis por defecto que incluirá -secuencialmente- la estimación de los size factors, la estimación de la dispersión y la adaptación de un modelo binomial negativo.
Llegados a este punto, una vez hecho el análisis con DESeq(), podemos utilizar la función results() del paquete DESeq2 (Love, Huber, and Anders 2014) para consultar los resultados de cada uno de los contrastes. En esta dirección, es importante utilizar el argumento contrast y especificar -como un vector string de tres entradas- el factor y los dos niveles que queremos utilizar durante el contraste. Como veremos más adelante, el output resultante de results() contiene información similar y tiene en un formato muy parecido a las topTables que vimos en la PEC1.
Otra opción muy interesante que ofrece el output de la función DESeq() es la capacidad de aplicarle la función summary() del paquete base (R Core Team 2019). Esta opción permite -fijado un p-valor ajustado mediante el argumento alpha- obtener una tabla que contiene información, entre otros, sobre el número y porcentaje de genes que están upregulated o downregulated. Es importante tener en mente
Ahora ya tenemos construidas las topTables. Sin embargo, la única identificación que tienen las entradas de estas tablas es un identificador de ENSEMBL (ENSEMBL ID). Con el objetivo de asociar cada uno de estos identificadores con el nombre del gen al que pertenecen, utilizaremos la función mapIds() del paquete AnnotationDbi (Pagès et al. 2019) y el paquete org.Hs.eg.db (Carlson 2019). Adicionalemnte, también incorporaremos el identificador de Entrez Gene. Es importante remarcar que es probable que algunos de los geneids de las topTables no sean encontrados en la base de datos y por lo tanto se les asigne un valor NA. Consecuentemente, estas entradas deberán ser eliminadas mediante -por ejemolo- el uso de la función na.omit() del paquete stats (R Core Team 2019).
En este punto, si así nos conviene, podemos guardar el contenido de estas topTables en un archivo .csv mediante el uso de la función write.csv() del paquete utils (R Core Team 2019). El contenido de las tres topTables generadas lo guardaremos en el directorio results/topTables presente en nuestro working directory.
A partir de las topTables generadas mediante la función results() podemos filtrar aquellos genes que consideremos como diferencialmente expresados (DEG). Igual que para la PEC 1, consideraremos que estos son aquellos que tienen un p-valor ajustado menor que 0.1 y un log2FC superior o inferior a 2. Para el filtrado podemos utilizar la función which() del paquete BiocGenerics (Huber et al. 2015) y la sintaxis de corchetes.
La visualización de las tablas de genes diferencialmente expresados (DEG) se puede realizar fácilmente mediante volcano plots. Estos gráficos relacionan el cambio de expresión entre condiciones (log2 FoldChange) con la evidencia estadística (-log10(P-value)), siendo aquellos genes con valores más extremos en el eje x y con valores superiores en el eje y los que tienen una evidencia más fuerte de estar diferencialmente expresados. Una de las funciones más utilizadas para su construcción es volcanoplot() del paquete limma (Ritchie et al. 2015). Aún siendo una buena solución, nosotros hemos preferido emplear la función EnhancedVolcano() del paquete con el mismo nombre (Blighe, Rana, and Lewis 2019). A diferencia de volcanoplot(), EnhancedVolcano() permite dibujar el FDR y los logFC cutoffs, diferenciando las 4 categorías de genes que nos podemos encontrar mediante una paleta de colores. De este modo, es mucho más fácil identificar que genes presentan evidencia de estar diferencialmente expresados y establecer comparaciones entre los resultados de cada una de las comparaciones.
Resulta mucho más interesante y fácilmente interpretable estudiar -en vez de los genes uno por uno- que vías metabólicas están diferencialmente expresadas en cada una de las tres comparaciones. Para obtener esta información debemos realizar lo que se conoce como análisis de significación o gene enrichment analysis.
Aunque no es la única alternativa, el paquete enrichplot (Yu 2019) dispone de funciones que nos permiten generar, para cada comparación, tablas que muestran las vías que presentan evidencias significativas de estar diferencialmente expresadas. Estas tablas, a las que nos vamos a referir como GOtables o pathwaytables contienen -entre otros- el identificador de Gene Ontology, una corta descripción (Description), la proporción de genes differencialmente expresados (GeneRatio), el p-valor (pvalue), el p-valor ajustado (p.adjust) y el q-valor (qvalue) para cada vía. Si ordenamos las vías por p-valor o p-valor ajustado (orden ascendiente), podremos visualizar aquellas con una mayor evidencia de estar diferencialmente expresadas.
Uno de las modos más clásicos para representar el contenido de las GOtables o pathwaytables consiste en utilizar barplots. Utilizando la función barplot() del paquete graphics [RCore@2019] directamente sobre el objeto enrichGO, podemos generar un gràfico que muestre el número especificado de vías que tienen una mayor evidencia de estar diferencialmente expresadas. A parte de mostrarse el número de genes que forman cada una de estas vías (largo de la barra) también podemos visualizar -mediante una escala de color- el pvalor que indica la evidencia de que esa vía esté realmente diferencialmente expresada.
Otra opción muy interesante para representar el contenido de las pathway tables consiste en construir cnetplots mediante la función cnetplot() del paquete enrichplot (Yu 2019). Estos gráficos tienen una estructura en forma de red que permite, además de visualizar que vías metabólicas presentan una mayor evidencia de estar diferencialmente expresadas, identificar las conexiones entre genes que pertenecen a más de una vía. Adicionalmente, si así se desea, también permite classificar, mediante una escala de color, aquellos genes que están sobrexpresados o infraexpresados.
En la sección de métodos se ha explicado como eran los datos originales (counts.csv, targets.csv) y como se ha realizado el subset para obtener únicamente información de 30 muestras aleatorias. A continuación, se muestran dos tablas: una que contiene la matriz cruda con los counts de 100/5.620210^{4} genes para las 30 muestras seleccionadas (Tabla 2) y una con los metadatos de estas muestras (Tabla 3).
| NIT_1 | NIT_2 | NIT_3 | NIT_4 | NIT_5 | NIT_6 | NIT_7 | NIT_8 | NIT_9 | NIT_10 | SFI_1 | SFI_2 | SFI_3 | SFI_4 | SFI_5 | SFI_6 | SFI_7 | SFI_8 | SFI_9 | SFI_10 | ELI_1 | ELI_2 | ELI_3 | ELI_4 | ELI_5 | ELI_6 | ELI_7 | ELI_8 | ELI_9 | ELI_10 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ENSG00000223972.4 | 0 | 7 | 2 | 2 | 8 | 0 | 4 | 1 | 3 | 3 | 3 | 2 | 6 | 2 | 3 | 2 | 9 | 6 | 9 | 1 | 0 | 0 | 1 | 0 | 4 | 2 | 5 | 3 | 1 | 3 |
| ENSG00000227232.4 | 555 | 401 | 890 | 468 | 636 | 1487 | 840 | 925 | 517 | 600 | 460 | 430 | 640 | 457 | 1704 | 491 | 302 | 820 | 568 | 713 | 834 | 825 | 1472 | 1002 | 1325 | 423 | 489 | 1301 | 775 | 979 |
| ENSG00000243485.2 | 1 | 4 | 1 | 1 | 5 | 1 | 0 | 0 | 2 | 1 | 0 | 0 | 4 | 1 | 1 | 2 | 4 | 0 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 2 | 3 |
| ENSG00000237613.2 | 2 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 3 | 2 | 1 | 0 | 2 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 2 |
| ENSG00000268020.2 | 1 | 0 | 1 | 0 | 2 | 0 | 0 | 0 | 1 | 4 | 2 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 0 | 0 | 5 |
| ENSG00000240361.1 | 1 | 0 | 0 | 1 | 3 | 2 | 2 | 0 | 3 | 0 | 0 | 0 | 3 | 2 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 8 |
| ENSG00000186092.4 | 1 | 0 | 2 | 1 | 4 | 2 | 2 | 1 | 2 | 0 | 1 | 0 | 1 | 3 | 0 | 1 | 2 | 5 | 1 | 1 | 0 | 1 | 2 | 0 | 2 | 0 | 3 | 0 | 1 | 3 |
| ENSG00000238009.2 | 5 | 6 | 5 | 8 | 4 | 26 | 7 | 17 | 8 | 9 | 7 | 9 | 5 | 9 | 5 | 7 | 10 | 12 | 5 | 18 | 6 | 10 | 38 | 15 | 4 | 18 | 7 | 5 | 10 | 4 |
| ENSG00000233750.3 | 11 | 16 | 16 | 16 | 123 | 46 | 26 | 19 | 14 | 25 | 12 | 9 | 16 | 14 | 22 | 4 | 74 | 18 | 14 | 2 | 6 | 21 | 24 | 19 | 8 | 6 | 100 | 7 | 2 | 81 |
| ENSG00000237683.5 | 326 | 744 | 1126 | 528 | 1400 | 2032 | 522 | 813 | 154 | 1184 | 279 | 679 | 415 | 565 | 2536 | 552 | 674 | 973 | 738 | 511 | 445 | 853 | 2020 | 602 | 853 | 325 | 523 | 1132 | 580 | 527 |
| ENSG00000268903.1 | 1 | 1 | 6 | 1 | 2 | 7 | 2 | 2 | 1 | 3 | 2 | 1 | 0 | 5 | 9 | 2 | 4 | 0 | 1 | 4 | 2 | 6 | 13 | 2 | 7 | 1 | 2 | 4 | 1 | 1 |
| ENSG00000239906.1 | 0 | 10 | 10 | 4 | 13 | 19 | 8 | 2 | 0 | 35 | 7 | 8 | 4 | 10 | 84 | 5 | 8 | 20 | 10 | 8 | 2 | 16 | 25 | 32 | 17 | 4 | 3 | 2 | 4 | 5 |
| ENSG00000241860.2 | 31 | 58 | 52 | 71 | 138 | 140 | 42 | 40 | 65 | 80 | 41 | 95 | 66 | 47 | 120 | 102 | 116 | 101 | 67 | 70 | 40 | 94 | 196 | 96 | 94 | 41 | 183 | 46 | 69 | 115 |
| ENSG00000222623.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ENSG00000241599.1 | 0 | 2 | 0 | 0 | 1 | 0 | 1 | 0 | 2 | 1 | 1 | 0 | 1 | 0 | 4 | 1 | 1 | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 3 |
| ENSG00000228463.4 | 66 | 40 | 29 | 31 | 113 | 258 | 42 | 58 | 8 | 64 | 16 | 26 | 18 | 64 | 53 | 95 | 16 | 66 | 52 | 7 | 66 | 98 | 52 | 39 | 44 | 42 | 21 | 92 | 5 | 42 |
| ENSG00000237094.7 | 36 | 24 | 63 | 21 | 50 | 101 | 30 | 41 | 19 | 69 | 37 | 10 | 26 | 27 | 99 | 39 | 22 | 43 | 30 | 63 | 38 | 58 | 70 | 43 | 64 | 14 | 95 | 16 | 11 | 46 |
| ENSG00000250575.1 | 1 | 4 | 2 | 1 | 1 | 6 | 0 | 4 | 4 | 1 | 1 | 4 | 1 | 3 | 3 | 2 | 3 | 6 | 7 | 1 | 1 | 6 | 5 | 6 | 6 | 0 | 2 | 2 | 1 | 2 |
| ENSG00000233653.3 | 6 | 5 | 3 | 8 | 16 | 9 | 5 | 2 | 10 | 7 | 6 | 5 | 7 | 3 | 6 | 3 | 8 | 9 | 7 | 5 | 2 | 8 | 7 | 4 | 7 | 2 | 13 | 1 | 5 | 16 |
| ENSG00000224813.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ENSG00000235249.1 | 0 | 3 | 3 | 0 | 2 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 0 | 2 | 2 | 0 | 3 | 3 | 2 | 1 | 0 | 1 | 3 | 0 | 0 | 0 | 5 | 0 | 1 | 3 |
| ENSG00000269732.1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 4 | 0 | 1 | 0 | 0 | 0 |
| ENSG00000256186.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ENSG00000236601.1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 2 | 0 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 |
| ENSG00000236743.1 | 1 | 1 | 1 | 0 | 9 | 0 | 0 | 2 | 2 | 0 | 3 | 0 | 3 | 0 | 2 | 2 | 4 | 3 | 3 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 3 | 1 | 0 | 1 |
| ENSG00000236679.2 | 0 | 1 | 1 | 0 | 7 | 2 | 1 | 1 | 4 | 0 | 4 | 2 | 5 | 3 | 2 | 3 | 63 | 2 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 7 | 1 | 3 | 7 |
| ENSG00000231709.1 | 0 | 0 | 3 | 0 | 9 | 2 | 1 | 2 | 1 | 0 | 2 | 2 | 6 | 0 | 5 | 3 | 5 | 6 | 10 | 0 | 1 | 4 | 2 | 11 | 6 | 2 | 2 | 1 | 2 | 1 |
| ENSG00000235146.2 | 1 | 2 | 2 | 2 | 3 | 0 | 2 | 2 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 0 | 1 | 0 | 2 | 0 | 2 | 19 | 0 | 6 |
| ENSG00000239664.2 | 3 | 0 | 2 | 1 | 2 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9 | 0 | 5 |
| ENSG00000230021.3 | 1 | 0 | 2 | 2 | 9 | 7 | 2 | 5 | 1 | 4 | 3 | 2 | 5 | 1 | 5 | 3 | 3 | 9 | 3 | 2 | 7 | 3 | 2 | 6 | 2 | 4 | 13 | 11 | 0 | 5 |
| ENSG00000223659.1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 1 | 1 | 0 | 1 | 2 | 1 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5 | 0 | 0 | 1 |
| ENSG00000225972.1 | 85 | 90 | 44 | 40 | 245 | 65 | 21820 | 82 | 72 | 66 | 99 | 54 | 137 | 18178 | 112 | 50 | 198 | 49 | 81 | 37 | 33 | 55 | 54 | 4678 | 50 | 25 | 132 | 23 | 37 | 330 |
| ENSG00000225630.1 | 9976 | 21118 | 25431 | 14239 | 13191 | 9374 | 7184 | 15349 | 15277 | 11952 | 13275 | 7455 | 22629 | 10859 | 13990 | 6257 | 10602 | 14976 | 34546 | 6973 | 9934 | 18090 | 12782 | 8450 | 27107 | 7614 | 12211 | 8718 | 10398 | 64325 |
| ENSG00000237973.1 | 763 | 2056 | 439 | 1787 | 3819 | 599 | 13349 | 1553 | 3465 | 732 | 598 | 640 | 3860 | 8778 | 841 | 1202 | 3276 | 4620 | 2456 | 347 | 2421 | 1134 | 483 | 136 | 2583 | 821 | 1117 | 242 | 232 | 6292 |
| ENSG00000229344.1 | 201 | 317 | 158 | 175 | 646 | 181 | 396 | 262 | 332 | 187 | 265 | 132 | 574 | 188 | 375 | 201 | 320 | 319 | 211 | 132 | 108 | 161 | 164 | 85 | 212 | 88 | 651 | 93 | 125 | 694 |
| ENSG00000240409.1 | 87 | 125 | 61 | 45 | 119 | 30 | 117 | 97 | 64 | 40 | 54 | 30 | 136 | 102 | 180 | 60 | 67 | 84 | 75 | 26 | 28 | 28 | 23 | 15 | 874 | 17 | 84 | 17 | 36 | 187 |
| ENSG00000248527.1 | 40212 | 64520 | 22403 | 42558 | 59705 | 15094 | 38541 | 42834 | 35428 | 49856 | 34733 | 19953 | 78315 | 49299 | 26600 | 25829 | 35965 | 60613 | 36803 | 7805 | 32781 | 37487 | 34261 | 24593 | 54523 | 22813 | 32813 | 15457 | 24181 | 67070 |
| ENSG00000198744.5 | 243 | 268 | 210 | 154 | 19806 | 152 | 360 | 272 | 263 | 214 | 335 | 181 | 809 | 183 | 665 | 231 | 512 | 322 | 270 | 97 | 146 | 120 | 183 | 43 | 291 | 70 | 656 | 76 | 217 | 910 |
| ENSG00000268663.1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 0 | 1 | 1 | 1 | 0 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
| ENSG00000185097.2 | 1 | 0 | 0 | 0 | 1 | 0 | 2 | 1 | 2 | 0 | 1 | 1 | 0 | 2 | 2 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 2 |
| ENSG00000229376.3 | 17 | 25 | 11 | 9 | 38 | 44 | 32 | 21 | 14 | 23 | 9 | 5 | 29 | 7 | 20 | 16 | 19 | 22 | 18 | 5 | 15 | 18 | 14 | 20 | 16 | 25 | 37 | 5 | 13 | 23 |
| ENSG00000224956.5 | 403 | 143 | 366 | 232 | 281 | 435 | 256 | 347 | 164 | 441 | 385 | 247 | 283 | 9 | 737 | 202 | 79 | 434 | 242 | 243 | 217 | 260 | 331 | 284 | 676 | 130 | 218 | 195 | 204 | 323 |
| ENSG00000235373.1 | 17 | 24 | 28 | 13 | 33 | 21 | 23 | 15 | 15 | 29 | 27 | 15 | 28 | 13 | 16 | 9 | 19 | 33 | 35 | 8 | 8 | 11 | 31 | 26 | 15 | 8 | 41 | 11 | 24 | 33 |
| ENSG00000223181.1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| ENSG00000240618.1 | 11 | 3 | 26 | 6 | 0 | 2 | 2 | 0 | 7 | 7 | 5 | 1 | 8 | 1 | 16 | 0 | 9 | 9 | 9 | 0 | 2 | 6 | 14 | 3 | 5 | 0 | 9 | 2 | 3 | 5 |
| ENSG00000229905.1 | 0 | 0 | 0 | 2 | 2 | 0 | 4 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 3 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
| ENSG00000228327.2 | 72 | 114 | 106 | 146 | 152 | 72 | 83 | 71 | 73 | 156 | 165 | 72 | 110 | 119 | 135 | 78 | 64 | 147 | 153 | 56 | 75 | 160 | 313 | 196 | 118 | 89 | 140 | 43 | 99 | 213 |
| ENSG00000237491.4 | 96 | 113 | 101 | 125 | 306 | 209 | 116 | 53 | 66 | 215 | 159 | 60 | 175 | 153 | 241 | 95 | 152 | 161 | 224 | 64 | 240 | 166 | 638 | 342 | 155 | 108 | 110 | 224 | 90 | 283 |
| ENSG00000230092.3 | 12 | 13 | 12 | 16 | 28 | 18 | 5 | 5 | 5 | 11 | 10 | 13 | 18 | 21 | 55 | 18 | 5 | 15 | 37 | 15 | 19 | 10 | 92 | 23 | 9 | 18 | 13 | 18 | 13 | 47 |
| ENSG00000269831.1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 3 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| ENSG00000240453.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ENSG00000177757.1 | 12 | 41 | 18 | 32 | 47 | 34 | 44 | 7 | 31 | 40 | 72 | 22 | 65 | 28 | 21 | 18 | 36 | 53 | 57 | 30 | 28 | 24 | 81 | 41 | 14 | 42 | 25 | 35 | 18 | 70 |
| ENSG00000225880.4 | 297 | 223 | 279 | 158 | 198 | 728 | 317 | 295 | 118 | 401 | 342 | 173 | 271 | 256 | 724 | 184 | 110 | 331 | 249 | 228 | 347 | 411 | 1385 | 912 | 623 | 175 | 350 | 503 | 172 | 175 |
| ENSG00000228794.4 | 1141 | 1444 | 1059 | 1056 | 1618 | 2003 | 1005 | 1375 | 1127 | 1371 | 2204 | 1366 | 1954 | 1118 | 1930 | 798 | 838 | 1251 | 1133 | 897 | 660 | 1033 | 1475 | 1710 | 1579 | 651 | 837 | 802 | 1499 | 2125 |
| ENSG00000230368.2 | 7 | 1 | 1 | 2 | 11 | 8 | 2 | 8 | 3 | 2 | 3 | 1 | 5 | 3 | 14 | 7 | 2 | 3 | 5 | 3 | 5 | 6 | 0 | 58 | 10 | 0 | 3 | 0 | 4 | 9 |
| ENSG00000234711.1 | 0 | 4 | 1 | 0 | 3 | 4 | 5 | 2 | 4 | 0 | 1 | 0 | 3 | 3 | 1 | 3 | 2 | 3 | 1 | 5 | 1 | 3 | 2 | 31 | 2 | 0 | 6 | 46 | 0 | 4 |
| ENSG00000269308.1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ENSG00000272438.1 | 5 | 1 | 3 | 0 | 8 | 17 | 3 | 20 | 9 | 8 | 3 | 1 | 8 | 2 | 7 | 4 | 3 | 4 | 3 | 2 | 1 | 1 | 26 | 7 | 19 | 2 | 6 | 3 | 3 | 2 |
| ENSG00000230699.2 | 26 | 7 | 44 | 10 | 74 | 114 | 32 | 70 | 89 | 26 | 24 | 19 | 58 | 35 | 12 | 27 | 33 | 52 | 9 | 18 | 11 | 26 | 93 | 1393 | 61 | 23 | 42 | 38 | 28 | 31 |
| ENSG00000241180.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ENSG00000223764.2 | 166 | 116 | 273 | 103 | 290 | 181 | 198 | 153 | 246 | 244 | 46 | 112 | 247 | 189 | 107 | 99 | 84 | 258 | 92 | 340 | 58 | 86 | 369 | 348 | 192 | 117 | 83 | 173 | 176 | 196 |
| ENSG00000187634.6 | 348 | 283 | 286 | 182 | 654 | 3256 | 349 | 580 | 1210 | 541 | 58 | 239 | 700 | 336 | 152 | 246 | 115 | 782 | 224 | 761 | 165 | 249 | 573 | 908 | 503 | 430 | 160 | 625 | 364 | 885 |
| ENSG00000268179.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ENSG00000188976.6 | 3111 | 4934 | 3177 | 3286 | 4670 | 7739 | 2922 | 3236 | 3554 | 5370 | 5505 | 2641 | 4600 | 3396 | 5058 | 3223 | 2464 | 4601 | 4211 | 2414 | 2863 | 2831 | 5100 | 4272 | 6149 | 3130 | 3182 | 4305 | 3545 | 5177 |
| ENSG00000187961.9 | 896 | 593 | 890 | 942 | 583 | 3737 | 854 | 1056 | 841 | 935 | 618 | 542 | 1355 | 863 | 2017 | 507 | 573 | 1059 | 724 | 656 | 1411 | 1234 | 2404 | 2519 | 1752 | 968 | 1092 | 1490 | 633 | 1874 |
| ENSG00000187583.6 | 53 | 48 | 37 | 56 | 54 | 150 | 58 | 263 | 64 | 35 | 454 | 111 | 77 | 101 | 300 | 29 | 14 | 151 | 72 | 124 | 89 | 119 | 614 | 304 | 273 | 133 | 63 | 368 | 72 | 231 |
| ENSG00000187642.5 | 19 | 31 | 14 | 22 | 27 | 109 | 26 | 89 | 10 | 22 | 97 | 45 | 32 | 25 | 90 | 22 | 16 | 64 | 31 | 77 | 18 | 63 | 207 | 95 | 105 | 46 | 24 | 181 | 72 | 113 |
| ENSG00000272512.1 | 318 | 85 | 145 | 175 | 82 | 408 | 190 | 659 | 43 | 121 | 151 | 163 | 107 | 65 | 79 | 18 | 191 | 150 | 196 | 246 | 37 | 75 | 207 | 234 | 250 | 38 | 70 | 106 | 127 | 241 |
| ENSG00000188290.6 | 854 | 354 | 725 | 367 | 238 | 810 | 631 | 1692 | 296 | 842 | 766 | 721 | 387 | 274 | 410 | 200 | 129 | 641 | 642 | 736 | 282 | 186 | 417 | 391 | 450 | 254 | 174 | 426 | 616 | 445 |
| ENSG00000231702.2 | 1 | 4 | 1 | 4 | 1 | 17 | 1 | 1 | 1 | 1 | 5 | 2 | 7 | 2 | 3 | 1 | 4 | 1 | 1 | 4 | 15 | 3 | 5 | 2 | 1 | 4 | 25 | 0 | 2 | 6 |
| ENSG00000224969.1 | 5 | 4 | 7 | 1 | 4 | 75 | 4 | 20 | 1 | 3 | 1 | 10 | 10 | 2 | 2 | 2 | 2 | 2 | 2 | 4 | 12 | 7 | 11 | 6 | 6 | 2 | 29 | 4 | 1 | 14 |
| ENSG00000187608.5 | 614 | 584 | 1037 | 297 | 632 | 1380 | 396 | 3197 | 787 | 755 | 5505 | 484 | 663 | 710 | 443 | 611 | 174 | 1050 | 691 | 834 | 716 | 413 | 1231 | 1650 | 1622 | 732 | 353 | 1051 | 1034 | 710 |
| ENSG00000188157.9 | 13046 | 17757 | 13573 | 14742 | 12621 | 40113 | 13808 | 13967 | 13776 | 16136 | 19950 | 19135 | 18902 | 18831 | 21424 | 9626 | 7208 | 17856 | 19340 | 9206 | 10900 | 12729 | 13701 | 21822 | 23783 | 9633 | 17342 | 10638 | 17499 | 10845 |
| ENSG00000217801.5 | 179 | 34 | 186 | 100 | 112 | 183 | 123 | 115 | 166 | 188 | 74 | 72 | 70 | 79 | 254 | 114 | 51 | 162 | 92 | 106 | 361 | 154 | 483 | 158 | 422 | 86 | 229 | 298 | 137 | 178 |
| ENSG00000273443.1 | 3 | 2 | 4 | 0 | 5 | 12 | 1 | 17 | 5 | 2 | 7 | 1 | 3 | 1 | 11 | 5 | 2 | 9 | 8 | 0 | 0 | 0 | 11 | 8 | 9 | 0 | 8 | 2 | 0 | 5 |
| ENSG00000237330.2 | 3 | 4 | 3 | 1 | 12 | 5 | 9 | 10 | 7 | 5 | 4 | 5 | 7 | 3 | 6 | 6 | 10 | 6 | 4 | 1 | 4 | 0 | 2 | 6 | 8 | 0 | 7 | 5 | 2 | 8 |
| ENSG00000131591.13 | 1647 | 872 | 1779 | 1242 | 1507 | 1195 | 1151 | 1473 | 753 | 1648 | 2192 | 1463 | 1699 | 1540 | 2700 | 985 | 690 | 1726 | 1394 | 993 | 757 | 928 | 2165 | 1676 | 2486 | 640 | 750 | 1832 | 1267 | 1514 |
| ENSG00000223823.1 | 6 | 3 | 1 | 0 | 16 | 9 | 1 | 3 | 3 | 1 | 0 | 3 | 1 | 4 | 8 | 4 | 8 | 4 | 4 | 4 | 16 | 19 | 81 | 48 | 8 | 15 | 9 | 27 | 6 | 34 |
| ENSG00000207730.1 | 0 | 0 | 1 | 2 | 2 | 3 | 0 | 1 | 0 | 1 | 0 | 0 | 2 | 1 | 5 | 0 | 1 | 1 | 0 | 1 | 3 | 0 | 1 | 0 | 2 | 1 | 3 | 0 | 0 | 0 |
| ENSG00000207607.1 | 0 | 1 | 0 | 2 | 1 | 1 | 5 | 2 | 2 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 0 | 2 |
| ENSG00000198976.1 | 1 | 0 | 2 | 1 | 1 | 4 | 1 | 0 | 2 | 0 | 1 | 1 | 2 | 7 | 1 | 0 | 1 | 4 | 1 | 0 | 2 | 1 | 2 | 1 | 4 | 1 | 0 | 1 | 0 | 0 |
| ENSG00000272141.1 | 338 | 218 | 330 | 544 | 461 | 829 | 613 | 281 | 217 | 552 | 194 | 128 | 511 | 411 | 562 | 162 | 108 | 691 | 493 | 156 | 478 | 333 | 501 | 283 | 450 | 55 | 305 | 158 | 78 | 210 |
| ENSG00000205231.1 | 10 | 6 | 8 | 8 | 25 | 10 | 12 | 7 | 3 | 20 | 7 | 2 | 8 | 9 | 19 | 8 | 10 | 22 | 10 | 8 | 19 | 12 | 23 | 12 | 26 | 1 | 9 | 20 | 2 | 38 |
| ENSG00000162571.9 | 47 | 14 | 31 | 51 | 75 | 45 | 24 | 36 | 30 | 192 | 61 | 33 | 16 | 20 | 63 | 69 | 14 | 42 | 30 | 31 | 48 | 24 | 51 | 38 | 55 | 3 | 19 | 36 | 12 | 70 |
| ENSG00000186891.9 | 32 | 11 | 41 | 23 | 37 | 263 | 14 | 124 | 31 | 28 | 114 | 600 | 22 | 29 | 197 | 39 | 23 | 204 | 66 | 138 | 154 | 127 | 1312 | 528 | 687 | 270 | 9 | 566 | 98 | 377 |
| ENSG00000186827.6 | 366 | 329 | 308 | 362 | 295 | 419 | 83 | 201 | 244 | 252 | 448 | 191 | 95 | 175 | 690 | 120 | 71 | 338 | 407 | 239 | 284 | 219 | 2053 | 1042 | 876 | 328 | 138 | 382 | 174 | 549 |
| ENSG00000078808.12 | 6325 | 11415 | 7244 | 6681 | 8001 | 16069 | 7918 | 6605 | 9729 | 10872 | 10761 | 7149 | 10552 | 8896 | 8649 | 6452 | 4655 | 9425 | 9384 | 7007 | 5031 | 5497 | 11858 | 10105 | 10908 | 10329 | 7330 | 7251 | 8946 | 7627 |
| ENSG00000176022.3 | 767 | 1634 | 959 | 938 | 1476 | 1659 | 840 | 513 | 1468 | 1347 | 1430 | 570 | 1432 | 1360 | 661 | 761 | 636 | 1098 | 1576 | 817 | 499 | 554 | 1531 | 1257 | 1487 | 1299 | 623 | 1014 | 1271 | 1491 |
| ENSG00000184163.3 | 79 | 44 | 46 | 40 | 76 | 94 | 65 | 50 | 62 | 57 | 194 | 81 | 66 | 69 | 55 | 18 | 16 | 52 | 34 | 83 | 42 | 44 | 50 | 37 | 85 | 41 | 34 | 48 | 32 | 73 |
| ENSG00000260179.1 | 24 | 25 | 4 | 19 | 77 | 53 | 24 | 19 | 20 | 25 | 56 | 35 | 46 | 19 | 22 | 23 | 127 | 56 | 27 | 10 | 29 | 43 | 28 | 25 | 27 | 17 | 25 | 13 | 8 | 30 |
| ENSG00000160087.16 | 2038 | 3378 | 1713 | 2236 | 2740 | 8086 | 2342 | 2341 | 2989 | 3222 | 3355 | 2407 | 3557 | 2605 | 3422 | 1696 | 1484 | 4060 | 2864 | 1664 | 2342 | 2287 | 4604 | 3685 | 3637 | 2710 | 2202 | 3297 | 2186 | 3400 |
| ENSG00000230415.1 | 83 | 48 | 102 | 50 | 68 | 113 | 67 | 48 | 82 | 127 | 32 | 49 | 95 | 94 | 63 | 53 | 30 | 117 | 56 | 40 | 143 | 57 | 220 | 144 | 198 | 60 | 186 | 76 | 53 | 74 |
| ENSG00000162572.15 | 1044 | 332 | 1193 | 581 | 677 | 2708 | 772 | 689 | 948 | 1382 | 265 | 469 | 755 | 1004 | 1277 | 526 | 254 | 1160 | 746 | 826 | 1617 | 785 | 2589 | 1535 | 2849 | 575 | 1515 | 918 | 720 | 1053 |
| ENSG00000131584.14 | 6325 | 3683 | 5951 | 3606 | 4910 | 9622 | 3839 | 5792 | 3677 | 6961 | 2875 | 3224 | 7823 | 5214 | 5451 | 3173 | 2542 | 4972 | 5452 | 4347 | 3471 | 4136 | 8329 | 9033 | 8497 | 3493 | 2594 | 5850 | 4125 | 5342 |
| ENSG00000169972.7 | 412 | 448 | 350 | 409 | 509 | 947 | 331 | 344 | 439 | 675 | 382 | 328 | 639 | 501 | 750 | 351 | 207 | 811 | 633 | 251 | 267 | 307 | 693 | 664 | 575 | 473 | 278 | 503 | 360 | 747 |
| ENSG00000127054.14 | 8580 | 6876 | 8249 | 6986 | 7672 | 18996 | 7345 | 9752 | 7067 | 11663 | 8356 | 6811 | 10109 | 8198 | 17346 | 6006 | 4096 | 12994 | 7372 | 5965 | 8423 | 8452 | 15686 | 12536 | 14403 | 5409 | 11132 | 9282 | 6396 | 10527 |
| ENSG00000240731.1 | 305 | 222 | 251 | 282 | 359 | 715 | 267 | 349 | 314 | 466 | 269 | 292 | 356 | 359 | 683 | 269 | 234 | 526 | 343 | 180 | 349 | 311 | 562 | 453 | 422 | 174 | 552 | 253 | 187 | 459 |
| ENSG00000224051.2 | 1224 | 1655 | 1574 | 1198 | 1578 | 3155 | 1159 | 954 | 1692 | 1879 | 1391 | 1145 | 1912 | 1683 | 2324 | 1074 | 1152 | 1634 | 1337 | 1230 | 1101 | 1107 | 2464 | 2313 | 3042 | 1785 | 1227 | 2174 | 1566 | 2596 |
| ENSG00000169962.4 | 103 | 131 | 88 | 73 | 80 | 660 | 115 | 192 | 116 | 112 | 82 | 157 | 99 | 107 | 223 | 63 | 36 | 232 | 100 | 84 | 170 | 241 | 1481 | 710 | 374 | 391 | 122 | 733 | 112 | 441 |
| ENSG00000107404.13 | 5411 | 4415 | 5534 | 4810 | 4774 | 17137 | 4592 | 5723 | 4993 | 6692 | 5775 | 5918 | 7387 | 5839 | 9026 | 3745 | 3082 | 8265 | 6086 | 3969 | 3984 | 4702 | 7338 | 8266 | 8374 | 3795 | 5249 | 5436 | 4778 | 6645 |
Tabla 2: tabla que muestra los 100 primeros genes de la matriz cruda contenida en el archivo counts_sub.csv.
| X | Experiment | SRA_Sample | Sample_Name | Grupo_analisis | body_site | molecular_data_type | sex | Group | ShortName | color |
|---|---|---|---|---|---|---|---|---|---|---|
| NIT_1 | SRX624388 | SRS645976 | GTEX-ZAK1-0726-SM-5HL8Q | 1 | Thyroid | RNA Seq (NGS) | female | NIT | ZAK1-_NIT | #238A8DFF |
| NIT_2 | SRX567480 | SRS626942 | GTEX-111CU-0226-SM-5GZXC | 1 | Thyroid | Allele-Specific Expression | male | NIT | 111CU_NIT | #238A8DFF |
| NIT_3 | SRX641246 | SRS650218 | GTEX-1313W-0726-SM-5EGK1 | 1 | Thyroid | Allele-Specific Expression | female | NIT | 1313W_NIT | #238A8DFF |
| NIT_4 | SRX618348 | SRS644565 | GTEX-13X6H-0526-SM-5LU4Q | 1 | Thyroid | RNA Seq (NGS) | female | NIT | 13X6H_NIT | #238A8DFF |
| NIT_5 | SRX199266 | SRS333318 | GTEX-PX3G-2626-SM-2I3EG | 1 | Thyroid | RNA Seq (NGS) | female | NIT | PX3G-_NIT | #238A8DFF |
| NIT_6 | SRX628518 | SRS648208 | GTEX-13PDP-1026-SM-5L3FA | 1 | Thyroid | RNA Seq (NGS) | male | NIT | 13PDP_NIT | #238A8DFF |
| NIT_7 | SRX578920 | SRS629748 | GTEX-11P7K-0226-SM-5986Z | 1 | Thyroid | RNA Seq (NGS) | male | NIT | 11P7K_NIT | #238A8DFF |
| NIT_8 | SRX633577 | SRS648785 | GTEX-1269C-0226-SM-5EGKS | 1 | Thyroid | RNA Seq (NGS) | female | NIT | 1269C_NIT | #238A8DFF |
| NIT_9 | SRX570501 | SRS627527 | GTEX-1399R-0126-SM-5IFEV | 1 | Thyroid | RNA Seq (NGS) | male | NIT | 1399R_NIT | #238A8DFF |
| NIT_10 | SRX630361 | SRS648411 | GTEX-13112-0326-SM-5P9IW | 1 | Thyroid | Allele-Specific Expression | male | NIT | 13112_NIT | #238A8DFF |
| SFI_1 | SRX614680 | SRS644012 | GTEX-13O1R-0826-SM-5J2MB | 2 | Thyroid | RNA Seq (NGS) | male | SFI | 13O1R_SFI | #DCE319FF |
| SFI_2 | SRX597654 | SRS637303 | GTEX-139UW-0126-SM-5KM1B | 2 | Thyroid | Allele-Specific Expression | male | SFI | 139UW_SFI | #DCE319FF |
| SFI_3 | SRX558144 | SRS623916 | GTEX-11EQ9-0626-SM-5A5K1 | 2 | Thyroid | RNA Seq (NGS) | male | SFI | 11EQ9_SFI | #DCE319FF |
| SFI_4 | SRX622888 | SRS645805 | GTEX-S341-0226-SM-5S2VG | 2 | Thyroid | RNA Seq (NGS) | female | SFI | S341-_SFI | #DCE319FF |
| SFI_5 | SRX221390 | SRS389060 | GTEX-TSE9-0626-SM-3DB8B | 2 | Thyroid | RNA Seq (NGS) | female | SFI | TSE9-_SFI | #DCE319FF |
| SFI_6 | SRX567279 | SRS626844 | GTEX-12ZZY-0826-SM-5EQMT | 2 | Thyroid | RNA Seq (NGS) | male | SFI | 12ZZY_SFI | #DCE319FF |
| SFI_7 | SRX204008 | SRS374961 | GTEX-R55C-0626-SM-2TF4Q | 2 | Thyroid | Allele-Specific Expression | male | SFI | R55C-_SFI | #DCE319FF |
| SFI_8 | SRX260552 | SRS408366 | GTEX-WYVS-0326-SM-3NM9V | 2 | Thyroid | RNA Seq (NGS) | female | SFI | WYVS-_SFI | #DCE319FF |
| SFI_9 | SRX407488 | SRS524425 | GTEX-XMK1-0626-SM-4B65A | 2 | Thyroid | RNA Seq (NGS) | male | SFI | XMK1-_SFI | #DCE319FF |
| SFI_10 | SRX596158 | SRS636581 | GTEX-ZE7O-1126-SM-57WC8 | 2 | Thyroid | Allele-Specific Expression | female | SFI | ZE7O-_SFI | #DCE319FF |
| ELI_1 | SRX607358 | SRS639491 | GTEX-14AS3-0226-SM-5Q5B6 | 3 | Thyroid | RNA Seq (NGS) | female | ELI | 14AS3_ELI | #481567FF |
| ELI_2 | SRX601511 | SRS638114 | GTEX-13QJC-0826-SM-5RQKC | 3 | Thyroid | Allele-Specific Expression | female | ELI | 13QJC_ELI | #481567FF |
| ELI_3 | SRX615373 | SRS644099 | GTEX-YFC4-2626-SM-5P9FQ | 3 | Thyroid | Allele-Specific Expression | female | ELI | YFC4-_ELI | #481567FF |
| ELI_4 | SRX582762 | SRS631169 | GTEX-13NZ9-1126-SM-5MR37 | 3 | Thyroid | RNA Seq (NGS) | male | ELI | 13NZ9_ELI | #481567FF |
| ELI_5 | SRX583148 | SRS631283 | GTEX-YJ89-0726-SM-5P9F7 | 3 | Thyroid | RNA Seq (NGS) | male | ELI | YJ89-_ELI | #481567FF |
| ELI_6 | SRX568916 | SRS627158 | GTEX-14BMU-0226-SM-5S2QA | 3 | Thyroid | Allele-Specific Expression | female | ELI | 14BMU_ELI | #481567FF |
| ELI_7 | SRX199272 | SRS333099 | GTEX-PLZ4-1226-SM-2I5FE | 3 | Thyroid | RNA Seq (NGS) | female | ELI | PLZ4-_ELI | #481567FF |
| ELI_8 | SRX628009 | SRS648152 | GTEX-11NV4-0626-SM-5N9BR | 3 | Thyroid | RNA Seq (NGS) | male | ELI | 11NV4_ELI | #481567FF |
| ELI_9 | SRX575932 | SRS629299 | GTEX-14ABY-0926-SM-5Q5DY | 3 | Thyroid | Allele-Specific Expression | male | ELI | 14ABY_ELI | #481567FF |
| ELI_10 | SRX222429 | SRS389623 | GTEX-TMMY-0826-SM-33HB9 | 3 | Thyroid | Allele-Specific Expression | female | ELI | TMMY-_ELI | #481567FF |
Tabla 3: tabla que muestra los metadatos relacionados con las 30 muestras seleccionadas.
Una vez creado el objeto DESeqDataSet, se ha realizado un filtrado con el objetivo de eliminar aquellos genes que no están expresados en ninguna de las 30 muestras. Este filtrado ha permitido eliminar 9421 genes, pasando de a 46781. A continuación se muestran los primeros 100 genes de la matriz de counts filtrada (Tabla 4).
| NIT_1 | NIT_2 | NIT_3 | NIT_4 | NIT_5 | NIT_6 | NIT_7 | NIT_8 | NIT_9 | NIT_10 | SFI_1 | SFI_2 | SFI_3 | SFI_4 | SFI_5 | SFI_6 | SFI_7 | SFI_8 | SFI_9 | SFI_10 | ELI_1 | ELI_2 | ELI_3 | ELI_4 | ELI_5 | ELI_6 | ELI_7 | ELI_8 | ELI_9 | ELI_10 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ENSG00000223972.4 | 0 | 7 | 2 | 2 | 8 | 0 | 4 | 1 | 3 | 3 | 3 | 2 | 6 | 2 | 3 | 2 | 9 | 6 | 9 | 1 | 0 | 0 | 1 | 0 | 4 | 2 | 5 | 3 | 1 | 3 |
| ENSG00000227232.4 | 555 | 401 | 890 | 468 | 636 | 1487 | 840 | 925 | 517 | 600 | 460 | 430 | 640 | 457 | 1704 | 491 | 302 | 820 | 568 | 713 | 834 | 825 | 1472 | 1002 | 1325 | 423 | 489 | 1301 | 775 | 979 |
| ENSG00000243485.2 | 1 | 4 | 1 | 1 | 5 | 1 | 0 | 0 | 2 | 1 | 0 | 0 | 4 | 1 | 1 | 2 | 4 | 0 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 2 | 3 |
| ENSG00000237613.2 | 2 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 3 | 2 | 1 | 0 | 2 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 2 |
| ENSG00000268020.2 | 1 | 0 | 1 | 0 | 2 | 0 | 0 | 0 | 1 | 4 | 2 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 0 | 0 | 5 |
| ENSG00000240361.1 | 1 | 0 | 0 | 1 | 3 | 2 | 2 | 0 | 3 | 0 | 0 | 0 | 3 | 2 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 8 |
| ENSG00000186092.4 | 1 | 0 | 2 | 1 | 4 | 2 | 2 | 1 | 2 | 0 | 1 | 0 | 1 | 3 | 0 | 1 | 2 | 5 | 1 | 1 | 0 | 1 | 2 | 0 | 2 | 0 | 3 | 0 | 1 | 3 |
| ENSG00000238009.2 | 5 | 6 | 5 | 8 | 4 | 26 | 7 | 17 | 8 | 9 | 7 | 9 | 5 | 9 | 5 | 7 | 10 | 12 | 5 | 18 | 6 | 10 | 38 | 15 | 4 | 18 | 7 | 5 | 10 | 4 |
| ENSG00000233750.3 | 11 | 16 | 16 | 16 | 123 | 46 | 26 | 19 | 14 | 25 | 12 | 9 | 16 | 14 | 22 | 4 | 74 | 18 | 14 | 2 | 6 | 21 | 24 | 19 | 8 | 6 | 100 | 7 | 2 | 81 |
| ENSG00000237683.5 | 326 | 744 | 1126 | 528 | 1400 | 2032 | 522 | 813 | 154 | 1184 | 279 | 679 | 415 | 565 | 2536 | 552 | 674 | 973 | 738 | 511 | 445 | 853 | 2020 | 602 | 853 | 325 | 523 | 1132 | 580 | 527 |
| ENSG00000268903.1 | 1 | 1 | 6 | 1 | 2 | 7 | 2 | 2 | 1 | 3 | 2 | 1 | 0 | 5 | 9 | 2 | 4 | 0 | 1 | 4 | 2 | 6 | 13 | 2 | 7 | 1 | 2 | 4 | 1 | 1 |
| ENSG00000239906.1 | 0 | 10 | 10 | 4 | 13 | 19 | 8 | 2 | 0 | 35 | 7 | 8 | 4 | 10 | 84 | 5 | 8 | 20 | 10 | 8 | 2 | 16 | 25 | 32 | 17 | 4 | 3 | 2 | 4 | 5 |
| ENSG00000241860.2 | 31 | 58 | 52 | 71 | 138 | 140 | 42 | 40 | 65 | 80 | 41 | 95 | 66 | 47 | 120 | 102 | 116 | 101 | 67 | 70 | 40 | 94 | 196 | 96 | 94 | 41 | 183 | 46 | 69 | 115 |
| ENSG00000222623.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ENSG00000241599.1 | 0 | 2 | 0 | 0 | 1 | 0 | 1 | 0 | 2 | 1 | 1 | 0 | 1 | 0 | 4 | 1 | 1 | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 3 |
| ENSG00000228463.4 | 66 | 40 | 29 | 31 | 113 | 258 | 42 | 58 | 8 | 64 | 16 | 26 | 18 | 64 | 53 | 95 | 16 | 66 | 52 | 7 | 66 | 98 | 52 | 39 | 44 | 42 | 21 | 92 | 5 | 42 |
| ENSG00000237094.7 | 36 | 24 | 63 | 21 | 50 | 101 | 30 | 41 | 19 | 69 | 37 | 10 | 26 | 27 | 99 | 39 | 22 | 43 | 30 | 63 | 38 | 58 | 70 | 43 | 64 | 14 | 95 | 16 | 11 | 46 |
| ENSG00000250575.1 | 1 | 4 | 2 | 1 | 1 | 6 | 0 | 4 | 4 | 1 | 1 | 4 | 1 | 3 | 3 | 2 | 3 | 6 | 7 | 1 | 1 | 6 | 5 | 6 | 6 | 0 | 2 | 2 | 1 | 2 |
| ENSG00000233653.3 | 6 | 5 | 3 | 8 | 16 | 9 | 5 | 2 | 10 | 7 | 6 | 5 | 7 | 3 | 6 | 3 | 8 | 9 | 7 | 5 | 2 | 8 | 7 | 4 | 7 | 2 | 13 | 1 | 5 | 16 |
| ENSG00000235249.1 | 0 | 3 | 3 | 0 | 2 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 0 | 2 | 2 | 0 | 3 | 3 | 2 | 1 | 0 | 1 | 3 | 0 | 0 | 0 | 5 | 0 | 1 | 3 |
| ENSG00000269732.1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 4 | 0 | 1 | 0 | 0 | 0 |
| ENSG00000256186.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ENSG00000236601.1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 2 | 0 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 |
| ENSG00000236743.1 | 1 | 1 | 1 | 0 | 9 | 0 | 0 | 2 | 2 | 0 | 3 | 0 | 3 | 0 | 2 | 2 | 4 | 3 | 3 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 3 | 1 | 0 | 1 |
| ENSG00000236679.2 | 0 | 1 | 1 | 0 | 7 | 2 | 1 | 1 | 4 | 0 | 4 | 2 | 5 | 3 | 2 | 3 | 63 | 2 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 7 | 1 | 3 | 7 |
| ENSG00000231709.1 | 0 | 0 | 3 | 0 | 9 | 2 | 1 | 2 | 1 | 0 | 2 | 2 | 6 | 0 | 5 | 3 | 5 | 6 | 10 | 0 | 1 | 4 | 2 | 11 | 6 | 2 | 2 | 1 | 2 | 1 |
| ENSG00000235146.2 | 1 | 2 | 2 | 2 | 3 | 0 | 2 | 2 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 0 | 1 | 0 | 2 | 0 | 2 | 19 | 0 | 6 |
| ENSG00000239664.2 | 3 | 0 | 2 | 1 | 2 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9 | 0 | 5 |
| ENSG00000230021.3 | 1 | 0 | 2 | 2 | 9 | 7 | 2 | 5 | 1 | 4 | 3 | 2 | 5 | 1 | 5 | 3 | 3 | 9 | 3 | 2 | 7 | 3 | 2 | 6 | 2 | 4 | 13 | 11 | 0 | 5 |
| ENSG00000223659.1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 1 | 1 | 0 | 1 | 2 | 1 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5 | 0 | 0 | 1 |
| ENSG00000225972.1 | 85 | 90 | 44 | 40 | 245 | 65 | 21820 | 82 | 72 | 66 | 99 | 54 | 137 | 18178 | 112 | 50 | 198 | 49 | 81 | 37 | 33 | 55 | 54 | 4678 | 50 | 25 | 132 | 23 | 37 | 330 |
| ENSG00000225630.1 | 9976 | 21118 | 25431 | 14239 | 13191 | 9374 | 7184 | 15349 | 15277 | 11952 | 13275 | 7455 | 22629 | 10859 | 13990 | 6257 | 10602 | 14976 | 34546 | 6973 | 9934 | 18090 | 12782 | 8450 | 27107 | 7614 | 12211 | 8718 | 10398 | 64325 |
| ENSG00000237973.1 | 763 | 2056 | 439 | 1787 | 3819 | 599 | 13349 | 1553 | 3465 | 732 | 598 | 640 | 3860 | 8778 | 841 | 1202 | 3276 | 4620 | 2456 | 347 | 2421 | 1134 | 483 | 136 | 2583 | 821 | 1117 | 242 | 232 | 6292 |
| ENSG00000229344.1 | 201 | 317 | 158 | 175 | 646 | 181 | 396 | 262 | 332 | 187 | 265 | 132 | 574 | 188 | 375 | 201 | 320 | 319 | 211 | 132 | 108 | 161 | 164 | 85 | 212 | 88 | 651 | 93 | 125 | 694 |
| ENSG00000240409.1 | 87 | 125 | 61 | 45 | 119 | 30 | 117 | 97 | 64 | 40 | 54 | 30 | 136 | 102 | 180 | 60 | 67 | 84 | 75 | 26 | 28 | 28 | 23 | 15 | 874 | 17 | 84 | 17 | 36 | 187 |
| ENSG00000248527.1 | 40212 | 64520 | 22403 | 42558 | 59705 | 15094 | 38541 | 42834 | 35428 | 49856 | 34733 | 19953 | 78315 | 49299 | 26600 | 25829 | 35965 | 60613 | 36803 | 7805 | 32781 | 37487 | 34261 | 24593 | 54523 | 22813 | 32813 | 15457 | 24181 | 67070 |
| ENSG00000198744.5 | 243 | 268 | 210 | 154 | 19806 | 152 | 360 | 272 | 263 | 214 | 335 | 181 | 809 | 183 | 665 | 231 | 512 | 322 | 270 | 97 | 146 | 120 | 183 | 43 | 291 | 70 | 656 | 76 | 217 | 910 |
| ENSG00000268663.1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 0 | 1 | 1 | 1 | 0 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
| ENSG00000185097.2 | 1 | 0 | 0 | 0 | 1 | 0 | 2 | 1 | 2 | 0 | 1 | 1 | 0 | 2 | 2 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 2 |
| ENSG00000229376.3 | 17 | 25 | 11 | 9 | 38 | 44 | 32 | 21 | 14 | 23 | 9 | 5 | 29 | 7 | 20 | 16 | 19 | 22 | 18 | 5 | 15 | 18 | 14 | 20 | 16 | 25 | 37 | 5 | 13 | 23 |
| ENSG00000224956.5 | 403 | 143 | 366 | 232 | 281 | 435 | 256 | 347 | 164 | 441 | 385 | 247 | 283 | 9 | 737 | 202 | 79 | 434 | 242 | 243 | 217 | 260 | 331 | 284 | 676 | 130 | 218 | 195 | 204 | 323 |
| ENSG00000235373.1 | 17 | 24 | 28 | 13 | 33 | 21 | 23 | 15 | 15 | 29 | 27 | 15 | 28 | 13 | 16 | 9 | 19 | 33 | 35 | 8 | 8 | 11 | 31 | 26 | 15 | 8 | 41 | 11 | 24 | 33 |
| ENSG00000223181.1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| ENSG00000240618.1 | 11 | 3 | 26 | 6 | 0 | 2 | 2 | 0 | 7 | 7 | 5 | 1 | 8 | 1 | 16 | 0 | 9 | 9 | 9 | 0 | 2 | 6 | 14 | 3 | 5 | 0 | 9 | 2 | 3 | 5 |
| ENSG00000229905.1 | 0 | 0 | 0 | 2 | 2 | 0 | 4 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 3 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
| ENSG00000228327.2 | 72 | 114 | 106 | 146 | 152 | 72 | 83 | 71 | 73 | 156 | 165 | 72 | 110 | 119 | 135 | 78 | 64 | 147 | 153 | 56 | 75 | 160 | 313 | 196 | 118 | 89 | 140 | 43 | 99 | 213 |
| ENSG00000237491.4 | 96 | 113 | 101 | 125 | 306 | 209 | 116 | 53 | 66 | 215 | 159 | 60 | 175 | 153 | 241 | 95 | 152 | 161 | 224 | 64 | 240 | 166 | 638 | 342 | 155 | 108 | 110 | 224 | 90 | 283 |
| ENSG00000230092.3 | 12 | 13 | 12 | 16 | 28 | 18 | 5 | 5 | 5 | 11 | 10 | 13 | 18 | 21 | 55 | 18 | 5 | 15 | 37 | 15 | 19 | 10 | 92 | 23 | 9 | 18 | 13 | 18 | 13 | 47 |
| ENSG00000269831.1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 3 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| ENSG00000177757.1 | 12 | 41 | 18 | 32 | 47 | 34 | 44 | 7 | 31 | 40 | 72 | 22 | 65 | 28 | 21 | 18 | 36 | 53 | 57 | 30 | 28 | 24 | 81 | 41 | 14 | 42 | 25 | 35 | 18 | 70 |
| ENSG00000225880.4 | 297 | 223 | 279 | 158 | 198 | 728 | 317 | 295 | 118 | 401 | 342 | 173 | 271 | 256 | 724 | 184 | 110 | 331 | 249 | 228 | 347 | 411 | 1385 | 912 | 623 | 175 | 350 | 503 | 172 | 175 |
| ENSG00000228794.4 | 1141 | 1444 | 1059 | 1056 | 1618 | 2003 | 1005 | 1375 | 1127 | 1371 | 2204 | 1366 | 1954 | 1118 | 1930 | 798 | 838 | 1251 | 1133 | 897 | 660 | 1033 | 1475 | 1710 | 1579 | 651 | 837 | 802 | 1499 | 2125 |
| ENSG00000230368.2 | 7 | 1 | 1 | 2 | 11 | 8 | 2 | 8 | 3 | 2 | 3 | 1 | 5 | 3 | 14 | 7 | 2 | 3 | 5 | 3 | 5 | 6 | 0 | 58 | 10 | 0 | 3 | 0 | 4 | 9 |
| ENSG00000234711.1 | 0 | 4 | 1 | 0 | 3 | 4 | 5 | 2 | 4 | 0 | 1 | 0 | 3 | 3 | 1 | 3 | 2 | 3 | 1 | 5 | 1 | 3 | 2 | 31 | 2 | 0 | 6 | 46 | 0 | 4 |
| ENSG00000269308.1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ENSG00000272438.1 | 5 | 1 | 3 | 0 | 8 | 17 | 3 | 20 | 9 | 8 | 3 | 1 | 8 | 2 | 7 | 4 | 3 | 4 | 3 | 2 | 1 | 1 | 26 | 7 | 19 | 2 | 6 | 3 | 3 | 2 |
| ENSG00000230699.2 | 26 | 7 | 44 | 10 | 74 | 114 | 32 | 70 | 89 | 26 | 24 | 19 | 58 | 35 | 12 | 27 | 33 | 52 | 9 | 18 | 11 | 26 | 93 | 1393 | 61 | 23 | 42 | 38 | 28 | 31 |
| ENSG00000223764.2 | 166 | 116 | 273 | 103 | 290 | 181 | 198 | 153 | 246 | 244 | 46 | 112 | 247 | 189 | 107 | 99 | 84 | 258 | 92 | 340 | 58 | 86 | 369 | 348 | 192 | 117 | 83 | 173 | 176 | 196 |
| ENSG00000187634.6 | 348 | 283 | 286 | 182 | 654 | 3256 | 349 | 580 | 1210 | 541 | 58 | 239 | 700 | 336 | 152 | 246 | 115 | 782 | 224 | 761 | 165 | 249 | 573 | 908 | 503 | 430 | 160 | 625 | 364 | 885 |
| ENSG00000268179.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ENSG00000188976.6 | 3111 | 4934 | 3177 | 3286 | 4670 | 7739 | 2922 | 3236 | 3554 | 5370 | 5505 | 2641 | 4600 | 3396 | 5058 | 3223 | 2464 | 4601 | 4211 | 2414 | 2863 | 2831 | 5100 | 4272 | 6149 | 3130 | 3182 | 4305 | 3545 | 5177 |
| ENSG00000187961.9 | 896 | 593 | 890 | 942 | 583 | 3737 | 854 | 1056 | 841 | 935 | 618 | 542 | 1355 | 863 | 2017 | 507 | 573 | 1059 | 724 | 656 | 1411 | 1234 | 2404 | 2519 | 1752 | 968 | 1092 | 1490 | 633 | 1874 |
| ENSG00000187583.6 | 53 | 48 | 37 | 56 | 54 | 150 | 58 | 263 | 64 | 35 | 454 | 111 | 77 | 101 | 300 | 29 | 14 | 151 | 72 | 124 | 89 | 119 | 614 | 304 | 273 | 133 | 63 | 368 | 72 | 231 |
| ENSG00000187642.5 | 19 | 31 | 14 | 22 | 27 | 109 | 26 | 89 | 10 | 22 | 97 | 45 | 32 | 25 | 90 | 22 | 16 | 64 | 31 | 77 | 18 | 63 | 207 | 95 | 105 | 46 | 24 | 181 | 72 | 113 |
| ENSG00000272512.1 | 318 | 85 | 145 | 175 | 82 | 408 | 190 | 659 | 43 | 121 | 151 | 163 | 107 | 65 | 79 | 18 | 191 | 150 | 196 | 246 | 37 | 75 | 207 | 234 | 250 | 38 | 70 | 106 | 127 | 241 |
| ENSG00000188290.6 | 854 | 354 | 725 | 367 | 238 | 810 | 631 | 1692 | 296 | 842 | 766 | 721 | 387 | 274 | 410 | 200 | 129 | 641 | 642 | 736 | 282 | 186 | 417 | 391 | 450 | 254 | 174 | 426 | 616 | 445 |
| ENSG00000231702.2 | 1 | 4 | 1 | 4 | 1 | 17 | 1 | 1 | 1 | 1 | 5 | 2 | 7 | 2 | 3 | 1 | 4 | 1 | 1 | 4 | 15 | 3 | 5 | 2 | 1 | 4 | 25 | 0 | 2 | 6 |
| ENSG00000224969.1 | 5 | 4 | 7 | 1 | 4 | 75 | 4 | 20 | 1 | 3 | 1 | 10 | 10 | 2 | 2 | 2 | 2 | 2 | 2 | 4 | 12 | 7 | 11 | 6 | 6 | 2 | 29 | 4 | 1 | 14 |
| ENSG00000187608.5 | 614 | 584 | 1037 | 297 | 632 | 1380 | 396 | 3197 | 787 | 755 | 5505 | 484 | 663 | 710 | 443 | 611 | 174 | 1050 | 691 | 834 | 716 | 413 | 1231 | 1650 | 1622 | 732 | 353 | 1051 | 1034 | 710 |
| ENSG00000188157.9 | 13046 | 17757 | 13573 | 14742 | 12621 | 40113 | 13808 | 13967 | 13776 | 16136 | 19950 | 19135 | 18902 | 18831 | 21424 | 9626 | 7208 | 17856 | 19340 | 9206 | 10900 | 12729 | 13701 | 21822 | 23783 | 9633 | 17342 | 10638 | 17499 | 10845 |
| ENSG00000217801.5 | 179 | 34 | 186 | 100 | 112 | 183 | 123 | 115 | 166 | 188 | 74 | 72 | 70 | 79 | 254 | 114 | 51 | 162 | 92 | 106 | 361 | 154 | 483 | 158 | 422 | 86 | 229 | 298 | 137 | 178 |
| ENSG00000273443.1 | 3 | 2 | 4 | 0 | 5 | 12 | 1 | 17 | 5 | 2 | 7 | 1 | 3 | 1 | 11 | 5 | 2 | 9 | 8 | 0 | 0 | 0 | 11 | 8 | 9 | 0 | 8 | 2 | 0 | 5 |
| ENSG00000237330.2 | 3 | 4 | 3 | 1 | 12 | 5 | 9 | 10 | 7 | 5 | 4 | 5 | 7 | 3 | 6 | 6 | 10 | 6 | 4 | 1 | 4 | 0 | 2 | 6 | 8 | 0 | 7 | 5 | 2 | 8 |
| ENSG00000131591.13 | 1647 | 872 | 1779 | 1242 | 1507 | 1195 | 1151 | 1473 | 753 | 1648 | 2192 | 1463 | 1699 | 1540 | 2700 | 985 | 690 | 1726 | 1394 | 993 | 757 | 928 | 2165 | 1676 | 2486 | 640 | 750 | 1832 | 1267 | 1514 |
| ENSG00000223823.1 | 6 | 3 | 1 | 0 | 16 | 9 | 1 | 3 | 3 | 1 | 0 | 3 | 1 | 4 | 8 | 4 | 8 | 4 | 4 | 4 | 16 | 19 | 81 | 48 | 8 | 15 | 9 | 27 | 6 | 34 |
| ENSG00000207730.1 | 0 | 0 | 1 | 2 | 2 | 3 | 0 | 1 | 0 | 1 | 0 | 0 | 2 | 1 | 5 | 0 | 1 | 1 | 0 | 1 | 3 | 0 | 1 | 0 | 2 | 1 | 3 | 0 | 0 | 0 |
| ENSG00000207607.1 | 0 | 1 | 0 | 2 | 1 | 1 | 5 | 2 | 2 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 0 | 2 |
| ENSG00000198976.1 | 1 | 0 | 2 | 1 | 1 | 4 | 1 | 0 | 2 | 0 | 1 | 1 | 2 | 7 | 1 | 0 | 1 | 4 | 1 | 0 | 2 | 1 | 2 | 1 | 4 | 1 | 0 | 1 | 0 | 0 |
| ENSG00000272141.1 | 338 | 218 | 330 | 544 | 461 | 829 | 613 | 281 | 217 | 552 | 194 | 128 | 511 | 411 | 562 | 162 | 108 | 691 | 493 | 156 | 478 | 333 | 501 | 283 | 450 | 55 | 305 | 158 | 78 | 210 |
| ENSG00000205231.1 | 10 | 6 | 8 | 8 | 25 | 10 | 12 | 7 | 3 | 20 | 7 | 2 | 8 | 9 | 19 | 8 | 10 | 22 | 10 | 8 | 19 | 12 | 23 | 12 | 26 | 1 | 9 | 20 | 2 | 38 |
| ENSG00000162571.9 | 47 | 14 | 31 | 51 | 75 | 45 | 24 | 36 | 30 | 192 | 61 | 33 | 16 | 20 | 63 | 69 | 14 | 42 | 30 | 31 | 48 | 24 | 51 | 38 | 55 | 3 | 19 | 36 | 12 | 70 |
| ENSG00000186891.9 | 32 | 11 | 41 | 23 | 37 | 263 | 14 | 124 | 31 | 28 | 114 | 600 | 22 | 29 | 197 | 39 | 23 | 204 | 66 | 138 | 154 | 127 | 1312 | 528 | 687 | 270 | 9 | 566 | 98 | 377 |
| ENSG00000186827.6 | 366 | 329 | 308 | 362 | 295 | 419 | 83 | 201 | 244 | 252 | 448 | 191 | 95 | 175 | 690 | 120 | 71 | 338 | 407 | 239 | 284 | 219 | 2053 | 1042 | 876 | 328 | 138 | 382 | 174 | 549 |
| ENSG00000078808.12 | 6325 | 11415 | 7244 | 6681 | 8001 | 16069 | 7918 | 6605 | 9729 | 10872 | 10761 | 7149 | 10552 | 8896 | 8649 | 6452 | 4655 | 9425 | 9384 | 7007 | 5031 | 5497 | 11858 | 10105 | 10908 | 10329 | 7330 | 7251 | 8946 | 7627 |
| ENSG00000176022.3 | 767 | 1634 | 959 | 938 | 1476 | 1659 | 840 | 513 | 1468 | 1347 | 1430 | 570 | 1432 | 1360 | 661 | 761 | 636 | 1098 | 1576 | 817 | 499 | 554 | 1531 | 1257 | 1487 | 1299 | 623 | 1014 | 1271 | 1491 |
| ENSG00000184163.3 | 79 | 44 | 46 | 40 | 76 | 94 | 65 | 50 | 62 | 57 | 194 | 81 | 66 | 69 | 55 | 18 | 16 | 52 | 34 | 83 | 42 | 44 | 50 | 37 | 85 | 41 | 34 | 48 | 32 | 73 |
| ENSG00000260179.1 | 24 | 25 | 4 | 19 | 77 | 53 | 24 | 19 | 20 | 25 | 56 | 35 | 46 | 19 | 22 | 23 | 127 | 56 | 27 | 10 | 29 | 43 | 28 | 25 | 27 | 17 | 25 | 13 | 8 | 30 |
| ENSG00000160087.16 | 2038 | 3378 | 1713 | 2236 | 2740 | 8086 | 2342 | 2341 | 2989 | 3222 | 3355 | 2407 | 3557 | 2605 | 3422 | 1696 | 1484 | 4060 | 2864 | 1664 | 2342 | 2287 | 4604 | 3685 | 3637 | 2710 | 2202 | 3297 | 2186 | 3400 |
| ENSG00000230415.1 | 83 | 48 | 102 | 50 | 68 | 113 | 67 | 48 | 82 | 127 | 32 | 49 | 95 | 94 | 63 | 53 | 30 | 117 | 56 | 40 | 143 | 57 | 220 | 144 | 198 | 60 | 186 | 76 | 53 | 74 |
| ENSG00000162572.15 | 1044 | 332 | 1193 | 581 | 677 | 2708 | 772 | 689 | 948 | 1382 | 265 | 469 | 755 | 1004 | 1277 | 526 | 254 | 1160 | 746 | 826 | 1617 | 785 | 2589 | 1535 | 2849 | 575 | 1515 | 918 | 720 | 1053 |
| ENSG00000131584.14 | 6325 | 3683 | 5951 | 3606 | 4910 | 9622 | 3839 | 5792 | 3677 | 6961 | 2875 | 3224 | 7823 | 5214 | 5451 | 3173 | 2542 | 4972 | 5452 | 4347 | 3471 | 4136 | 8329 | 9033 | 8497 | 3493 | 2594 | 5850 | 4125 | 5342 |
| ENSG00000169972.7 | 412 | 448 | 350 | 409 | 509 | 947 | 331 | 344 | 439 | 675 | 382 | 328 | 639 | 501 | 750 | 351 | 207 | 811 | 633 | 251 | 267 | 307 | 693 | 664 | 575 | 473 | 278 | 503 | 360 | 747 |
| ENSG00000127054.14 | 8580 | 6876 | 8249 | 6986 | 7672 | 18996 | 7345 | 9752 | 7067 | 11663 | 8356 | 6811 | 10109 | 8198 | 17346 | 6006 | 4096 | 12994 | 7372 | 5965 | 8423 | 8452 | 15686 | 12536 | 14403 | 5409 | 11132 | 9282 | 6396 | 10527 |
| ENSG00000240731.1 | 305 | 222 | 251 | 282 | 359 | 715 | 267 | 349 | 314 | 466 | 269 | 292 | 356 | 359 | 683 | 269 | 234 | 526 | 343 | 180 | 349 | 311 | 562 | 453 | 422 | 174 | 552 | 253 | 187 | 459 |
| ENSG00000224051.2 | 1224 | 1655 | 1574 | 1198 | 1578 | 3155 | 1159 | 954 | 1692 | 1879 | 1391 | 1145 | 1912 | 1683 | 2324 | 1074 | 1152 | 1634 | 1337 | 1230 | 1101 | 1107 | 2464 | 2313 | 3042 | 1785 | 1227 | 2174 | 1566 | 2596 |
| ENSG00000169962.4 | 103 | 131 | 88 | 73 | 80 | 660 | 115 | 192 | 116 | 112 | 82 | 157 | 99 | 107 | 223 | 63 | 36 | 232 | 100 | 84 | 170 | 241 | 1481 | 710 | 374 | 391 | 122 | 733 | 112 | 441 |
| ENSG00000107404.13 | 5411 | 4415 | 5534 | 4810 | 4774 | 17137 | 4592 | 5723 | 4993 | 6692 | 5775 | 5918 | 7387 | 5839 | 9026 | 3745 | 3082 | 8265 | 6086 | 3969 | 3984 | 4702 | 7338 | 8266 | 8374 | 3795 | 5249 | 5436 | 4778 | 6645 |
| ENSG00000162576.12 | 9211 | 8502 | 9092 | 10644 | 8504 | 10171 | 6366 | 8490 | 11198 | 15906 | 5771 | 7876 | 11217 | 6591 | 8388 | 10148 | 3659 | 10514 | 9340 | 11482 | 6480 | 5189 | 8207 | 10450 | 9912 | 5679 | 6604 | 4820 | 9702 | 2971 |
| ENSG00000175756.9 | 2879 | 4431 | 3369 | 2509 | 3735 | 6832 | 2855 | 2900 | 3132 | 3830 | 5132 | 2688 | 4287 | 3633 | 2946 | 2111 | 1685 | 3523 | 4423 | 1996 | 2182 | 2241 | 4725 | 3764 | 4650 | 3231 | 2088 | 3626 | 3545 | 3826 |
| ENSG00000223663.2 | 3 | 12 | 5 | 4 | 5 | 20 | 7 | 6 | 0 | 3 | 6 | 1 | 6 | 3 | 3 | 3 | 4 | 2 | 8 | 0 | 0 | 5 | 6 | 0 | 2 | 0 | 8 | 3 | 1 | 4 |
Tabla 4: tabla que muestra los 100 primeros genes de la matriz cruda filtrada.
Préviamente al control de calidad, se ha realizado una transformación vst con el objetivo de estabilizar la varianza, reducir el sesgo y normalizar los datos. Podemos visualizar parte del resultado de esta transformación analizando el contenido de la Tabla 5, que contiene los 100 primeros genes de la matriz de counts normalizada.
| NIT_1 | NIT_2 | NIT_3 | NIT_4 | NIT_5 | NIT_6 | NIT_7 | NIT_8 | NIT_9 | NIT_10 | SFI_1 | SFI_2 | SFI_3 | SFI_4 | SFI_5 | SFI_6 | SFI_7 | SFI_8 | SFI_9 | SFI_10 | ELI_1 | ELI_2 | ELI_3 | ELI_4 | ELI_5 | ELI_6 | ELI_7 | ELI_8 | ELI_9 | ELI_10 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ENSG00000223972.4 | 4.214794 | 5.094837 | 4.720677 | 4.749960 | 5.091288 | 4.214794 | 4.983472 | 4.579396 | 4.777543 | 4.737504 | 4.805028 | 4.747693 | 4.971263 | 4.714860 | 4.693056 | 4.736153 | 5.396492 | 4.908645 | 5.237513 | 4.607337 | 4.214794 | 4.214794 | 4.484441 | 4.214794 | 4.777859 | 4.756698 | 4.914162 | 4.798252 | 4.531836 | 4.714171 |
| ENSG00000227232.4 | 9.477658 | 8.796351 | 10.054278 | 9.325032 | 9.224970 | 9.629893 | 10.192608 | 10.154428 | 9.048699 | 9.048079 | 9.021579 | 9.198377 | 9.213594 | 9.106962 | 10.236705 | 9.318384 | 8.901915 | 9.310563 | 9.345618 | 9.998614 | 10.075999 | 9.989575 | 9.957695 | 9.760677 | 9.944949 | 9.222075 | 8.881376 | 10.422059 | 9.520491 | 9.588688 |
| ENSG00000243485.2 | 4.583370 | 4.884380 | 4.573419 | 4.594292 | 4.911636 | 4.453179 | 4.214794 | 4.214794 | 4.675238 | 4.517678 | 4.214794 | 4.214794 | 4.834767 | 4.569275 | 4.491760 | 4.736153 | 5.014522 | 4.214794 | 4.562045 | 4.768248 | 4.588082 | 4.578695 | 4.484441 | 4.519077 | 4.497664 | 4.214794 | 4.530005 | 4.553178 | 4.662265 | 4.714171 |
| ENSG00000237613.2 | 4.734641 | 4.690368 | 4.214794 | 4.214794 | 4.658067 | 4.214794 | 4.214794 | 4.214794 | 4.541065 | 4.214794 | 4.557144 | 4.214794 | 4.752726 | 4.714860 | 4.491760 | 4.214794 | 4.783859 | 4.500329 | 4.562045 | 4.214794 | 4.588082 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.758617 | 4.214794 | 4.214794 | 4.623207 |
| ENSG00000268020.2 | 4.583370 | 4.214794 | 4.573419 | 4.214794 | 4.658067 | 4.214794 | 4.214794 | 4.214794 | 4.541065 | 4.817287 | 4.697827 | 4.214794 | 4.526564 | 4.214794 | 4.214794 | 4.214794 | 4.783859 | 4.214794 | 4.562045 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.614196 | 4.756698 | 4.659692 | 4.214794 | 4.214794 | 4.857385 |
| ENSG00000240361.1 | 4.583370 | 4.214794 | 4.214794 | 4.594292 | 4.756638 | 4.551540 | 4.761507 | 4.214794 | 4.777543 | 4.214794 | 4.214794 | 4.214794 | 4.752726 | 4.714860 | 4.214794 | 4.214794 | 4.214794 | 4.783115 | 4.214794 | 4.214794 | 4.214794 | 4.578695 | 4.484441 | 4.519077 | 4.497664 | 4.599098 | 4.530005 | 4.553178 | 4.214794 | 5.023712 |
| ENSG00000186092.4 | 4.583370 | 4.214794 | 4.720677 | 4.594292 | 4.839259 | 4.551540 | 4.761507 | 4.579396 | 4.675238 | 4.214794 | 4.557144 | 4.214794 | 4.526564 | 4.825743 | 4.214794 | 4.584448 | 4.783859 | 4.849189 | 4.562045 | 4.607337 | 4.214794 | 4.578695 | 4.595581 | 4.214794 | 4.614196 | 4.214794 | 4.758617 | 4.214794 | 4.531836 | 4.714171 |
| ENSG00000238009.2 | 5.030297 | 5.031305 | 5.008714 | 5.267746 | 4.839259 | 5.398246 | 5.223084 | 5.660797 | 5.124452 | 5.110652 | 5.108342 | 5.324147 | 4.906642 | 5.258034 | 4.830379 | 5.177520 | 5.456815 | 5.187029 | 4.984002 | 5.803809 | 5.116941 | 5.339874 | 5.798678 | 5.364775 | 4.777859 | 5.773200 | 5.039162 | 4.964708 | 5.200123 | 4.790480 |
| ENSG00000233750.3 | 5.406388 | 5.520950 | 5.599252 | 5.674145 | 7.163805 | 5.758706 | 6.067788 | 5.736728 | 5.404218 | 5.669571 | 5.372222 | 5.324147 | 5.428218 | 5.501414 | 5.475386 | 4.948202 | 7.160013 | 5.395009 | 5.476620 | 4.768248 | 5.116941 | 5.805075 | 5.495267 | 5.500610 | 5.006192 | 5.142843 | 6.946443 | 5.098258 | 4.662265 | 6.556828 |
| ENSG00000237683.5 | 8.760188 | 9.633223 | 10.383171 | 9.489792 | 10.314721 | 10.062504 | 9.533344 | 9.974581 | 7.508764 | 9.979255 | 8.362762 | 9.824483 | 8.634970 | 9.394884 | 10.795880 | 9.478276 | 9.998727 | 9.544402 | 9.704728 | 9.538160 | 9.211508 | 10.036026 | 10.399817 | 9.065005 | 9.338658 | 8.867750 | 8.971220 | 10.227047 | 9.125982 | 8.751792 |
| ENSG00000268903.1 | 4.583370 | 4.551833 | 5.082374 | 4.594292 | 4.658067 | 4.841286 | 4.761507 | 4.729065 | 4.541065 | 4.737504 | 4.697827 | 4.592675 | 4.214794 | 4.999715 | 5.035842 | 4.736153 | 5.014522 | 4.214794 | 4.562045 | 4.992841 | 4.741251 | 5.094822 | 5.170845 | 4.644325 | 4.956210 | 4.599098 | 4.659692 | 4.887016 | 4.531836 | 4.504066 |
| ENSG00000239906.1 | 4.214794 | 5.260021 | 5.324247 | 4.967416 | 5.321999 | 5.233761 | 5.289735 | 4.729065 | 4.214794 | 5.910636 | 5.108342 | 5.263424 | 4.834767 | 5.311951 | 6.507974 | 5.032632 | 5.332178 | 5.455264 | 5.290460 | 5.302553 | 4.741251 | 5.618258 | 5.520020 | 5.850277 | 5.353198 | 4.976788 | 4.758617 | 4.692257 | 4.845128 | 4.857385 |
| ENSG00000241860.2 | 6.128989 | 6.530668 | 6.545637 | 6.979051 | 7.293221 | 6.714131 | 6.491466 | 6.331772 | 6.577757 | 6.634929 | 6.241290 | 7.291415 | 6.504546 | 6.427703 | 6.864856 | 7.321988 | 7.680924 | 6.750034 | 6.732255 | 7.037113 | 6.374792 | 7.194004 | 7.344515 | 6.829037 | 6.658800 | 6.451866 | 7.631226 | 6.322563 | 6.579792 | 6.911833 |
| ENSG00000222623.1 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.500329 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 |
| ENSG00000241599.1 | 4.214794 | 4.690368 | 4.214794 | 4.214794 | 4.528849 | 4.214794 | 4.602528 | 4.214794 | 4.675238 | 4.517678 | 4.557144 | 4.214794 | 4.526564 | 4.214794 | 4.766213 | 4.584448 | 4.618479 | 4.783115 | 4.562045 | 4.607337 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.599098 | 4.530005 | 4.214794 | 4.531836 | 4.714171 |
| ENSG00000228463.4 | 6.839856 | 6.192688 | 6.029085 | 6.178665 | 7.070341 | 7.376431 | 6.491466 | 6.685658 | 5.124452 | 6.420979 | 5.540293 | 6.025850 | 5.497435 | 6.727804 | 6.097716 | 7.241293 | 5.759898 | 6.340660 | 6.483732 | 5.235171 | 6.866513 | 7.240786 | 6.038254 | 6.002061 | 5.981638 | 6.474542 | 5.607442 | 7.009815 | 4.918161 | 5.980371 |
| ENSG00000237094.7 | 6.257348 | 5.790243 | 6.735524 | 5.867092 | 6.263385 | 6.398692 | 6.187563 | 6.354132 | 5.587624 | 6.491612 | 6.153024 | 5.381153 | 5.736135 | 5.954101 | 6.668270 | 6.333895 | 5.998608 | 5.978357 | 6.004393 | 6.924090 | 6.328213 | 6.681782 | 6.290406 | 6.080958 | 6.296126 | 5.602823 | 6.892130 | 5.525852 | 5.246306 | 6.053106 |
| ENSG00000250575.1 | 4.583370 | 4.884380 | 4.720677 | 4.594292 | 4.528849 | 4.795453 | 4.214794 | 4.938333 | 4.863255 | 4.517678 | 4.557144 | 4.964262 | 4.526564 | 4.825743 | 4.693056 | 4.736153 | 4.909548 | 4.908645 | 5.120791 | 4.607337 | 4.588082 | 5.094822 | 4.814298 | 4.953421 | 4.902267 | 4.214794 | 4.659692 | 4.692257 | 4.531836 | 4.623207 |
| ENSG00000233653.3 | 5.105843 | 4.961779 | 4.832815 | 5.267746 | 5.436649 | 4.923613 | 5.071750 | 4.729065 | 5.227814 | 5.007607 | 5.043889 | 5.050448 | 5.030363 | 4.825743 | 4.888132 | 4.851623 | 5.332178 | 5.060631 | 5.120791 | 5.082136 | 4.741251 | 5.225966 | 4.922145 | 4.820040 | 4.956210 | 4.756698 | 5.325900 | 4.553178 | 4.918161 | 5.344719 |
| ENSG00000235249.1 | 4.214794 | 4.795954 | 4.832815 | 4.214794 | 4.658067 | 4.453179 | 4.214794 | 4.579396 | 4.541065 | 4.517678 | 4.697827 | 4.592675 | 4.214794 | 4.714860 | 4.605886 | 4.214794 | 4.909548 | 4.707761 | 4.704710 | 4.607337 | 4.214794 | 4.578695 | 4.680492 | 4.214794 | 4.214794 | 4.214794 | 4.914162 | 4.214794 | 4.531836 | 4.714171 |
| ENSG00000269732.1 | 4.214794 | 4.551833 | 4.573419 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.729065 | 4.214794 | 4.214794 | 4.214794 | 4.592675 | 4.214794 | 4.214794 | 4.491760 | 4.214794 | 4.214794 | 4.214794 | 4.562045 | 4.214794 | 4.214794 | 4.578695 | 4.214794 | 4.214794 | 4.777859 | 4.214794 | 4.530005 | 4.214794 | 4.214794 | 4.214794 |
| ENSG00000256186.1 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.541065 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 |
| ENSG00000236601.1 | 4.583370 | 4.551833 | 4.573419 | 4.214794 | 4.528849 | 4.453179 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.557144 | 4.592675 | 4.526564 | 4.214794 | 4.605886 | 4.214794 | 4.783859 | 4.500329 | 4.562045 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.519077 | 4.497664 | 4.599098 | 4.214794 | 4.214794 | 4.214794 | 4.504066 |
| ENSG00000236743.1 | 4.583370 | 4.551833 | 4.573419 | 4.214794 | 5.142741 | 4.214794 | 4.214794 | 4.729065 | 4.675238 | 4.214794 | 4.805028 | 4.214794 | 4.752726 | 4.214794 | 4.605886 | 4.736153 | 5.014522 | 4.707761 | 4.813400 | 4.214794 | 4.741251 | 4.578695 | 4.214794 | 4.214794 | 4.614196 | 4.214794 | 4.758617 | 4.553178 | 4.214794 | 4.504066 |
| ENSG00000236679.2 | 4.214794 | 4.551833 | 4.573419 | 4.214794 | 5.036207 | 4.551540 | 4.602528 | 4.579396 | 4.863255 | 4.214794 | 4.894789 | 4.747693 | 4.906642 | 4.825743 | 4.605886 | 4.851623 | 6.984188 | 4.617948 | 4.562045 | 4.607337 | 4.214794 | 4.214794 | 4.214794 | 4.519077 | 4.497664 | 4.214794 | 5.039162 | 4.553178 | 4.761750 | 4.972673 |
| ENSG00000231709.1 | 4.214794 | 4.214794 | 4.832815 | 4.214794 | 5.142741 | 4.551540 | 4.602528 | 4.729065 | 4.541065 | 4.214794 | 4.697827 | 4.747693 | 4.971263 | 4.214794 | 4.830379 | 4.851623 | 5.106164 | 4.908645 | 5.290460 | 4.214794 | 4.588082 | 4.936962 | 4.595581 | 5.206233 | 4.902267 | 4.756698 | 4.659692 | 4.553178 | 4.662265 | 4.504066 |
| ENSG00000235146.2 | 4.583370 | 4.690368 | 4.720677 | 4.749960 | 4.756638 | 4.214794 | 4.761507 | 4.729065 | 4.541065 | 4.214794 | 4.557144 | 4.214794 | 4.526564 | 4.569275 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.704710 | 4.607337 | 4.588082 | 4.214794 | 4.484441 | 4.214794 | 4.614196 | 4.214794 | 4.659692 | 5.635102 | 4.214794 | 4.917581 |
| ENSG00000239664.2 | 4.849785 | 4.214794 | 4.720677 | 4.594292 | 4.658067 | 4.453179 | 4.602528 | 4.729065 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.605886 | 4.214794 | 4.783859 | 4.617948 | 4.562045 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 5.212286 | 4.214794 | 4.857385 |
| ENSG00000230021.3 | 4.583370 | 4.214794 | 4.720677 | 4.749960 | 5.142741 | 4.841286 | 4.761507 | 5.021681 | 4.541065 | 4.817287 | 4.805028 | 4.747693 | 4.906642 | 4.569275 | 4.830379 | 4.851623 | 4.909548 | 5.060631 | 4.813400 | 4.768248 | 5.186695 | 4.841814 | 4.595581 | 4.953421 | 4.614196 | 4.976788 | 5.325900 | 5.312956 | 4.214794 | 4.857385 |
| ENSG00000223659.1 | 4.583370 | 4.551833 | 4.214794 | 4.214794 | 4.528849 | 4.214794 | 4.214794 | 4.214794 | 4.675238 | 4.517678 | 4.557144 | 4.592675 | 4.214794 | 4.569275 | 4.605886 | 4.584448 | 4.214794 | 4.617948 | 4.704710 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.614196 | 4.214794 | 4.914162 | 4.214794 | 4.214794 | 4.504066 |
| ENSG00000225972.1 | 7.110819 | 6.977566 | 6.388306 | 6.405309 | 7.978438 | 6.019011 | 14.847394 | 7.047645 | 6.678662 | 6.449687 | 7.115331 | 6.686142 | 7.268327 | 14.324590 | 6.793271 | 6.566603 | 8.347939 | 6.083417 | 6.929154 | 6.396116 | 6.203837 | 6.629000 | 6.068910 | 11.934969 | 6.084555 | 6.021584 | 7.251206 | 5.765598 | 6.025879 | 8.145157 |
| ENSG00000225630.1 | 13.573812 | 14.394469 | 14.841906 | 14.170367 | 13.512986 | 12.228907 | 13.248296 | 14.162501 | 13.834435 | 13.266634 | 13.771371 | 13.227097 | 14.268582 | 13.583045 | 13.234917 | 12.911856 | 13.924769 | 13.420702 | 15.189986 | 13.241105 | 13.604490 | 14.393531 | 13.027993 | 12.781930 | 14.247431 | 13.306156 | 13.412587 | 13.133088 | 13.198275 | 15.557291 |
| ENSG00000237973.1 | 9.916680 | 11.056683 | 9.084291 | 11.196149 | 11.735864 | 8.411493 | 14.139627 | 10.883073 | 11.706408 | 9.317166 | 9.376849 | 9.742666 | 11.730180 | 13.277151 | 9.261831 | 10.560557 | 12.238104 | 11.734887 | 11.394388 | 9.012450 | 11.580956 | 10.434323 | 8.452742 | 7.205108 | 10.881666 | 10.135684 | 10.009637 | 8.151112 | 7.934326 | 12.213692 |
| ENSG00000229344.1 | 8.133597 | 8.487419 | 7.766708 | 8.033241 | 9.246132 | 6.981635 | 9.156985 | 8.445117 | 8.462734 | 7.561643 | 8.296596 | 7.676465 | 9.066584 | 7.951631 | 8.196647 | 8.141020 | 8.979355 | 8.069529 | 8.043927 | 7.769098 | 7.410406 | 7.825482 | 7.143534 | 6.704637 | 7.547777 | 7.243137 | 9.266615 | 7.021497 | 7.203008 | 9.119827 |
| ENSG00000240409.1 | 7.136486 | 7.342230 | 6.702928 | 6.516042 | 7.127169 | 5.480942 | 7.594108 | 7.233592 | 6.562702 | 6.014861 | 6.492432 | 6.143568 | 7.260036 | 7.226468 | 7.308565 | 6.747827 | 7.050729 | 6.566784 | 6.848211 | 6.088145 | 6.065936 | 6.024481 | 5.469901 | 5.364775 | 9.371811 | 5.732980 | 6.764482 | 5.563531 | 6.003987 | 7.453168 |
| ENSG00000248527.1 | 15.581600 | 16.004069 | 14.659256 | 15.748015 | 15.687713 | 12.911923 | 15.667349 | 15.641238 | 15.045878 | 15.323015 | 15.156599 | 14.643923 | 16.057768 | 15.762307 | 14.159314 | 14.952034 | 15.684596 | 15.433997 | 15.281203 | 13.403136 | 15.323905 | 15.443441 | 14.446425 | 14.318161 | 15.254245 | 14.885761 | 14.835589 | 13.956681 | 14.412594 | 15.617534 |
| ENSG00000198744.5 | 8.375941 | 8.270789 | 8.119421 | 7.874529 | 14.097841 | 6.797982 | 9.028529 | 8.493777 | 8.163763 | 7.723106 | 8.600564 | 8.064738 | 9.533209 | 7.918228 | 8.945248 | 8.318318 | 9.618261 | 8.081293 | 8.357317 | 7.403183 | 7.768638 | 7.473444 | 7.266312 | 6.080958 | 7.931442 | 6.991004 | 9.277010 | 6.808033 | 7.851872 | 9.488384 |
| ENSG00000268663.1 | 4.214794 | 4.214794 | 4.573419 | 4.594292 | 4.528849 | 4.453179 | 4.602528 | 4.214794 | 4.675238 | 4.214794 | 4.557144 | 4.592675 | 4.526564 | 4.214794 | 4.214794 | 4.851623 | 4.618479 | 4.214794 | 4.214794 | 4.768248 | 4.214794 | 4.214794 | 4.214794 | 4.519077 | 4.214794 | 4.599098 | 4.214794 | 4.214794 | 4.531836 | 4.214794 |
| ENSG00000185097.2 | 4.583370 | 4.214794 | 4.214794 | 4.214794 | 4.528849 | 4.214794 | 4.761507 | 4.579396 | 4.675238 | 4.214794 | 4.557144 | 4.592675 | 4.214794 | 4.714860 | 4.605886 | 4.214794 | 4.618479 | 4.500329 | 4.562045 | 4.214794 | 4.214794 | 4.578695 | 4.484441 | 4.214794 | 4.497664 | 4.214794 | 4.214794 | 4.553178 | 4.214794 | 4.623207 |
| ENSG00000229376.3 | 5.675421 | 5.819770 | 5.375707 | 5.328697 | 6.032040 | 5.727595 | 6.243440 | 5.807877 | 5.404218 | 5.614495 | 5.223577 | 5.050448 | 5.813873 | 5.139131 | 5.419975 | 5.638926 | 5.885269 | 5.512106 | 5.633726 | 5.082136 | 5.609606 | 5.696766 | 5.205602 | 5.531893 | 5.320801 | 6.021584 | 6.016564 | 4.964708 | 5.332074 | 5.555636 |
| ENSG00000224956.5 | 9.043192 | 7.498331 | 8.840768 | 8.391955 | 8.150551 | 8.004682 | 8.576125 | 8.814075 | 7.583120 | 8.638535 | 8.784005 | 8.461967 | 8.140975 | 5.258034 | 9.083272 | 8.147298 | 7.233140 | 8.462975 | 8.217096 | 8.540427 | 8.263427 | 8.430169 | 7.972107 | 8.083873 | 9.023976 | 7.698907 | 7.843244 | 7.881342 | 7.776334 | 8.118067 |
| ENSG00000235373.1 | 5.675421 | 5.790243 | 6.001046 | 5.539961 | 5.921237 | 5.283829 | 5.969689 | 5.579228 | 5.443644 | 5.772146 | 5.900354 | 5.625616 | 5.788542 | 5.457347 | 5.298686 | 5.300956 | 5.885269 | 5.779865 | 6.130289 | 5.302553 | 5.251134 | 5.391986 | 5.657447 | 5.702427 | 5.287235 | 5.280583 | 6.100103 | 5.312956 | 5.704086 | 5.798582 |
| ENSG00000223181.1 | 4.214794 | 4.551833 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.491760 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.741251 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.504066 |
| ENSG00000240618.1 | 5.406388 | 4.795954 | 5.942951 | 5.131550 | 4.214794 | 4.551540 | 4.761507 | 4.214794 | 5.067404 | 5.007607 | 4.973341 | 4.592675 | 5.085074 | 4.569275 | 5.298686 | 4.214794 | 5.396492 | 5.060631 | 5.237513 | 4.214794 | 4.741251 | 5.094822 | 5.205602 | 4.739902 | 4.843340 | 4.214794 | 5.146056 | 4.692257 | 4.761750 | 4.857385 |
| ENSG00000229905.1 | 4.214794 | 4.214794 | 4.214794 | 4.749960 | 4.658067 | 4.214794 | 4.983472 | 4.214794 | 4.214794 | 4.517678 | 4.557144 | 4.214794 | 4.214794 | 4.569275 | 4.491760 | 4.214794 | 4.909548 | 4.500329 | 4.214794 | 4.607337 | 4.588082 | 4.214794 | 4.484441 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.553178 | 4.214794 | 4.504066 |
| ENSG00000228327.2 | 6.931304 | 7.237536 | 7.296409 | 7.809094 | 7.404102 | 6.102327 | 7.197514 | 6.893469 | 6.692479 | 7.350222 | 7.706136 | 6.984845 | 7.025132 | 7.402360 | 6.989779 | 7.023407 | 7.001125 | 7.149544 | 7.649673 | 6.800949 | 7.002300 | 7.817857 | 7.902800 | 7.628583 | 6.891625 | 7.255892 | 7.318025 | 6.262537 | 6.948123 | 7.606670 |
| ENSG00000237491.4 | 7.246481 | 7.227619 | 7.241682 | 7.621459 | 8.258948 | 7.138421 | 7.583903 | 6.596410 | 6.592645 | 7.728747 | 7.661550 | 6.793129 | 7.551855 | 7.699467 | 7.650027 | 7.241293 | 8.012517 | 7.251357 | 8.119115 | 6.940814 | 8.392884 | 7.863007 | 8.818352 | 8.320135 | 7.187573 | 7.478540 | 7.049050 | 8.053721 | 6.847679 | 7.952565 |
| ENSG00000230092.3 | 5.456381 | 5.399226 | 5.424552 | 5.674145 | 5.799085 | 5.207620 | 5.071750 | 5.021681 | 4.938308 | 5.201828 | 5.275863 | 5.534649 | 5.497435 | 5.767314 | 6.128548 | 5.718411 | 5.106164 | 5.296925 | 6.177291 | 5.676477 | 5.770050 | 5.339874 | 6.543690 | 5.620518 | 5.052926 | 5.773200 | 5.325900 | 5.599913 | 5.332074 | 6.070636 |
| ENSG00000269831.1 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.602528 | 4.579396 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.526564 | 4.214794 | 4.491760 | 4.851623 | 4.214794 | 4.500329 | 4.562045 | 4.214794 | 4.588082 | 4.578695 | 4.484441 | 4.519077 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 |
| ENSG00000177757.1 | 5.456381 | 6.213971 | 5.676857 | 6.205917 | 6.209401 | 5.557411 | 6.535908 | 5.164753 | 5.932074 | 6.014861 | 6.776500 | 5.895599 | 6.490031 | 5.982566 | 5.448064 | 5.718411 | 6.422891 | 6.148809 | 6.571794 | 6.208905 | 6.065936 | 5.904090 | 6.423147 | 6.042142 | 5.252383 | 6.474542 | 5.724195 | 6.087104 | 5.517849 | 6.418497 |
| ENSG00000225880.4 | 8.637282 | 8.038088 | 8.483605 | 7.906153 | 7.717067 | 8.666077 | 8.858363 | 8.599803 | 7.203008 | 8.514090 | 8.627700 | 8.008137 | 8.086321 | 8.342091 | 9.059310 | 8.029851 | 7.617280 | 8.116017 | 8.253459 | 8.457481 | 8.877080 | 9.035110 | 9.873120 | 9.630849 | 8.914603 | 8.064979 | 8.441382 | 9.110355 | 7.571249 | 7.376269 |
| ENSG00000228794.4 | 10.479037 | 10.557424 | 10.297167 | 10.452777 | 10.517903 | 10.042478 | 10.443915 | 10.711076 | 10.118564 | 10.183680 | 11.199887 | 10.803390 | 10.763189 | 10.340400 | 10.411246 | 9.987163 | 10.302810 | 9.891289 | 10.301037 | 10.319211 | 9.751198 | 10.303472 | 9.960525 | 10.506427 | 10.189347 | 9.813118 | 9.610238 | 9.747794 | 10.437238 | 10.669422 |
| ENSG00000230368.2 | 5.174798 | 4.551833 | 4.573419 | 4.749960 | 5.236941 | 4.883806 | 4.761507 | 5.227848 | 4.777543 | 4.642357 | 4.805028 | 4.592675 | 4.906642 | 4.825743 | 5.231524 | 5.177520 | 4.783859 | 4.707761 | 4.984002 | 4.890602 | 5.040505 | 5.094822 | 4.214794 | 6.339228 | 5.096933 | 4.214794 | 4.758617 | 4.214794 | 4.845128 | 5.071424 |
| ENSG00000234711.1 | 4.214794 | 4.884380 | 4.573419 | 4.214794 | 4.756638 | 4.689957 | 5.071750 | 4.729065 | 4.863255 | 4.214794 | 4.557144 | 4.214794 | 4.752726 | 4.825743 | 4.491760 | 4.851623 | 4.783859 | 4.707761 | 4.562045 | 5.082136 | 4.588082 | 4.841814 | 4.595581 | 5.826917 | 4.614196 | 4.214794 | 4.979455 | 6.322563 | 4.214794 | 4.790480 |
| ENSG00000269308.1 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.658067 | 4.214794 | 4.214794 | 4.214794 | 4.541065 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.588082 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 |
| ENSG00000272438.1 | 5.030297 | 4.551833 | 4.832815 | 4.214794 | 5.091288 | 5.180660 | 4.882418 | 5.772856 | 5.177720 | 5.060875 | 4.805028 | 4.592675 | 5.085074 | 4.714860 | 4.941010 | 4.948202 | 4.909548 | 4.783115 | 4.813400 | 4.768248 | 4.588082 | 4.578695 | 5.544195 | 5.011193 | 5.414869 | 4.756698 | 4.979455 | 4.798252 | 4.761750 | 4.623207 |
| ENSG00000230699.2 | 5.985943 | 5.094837 | 6.388306 | 5.385913 | 6.629747 | 6.512342 | 6.243440 | 6.878559 | 6.896358 | 5.696108 | 5.812923 | 5.787599 | 6.383691 | 6.165239 | 5.158775 | 6.020612 | 6.343060 | 6.132779 | 5.237513 | 5.803809 | 5.420877 | 5.965784 | 6.554124 | 10.218867 | 6.253658 | 5.955732 | 6.120138 | 6.155780 | 5.812838 | 5.754038 |
| ENSG00000223764.2 | 7.894624 | 7.257162 | 8.455363 | 7.393950 | 8.190526 | 6.981635 | 8.243943 | 7.768012 | 8.079412 | 7.883305 | 6.343693 | 7.481426 | 7.970311 | 7.958219 | 6.746545 | 7.287972 | 7.302634 | 7.806511 | 7.066232 | 8.985109 | 6.733377 | 7.095458 | 8.108226 | 8.342490 | 7.431600 | 7.572871 | 6.752263 | 7.735079 | 7.598566 | 7.508210 |
| ENSG00000187634.6 | 8.846884 | 8.340647 | 8.515866 | 8.082452 | 9.262840 | 10.724012 | 8.986877 | 9.508161 | 10.217826 | 8.909351 | 6.560958 | 8.419287 | 9.335348 | 8.696513 | 7.118925 | 8.399365 | 7.670513 | 9.246083 | 8.119115 | 10.089359 | 7.918723 | 8.374294 | 8.676179 | 9.624798 | 8.631111 | 9.244337 | 7.472371 | 9.405172 | 8.507459 | 9.450247 |
| ENSG00000268179.1 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.592675 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.617948 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.214794 |
| ENSG00000188976.6 | 11.902362 | 12.304945 | 11.853743 | 12.064551 | 12.023240 | 11.954736 | 11.958447 | 11.927504 | 11.742597 | 12.119004 | 12.506859 | 11.740085 | 11.980687 | 11.915595 | 11.776906 | 11.961296 | 11.830805 | 11.729006 | 12.163967 | 11.721126 | 11.820193 | 11.731037 | 11.712041 | 11.805282 | 12.116523 | 12.031198 | 11.486231 | 12.121185 | 11.656762 | 11.934707 |
| ENSG00000187961.9 | 10.140389 | 9.322597 | 10.054278 | 10.292521 | 9.107302 | 10.918750 | 10.215716 | 10.339757 | 9.712242 | 9.652407 | 9.421770 | 9.513892 | 10.248443 | 9.978877 | 10.473181 | 9.362070 | 9.773537 | 9.660891 | 9.678311 | 9.882867 | 10.814435 | 10.553144 | 10.644630 | 11.053531 | 10.334869 | 10.366167 | 9.978149 | 10.612851 | 9.244333 | 10.492427 |
| ENSG00000187583.6 | 6.617794 | 6.353808 | 6.233165 | 6.731442 | 6.332005 | 6.784361 | 6.811563 | 8.450058 | 6.562702 | 5.910636 | 9.003952 | 7.470931 | 6.654584 | 7.215401 | 7.916764 | 6.078556 | 5.667963 | 7.179398 | 6.805874 | 7.693399 | 7.190158 | 7.463662 | 8.767481 | 8.169820 | 7.852683 | 7.726469 | 6.481301 | 8.693321 | 6.621469 | 7.703963 |
| ENSG00000187642.5 | 5.751995 | 5.982874 | 5.515591 | 5.902106 | 5.773039 | 6.469780 | 6.067788 | 7.137515 | 5.227814 | 5.585871 | 7.092890 | 6.507843 | 5.886722 | 5.895067 | 6.574413 | 5.862367 | 5.759898 | 6.312947 | 6.030621 | 7.141609 | 5.732047 | 6.765419 | 7.407450 | 6.818186 | 6.770470 | 6.561556 | 5.696141 | 7.790021 | 6.621469 | 6.893323 |
| ENSG00000272512.1 | 8.727320 | 6.916677 | 7.662960 | 8.033241 | 6.732448 | 7.925028 | 8.191429 | 9.683747 | 6.198784 | 7.065633 | 7.599833 | 7.934076 | 6.995286 | 6.743534 | 6.449950 | 5.718411 | 8.301697 | 7.171995 | 7.951950 | 8.556456 | 6.304282 | 6.947420 | 7.407450 | 7.843228 | 7.745259 | 6.381393 | 6.582482 | 7.165045 | 7.220810 | 7.755266 |
| ENSG00000188290.6 | 10.073420 | 8.631739 | 9.769660 | 8.996396 | 7.942420 | 8.807208 | 9.794673 | 11.004434 | 8.314542 | 9.508422 | 9.716700 | 9.907692 | 8.543464 | 8.429811 | 8.310611 | 8.134715 | 7.809751 | 8.977894 | 9.513028 | 10.042809 | 8.602789 | 8.003945 | 8.263490 | 8.493252 | 8.485566 | 8.542501 | 7.571171 | 8.887458 | 9.207421 | 8.529511 |
| ENSG00000231702.2 | 4.583370 | 4.884380 | 4.573419 | 4.967416 | 4.528849 | 5.180660 | 4.602528 | 4.579396 | 4.541065 | 4.517678 | 4.973341 | 4.747693 | 5.030363 | 4.714860 | 4.693056 | 4.584448 | 5.014522 | 4.500329 | 4.562045 | 4.992841 | 5.609606 | 4.841814 | 4.814298 | 4.644325 | 4.497664 | 4.976788 | 5.724195 | 4.214794 | 4.662265 | 4.917581 |
| ENSG00000224969.1 | 5.030297 | 4.884380 | 5.149630 | 4.594292 | 4.839259 | 6.136391 | 4.983472 | 5.772856 | 4.541065 | 4.737504 | 4.557144 | 5.381153 | 5.184272 | 4.714860 | 4.605886 | 4.736153 | 4.783859 | 4.617948 | 4.704710 | 4.992841 | 5.471410 | 5.162980 | 5.096622 | 4.953421 | 4.902267 | 4.756698 | 5.829953 | 4.887016 | 4.531836 | 5.274949 |
| ENSG00000187608.5 | 9.616345 | 9.301786 | 10.267770 | 8.714652 | 9.216417 | 9.527266 | 9.156985 | 11.910178 | 9.620778 | 9.359310 | 12.506859 | 9.359134 | 9.261491 | 9.708506 | 8.410346 | 9.617685 | 8.182757 | 9.649132 | 9.614056 | 10.217268 | 9.863920 | 9.041635 | 9.710049 | 10.456218 | 10.226912 | 9.975825 | 8.452451 | 10.123323 | 9.918472 | 9.150608 |
| ENSG00000188157.9 | 13.959853 | 14.144854 | 13.937649 | 14.220352 | 13.449465 | 14.317682 | 14.188301 | 14.026667 | 13.685630 | 13.698257 | 14.357766 | 14.583620 | 14.009483 | 14.375416 | 13.847822 | 13.530890 | 13.369722 | 13.673672 | 14.354181 | 13.640560 | 13.737991 | 13.887505 | 13.127731 | 14.146029 | 14.059080 | 13.644379 | 13.917224 | 13.419171 | 13.946929 | 12.994403 |
| ENSG00000217801.5 | 7.988118 | 6.056828 | 7.967372 | 7.359877 | 7.060640 | 6.993441 | 7.653843 | 7.428339 | 7.597534 | 7.567963 | 6.804672 | 6.984845 | 6.561073 | 6.946606 | 7.713248 | 7.450377 | 6.762785 | 7.258354 | 7.066232 | 7.506683 | 8.929883 | 7.771228 | 8.452742 | 7.375516 | 8.402269 | 7.217270 | 7.903841 | 8.417606 | 7.306577 | 7.395891 |
| ENSG00000273443.1 | 4.849785 | 4.690368 | 4.926649 | 4.214794 | 4.911636 | 5.030611 | 4.602528 | 5.660797 | 4.938308 | 4.642357 | 5.108342 | 4.592675 | 4.752726 | 4.569275 | 5.119880 | 5.032632 | 4.783859 | 5.060631 | 5.181171 | 4.214794 | 4.214794 | 4.214794 | 5.096622 | 5.064689 | 5.052926 | 4.214794 | 5.094431 | 4.692257 | 4.214794 | 4.857385 |
| ENSG00000237330.2 | 4.849785 | 4.884380 | 4.832815 | 4.594292 | 5.280468 | 4.745450 | 5.351840 | 5.341949 | 5.067404 | 4.887204 | 4.894789 | 5.050448 | 5.030363 | 4.825743 | 4.888132 | 5.108383 | 5.456815 | 4.908645 | 4.904389 | 4.607337 | 4.955299 | 4.214794 | 4.595581 | 4.953421 | 5.006192 | 4.214794 | 5.039162 | 4.964708 | 4.662265 | 5.023712 |
| ENSG00000131591.13 | 10.997126 | 9.852523 | 11.028397 | 10.681166 | 10.418025 | 9.330512 | 10.634780 | 10.808297 | 9.560062 | 10.441516 | 11.192135 | 10.900393 | 10.566012 | 10.791182 | 10.884472 | 10.281006 | 10.031381 | 10.340291 | 10.592252 | 10.461892 | 9.941196 | 10.153544 | 10.497205 | 10.478190 | 10.827542 | 9.789534 | 9.459638 | 10.904625 | 10.201611 | 10.193363 |
| ENSG00000223823.1 | 5.105843 | 4.795954 | 4.573419 | 4.214794 | 5.436649 | 4.923613 | 4.602528 | 4.843009 | 4.777543 | 4.517678 | 4.214794 | 4.865642 | 4.526564 | 4.918542 | 4.990014 | 4.948202 | 5.332178 | 4.783115 | 4.904389 | 4.992841 | 5.651950 | 5.734031 | 6.423147 | 6.173014 | 5.006192 | 5.647941 | 5.146056 | 5.882674 | 4.983810 | 5.820224 |
| ENSG00000207730.1 | 4.214794 | 4.214794 | 4.573419 | 4.749960 | 4.658067 | 4.626758 | 4.214794 | 4.579396 | 4.214794 | 4.517678 | 4.214794 | 4.214794 | 4.654854 | 4.569275 | 4.830379 | 4.214794 | 4.618479 | 4.500329 | 4.214794 | 4.607337 | 4.857817 | 4.214794 | 4.484441 | 4.214794 | 4.614196 | 4.599098 | 4.758617 | 4.214794 | 4.214794 | 4.214794 |
| ENSG00000207607.1 | 4.214794 | 4.551833 | 4.214794 | 4.749960 | 4.528849 | 4.453179 | 5.071750 | 4.729065 | 4.675238 | 4.517678 | 4.214794 | 4.214794 | 4.526564 | 4.569275 | 4.214794 | 4.214794 | 4.214794 | 4.500329 | 4.214794 | 4.607337 | 4.588082 | 4.214794 | 4.751768 | 4.214794 | 4.214794 | 4.214794 | 4.214794 | 4.553178 | 4.214794 | 4.623207 |
| ENSG00000198976.1 | 4.583370 | 4.214794 | 4.720677 | 4.594292 | 4.528849 | 4.689957 | 4.602528 | 4.214794 | 4.675238 | 4.214794 | 4.557144 | 4.592675 | 4.654854 | 5.139131 | 4.491760 | 4.214794 | 4.618479 | 4.783115 | 4.562045 | 4.214794 | 4.741251 | 4.578695 | 4.595581 | 4.519077 | 4.777859 | 4.599098 | 4.214794 | 4.553178 | 4.214794 | 4.214794 |
| ENSG00000272141.1 | 8.808124 | 8.009729 | 8.703567 | 9.530722 | 8.793135 | 8.838023 | 9.754653 | 8.536203 | 7.922920 | 8.936251 | 7.903880 | 7.639547 | 8.910692 | 8.964372 | 8.721477 | 7.871802 | 7.595414 | 9.078811 | 9.153420 | 7.974671 | 9.308644 | 8.754331 | 8.500298 | 8.079437 | 8.485566 | 6.738845 | 8.264193 | 7.625958 | 6.701139 | 7.589785 |
| ENSG00000205231.1 | 5.353700 | 5.031305 | 5.211794 | 5.267746 | 5.719093 | 4.961142 | 5.517299 | 5.164753 | 4.777543 | 5.526201 | 5.108342 | 4.747693 | 5.085074 | 5.258034 | 5.391061 | 5.241397 | 5.456815 | 5.512106 | 5.290460 | 5.302553 | 5.770050 | 5.441442 | 5.469901 | 5.248557 | 5.605042 | 4.599098 | 5.146056 | 5.669189 | 4.662265 | 5.902993 |
| ENSG00000162571.9 | 6.501498 | 5.441463 | 6.083315 | 6.637786 | 6.643020 | 5.743257 | 6.003271 | 6.238251 | 5.906979 | 7.592965 | 6.610137 | 6.225126 | 5.428218 | 5.733035 | 6.244843 | 6.892518 | 5.667963 | 5.959933 | 6.004393 | 6.237375 | 6.546150 | 5.904090 | 6.022635 | 5.981516 | 6.164238 | 4.876580 | 5.543988 | 6.110417 | 5.290198 | 6.418497 |
| ENSG00000186891.9 | 6.155724 | 5.308771 | 6.324081 | 5.936119 | 6.010673 | 7.398594 | 5.614395 | 7.516461 | 5.932074 | 5.747364 | 7.273031 | 9.653629 | 5.623356 | 6.010378 | 7.412321 | 6.333895 | 6.034146 | 7.524588 | 6.717040 | 7.823339 | 7.833769 | 7.540081 | 9.798114 | 8.889237 | 9.045670 | 8.622488 | 5.146056 | 9.270103 | 6.937318 | 8.314865 |
| ENSG00000186827.6 | 8.914124 | 8.535834 | 8.612780 | 8.978002 | 8.212261 | 7.958018 | 7.197514 | 8.106085 | 8.069153 | 7.923147 | 8.986107 | 8.132476 | 6.868992 | 7.863099 | 8.994688 | 7.510437 | 7.114224 | 8.142454 | 8.895928 | 8.518772 | 8.612058 | 8.209808 | 10.422567 | 9.814825 | 9.374929 | 8.879997 | 7.301616 | 8.742637 | 7.584974 | 8.806009 |
| ENSG00000078808.12 | 12.918945 | 13.509038 | 13.034743 | 13.081933 | 12.794648 | 13.001807 | 13.388135 | 12.949843 | 13.185524 | 13.130538 | 13.469364 | 13.166869 | 13.171025 | 13.296344 | 12.544545 | 12.955921 | 12.741671 | 12.755483 | 13.313576 | 13.248096 | 12.627137 | 12.680737 | 12.920238 | 13.038732 | 12.938230 | 13.744741 | 12.679552 | 12.868474 | 12.982206 | 12.489321 |
| ENSG00000176022.3 | 9.923940 | 10.731669 | 10.158433 | 10.286562 | 10.388850 | 9.780927 | 10.192608 | 9.340393 | 10.488855 | 10.159008 | 10.587933 | 9.583044 | 10.325846 | 10.615810 | 8.937178 | 9.921188 | 9.918073 | 9.710766 | 10.765320 | 10.188478 | 9.367213 | 9.440061 | 10.012351 | 10.075434 | 10.105531 | 10.780236 | 9.206978 | 10.073340 | 10.206018 | 10.171973 |
| ENSG00000184163.3 | 7.030845 | 6.275770 | 6.429433 | 6.405309 | 6.656163 | 6.333158 | 6.930927 | 6.539864 | 6.532073 | 6.315228 | 7.903880 | 7.112958 | 6.504546 | 6.804695 | 6.128548 | 5.718411 | 5.759898 | 6.132779 | 6.106112 | 7.225333 | 6.419766 | 6.415408 | 6.006814 | 5.960617 | 6.560014 | 6.451866 | 5.949943 | 6.361087 | 5.912243 | 6.457681 |
| ENSG00000260179.1 | 5.923682 | 5.819770 | 4.926649 | 5.793764 | 6.669180 | 5.861399 | 6.003271 | 5.736728 | 5.620735 | 5.669571 | 6.527136 | 6.276732 | 6.178338 | 5.697683 | 5.475386 | 5.895734 | 7.790676 | 6.195712 | 5.922130 | 5.424230 | 6.094760 | 6.394166 | 5.590940 | 5.675795 | 5.629603 | 5.732980 | 5.724195 | 5.403722 | 5.099405 | 5.731096 |
| ENSG00000160087.16 | 11.299443 | 11.763204 | 10.974835 | 11.514969 | 11.262978 | 12.017438 | 11.642545 | 11.465637 | 11.495751 | 11.390002 | 11.798292 | 11.607750 | 11.613575 | 11.537224 | 11.220412 | 11.046994 | 11.108909 | 11.550627 | 11.613289 | 11.191444 | 11.533680 | 11.426903 | 11.566141 | 11.594404 | 11.367184 | 11.825302 | 10.963335 | 11.739981 | 10.969473 | 11.335218 |
| ENSG00000230415.1 | 7.084670 | 6.353808 | 7.252799 | 6.618248 | 6.547225 | 6.503938 | 6.963210 | 6.500789 | 6.810882 | 7.118726 | 6.033185 | 6.590028 | 6.868992 | 7.135374 | 6.244843 | 6.623576 | 6.258000 | 6.902488 | 6.554642 | 6.468781 | 7.743424 | 6.664417 | 7.478374 | 7.269496 | 7.467468 | 6.828155 | 7.650691 | 6.808033 | 6.332286 | 6.470487 |
| ENSG00000162572.15 | 10.354297 | 8.547686 | 10.464334 | 9.621143 | 9.309825 | 10.464458 | 10.074781 | 9.745195 | 9.877945 | 10.194848 | 8.296596 | 9.316249 | 9.438579 | 10.189855 | 9.835052 | 9.412283 | 8.672363 | 9.786663 | 9.719609 | 10.203791 | 11.007278 | 9.920507 | 10.749221 | 10.354807 | 11.020445 | 9.641704 | 10.435820 | 9.934948 | 9.419712 | 9.689026 |
| ENSG00000131584.14 | 12.918945 | 11.886645 | 12.752472 | 12.197512 | 12.094914 | 12.266293 | 12.349016 | 12.761294 | 11.791162 | 12.490631 | 11.578036 | 12.025031 | 12.741323 | 12.529324 | 11.883764 | 11.938950 | 11.875317 | 11.839713 | 12.533939 | 12.562677 | 12.095431 | 12.273002 | 12.413510 | 12.877694 | 12.579799 | 12.188177 | 11.195673 | 12.560441 | 11.873048 | 11.979550 |
| ENSG00000169972.7 | 9.072912 | 8.944036 | 8.781400 | 9.142266 | 8.925040 | 9.015895 | 8.916005 | 8.802544 | 8.829971 | 9.207078 | 8.773635 | 8.834851 | 9.211475 | 9.231288 | 9.106841 | 8.866132 | 8.405283 | 9.295550 | 9.493676 | 8.582780 | 8.531296 | 8.647071 | 8.928562 | 9.197355 | 8.807817 | 9.374017 | 8.146303 | 9.110355 | 8.493073 | 9.219365 |
| ENSG00000127054.14 | 13.357041 | 12.780772 | 13.221400 | 13.146067 | 12.734393 | 13.242218 | 13.280150 | 13.509800 | 12.726490 | 13.231455 | 13.105793 | 13.097282 | 13.109403 | 13.178912 | 13.544050 | 12.853079 | 12.558170 | 13.216639 | 12.966861 | 13.016781 | 13.367220 | 13.298536 | 13.322171 | 13.348507 | 13.337559 | 12.815013 | 13.279594 | 13.223165 | 12.500763 | 12.951666 |
| ENSG00000240731.1 | 8.672251 | 8.032461 | 8.346775 | 8.646360 | 8.464753 | 8.642372 | 8.631291 | 8.821711 | 8.390552 | 8.711171 | 8.315814 | 8.680927 | 8.434848 | 8.784084 | 8.981015 | 8.515368 | 8.564721 | 8.714788 | 8.669103 | 8.154321 | 8.884743 | 8.664103 | 8.650663 | 8.686051 | 8.402269 | 8.057786 | 9.043655 | 8.207521 | 7.671081 | 8.569980 |
| ENSG00000224051.2 | 10.577825 | 10.749697 | 10.855072 | 10.630313 | 10.482703 | 10.679553 | 10.644543 | 10.197557 | 10.688847 | 10.626079 | 10.549004 | 10.554491 | 10.732511 | 10.916741 | 10.672653 | 10.402282 | 10.750467 | 10.263558 | 10.533482 | 10.763433 | 10.464788 | 10.400490 | 10.679389 | 10.932668 | 11.113387 | 11.230515 | 10.140555 | 11.147193 | 10.498689 | 10.952330 |
| ENSG00000169962.4 | 7.326429 | 7.396209 | 7.088471 | 7.008936 | 6.707495 | 8.537515 | 7.573624 | 8.048499 | 7.183899 | 6.981978 | 6.911896 | 7.887720 | 6.912390 | 7.280528 | 7.557559 | 6.797780 | 6.422891 | 7.677734 | 7.158050 | 7.238813 | 7.955725 | 8.332244 | 9.966168 | 9.288243 | 8.247147 | 9.115681 | 7.162931 | 9.623731 | 7.081403 | 8.517736 |
| ENSG00000107404.13 | 12.694940 | 12.145840 | 12.648246 | 12.610302 | 12.054737 | 13.094235 | 12.605728 | 12.744096 | 12.228568 | 12.434147 | 12.575508 | 12.895446 | 12.659050 | 12.691688 | 12.605725 | 12.175991 | 12.150730 | 12.567089 | 12.691709 | 12.432273 | 12.292727 | 12.456741 | 12.232075 | 12.750336 | 12.558891 | 12.306900 | 12.201005 | 12.455223 | 12.083116 | 12.291846 |
| ENSG00000162576.12 | 13.459072 | 13.085552 | 13.361259 | 13.751539 | 12.882165 | 12.345760 | 13.074601 | 13.310548 | 13.387648 | 13.677603 | 12.574515 | 13.306054 | 13.258852 | 12.865542 | 12.500617 | 13.606845 | 12.396461 | 12.912429 | 13.306820 | 13.958457 | 12.990396 | 12.598031 | 12.392367 | 13.086956 | 12.800776 | 12.884935 | 12.529974 | 12.282925 | 13.098731 | 11.143601 |
| ENSG00000175756.9 | 11.791673 | 12.151016 | 11.937577 | 11.679180 | 11.704129 | 11.776678 | 11.925296 | 11.770930 | 11.562331 | 11.636238 | 12.406304 | 11.765261 | 11.879984 | 12.012019 | 11.007923 | 11.357837 | 11.289293 | 11.348654 | 12.234272 | 11.450112 | 11.432906 | 11.397986 | 11.603118 | 11.624645 | 11.717268 | 12.076618 | 10.888092 | 11.875791 | 11.656762 | 11.503225 |
| ENSG00000223663.2 | 4.849785 | 5.355075 | 5.008714 | 4.967416 | 4.911636 | 5.259146 | 5.223084 | 5.096476 | 4.214794 | 4.737504 | 5.043889 | 4.592675 | 4.971263 | 4.825743 | 4.693056 | 4.851623 | 5.014522 | 4.617948 | 5.181171 | 4.214794 | 4.214794 | 5.020161 | 4.870592 | 4.214794 | 4.614196 | 4.214794 | 5.094431 | 4.798252 | 4.531836 | 4.790480 |
Tabla 6: tabla que muestra los 100 primeros genes de la matriz cruda filtrada y normalizada mediante la transformación vst.
Ahora que ya disponemos de unos datos con menor sesgo y que están normalizados, ya podemos proseguir con el control de calidad. Tal y como hemos comentado con anterioridad, este control gira principalmente entorno a un análisis gráfico basado la contrucción de un boxplot, un PCA plot y un dendrograma. A continuación se presentan e interpretan conjuntamente los resutados de estas pruebas gráficas. En la Figura 1 se muestran el boxplot y el PCA plot esmentados. En primer lugar, observamos que, tal y como se esperaba, la distribución de pseudocounts inter e intragrupales del boxplot son significativamente homogenéos (Figura 1.A).
Adicionalmente, si nos fijamos en el PCA plot (Figura 1.B), podemos extraer bastante información. Por un lado, identificamos que las dos componentes principales que explican mejor la varianza de las muestras explican un 25.7% (PC1) y un 10.8 % (PC2) de esta. Adicionalmente vemos que -aunque no es perfecta- existe cierta homogeneidad entre las muestras de un mismo grupo. Las muestras del grupo NIT presentan valores negativos y parecidos entre sí para la PC1 mientras que los valores para la PC2 son mucho más variables. Las muestras del grupo SFI presentan valores cercanos a 0 y bastante parecidos entre sí para la PC1 mientras que -análogamente al grupo NIT- los valores para la PC2 difieren significativamente. Finalmente -a excepción de dos muestras (ELI-7 y ELI-9)- todas las muestras del grupo ELI presentan valores positivos y significativamente elevados para la PC1. En cuanto a la PC2, observamos una dispersión parecida a la de los otros grupos pero no tan acentuada. En síntesis, podríamos concluir que -aunque no es muy clara- observamos una segmentación de las muestras por grupos. Los grupos NIT y SFI son bastante parecidos entre ellos, mientras que el grupo ELI es el que está más alejado del resto. Si así nos conviene, podríamos considerar las muestras ELI-7 y ELI-9 como problemáticas y eliminarlas.
Figura 1: boxplot de los pseudocounts (A). PCA plot de los pseudocounts (B).
En la Figura 2 se muestra el dendrograma. Primeramente, podemos identificar que la división óptima implica la construcción de únicamente dos clústers. El primero incluye todas las muestras NIT, 7/10 muestras SFI y 2/10 muestras ELI. En cambio, el segundo no incluye ninguna muestra NIT, e incluye 3/10 muestras SFI y 8/10 muestras ELI. Estos resultados sustentan lo observado en el PCA plot. Esto es -básicamente- que los grupos NIT y SFI son significativamente parecidos entre ellos y -a su vez- considerablemente diferentes al grupo EFI.
Figura 2: dendrograma resultante del análisis de clustering jerarárquico de las 30 muestras.
Una vez los datos han pasado el control de calidad y se han establecido las comparaciones, identificaremos que genes estan diferencialmente expresados en cada una de ellas. A continuación se muestra, para cada una de las 3 comparaciones, una topTable con los 75 genes que parecen presentar una mayor expresión diferencial. Estos son -de los genes que presentan un p-valor ajustado < 0.1- aquellos que presentan valores absolutos más grandes para el log2FC. Adicionalmente, también se muestra un un resumen que contiene -entre otros- el número y el porcentaje de genes up-regulated y down-regulated.
NIT vs SFI:
En primer lugar, vamos a analizar los resultados obtenidos para la comparación NIT vs SFI. Tal y como podemos observar en la Tabla 7, la aplicación de pequeñas infilitraciones focales en el tejido tiroideo (SFI) desencadena una respuesta que implica -almenos- la expresión diferencial de 330 (0.71%) genes respecto a la condición normal (NIT). De estos genes, 51 (0.11%) están sobrexpresados y 279 (0.6%) infraexpresados.
| baseMean | log2FoldChange | lfcSE | stat | pvalue | padj | symbol | entrez | |
|---|---|---|---|---|---|---|---|---|
| ENSG00000105369 | 1948.87 | -4.90 | 0.80 | -6.14 | 8.4e-10 | 4.6e-07 | CD79A | 973 |
| ENSG00000170476 | 1628.40 | -4.15 | 0.74 | -5.61 | 2.0e-08 | 7.4e-06 | MZB1 | 51237 |
| ENSG00000156738 | 5112.78 | -4.50 | 0.81 | -5.54 | 3.0e-08 | 1.0e-05 | MS4A1 | 931 |
| ENSG00000181847 | 505.03 | -3.02 | 0.55 | -5.52 | 3.3e-08 | 1.1e-05 | TIGIT | 201633 |
| ENSG00000156234 | 561.78 | -4.44 | 0.83 | -5.32 | 1.0e-07 | 3.0e-05 | CXCL13 | 10563 |
| ENSG00000110777 | 1986.24 | -3.24 | 0.62 | -5.19 | 2.1e-07 | 5.7e-05 | POU2AF1 | 5450 |
| ENSG00000226777 | 416.84 | -3.91 | 0.76 | -5.13 | 2.8e-07 | 7.5e-05 | FAM30A | 9834 |
| ENSG00000132465 | 7603.68 | -3.78 | 0.74 | -5.09 | 3.6e-07 | 9.1e-05 | JCHAIN | 3512 |
| ENSG00000129204 | 428.14 | 2.15 | 0.44 | 4.89 | 1.0e-06 | 2.4e-04 | USP6 | 9098 |
| ENSG00000187862 | 90.87 | -2.94 | 0.60 | -4.86 | 1.2e-06 | 2.7e-04 | TTC24 | 164118 |
| ENSG00000235304 | 36.49 | -5.87 | 1.24 | -4.74 | 2.1e-06 | 4.8e-04 | LINC01281 | 286442 |
| ENSG00000048462 | 108.47 | -2.52 | 0.54 | -4.68 | 2.8e-06 | 6.3e-04 | TNFRSF17 | 608 |
| ENSG00000163534 | 804.39 | -3.53 | 0.76 | -4.63 | 3.7e-06 | 8.2e-04 | FCRL1 | 115350 |
| ENSG00000160856 | 926.56 | -3.03 | 0.66 | -4.57 | 4.8e-06 | 1.0e-03 | FCRL3 | 115352 |
| ENSG00000177455 | 1184.57 | -3.51 | 0.77 | -4.56 | 5.1e-06 | 1.1e-03 | CD19 | 930 |
| ENSG00000254709 | 101.05 | -4.44 | 0.98 | -4.54 | 5.6e-06 | 1.1e-03 | IGLL5 | 100423062 |
| ENSG00000122188 | 236.81 | -2.19 | 0.49 | -4.51 | 6.6e-06 | 1.3e-03 | LAX1 | 54900 |
| ENSG00000235532 | 73.30 | -4.17 | 0.93 | -4.51 | 6.6e-06 | 1.3e-03 | LINC00402 | 100507612 |
| ENSG00000026751 | 787.52 | -2.25 | 0.50 | -4.49 | 7.2e-06 | 1.4e-03 | SLAMF7 | 57823 |
| ENSG00000197057 | 177.97 | -2.42 | 0.54 | -4.45 | 8.5e-06 | 1.7e-03 | DTHD1 | 401124 |
| ENSG00000086967 | 152.58 | -3.35 | 0.76 | -4.38 | 1.2e-05 | 2.3e-03 | MYBPC2 | 4606 |
| ENSG00000136573 | 911.22 | -2.90 | 0.66 | -4.38 | 1.2e-05 | 2.3e-03 | BLK | 640 |
| ENSG00000083454 | 913.26 | -2.62 | 0.60 | -4.37 | 1.2e-05 | 2.3e-03 | P2RX5 | 5026 |
| ENSG00000140465 | 120.99 | -3.68 | 0.84 | -4.36 | 1.3e-05 | 2.4e-03 | CYP1A1 | 1543 |
| ENSG00000089012 | 258.32 | -2.24 | 0.51 | -4.36 | 1.3e-05 | 2.4e-03 | SIRPG | 55423 |
| ENSG00000121895 | 207.04 | -2.60 | 0.60 | -4.32 | 1.5e-05 | 2.8e-03 | TMEM156 | 80008 |
| ENSG00000196092 | 398.98 | -3.43 | 0.80 | -4.31 | 1.6e-05 | 2.8e-03 | PAX5 | 5079 |
| ENSG00000159958 | 162.27 | -3.54 | 0.82 | -4.30 | 1.7e-05 | 3.0e-03 | TNFRSF13C | 115650 |
| ENSG00000122224 | 497.02 | -2.47 | 0.58 | -4.28 | 1.8e-05 | 3.2e-03 | LY9 | 4063 |
| ENSG00000143297 | 1671.07 | -3.42 | 0.80 | -4.27 | 2.0e-05 | 3.4e-03 | FCRL5 | 83416 |
| ENSG00000113088 | 259.07 | -2.48 | 0.58 | -4.26 | 2.0e-05 | 3.4e-03 | GZMK | 3003 |
| ENSG00000116748 | 50.56 | -2.34 | 0.55 | -4.24 | 2.2e-05 | 3.7e-03 | AMPD1 | 270 |
| ENSG00000198576 | 199.58 | 2.48 | 0.59 | 4.18 | 2.9e-05 | 4.7e-03 | ARC | 23237 |
| ENSG00000086159 | 5.21 | 2.72 | 0.66 | 4.13 | 3.6e-05 | 5.6e-03 | AQP6 | 363 |
| ENSG00000138755 | 1841.40 | -2.50 | 0.61 | -4.13 | 3.6e-05 | 5.7e-03 | CXCL9 | 4283 |
| ENSG00000168081 | 68.51 | -2.60 | 0.64 | -4.07 | 4.7e-05 | 7.1e-03 | PNOC | 5368 |
| ENSG00000092345 | 4.26 | 4.26 | 1.07 | 3.97 | 7.0e-05 | 1.0e-02 | DAZL | 1618 |
| ENSG00000257242 | 72.86 | -2.07 | 0.52 | -3.96 | 7.5e-05 | 1.1e-02 | LINC01619 | 256021 |
| ENSG00000240505 | 194.19 | -4.25 | 1.08 | -3.92 | 8.7e-05 | 1.2e-02 | TNFRSF13B | 23495 |
| ENSG00000131096 | 18.83 | 2.26 | 0.58 | 3.91 | 9.2e-05 | 1.3e-02 | PYY | 5697 |
| ENSG00000165076 | 9.47 | 2.28 | 0.59 | 3.89 | 1.0e-04 | 1.4e-02 | PRSS37 | 136242 |
| ENSG00000225362 | 35.25 | 2.07 | 0.54 | 3.85 | 1.2e-04 | 1.6e-02 | CT62 | 196993 |
| ENSG00000183918 | 263.35 | -2.09 | 0.54 | -3.85 | 1.2e-04 | 1.6e-02 | SH2D1A | 4068 |
| ENSG00000255760 | 66.56 | -4.18 | 1.09 | -3.84 | 1.2e-04 | 1.6e-02 | LINC02422 | 105369723 |
| ENSG00000269404 | 416.45 | -2.45 | 0.64 | -3.82 | 1.3e-04 | 1.8e-02 | SPIB | 6689 |
| ENSG00000171903 | 519.64 | -2.20 | 0.58 | -3.80 | 1.5e-04 | 1.9e-02 | CYP4F11 | 57834 |
| ENSG00000234184 | 32.14 | -4.48 | 1.18 | -3.79 | 1.5e-04 | 2.0e-02 | LINC01781 | 101927412 |
| ENSG00000178562 | 397.88 | -2.24 | 0.60 | -3.76 | 1.7e-04 | 2.1e-02 | CD28 | 940 |
| ENSG00000136931 | 7.75 | 2.98 | 0.80 | 3.73 | 1.9e-04 | 2.4e-02 | NR5A1 | 2516 |
| ENSG00000158477 | 22.99 | -3.95 | 1.07 | -3.70 | 2.2e-04 | 2.7e-02 | CD1A | 909 |
| ENSG00000137673 | 23.60 | -2.89 | 0.78 | -3.69 | 2.2e-04 | 2.7e-02 | MMP7 | 4316 |
| ENSG00000135248 | 11.80 | 2.57 | 0.70 | 3.68 | 2.3e-04 | 2.8e-02 | FAM71F1 | 84691 |
| ENSG00000102970 | 22.77 | -3.33 | 0.91 | -3.65 | 2.6e-04 | 3.1e-02 | CCL17 | 6361 |
| ENSG00000049249 | 22.64 | -2.35 | 0.65 | -3.64 | 2.8e-04 | 3.3e-02 | TNFRSF9 | 3604 |
| ENSG00000249923 | 7.03 | 2.03 | 0.56 | 3.62 | 3.0e-04 | 3.5e-02 | LOC284865 | 284865 |
| ENSG00000255733 | 55.44 | -2.68 | 0.75 | -3.55 | 3.9e-04 | 4.4e-02 | IFNG-AS1 | 100885789 |
| ENSG00000185972 | 11.61 | 2.40 | 0.68 | 3.52 | 4.2e-04 | 4.7e-02 | CCIN | 881 |
| ENSG00000163599 | 420.70 | -2.19 | 0.63 | -3.49 | 4.9e-04 | 5.4e-02 | CTLA4 | 1493 |
| ENSG00000254211 | 7.61 | -2.54 | 0.73 | -3.47 | 5.2e-04 | 5.6e-02 | LINC01485 | 101928154 |
| ENSG00000078589 | 193.96 | -2.04 | 0.59 | -3.47 | 5.3e-04 | 5.7e-02 | P2RY10 | 27334 |
| ENSG00000234572 | 10.73 | -3.91 | 1.14 | -3.44 | 5.8e-04 | 6.0e-02 | LINC01800 | 101927438 |
| ENSG00000163508 | 258.50 | -2.01 | 0.58 | -3.44 | 5.9e-04 | 6.1e-02 | EOMES | 8320 |
| ENSG00000169245 | 334.62 | -2.56 | 0.75 | -3.43 | 6.1e-04 | 6.3e-02 | CXCL10 | 3627 |
| ENSG00000159556 | 10.15 | -2.90 | 0.85 | -3.40 | 6.7e-04 | 6.8e-02 | ISL2 | 64843 |
| ENSG00000256574 | 14.46 | -3.47 | 1.02 | -3.39 | 6.9e-04 | 6.9e-02 | OR13A1 | 79290 |
| ENSG00000231439 | 54.87 | 2.28 | 0.68 | 3.34 | 8.3e-04 | 8.0e-02 | WASIR2 | 100132169 |
| ENSG00000144460 | 7.44 | -3.25 | 0.98 | -3.33 | 8.6e-04 | 8.2e-02 | NYAP2 | 57624 |
| ENSG00000100721 | 310.88 | -3.08 | 0.93 | -3.30 | 9.6e-04 | 8.9e-02 | TCL1A | 8115 |
| ENSG00000204595 | 1.65 | 3.59 | 1.09 | 3.29 | 9.9e-04 | 9.2e-02 | DPRX | 503834 |
| ENSG00000185155 | 28.43 | -2.44 | 0.75 | -3.27 | 1.1e-03 | 9.9e-02 | MIXL1 | 83881 |
out of 46777 with nonzero total read count
adjusted p-value < 0.1
LFC > 0 (up) : 51, 0.11%
LFC < 0 (down) : 279, 0.6%
outliers [1] : 0, 0%
low counts [2] : 17235, 37%
(mean count < 2)
[1] see 'cooksCutoff' argument of ?results
[2] see 'independentFiltering' argument of ?results
Tabla 7: toptable y tabla resumen que contienen tanto la lista como el resumen de los genes que presentan evidencia de estar diferencialmente expresados entre las condiciones NIT y SFI.
NIT vs ELI:
A continuación, comentaremos el output obtenido en la comparación NIT vs ELI. Si nos fijamos en la Tabla 8, la aplicación de infilitraciones extensivas en el tejido tiroideo (ELI) desencadena una respuesta que implica -por lo menos- la expresión diferencial de 3814 (8.1%) genes respecto a la condición normal (NIT). De estos genes, un 2% están sobrexpresados y un 6.1% infraexpresados.
| baseMean | log2FoldChange | lfcSE | stat | pvalue | padj | symbol | entrez | |
|---|---|---|---|---|---|---|---|---|
| ENSG00000048462 | 108.47 | -6.00 | 0.53 | -11.28 | 1.6e-29 | 2.6e-25 | TNFRSF17 | 608 |
| ENSG00000156234 | 561.78 | -9.23 | 0.83 | -11.09 | 1.4e-28 | 1.6e-24 | CXCL13 | 10563 |
| ENSG00000160856 | 926.56 | -6.91 | 0.66 | -10.46 | 1.4e-25 | 4.9e-22 | FCRL3 | 115352 |
| ENSG00000163534 | 804.39 | -7.87 | 0.76 | -10.33 | 5.2e-25 | 1.5e-21 | FCRL1 | 115350 |
| ENSG00000196092 | 398.98 | -8.19 | 0.79 | -10.33 | 5.1e-25 | 1.5e-21 | PAX5 | 5079 |
| ENSG00000271856 | 177.49 | -6.05 | 0.59 | -10.27 | 9.4e-25 | 2.5e-21 | LINC01215 | 101929623 |
| ENSG00000269404 | 416.45 | -6.52 | 0.64 | -10.18 | 2.4e-24 | 5.4e-21 | SPIB | 6689 |
| ENSG00000168081 | 68.51 | -6.38 | 0.63 | -10.16 | 2.9e-24 | 6.1e-21 | PNOC | 5368 |
| ENSG00000177455 | 1184.57 | -7.79 | 0.77 | -10.13 | 3.9e-24 | 7.9e-21 | CD19 | 930 |
| ENSG00000100721 | 310.88 | -9.30 | 0.92 | -10.07 | 7.2e-24 | 1.3e-20 | TCL1A | 8115 |
| ENSG00000083454 | 913.26 | -6.02 | 0.60 | -10.08 | 7.0e-24 | 1.3e-20 | P2RX5 | 5026 |
| ENSG00000167483 | 842.93 | -6.36 | 0.64 | -10.00 | 1.6e-23 | 2.6e-20 | NIBAN3 | 199786 |
| ENSG00000089012 | 258.32 | -5.10 | 0.51 | -9.98 | 1.8e-23 | 2.8e-20 | SIRPG | 55423 |
| ENSG00000105369 | 1948.87 | -7.92 | 0.80 | -9.93 | 3.2e-23 | 4.6e-20 | CD79A | 973 |
| ENSG00000122188 | 236.81 | -4.79 | 0.48 | -9.91 | 3.7e-23 | 5.0e-20 | LAX1 | 54900 |
| ENSG00000117322 | 963.92 | -7.51 | 0.76 | -9.83 | 8.1e-23 | 1.0e-19 | CR2 | 1380 |
| ENSG00000187862 | 90.87 | -5.81 | 0.60 | -9.71 | 2.8e-22 | 3.0e-19 | TTC24 | 164118 |
| ENSG00000136573 | 911.22 | -6.39 | 0.66 | -9.65 | 5.0e-22 | 4.8e-19 | BLK | 640 |
| ENSG00000181847 | 505.03 | -5.24 | 0.55 | -9.59 | 9.2e-22 | 8.7e-19 | TIGIT | 201633 |
| ENSG00000188404 | 1115.88 | -4.32 | 0.45 | -9.56 | 1.2e-21 | 1.1e-18 | SELL | 6402 |
| ENSG00000226777 | 416.84 | -7.22 | 0.76 | -9.51 | 1.9e-21 | 1.7e-18 | FAM30A | 9834 |
| ENSG00000007312 | 900.45 | -4.23 | 0.44 | -9.50 | 2.1e-21 | 1.8e-18 | CD79B | 974 |
| ENSG00000156738 | 5112.78 | -7.69 | 0.81 | -9.48 | 2.6e-21 | 2.1e-18 | MS4A1 | 931 |
| ENSG00000245164 | 881.80 | -4.87 | 0.51 | -9.47 | 2.7e-21 | 2.2e-18 | LINC00861 | 100130231 |
| ENSG00000162894 | 1340.03 | -4.33 | 0.46 | -9.46 | 3.1e-21 | 2.4e-18 | FCMR | 9214 |
| ENSG00000227507 | 832.23 | -5.23 | 0.56 | -9.40 | 5.4e-21 | 4.2e-18 | LTB | 4050 |
| ENSG00000110777 | 1986.24 | -5.83 | 0.62 | -9.35 | 8.7e-21 | 6.5e-18 | POU2AF1 | 5450 |
| ENSG00000009790 | 1329.73 | -4.06 | 0.44 | -9.24 | 2.6e-20 | 1.8e-17 | TRAF3IP3 | 80342 |
| ENSG00000241106 | 566.38 | -4.42 | 0.48 | -9.24 | 2.5e-20 | 1.8e-17 | HLA-DOB | 3112 |
| ENSG00000170476 | 1628.40 | -6.82 | 0.74 | -9.23 | 2.7e-20 | 1.9e-17 | MZB1 | 51237 |
| ENSG00000104921 | 387.71 | -5.87 | 0.64 | -9.21 | 3.4e-20 | 2.3e-17 | FCER2 | 2208 |
| ENSG00000104894 | 2626.16 | -4.10 | 0.45 | -9.15 | 5.5e-20 | 3.5e-17 | CD37 | 951 |
| ENSG00000247774 | 396.41 | -3.43 | 0.38 | -8.99 | 2.4e-19 | 1.4e-16 | PCED1B-AS1 | 100233209 |
| ENSG00000137265 | 1005.07 | -4.93 | 0.55 | -8.96 | 3.1e-19 | 1.7e-16 | IRF4 | 3662 |
| ENSG00000233355 | 329.66 | -5.42 | 0.61 | -8.95 | 3.5e-19 | 1.9e-16 | CHRM3-AS2 | 100506915 |
| ENSG00000026751 | 787.52 | -4.47 | 0.50 | -8.92 | 4.6e-19 | 2.3e-16 | SLAMF7 | 57823 |
| ENSG00000247982 | 1586.16 | -3.80 | 0.43 | -8.91 | 5.0e-19 | 2.5e-16 | LINC00926 | 283663 |
| ENSG00000121895 | 207.04 | -5.31 | 0.60 | -8.85 | 8.4e-19 | 4.1e-16 | TMEM156 | 80008 |
| ENSG00000173200 | 1754.14 | -4.39 | 0.50 | -8.80 | 1.4e-18 | 6.5e-16 | PARP15 | 165631 |
| ENSG00000170006 | 359.25 | -3.19 | 0.36 | -8.78 | 1.6e-18 | 7.1e-16 | TMEM154 | 201799 |
| ENSG00000169442 | 936.51 | -3.97 | 0.45 | -8.75 | 2.2e-18 | 9.4e-16 | CD52 | 1043 |
| ENSG00000113088 | 259.07 | -5.05 | 0.58 | -8.70 | 3.5e-18 | 1.4e-15 | GZMK | 3003 |
| ENSG00000162739 | 801.36 | -4.42 | 0.51 | -8.67 | 4.2e-18 | 1.7e-15 | SLAMF6 | 114836 |
| ENSG00000159618 | 310.73 | -3.66 | 0.42 | -8.67 | 4.3e-18 | 1.7e-15 | ADGRG5 | 221188 |
| ENSG00000128218 | 146.23 | -4.66 | 0.54 | -8.66 | 4.7e-18 | 1.8e-15 | VPREB3 | 29802 |
| ENSG00000111913 | 1438.34 | -3.13 | 0.36 | -8.61 | 7.2e-18 | 2.8e-15 | RIPOR2 | 9750 |
| ENSG00000137078 | 178.61 | -3.80 | 0.45 | -8.52 | 1.7e-17 | 6.0e-15 | SIT1 | 27240 |
| ENSG00000132185 | 270.99 | -7.08 | 0.84 | -8.45 | 3.0e-17 | 1.0e-14 | FCRLA | 84824 |
| ENSG00000205744 | 1692.35 | -2.85 | 0.34 | -8.42 | 3.9e-17 | 1.3e-14 | DENND1C | 79958 |
| ENSG00000198796 | 140.51 | -5.92 | 0.71 | -8.36 | 6.5e-17 | 2.1e-14 | ALPK2 | 115701 |
| ENSG00000101057 | 303.27 | -4.65 | 0.56 | -8.35 | 6.7e-17 | 2.2e-14 | MYBL2 | 4605 |
| ENSG00000159753 | 1359.38 | -4.25 | 0.51 | -8.33 | 8.3e-17 | 2.7e-14 | CARMIL2 | 146206 |
| ENSG00000124256 | 416.94 | -4.50 | 0.54 | -8.31 | 9.4e-17 | 3.0e-14 | ZBP1 | 81030 |
| ENSG00000185905 | 248.61 | -4.02 | 0.48 | -8.31 | 9.9e-17 | 3.1e-14 | C16orf54 | 283897 |
| ENSG00000174123 | 468.17 | -6.05 | 0.73 | -8.26 | 1.5e-16 | 4.5e-14 | TLR10 | 81793 |
| ENSG00000167895 | 4332.53 | -4.08 | 0.49 | -8.26 | 1.5e-16 | 4.6e-14 | TMC8 | 147138 |
| ENSG00000178199 | 404.14 | -3.94 | 0.48 | -8.23 | 1.8e-16 | 5.5e-14 | ZC3H12D | 340152 |
| ENSG00000079263 | 565.58 | -4.12 | 0.50 | -8.22 | 2.0e-16 | 6.0e-14 | SP140 | 11262 |
| ENSG00000162892 | 285.12 | -4.11 | 0.50 | -8.21 | 2.1e-16 | 6.2e-14 | IL24 | 11009 |
| ENSG00000110934 | 857.69 | -2.98 | 0.36 | -8.21 | 2.3e-16 | 6.6e-14 | BIN2 | 51411 |
| ENSG00000198286 | 937.24 | -3.64 | 0.44 | -8.19 | 2.5e-16 | 7.1e-14 | CARD11 | 84433 |
| ENSG00000143297 | 1671.07 | -6.54 | 0.80 | -8.17 | 3.0e-16 | 8.2e-14 | FCRL5 | 83416 |
| ENSG00000158517 | 297.79 | -3.28 | 0.40 | -8.17 | 3.1e-16 | 8.3e-14 | NCF1 | 653361 |
| ENSG00000102879 | 3973.52 | -3.46 | 0.42 | -8.15 | 3.5e-16 | 9.4e-14 | CORO1A | 11151 |
| ENSG00000186265 | 173.55 | -4.33 | 0.53 | -8.12 | 4.6e-16 | 1.2e-13 | BTLA | 151888 |
| ENSG00000143851 | 1011.88 | -3.71 | 0.46 | -8.11 | 5.2e-16 | 1.3e-13 | PTPN7 | 5778 |
| ENSG00000132704 | 642.49 | -7.26 | 0.90 | -8.10 | 5.5e-16 | 1.4e-13 | FCRL2 | 79368 |
| ENSG00000147168 | 1509.05 | -3.66 | 0.45 | -8.10 | 5.6e-16 | 1.4e-13 | IL2RG | 3561 |
| ENSG00000185862 | 1503.56 | -3.67 | 0.45 | -8.09 | 5.9e-16 | 1.5e-13 | EVI2B | 2124 |
| ENSG00000072858 | 325.17 | -3.09 | 0.38 | -8.08 | 6.3e-16 | 1.5e-13 | SIDT1 | 54847 |
| ENSG00000175857 | 189.92 | -4.34 | 0.54 | -8.08 | 6.4e-16 | 1.6e-13 | GAPT | 202309 |
| ENSG00000168421 | 538.54 | -3.84 | 0.48 | -8.06 | 7.6e-16 | 1.8e-13 | RHOH | 399 |
| ENSG00000104783 | 669.15 | -4.01 | 0.50 | -8.06 | 7.6e-16 | 1.8e-13 | KCNN4 | 3783 |
| ENSG00000165178 | 161.62 | -3.41 | 0.42 | -8.04 | 9.1e-16 | 2.1e-13 | NCF1C | 654817 |
| ENSG00000122122 | 1299.62 | -3.44 | 0.43 | -8.04 | 9.2e-16 | 2.2e-13 | SASH3 | 54440 |
| ENSG00000072818 | 2718.75 | -3.38 | 0.42 | -8.02 | 1.1e-15 | 2.5e-13 | ACAP1 | 9744 |
| ENSG00000167286 | 330.56 | -3.40 | 0.43 | -8.00 | 1.3e-15 | 3.0e-13 | CD3D | 915 |
| ENSG00000163518 | 29.59 | -8.07 | 1.01 | -7.99 | 1.4e-15 | 3.2e-13 | FCRL4 | 83417 |
| ENSG00000117091 | 569.45 | -3.62 | 0.45 | -7.98 | 1.4e-15 | 3.2e-13 | CD48 | 962 |
| ENSG00000123329 | 2274.26 | -3.45 | 0.43 | -7.98 | 1.5e-15 | 3.4e-13 | ARHGAP9 | 64333 |
| ENSG00000167077 | 426.96 | -3.39 | 0.43 | -7.97 | 1.6e-15 | 3.5e-13 | MEI1 | 150365 |
| ENSG00000112303 | 251.58 | -3.28 | 0.41 | -7.95 | 1.8e-15 | 4.0e-13 | VNN2 | 8875 |
| ENSG00000128340 | 714.24 | -3.42 | 0.43 | -7.92 | 2.4e-15 | 5.2e-13 | RAC2 | 5880 |
| ENSG00000104814 | 1148.80 | -3.57 | 0.45 | -7.91 | 2.7e-15 | 5.7e-13 | MAP4K1 | 11184 |
| ENSG00000224137 | 31.18 | -6.81 | 0.86 | -7.90 | 2.8e-15 | 5.9e-13 | LINC01857 | 102724714 |
| ENSG00000182866 | 1148.45 | -3.58 | 0.45 | -7.88 | 3.3e-15 | 6.8e-13 | LCK | 3932 |
| ENSG00000254709 | 101.05 | -7.65 | 0.97 | -7.86 | 3.9e-15 | 8.0e-13 | IGLL5 | 100423062 |
| ENSG00000010671 | 576.56 | -3.43 | 0.44 | -7.83 | 5.1e-15 | 1.0e-12 | BTK | 695 |
| ENSG00000185155 | 28.43 | -5.71 | 0.73 | -7.81 | 5.8e-15 | 1.2e-12 | MIXL1 | 83881 |
| ENSG00000172794 | 424.15 | -3.29 | 0.42 | -7.80 | 6.0e-15 | 1.2e-12 | RAB37 | 326624 |
| ENSG00000159958 | 162.27 | -6.40 | 0.82 | -7.80 | 6.1e-15 | 1.2e-12 | TNFRSF13C | 115650 |
| ENSG00000174130 | 414.53 | -3.52 | 0.45 | -7.80 | 6.4e-15 | 1.2e-12 | TLR6 | 10333 |
| ENSG00000197057 | 177.97 | -4.21 | 0.54 | -7.76 | 8.7e-15 | 1.6e-12 | DTHD1 | 401124 |
| ENSG00000198851 | 1165.38 | -3.33 | 0.43 | -7.73 | 1.1e-14 | 2.0e-12 | CD3E | 916 |
| ENSG00000234184 | 32.14 | -8.97 | 1.16 | -7.72 | 1.1e-14 | 2.1e-12 | LINC01781 | 101927412 |
| ENSG00000070190 | 337.18 | -3.99 | 0.52 | -7.70 | 1.4e-14 | 2.5e-12 | DAPP1 | 27071 |
| ENSG00000167208 | 325.76 | -3.36 | 0.44 | -7.68 | 1.6e-14 | 2.9e-12 | SNX20 | 124460 |
| ENSG00000185811 | 1556.16 | -3.30 | 0.43 | -7.67 | 1.8e-14 | 3.1e-12 | IKZF1 | 10320 |
| ENSG00000255733 | 55.44 | -5.72 | 0.75 | -7.66 | 1.9e-14 | 3.3e-12 | IFNG-AS1 | 100885789 |
| ENSG00000082293 | 54.95 | -4.33 | 0.57 | -7.64 | 2.2e-14 | 3.9e-12 | COL19A1 | 1310 |
| ENSG00000081059 | 1759.92 | -2.44 | 0.32 | -7.63 | 2.4e-14 | 4.2e-12 | TCF7 | 6932 |
| ENSG00000136490 | 2097.08 | -3.23 | 0.42 | -7.61 | 2.7e-14 | 4.7e-12 | LIMD2 | 80774 |
| ENSG00000145088 | 149.10 | -2.61 | 0.34 | -7.61 | 2.8e-14 | 4.9e-12 | EAF2 | 55840 |
| ENSG00000259772 | 161.19 | -3.62 | 0.48 | -7.60 | 3.0e-14 | 5.2e-12 | LOC283710 | 283710 |
| ENSG00000132465 | 7603.68 | -5.64 | 0.74 | -7.59 | 3.2e-14 | 5.4e-12 | JCHAIN | 3512 |
| ENSG00000161929 | 216.32 | -3.29 | 0.43 | -7.58 | 3.5e-14 | 6.0e-12 | SCIMP | 388325 |
| ENSG00000182487 | 188.13 | -3.25 | 0.43 | -7.57 | 3.6e-14 | 6.0e-12 | NCF1B | 654816 |
| ENSG00000163599 | 420.70 | -4.74 | 0.63 | -7.57 | 3.9e-14 | 6.4e-12 | CTLA4 | 1493 |
| ENSG00000188389 | 430.46 | -3.49 | 0.46 | -7.56 | 4.2e-14 | 6.9e-12 | PDCD1 | 5133 |
| ENSG00000076662 | 1215.60 | -2.35 | 0.31 | -7.54 | 4.7e-14 | 7.7e-12 | ICAM3 | 3385 |
| ENSG00000220008 | 92.53 | -3.75 | 0.50 | -7.54 | 4.9e-14 | 7.9e-12 | LINGO3 | 645191 |
| ENSG00000143119 | 2802.55 | -3.32 | 0.44 | -7.51 | 5.9e-14 | 9.5e-12 | CD53 | 963 |
| ENSG00000227039 | 991.70 | -4.34 | 0.58 | -7.50 | 6.5e-14 | 1.0e-11 | ITGB2-AS1 | 100505746 |
| ENSG00000166501 | 1072.68 | -3.40 | 0.45 | -7.49 | 6.7e-14 | 1.1e-11 | PRKCB | 5579 |
| ENSG00000213654 | 1540.42 | -2.31 | 0.31 | -7.49 | 6.8e-14 | 1.1e-11 | GPSM3 | 63940 |
| ENSG00000005844 | 2587.91 | -3.55 | 0.48 | -7.47 | 7.9e-14 | 1.2e-11 | ITGAL | 3683 |
| ENSG00000188452 | 404.31 | -2.86 | 0.38 | -7.46 | 8.8e-14 | 1.4e-11 | CERKL | 375298 |
| ENSG00000172578 | 1244.95 | -3.61 | 0.48 | -7.45 | 9.0e-14 | 1.4e-11 | KLHL6 | 89857 |
| ENSG00000234883 | 214.70 | -3.79 | 0.51 | -7.45 | 9.1e-14 | 1.4e-11 | MIR155HG | 114614 |
| ENSG00000035720 | 167.93 | -5.21 | 0.70 | -7.45 | 9.2e-14 | 1.4e-11 | STAP1 | 26228 |
| ENSG00000013725 | 901.29 | -3.68 | 0.49 | -7.45 | 9.6e-14 | 1.4e-11 | CD6 | 923 |
| ENSG00000028277 | 1067.70 | -3.54 | 0.47 | -7.45 | 9.6e-14 | 1.4e-11 | POU2F2 | 5452 |
| ENSG00000109943 | 74.47 | -3.55 | 0.48 | -7.44 | 1.0e-13 | 1.5e-11 | CRTAM | 56253 |
| ENSG00000235532 | 73.30 | -6.84 | 0.92 | -7.42 | 1.2e-13 | 1.7e-11 | LINC00402 | 100507612 |
| ENSG00000163568 | 230.72 | -4.66 | 0.63 | -7.39 | 1.4e-13 | 2.1e-11 | AIM2 | 9447 |
| ENSG00000238121 | 201.28 | -3.53 | 0.48 | -7.39 | 1.4e-13 | 2.1e-11 | LINC00426 | 100188949 |
| ENSG00000235304 | 36.49 | -9.06 | 1.23 | -7.36 | 1.8e-13 | 2.6e-11 | LINC01281 | 286442 |
| ENSG00000129173 | 41.16 | -3.68 | 0.50 | -7.36 | 1.8e-13 | 2.7e-11 | E2F8 | 79733 |
| ENSG00000068831 | 3363.16 | -2.89 | 0.39 | -7.36 | 1.9e-13 | 2.7e-11 | RASGRP2 | 10235 |
| ENSG00000110665 | 452.18 | -3.61 | 0.49 | -7.35 | 1.9e-13 | 2.8e-11 | C11orf21 | 29125 |
| ENSG00000015285 | 904.07 | -2.79 | 0.38 | -7.34 | 2.1e-13 | 2.9e-11 | WAS | 7454 |
| ENSG00000078589 | 193.96 | -4.30 | 0.59 | -7.33 | 2.4e-13 | 3.3e-11 | P2RY10 | 27334 |
| ENSG00000134061 | 253.71 | -4.35 | 0.59 | -7.32 | 2.5e-13 | 3.5e-11 | CD180 | 4064 |
| ENSG00000188820 | 94.81 | -2.87 | 0.39 | -7.31 | 2.6e-13 | 3.7e-11 | CALHM6 | 441168 |
| ENSG00000102096 | 2309.09 | -3.39 | 0.46 | -7.31 | 2.7e-13 | 3.7e-11 | PIM2 | 11040 |
| ENSG00000115085 | 1795.87 | -3.35 | 0.46 | -7.29 | 3.2e-13 | 4.4e-11 | ZAP70 | 7535 |
| ENSG00000168071 | 3370.62 | -3.11 | 0.43 | -7.26 | 3.8e-13 | 5.1e-11 | CCDC88B | 283234 |
| ENSG00000257242 | 72.86 | -3.77 | 0.52 | -7.25 | 4.1e-13 | 5.5e-11 | LINC01619 | 256021 |
| ENSG00000147138 | 203.08 | -3.81 | 0.53 | -7.23 | 4.7e-13 | 6.2e-11 | GPR174 | 84636 |
| ENSG00000130475 | 470.50 | -3.52 | 0.49 | -7.22 | 5.2e-13 | 6.8e-11 | FCHO1 | 23149 |
| ENSG00000122224 | 497.02 | -4.15 | 0.57 | -7.21 | 5.4e-13 | 7.1e-11 | LY9 | 4063 |
| ENSG00000100385 | 858.70 | -3.03 | 0.42 | -7.21 | 5.5e-13 | 7.1e-11 | IL2RB | 3560 |
| ENSG00000170054 | 54.55 | -9.79 | 1.36 | -7.19 | 6.3e-13 | 8.1e-11 | SERPINA9 | 327657 |
| ENSG00000270164 | 213.52 | -3.04 | 0.42 | -7.19 | 6.4e-13 | 8.1e-11 | LINC01480 | 101927931 |
| ENSG00000160185 | 255.17 | -3.47 | 0.48 | -7.19 | 6.6e-13 | 8.3e-11 | UBASH3A | 53347 |
| ENSG00000204475 | 66.12 | -4.24 | 0.59 | -7.19 | 6.7e-13 | 8.4e-11 | NCR3 | 259197 |
| ENSG00000226979 | 58.88 | -3.63 | 0.50 | -7.18 | 6.8e-13 | 8.5e-11 | LTA | 4049 |
| ENSG00000130487 | 114.08 | -4.20 | 0.58 | -7.18 | 7.0e-13 | 8.7e-11 | KLHDC7B | 113730 |
| ENSG00000187912 | 94.10 | -5.82 | 0.81 | -7.17 | 7.3e-13 | 9.1e-11 | CLEC17A | 388512 |
| ENSG00000153283 | 793.61 | -2.36 | 0.33 | -7.16 | 7.8e-13 | 9.6e-11 | CD96 | 10225 |
| ENSG00000112486 | 201.36 | -2.52 | 0.35 | -7.14 | 9.4e-13 | 1.2e-10 | CCR6 | 1235 |
| ENSG00000183918 | 263.35 | -3.87 | 0.54 | -7.12 | 1.1e-12 | 1.3e-10 | SH2D1A | 4068 |
| ENSG00000175643 | 135.27 | -2.51 | 0.35 | -7.11 | 1.2e-12 | 1.4e-10 | RMI2 | 116028 |
| ENSG00000146285 | 276.03 | -3.43 | 0.48 | -7.10 | 1.2e-12 | 1.5e-10 | SCML4 | 256380 |
| ENSG00000105122 | 2533.98 | -2.87 | 0.40 | -7.10 | 1.3e-12 | 1.5e-10 | RASAL3 | 64926 |
| ENSG00000255760 | 66.56 | -7.66 | 1.08 | -7.09 | 1.3e-12 | 1.6e-10 | LINC02422 | 105369723 |
| ENSG00000268041 | 43.27 | -4.37 | 0.62 | -7.09 | 1.3e-12 | 1.6e-10 | ERFL | 390937 |
| ENSG00000184293 | 66.17 | -3.93 | 0.56 | -7.08 | 1.4e-12 | 1.7e-10 | CLECL1 | 160365 |
| ENSG00000160654 | 225.41 | -3.39 | 0.48 | -7.08 | 1.4e-12 | 1.7e-10 | CD3G | 917 |
| ENSG00000139193 | 663.94 | -2.78 | 0.39 | -7.08 | 1.4e-12 | 1.7e-10 | CD27 | 939 |
| ENSG00000225783 | 2059.09 | -3.17 | 0.45 | -7.07 | 1.5e-12 | 1.8e-10 | MIAT | 440823 |
| ENSG00000106948 | 4666.65 | -2.00 | 0.28 | -7.06 | 1.7e-12 | 1.9e-10 | AKNA | 80709 |
| ENSG00000116852 | 1167.04 | -2.88 | 0.41 | -7.04 | 1.9e-12 | 2.2e-10 | KIF21B | 23046 |
| ENSG00000163508 | 258.50 | -4.10 | 0.58 | -7.04 | 1.9e-12 | 2.2e-10 | EOMES | 8320 |
| ENSG00000138964 | 1969.45 | -2.94 | 0.42 | -7.04 | 1.9e-12 | 2.2e-10 | PARVG | 64098 |
| ENSG00000066294 | 1082.72 | -3.37 | 0.48 | -7.04 | 2.0e-12 | 2.2e-10 | CD84 | 8832 |
| ENSG00000117009 | 83.18 | -2.74 | 0.39 | -7.04 | 2.0e-12 | 2.2e-10 | KMO | 8564 |
| ENSG00000096996 | 279.73 | -3.41 | 0.48 | -7.03 | 2.0e-12 | 2.3e-10 | IL12RB1 | 3594 |
| ENSG00000196684 | 1138.53 | -3.14 | 0.45 | -7.02 | 2.2e-12 | 2.5e-10 | HSH2D | 84941 |
| ENSG00000042980 | 1027.85 | -3.33 | 0.47 | -7.02 | 2.3e-12 | 2.6e-10 | ADAM28 | 10863 |
| ENSG00000230006 | 895.13 | -4.38 | 0.62 | -7.01 | 2.4e-12 | 2.6e-10 | ANKRD36BP2 | 645784 |
| ENSG00000106785 | 1091.58 | -2.04 | 0.29 | -7.00 | 2.5e-12 | 2.8e-10 | TRIM14 | 9830 |
| ENSG00000269220 | 126.20 | -2.87 | 0.41 | -6.99 | 2.7e-12 | 3.0e-10 | LINC00528 | 200298 |
| ENSG00000115232 | 745.68 | -2.68 | 0.38 | -6.98 | 2.9e-12 | 3.2e-10 | ITGA4 | 3676 |
| ENSG00000254838 | 1388.82 | -2.89 | 0.41 | -6.97 | 3.1e-12 | 3.4e-10 | GVINP1 | 387751 |
| ENSG00000116824 | 727.42 | -3.13 | 0.45 | -6.96 | 3.3e-12 | 3.6e-10 | CD2 | 914 |
| ENSG00000188282 | 89.78 | -4.19 | 0.60 | -6.95 | 3.7e-12 | 4.0e-10 | RUFY4 | 285180 |
| ENSG00000081237 | 4243.29 | -3.12 | 0.45 | -6.94 | 3.9e-12 | 4.2e-10 | PTPRC | 5788 |
| ENSG00000124203 | 510.86 | -3.29 | 0.47 | -6.94 | 3.9e-12 | 4.2e-10 | ZNF831 | 128611 |
| ENSG00000156886 | 47.34 | -4.91 | 0.71 | -6.93 | 4.3e-12 | 4.5e-10 | ITGAD | 3681 |
| ENSG00000110448 | 468.78 | -3.41 | 0.49 | -6.91 | 4.7e-12 | 5.0e-10 | CD5 | 921 |
| ENSG00000186517 | 1767.29 | -2.85 | 0.41 | -6.91 | 5.0e-12 | 5.2e-10 | ARHGAP30 | 257106 |
| ENSG00000198821 | 719.73 | -2.96 | 0.43 | -6.89 | 5.5e-12 | 5.7e-10 | CD247 | 919 |
| ENSG00000243811 | 486.16 | -2.36 | 0.34 | -6.85 | 7.2e-12 | 7.4e-10 | APOBEC3D | 140564 |
| ENSG00000229474 | 332.35 | -2.86 | 0.42 | -6.85 | 7.4e-12 | 7.5e-10 | PATL2 | 197135 |
| ENSG00000127152 | 675.15 | -2.20 | 0.32 | -6.85 | 7.5e-12 | 7.6e-10 | BCL11B | 64919 |
| ENSG00000154451 | 885.15 | -3.30 | 0.48 | -6.84 | 7.9e-12 | 8.0e-10 | GBP5 | 115362 |
| ENSG00000145649 | 265.76 | -3.38 | 0.50 | -6.82 | 8.9e-12 | 8.9e-10 | GZMA | 3001 |
| ENSG00000167984 | 1240.40 | -2.39 | 0.35 | -6.80 | 1.0e-11 | 1.0e-09 | NLRC3 | 197358 |
| ENSG00000214900 | 151.13 | -2.64 | 0.39 | -6.80 | 1.0e-11 | 1.0e-09 | LINC01588 | 283551 |
| ENSG00000065357 | 3663.02 | -2.46 | 0.36 | -6.79 | 1.1e-11 | 1.1e-09 | DGKA | 1606 |
| ENSG00000102962 | 87.49 | -4.27 | 0.63 | -6.79 | 1.1e-11 | 1.1e-09 | CCL22 | 6367 |
| ENSG00000168918 | 3150.63 | -2.35 | 0.35 | -6.77 | 1.3e-11 | 1.3e-09 | INPP5D | 3635 |
| ENSG00000126860 | 388.69 | -2.87 | 0.42 | -6.77 | 1.3e-11 | 1.3e-09 | EVI2A | 2123 |
| ENSG00000182010 | 303.05 | -3.14 | 0.46 | -6.76 | 1.4e-11 | 1.3e-09 | RTKN2 | 219790 |
| ENSG00000228427 | 26.74 | -3.57 | 0.53 | -6.76 | 1.4e-11 | 1.3e-09 | LOC107985688 | 107985688 |
| ENSG00000139626 | 1152.02 | -2.26 | 0.33 | -6.76 | 1.4e-11 | 1.3e-09 | ITGB7 | 3695 |
| ENSG00000015133 | 2228.14 | -2.40 | 0.36 | -6.75 | 1.5e-11 | 1.4e-09 | CCDC88C | 440193 |
| ENSG00000134516 | 1685.07 | -2.85 | 0.42 | -6.75 | 1.5e-11 | 1.4e-09 | DOCK2 | 1794 |
| ENSG00000146094 | 1017.42 | -2.61 | 0.39 | -6.74 | 1.5e-11 | 1.5e-09 | DOK3 | 79930 |
| ENSG00000197471 | 561.09 | -2.77 | 0.41 | -6.74 | 1.6e-11 | 1.5e-09 | SPN | 6693 |
| ENSG00000082074 | 535.10 | -2.90 | 0.43 | -6.74 | 1.6e-11 | 1.5e-09 | FYB1 | 2533 |
| ENSG00000237914 | 18.28 | -4.87 | 0.72 | -6.73 | 1.7e-11 | 1.5e-09 | SIRPG-AS1 | 101929010 |
| ENSG00000110324 | 2062.37 | -2.41 | 0.36 | -6.71 | 2.0e-11 | 1.8e-09 | IL10RA | 3587 |
| ENSG00000127084 | 1813.78 | -2.08 | 0.31 | -6.69 | 2.2e-11 | 2.0e-09 | FGD3 | 89846 |
| ENSG00000178999 | 92.96 | -3.55 | 0.53 | -6.68 | 2.4e-11 | 2.2e-09 | AURKB | 9212 |
| ENSG00000145287 | 218.06 | -2.88 | 0.43 | -6.68 | 2.4e-11 | 2.2e-09 | PLAC8 | 51316 |
| ENSG00000157303 | 360.65 | -2.02 | 0.30 | -6.68 | 2.4e-11 | 2.2e-09 | SUSD3 | 203328 |
| ENSG00000126882 | 674.55 | -2.40 | 0.36 | -6.67 | 2.6e-11 | 2.3e-09 | FAM78A | 286336 |
| ENSG00000100351 | 318.80 | -2.64 | 0.40 | -6.67 | 2.6e-11 | 2.3e-09 | GRAP2 | 9402 |
| ENSG00000125245 | 108.95 | -3.77 | 0.57 | -6.66 | 2.7e-11 | 2.4e-09 | GPR18 | 2841 |
| ENSG00000137571 | 57.48 | -3.57 | 0.54 | -6.66 | 2.8e-11 | 2.5e-09 | SLCO5A1 | 81796 |
| ENSG00000143167 | 36.86 | -4.33 | 0.65 | -6.65 | 2.9e-11 | 2.6e-09 | GPA33 | 10223 |
| ENSG00000086730 | 792.00 | -2.57 | 0.39 | -6.65 | 3.0e-11 | 2.6e-09 | LAT2 | 7462 |
| ENSG00000020633 | 828.13 | -2.99 | 0.45 | -6.64 | 3.0e-11 | 2.7e-09 | RUNX3 | 864 |
| ENSG00000135960 | 17.02 | -5.25 | 0.79 | -6.63 | 3.4e-11 | 3.0e-09 | EDAR | 10913 |
| ENSG00000180448 | 5433.87 | -2.48 | 0.37 | -6.62 | 3.5e-11 | 3.0e-09 | ARHGAP45 | 23526 |
| ENSG00000240505 | 194.19 | -7.15 | 1.08 | -6.61 | 3.8e-11 | 3.2e-09 | TNFRSF13B | 23495 |
| ENSG00000164362 | 16.92 | -5.78 | 0.87 | -6.61 | 3.9e-11 | 3.3e-09 | TERT | 7015 |
| ENSG00000178562 | 397.88 | -3.93 | 0.60 | -6.60 | 4.1e-11 | 3.5e-09 | CD28 | 940 |
| ENSG00000171848 | 191.86 | -3.55 | 0.54 | -6.60 | 4.2e-11 | 3.6e-09 | RRM2 | 6241 |
| ENSG00000134242 | 351.65 | -2.78 | 0.42 | -6.59 | 4.4e-11 | 3.7e-09 | PTPN22 | 26191 |
| ENSG00000135426 | 393.48 | -3.10 | 0.47 | -6.58 | 4.6e-11 | 3.8e-09 | TESPA1 | 9840 |
| ENSG00000102575 | 586.33 | -2.38 | 0.36 | -6.58 | 4.6e-11 | 3.9e-09 | ACP5 | 54 |
| ENSG00000140368 | 832.77 | -2.79 | 0.42 | -6.57 | 4.9e-11 | 4.1e-09 | PSTPIP1 | 9051 |
| ENSG00000184922 | 2543.64 | -2.33 | 0.35 | -6.56 | 5.2e-11 | 4.3e-09 | FMNL1 | 752 |
| ENSG00000134443 | 23.56 | 18.65 | 2.85 | 6.56 | 5.5e-11 | 4.5e-09 | GRP | 2922 |
| ENSG00000163600 | 196.23 | -3.96 | 0.60 | -6.55 | 5.6e-11 | 4.6e-09 | ICOS | 29851 |
| ENSG00000186854 | 220.97 | -2.71 | 0.41 | -6.54 | 6.1e-11 | 5.0e-09 | TRABD2A | 129293 |
| ENSG00000116748 | 50.56 | -3.58 | 0.55 | -6.53 | 6.5e-11 | 5.3e-09 | AMPD1 | 270 |
| ENSG00000117560 | 65.53 | -2.73 | 0.42 | -6.51 | 7.3e-11 | 5.9e-09 | FASLG | 356 |
| ENSG00000169679 | 127.09 | -3.05 | 0.47 | -6.51 | 7.3e-11 | 5.9e-09 | BUB1 | 699 |
| ENSG00000242258 | 54.79 | -4.57 | 0.70 | -6.51 | 7.7e-11 | 6.2e-09 | LINC00996 | 285972 |
| ENSG00000256574 | 14.46 | -6.51 | 1.00 | -6.50 | 7.8e-11 | 6.3e-09 | OR13A1 | 79290 |
| ENSG00000074966 | 380.15 | -2.87 | 0.44 | -6.50 | 8.0e-11 | 6.4e-09 | TXK | 7294 |
| ENSG00000077984 | 420.51 | -2.75 | 0.42 | -6.48 | 9.3e-11 | 7.4e-09 | CST7 | 8530 |
| ENSG00000140451 | 166.49 | -2.30 | 0.36 | -6.47 | 9.7e-11 | 7.7e-09 | PIF1 | 80119 |
| ENSG00000204282 | 959.51 | -2.45 | 0.38 | -6.47 | 1.0e-10 | 7.9e-09 | TNRC6C-AS1 | 100131096 |
| ENSG00000213809 | 904.34 | -2.82 | 0.44 | -6.46 | 1.1e-10 | 8.3e-09 | KLRK1 | 22914 |
| ENSG00000160683 | 17.08 | -5.61 | 0.87 | -6.44 | 1.2e-10 | 9.6e-09 | CXCR5 | 643 |
| ENSG00000117215 | 163.73 | -7.09 | 1.11 | -6.42 | 1.4e-10 | 1.1e-08 | PLA2G2D | 26279 |
| ENSG00000127074 | 130.32 | -5.36 | 0.83 | -6.42 | 1.4e-10 | 1.1e-08 | RGS13 | 6003 |
| ENSG00000117090 | 335.39 | -3.33 | 0.52 | -6.41 | 1.4e-10 | 1.1e-08 | SLAMF1 | 6504 |
| ENSG00000126353 | 492.55 | -2.60 | 0.41 | -6.41 | 1.5e-10 | 1.1e-08 | CCR7 | 1236 |
| ENSG00000066279 | 114.04 | -3.10 | 0.48 | -6.40 | 1.5e-10 | 1.2e-08 | ASPM | 259266 |
| ENSG00000064201 | 185.99 | -2.96 | 0.46 | -6.40 | 1.5e-10 | 1.2e-08 | TSPAN32 | 10077 |
| ENSG00000188011 | 83.08 | -3.47 | 0.54 | -6.39 | 1.6e-10 | 1.2e-08 | RTP5 | 285093 |
| ENSG00000166707 | 140.92 | -2.25 | 0.35 | -6.39 | 1.6e-10 | 1.2e-08 | ZCCHC18 | 644353 |
| ENSG00000112195 | 61.98 | -4.23 | 0.66 | -6.39 | 1.6e-10 | 1.2e-08 | TREML2 | 79865 |
| ENSG00000181617 | 403.51 | -8.85 | 1.39 | -6.38 | 1.7e-10 | 1.3e-08 | FDCSP | 260436 |
| ENSG00000141524 | 3991.16 | -2.14 | 0.34 | -6.38 | 1.8e-10 | 1.3e-08 | TMC6 | 11322 |
| ENSG00000049249 | 22.64 | -4.07 | 0.64 | -6.38 | 1.8e-10 | 1.4e-08 | TNFRSF9 | 3604 |
| ENSG00000179715 | 663.98 | -2.37 | 0.37 | -6.36 | 2.0e-10 | 1.5e-08 | PCED1B | 91523 |
| ENSG00000172116 | 199.75 | -2.75 | 0.43 | -6.36 | 2.1e-10 | 1.5e-08 | CD8B | 926 |
| ENSG00000137841 | 2627.68 | -2.55 | 0.40 | -6.34 | 2.3e-10 | 1.7e-08 | PLCB2 | 5330 |
| ENSG00000100365 | 986.25 | -2.17 | 0.34 | -6.34 | 2.3e-10 | 1.7e-08 | NCF4 | 4689 |
| ENSG00000103522 | 159.70 | -3.29 | 0.52 | -6.34 | 2.4e-10 | 1.7e-08 | IL21R | 50615 |
| ENSG00000162897 | 78.95 | -8.64 | 1.36 | -6.33 | 2.4e-10 | 1.7e-08 | FCAMR | 83953 |
| ENSG00000125910 | 380.75 | -2.24 | 0.35 | -6.33 | 2.4e-10 | 1.8e-08 | S1PR4 | 8698 |
| ENSG00000141506 | 998.02 | -2.72 | 0.43 | -6.33 | 2.4e-10 | 1.8e-08 | PIK3R5 | 23533 |
| ENSG00000144354 | 215.97 | -2.79 | 0.44 | -6.32 | 2.7e-10 | 2.0e-08 | CDCA7 | 83879 |
| ENSG00000188822 | 193.34 | -3.30 | 0.52 | -6.31 | 2.8e-10 | 2.1e-08 | CNR2 | 1269 |
| ENSG00000197549 | 30.14 | -8.87 | 1.41 | -6.30 | 2.9e-10 | 2.1e-08 | PRAMENP | 649179 |
| ENSG00000164691 | 537.55 | -2.90 | 0.46 | -6.29 | 3.3e-10 | 2.3e-08 | TAGAP | 117289 |
| ENSG00000162676 | 259.29 | -2.42 | 0.39 | -6.28 | 3.4e-10 | 2.4e-08 | GFI1 | 2672 |
| ENSG00000205045 | 197.51 | -2.34 | 0.37 | -6.28 | 3.4e-10 | 2.5e-08 | SLFN12L | 100506736 |
| ENSG00000197520 | 58.61 | -3.96 | 0.63 | -6.27 | 3.5e-10 | 2.5e-08 | FAM177B | 400823 |
| ENSG00000167664 | 28.86 | -3.05 | 0.49 | -6.27 | 3.6e-10 | 2.5e-08 | TMIGD2 | 126259 |
| ENSG00000122223 | 95.94 | -2.89 | 0.46 | -6.24 | 4.4e-10 | 3.1e-08 | CD244 | 51744 |
| ENSG00000128815 | 1099.25 | -3.31 | 0.53 | -6.23 | 4.6e-10 | 3.2e-08 | WDFY4 | 57705 |
| ENSG00000137101 | 691.00 | -2.37 | 0.38 | -6.23 | 4.6e-10 | 3.2e-08 | CD72 | 971 |
| ENSG00000204165 | 47.67 | -3.65 | 0.59 | -6.22 | 4.8e-10 | 3.4e-08 | CXorf65 | 158830 |
| ENSG00000136167 | 3536.69 | -2.57 | 0.41 | -6.22 | 4.9e-10 | 3.4e-08 | LCP1 | 3936 |
| ENSG00000246528 | 10.50 | -5.95 | 0.96 | -6.21 | 5.2e-10 | 3.6e-08 | LOC101929759 | 101929759 |
| ENSG00000237499 | 284.96 | -2.63 | 0.42 | -6.21 | 5.3e-10 | 3.7e-08 | WAKMAR2 | 100130476 |
| ENSG00000232788 | 28.13 | -2.34 | 0.38 | -6.21 | 5.4e-10 | 3.7e-08 | ITGA6-AS1 | 101929947 |
| ENSG00000163519 | 130.38 | -3.50 | 0.56 | -6.21 | 5.5e-10 | 3.7e-08 | TRAT1 | 50852 |
| ENSG00000267121 | 813.19 | -2.95 | 0.48 | -6.20 | 5.6e-10 | 3.8e-08 | LOC339192 | 339192 |
| ENSG00000165066 | 16.04 | -4.58 | 0.74 | -6.18 | 6.4e-10 | 4.3e-08 | NKX6-3 | 157848 |
| ENSG00000180096 | 34.62 | -2.22 | 0.36 | -6.18 | 6.6e-10 | 4.4e-08 | SEPTIN1 | 1731 |
| ENSG00000069493 | 1234.84 | -2.42 | 0.39 | -6.17 | 6.7e-10 | 4.5e-08 | CLEC2D | 29121 |
| ENSG00000073861 | 176.67 | -2.63 | 0.43 | -6.17 | 6.8e-10 | 4.5e-08 | TBX21 | 30009 |
| ENSG00000171241 | 105.73 | -2.94 | 0.48 | -6.17 | 7.0e-10 | 4.7e-08 | SHCBP1 | 79801 |
| ENSG00000136541 | 117.63 | -3.36 | 0.55 | -6.16 | 7.1e-10 | 4.7e-08 | ERMN | 57471 |
| ENSG00000123219 | 88.45 | -2.15 | 0.35 | -6.15 | 7.6e-10 | 5.0e-08 | CENPK | 64105 |
| ENSG00000130812 | 56.45 | -2.99 | 0.49 | -6.15 | 7.6e-10 | 5.0e-08 | ANGPTL6 | 83854 |
| ENSG00000164483 | 214.56 | -2.94 | 0.48 | -6.15 | 7.7e-10 | 5.0e-08 | SAMD3 | 154075 |
| ENSG00000049768 | 114.45 | -2.57 | 0.42 | -6.14 | 8.3e-10 | 5.4e-08 | FOXP3 | 50943 |
| ENSG00000186185 | 103.07 | -3.15 | 0.51 | -6.13 | 8.5e-10 | 5.6e-08 | KIF18B | 146909 |
| ENSG00000114200 | 124.34 | 2.11 | 0.34 | 6.13 | 8.9e-10 | 5.7e-08 | BCHE | 590 |
| ENSG00000153563 | 865.55 | -2.24 | 0.37 | -6.12 | 9.6e-10 | 6.2e-08 | CD8A | 925 |
| ENSG00000118308 | 1124.40 | -2.32 | 0.38 | -6.11 | 9.8e-10 | 6.3e-08 | LRMP | 4033 |
| ENSG00000198846 | 346.86 | -2.00 | 0.33 | -6.10 | 1.1e-09 | 6.9e-08 | TOX | 9760 |
| ENSG00000134539 | 112.52 | -2.08 | 0.34 | -6.10 | 1.1e-09 | 7.0e-08 | KLRD1 | 3824 |
| ENSG00000077420 | 829.05 | -2.03 | 0.33 | -6.09 | 1.2e-09 | 7.3e-08 | APBB1IP | 54518 |
| ENSG00000141293 | 239.61 | -2.44 | 0.40 | -6.07 | 1.3e-09 | 7.9e-08 | SKAP1 | 8631 |
| ENSG00000070915 | 19.21 | -3.38 | 0.56 | -6.07 | 1.3e-09 | 8.3e-08 | SLC12A3 | 6559 |
| ENSG00000138755 | 1841.40 | -3.67 | 0.61 | -6.06 | 1.4e-09 | 8.8e-08 | CXCL9 | 4283 |
| ENSG00000089820 | 4408.06 | -2.22 | 0.37 | -6.04 | 1.6e-09 | 9.7e-08 | ARHGAP4 | 393 |
| ENSG00000171320 | 23.91 | -2.98 | 0.49 | -6.03 | 1.6e-09 | 1.0e-07 | ESCO2 | 157570 |
| ENSG00000141968 | 727.95 | -2.62 | 0.43 | -6.03 | 1.6e-09 | 1.0e-07 | VAV1 | 7409 |
| ENSG00000104972 | 637.43 | -3.19 | 0.53 | -6.02 | 1.7e-09 | 1.1e-07 | LILRB1 | 10859 |
| ENSG00000182183 | 111.20 | -2.51 | 0.42 | -6.01 | 1.8e-09 | 1.1e-07 | SHISAL2A | 348378 |
| ENSG00000156970 | 124.85 | -2.54 | 0.42 | -6.01 | 1.9e-09 | 1.2e-07 | BUB1B | 701 |
| ENSG00000246582 | 56.58 | -2.20 | 0.37 | -6.01 | 1.9e-09 | 1.2e-07 | LOC389641 | 389641 |
| ENSG00000161405 | 184.89 | -3.57 | 0.60 | -6.00 | 2.0e-09 | 1.2e-07 | IKZF3 | 22806 |
| ENSG00000142347 | 1649.55 | -2.08 | 0.35 | -5.99 | 2.1e-09 | 1.2e-07 | MYO1F | 4542 |
| ENSG00000101194 | 1761.68 | -2.76 | 0.46 | -5.99 | 2.1e-09 | 1.3e-07 | SLC17A9 | 63910 |
| ENSG00000251002 | 13.47 | -4.61 | 0.77 | -5.98 | 2.2e-09 | 1.3e-07 | LOC105370401 | 105370401 |
| ENSG00000234572 | 10.73 | -6.66 | 1.11 | -5.98 | 2.3e-09 | 1.4e-07 | LINC01800 | 101927438 |
| ENSG00000175063 | 112.10 | -3.07 | 0.51 | -5.98 | 2.3e-09 | 1.4e-07 | UBE2C | 11065 |
| ENSG00000213886 | 44.34 | -5.57 | 0.93 | -5.96 | 2.5e-09 | 1.5e-07 | UBD | 10537 |
| ENSG00000165304 | 52.35 | -2.96 | 0.50 | -5.96 | 2.5e-09 | 1.5e-07 | MELK | 9833 |
| ENSG00000073737 | 48.66 | -2.77 | 0.46 | -5.96 | 2.6e-09 | 1.5e-07 | DHRS9 | 10170 |
| ENSG00000134028 | 162.53 | -4.53 | 0.76 | -5.95 | 2.6e-09 | 1.5e-07 | ADAMDEC1 | 27299 |
| ENSG00000181036 | 125.93 | -2.90 | 0.49 | -5.95 | 2.7e-09 | 1.6e-07 | FCRL6 | 343413 |
| ENSG00000172575 | 419.38 | -2.68 | 0.45 | -5.94 | 2.8e-09 | 1.6e-07 | RASGRP1 | 10125 |
| ENSG00000023892 | 2014.24 | -2.07 | 0.35 | -5.93 | 3.0e-09 | 1.7e-07 | DEF6 | 50619 |
| ENSG00000153898 | 283.70 | -3.35 | 0.57 | -5.92 | 3.1e-09 | 1.8e-07 | MCOLN2 | 255231 |
| ENSG00000137804 | 236.16 | -2.32 | 0.39 | -5.92 | 3.1e-09 | 1.8e-07 | NUSAP1 | 51203 |
| ENSG00000113263 | 1144.03 | -3.22 | 0.54 | -5.92 | 3.2e-09 | 1.8e-07 | ITK | 3702 |
| ENSG00000237945 | 471.01 | -2.07 | 0.35 | -5.91 | 3.4e-09 | 2.0e-07 | LINC00649 | 100506334 |
| ENSG00000148773 | 478.57 | -3.01 | 0.51 | -5.90 | 3.5e-09 | 2.0e-07 | MKI67 | 4288 |
| ENSG00000140030 | 129.41 | -2.45 | 0.42 | -5.89 | 3.9e-09 | 2.2e-07 | GPR65 | 8477 |
| ENSG00000143185 | 35.99 | -3.38 | 0.57 | -5.88 | 4.1e-09 | 2.4e-07 | XCL2 | 6846 |
| ENSG00000023445 | 2229.36 | -2.52 | 0.43 | -5.87 | 4.2e-09 | 2.4e-07 | BIRC3 | 330 |
| ENSG00000112799 | 152.99 | -2.73 | 0.47 | -5.86 | 4.7e-09 | 2.7e-07 | LY86 | 9450 |
| ENSG00000074370 | 5639.37 | -2.08 | 0.36 | -5.85 | 4.9e-09 | 2.8e-07 | ATP2A3 | 489 |
| ENSG00000089692 | 272.00 | -2.69 | 0.46 | -5.85 | 5.0e-09 | 2.8e-07 | LAG3 | 3902 |
| ENSG00000188263 | 29.39 | -4.31 | 0.74 | -5.84 | 5.2e-09 | 2.9e-07 | IL17REL | 400935 |
| ENSG00000167476 | 115.03 | -3.56 | 0.61 | -5.83 | 5.5e-09 | 3.0e-07 | JSRP1 | 126306 |
| ENSG00000088340 | 1127.95 | -3.14 | 0.54 | -5.82 | 5.9e-09 | 3.3e-07 | FER1L4 | 80307 |
| ENSG00000204252 | 1384.61 | -2.11 | 0.36 | -5.80 | 6.4e-09 | 3.5e-07 | HLA-DOA | 3111 |
| ENSG00000160593 | 792.04 | -2.25 | 0.39 | -5.80 | 6.6e-09 | 3.6e-07 | JAML | 120425 |
| ENSG00000123485 | 87.96 | -3.00 | 0.52 | -5.79 | 7.0e-09 | 3.8e-07 | HJURP | 55355 |
| ENSG00000135898 | 40.16 | -3.19 | 0.55 | -5.79 | 7.2e-09 | 3.9e-07 | GPR55 | 9290 |
| ENSG00000115165 | 1011.84 | -2.77 | 0.48 | -5.78 | 7.4e-09 | 4.0e-07 | CYTIP | 9595 |
| ENSG00000075218 | 77.28 | -2.32 | 0.40 | -5.77 | 7.9e-09 | 4.3e-07 | GTSE1 | 51512 |
| ENSG00000100162 | 71.73 | -2.87 | 0.50 | -5.77 | 8.0e-09 | 4.4e-07 | CENPM | 79019 |
| ENSG00000007264 | 256.05 | -2.12 | 0.37 | -5.76 | 8.2e-09 | 4.4e-07 | MATK | 4145 |
| ENSG00000120280 | 79.82 | -2.64 | 0.46 | -5.76 | 8.4e-09 | 4.5e-07 | CXorf21 | 80231 |
| ENSG00000140678 | 1886.44 | -2.69 | 0.47 | -5.74 | 9.2e-09 | 4.9e-07 | ITGAX | 3687 |
| ENSG00000183542 | 93.06 | -2.31 | 0.40 | -5.74 | 9.2e-09 | 4.9e-07 | KLRC4 | 8302 |
| ENSG00000235621 | 73.66 | -5.38 | 0.94 | -5.74 | 9.7e-09 | 5.2e-07 | LINC00494 | 284749 |
| ENSG00000205784 | 41.46 | -3.21 | 0.56 | -5.74 | 9.7e-09 | 5.2e-07 | ARRDC5 | 645432 |
| ENSG00000245648 | 48.61 | -2.54 | 0.44 | -5.73 | 1.0e-08 | 5.3e-07 | LOC101928100 | 101928100 |
| ENSG00000089685 | 44.79 | -2.80 | 0.49 | -5.73 | 1.0e-08 | 5.3e-07 | BIRC5 | 332 |
| ENSG00000121966 | 6073.41 | -2.95 | 0.52 | -5.73 | 1.0e-08 | 5.4e-07 | CXCR4 | 7852 |
| ENSG00000051341 | 75.63 | -2.93 | 0.51 | -5.72 | 1.0e-08 | 5.5e-07 | POLQ | 10721 |
| ENSG00000233360 | 7.79 | -2.98 | 0.52 | -5.72 | 1.1e-08 | 5.6e-07 | LOC101927051 | 101927051 |
| ENSG00000245954 | 30.44 | -4.55 | 0.79 | -5.72 | 1.1e-08 | 5.7e-07 | LINC02273 | 100996286 |
| ENSG00000177699 | 6.07 | -4.28 | 0.75 | -5.71 | 1.1e-08 | 5.8e-07 | LOC100129540 | 100129540 |
| ENSG00000101082 | 176.51 | -2.63 | 0.46 | -5.71 | 1.1e-08 | 5.9e-07 | SLA2 | 84174 |
| ENSG00000109805 | 81.66 | -2.60 | 0.46 | -5.70 | 1.2e-08 | 6.3e-07 | NCAPG | 64151 |
| ENSG00000118513 | 99.57 | -3.17 | 0.56 | -5.69 | 1.2e-08 | 6.5e-07 | MYB | 4602 |
| ENSG00000131401 | 548.49 | -3.11 | 0.55 | -5.69 | 1.3e-08 | 6.6e-07 | NAPSB | 256236 |
| ENSG00000163376 | 179.17 | -2.43 | 0.43 | -5.69 | 1.3e-08 | 6.7e-07 | KBTBD8 | 84541 |
| ENSG00000146670 | 143.35 | -2.02 | 0.36 | -5.68 | 1.4e-08 | 7.1e-07 | CDCA5 | 113130 |
| ENSG00000135476 | 124.18 | -2.42 | 0.43 | -5.67 | 1.4e-08 | 7.2e-07 | ESPL1 | 9700 |
| ENSG00000253490 | 17.07 | -4.63 | 0.82 | -5.67 | 1.4e-08 | 7.2e-07 | LINC02099 | 101929450 |
| ENSG00000203710 | 204.31 | -2.79 | 0.49 | -5.65 | 1.6e-08 | 8.2e-07 | CR1 | 1378 |
| ENSG00000049247 | 16.49 | -5.04 | 0.89 | -5.64 | 1.7e-08 | 8.5e-07 | UTS2 | 10911 |
| ENSG00000172543 | 365.24 | -2.55 | 0.45 | -5.64 | 1.7e-08 | 8.5e-07 | CTSW | 1521 |
| ENSG00000236320 | 24.36 | -3.13 | 0.56 | -5.64 | 1.7e-08 | 8.8e-07 | SLFN14 | 342618 |
| ENSG00000099958 | 2327.84 | -2.26 | 0.40 | -5.63 | 1.8e-08 | 9.1e-07 | DERL3 | 91319 |
| ENSG00000140968 | 1478.13 | -2.62 | 0.47 | -5.62 | 1.9e-08 | 9.8e-07 | IRF8 | 3394 |
| ENSG00000121152 | 76.69 | -2.36 | 0.42 | -5.60 | 2.2e-08 | 1.1e-06 | NCAPH | 23397 |
| ENSG00000111863 | 70.47 | -2.40 | 0.43 | -5.58 | 2.5e-08 | 1.2e-06 | ADTRP | 84830 |
| ENSG00000156127 | 169.87 | -2.45 | 0.44 | -5.57 | 2.6e-08 | 1.3e-06 | BATF | 10538 |
| ENSG00000100055 | 1351.72 | -2.22 | 0.40 | -5.56 | 2.7e-08 | 1.3e-06 | CYTH4 | 27128 |
| ENSG00000232810 | 92.96 | -4.01 | 0.72 | -5.55 | 2.9e-08 | 1.4e-06 | TNF | 7124 |
| ENSG00000183813 | 147.90 | -3.64 | 0.66 | -5.54 | 3.0e-08 | 1.4e-06 | CCR4 | 1233 |
| ENSG00000160224 | 54.03 | -3.37 | 0.61 | -5.54 | 3.0e-08 | 1.5e-06 | AIRE | 326 |
| ENSG00000154839 | 26.76 | -2.56 | 0.46 | -5.54 | 3.0e-08 | 1.5e-06 | SKA1 | 220134 |
| ENSG00000174255 | 90.92 | -3.50 | 0.63 | -5.54 | 3.0e-08 | 1.5e-06 | ZNF80 | 7634 |
| ENSG00000173762 | 528.24 | -2.47 | 0.45 | -5.53 | 3.1e-08 | 1.5e-06 | CD7 | 924 |
| ENSG00000105967 | 382.39 | -2.22 | 0.40 | -5.53 | 3.2e-08 | 1.6e-06 | TFEC | 22797 |
| ENSG00000152270 | 373.70 | -2.57 | 0.46 | -5.52 | 3.4e-08 | 1.6e-06 | PDE3B | 5140 |
| ENSG00000197540 | 144.50 | -2.58 | 0.47 | -5.52 | 3.4e-08 | 1.6e-06 | GZMM | 3004 |
| ENSG00000012779 | 1314.57 | -2.32 | 0.42 | -5.52 | 3.5e-08 | 1.7e-06 | ALOX5 | 240 |
| ENSG00000180535 | 31.95 | -2.96 | 0.54 | -5.50 | 3.8e-08 | 1.8e-06 | BHLHA15 | 168620 |
| ENSG00000163564 | 462.98 | -3.16 | 0.58 | -5.50 | 3.9e-08 | 1.8e-06 | PYHIN1 | 149628 |
| ENSG00000254887 | 12.31 | -4.04 | 0.73 | -5.50 | 3.9e-08 | 1.8e-06 | LOC100505622 | 100505622 |
| ENSG00000152207 | 56.44 | -2.42 | 0.44 | -5.48 | 4.2e-08 | 2.0e-06 | CYSLTR2 | 57105 |
| ENSG00000186810 | 186.95 | -2.71 | 0.49 | -5.48 | 4.3e-08 | 2.0e-06 | CXCR3 | 2833 |
| ENSG00000174946 | 225.35 | -3.15 | 0.57 | -5.48 | 4.3e-08 | 2.0e-06 | GPR171 | 29909 |
| ENSG00000108405 | 264.87 | -2.46 | 0.45 | -5.48 | 4.3e-08 | 2.0e-06 | P2RX1 | 5023 |
| ENSG00000179253 | 4.38 | -5.14 | 0.94 | -5.47 | 4.4e-08 | 2.1e-06 | LOC100128310 | 100128310 |
| ENSG00000123338 | 1092.73 | -2.30 | 0.42 | -5.47 | 4.4e-08 | 2.1e-06 | NCKAP1L | 3071 |
| ENSG00000139618 | 105.79 | -2.05 | 0.38 | -5.45 | 5.1e-08 | 2.4e-06 | BRCA2 | 675 |
| ENSG00000109684 | 106.06 | -3.63 | 0.67 | -5.44 | 5.2e-08 | 2.4e-06 | CLNK | 116449 |
| ENSG00000167094 | 141.40 | -2.20 | 0.40 | -5.44 | 5.2e-08 | 2.4e-06 | TTC16 | 158248 |
| ENSG00000211689 | 84.74 | -2.84 | 0.52 | -5.44 | 5.3e-08 | 2.5e-06 | TARP | 445347 |
| ENSG00000221946 | 32.26 | -2.66 | 0.49 | -5.44 | 5.5e-08 | 2.5e-06 | FXYD7 | 53822 |
| ENSG00000231964 | 36.37 | -2.94 | 0.54 | -5.43 | 5.6e-08 | 2.6e-06 | LOC102724323 | 102724323 |
| ENSG00000159556 | 10.15 | -4.55 | 0.84 | -5.43 | 5.7e-08 | 2.6e-06 | ISL2 | 64843 |
| ENSG00000253522 | 119.42 | -2.90 | 0.53 | -5.43 | 5.7e-08 | 2.6e-06 | MIR3142HG | 107075116 |
| ENSG00000135925 | 96.55 | -3.16 | 0.58 | -5.43 | 5.8e-08 | 2.6e-06 | WNT10A | 80326 |
| ENSG00000120949 | 46.74 | -2.30 | 0.42 | -5.42 | 5.8e-08 | 2.7e-06 | TNFRSF8 | 943 |
| ENSG00000224557 | 20.27 | -3.12 | 0.58 | -5.42 | 5.9e-08 | 2.7e-06 | HLA-DPB2 | 3116 |
| ENSG00000132744 | 36.52 | -3.97 | 0.73 | -5.41 | 6.2e-08 | 2.8e-06 | ACY3 | 91703 |
| ENSG00000153789 | 9.78 | -4.33 | 0.80 | -5.41 | 6.3e-08 | 2.9e-06 | FAM92B | 339145 |
| ENSG00000105501 | 58.61 | -2.22 | 0.41 | -5.40 | 6.6e-08 | 3.0e-06 | SIGLEC5 | 8778 |
| ENSG00000127561 | 73.49 | -2.25 | 0.42 | -5.39 | 7.2e-08 | 3.2e-06 | SYNGR3 | 9143 |
| ENSG00000105374 | 398.26 | -2.66 | 0.49 | -5.38 | 7.5e-08 | 3.4e-06 | NKG7 | 4818 |
| ENSG00000169495 | 33.19 | -2.13 | 0.40 | -5.37 | 7.7e-08 | 3.5e-06 | HTRA4 | 203100 |
| ENSG00000188042 | 1333.74 | -2.01 | 0.38 | -5.36 | 8.2e-08 | 3.6e-06 | ARL4C | 10123 |
| ENSG00000140379 | 152.40 | -2.57 | 0.48 | -5.35 | 9.0e-08 | 4.0e-06 | BCL2A1 | 597 |
| ENSG00000061656 | 239.64 | -2.11 | 0.40 | -5.34 | 9.2e-08 | 4.0e-06 | SPAG4 | 6676 |
| ENSG00000111732 | 35.65 | -5.37 | 1.01 | -5.34 | 9.4e-08 | 4.1e-06 | AICDA | 57379 |
| ENSG00000183150 | 19.99 | -2.44 | 0.46 | -5.33 | 9.7e-08 | 4.2e-06 | GPR19 | 2842 |
| ENSG00000102445 | 161.86 | -2.24 | 0.42 | -5.33 | 9.9e-08 | 4.3e-06 | RUBCNL | 80183 |
| ENSG00000136286 | 1442.80 | -2.61 | 0.49 | -5.32 | 1.0e-07 | 4.5e-06 | MYO1G | 64005 |
| ENSG00000126787 | 62.17 | -3.43 | 0.64 | -5.32 | 1.1e-07 | 4.6e-06 | DLGAP5 | 9787 |
| ENSG00000268758 | 74.59 | -2.79 | 0.53 | -5.30 | 1.1e-07 | 4.9e-06 | ADGRE4P | 326342 |
| ENSG00000152213 | 88.50 | -2.05 | 0.39 | -5.29 | 1.2e-07 | 5.1e-06 | ARL11 | 115761 |
| ENSG00000172673 | 171.59 | -2.58 | 0.49 | -5.29 | 1.2e-07 | 5.3e-06 | THEMIS | 387357 |
| ENSG00000163630 | 63.59 | -3.35 | 0.63 | -5.28 | 1.3e-07 | 5.5e-06 | SYNPR | 132204 |
| ENSG00000011590 | 135.48 | -2.63 | 0.50 | -5.27 | 1.3e-07 | 5.6e-06 | ZBTB32 | 27033 |
| ENSG00000229228 | 10.05 | -3.55 | 0.67 | -5.27 | 1.4e-07 | 5.8e-06 | LINC00582 | 100287814 |
| ENSG00000253686 | 25.08 | -3.11 | 0.59 | -5.27 | 1.4e-07 | 5.8e-06 | LINC01484 | 101928136 |
| ENSG00000226025 | 56.41 | -3.82 | 0.73 | -5.26 | 1.4e-07 | 6.1e-06 | LGALS17A | 400696 |
| ENSG00000142583 | 245.92 | -2.64 | 0.50 | -5.26 | 1.5e-07 | 6.1e-06 | SLC2A5 | 6518 |
| ENSG00000124557 | 16.19 | -3.00 | 0.57 | -5.26 | 1.5e-07 | 6.2e-06 | BTN1A1 | 696 |
| ENSG00000120659 | 43.46 | -5.10 | 0.97 | -5.25 | 1.5e-07 | 6.3e-06 | TNFSF11 | 8600 |
| ENSG00000060140 | 32.48 | -2.49 | 0.47 | -5.25 | 1.5e-07 | 6.4e-06 | STYK1 | 55359 |
| ENSG00000138623 | 426.67 | -2.17 | 0.41 | -5.25 | 1.5e-07 | 6.5e-06 | SEMA7A | 8482 |
| ENSG00000105011 | 107.44 | -2.20 | 0.42 | -5.24 | 1.6e-07 | 6.7e-06 | ASF1B | 55723 |
| ENSG00000026559 | 39.57 | -2.47 | 0.47 | -5.22 | 1.8e-07 | 7.2e-06 | KCNG1 | 3755 |
| ENSG00000110876 | 665.35 | -2.10 | 0.40 | -5.21 | 1.8e-07 | 7.6e-06 | SELPLG | 6404 |
| ENSG00000205436 | 152.67 | -2.95 | 0.56 | -5.21 | 1.9e-07 | 7.6e-06 | EXOC3L4 | 91828 |
| ENSG00000218018 | 17.34 | -2.29 | 0.44 | -5.20 | 2.0e-07 | 8.3e-06 | LOC100291105 | 100291105 |
| ENSG00000158485 | 9.84 | -4.25 | 0.82 | -5.19 | 2.1e-07 | 8.5e-06 | CD1B | 910 |
| ENSG00000151790 | 33.12 | -3.63 | 0.70 | -5.18 | 2.2e-07 | 9.1e-06 | TDO2 | 6999 |
| ENSG00000250155 | 11.68 | -3.10 | 0.60 | -5.18 | 2.2e-07 | 9.1e-06 | LOC107986412 | 107986412 |
| ENSG00000180549 | 69.07 | -2.54 | 0.49 | -5.17 | 2.4e-07 | 9.7e-06 | FUT7 | 2529 |
| ENSG00000115956 | 1084.22 | -2.20 | 0.43 | -5.17 | 2.4e-07 | 9.7e-06 | PLEK | 5341 |
| ENSG00000118193 | 44.21 | -2.21 | 0.43 | -5.15 | 2.6e-07 | 1.0e-05 | KIF14 | 9928 |
| ENSG00000197299 | 143.60 | -2.04 | 0.40 | -5.15 | 2.7e-07 | 1.1e-05 | BLM | 641 |
| ENSG00000174371 | 36.95 | -2.04 | 0.40 | -5.13 | 2.9e-07 | 1.2e-05 | EXO1 | 9156 |
| ENSG00000106952 | 151.55 | -2.80 | 0.55 | -5.11 | 3.2e-07 | 1.3e-05 | TNFSF8 | 944 |
| ENSG00000245466 | 17.39 | -3.46 | 0.68 | -5.10 | 3.4e-07 | 1.3e-05 | LOC101928075 | 101928075 |
| ENSG00000117724 | 179.32 | -2.09 | 0.41 | -5.10 | 3.5e-07 | 1.3e-05 | CENPF | 1063 |
| ENSG00000160791 | 277.00 | -2.13 | 0.42 | -5.07 | 4.0e-07 | 1.6e-05 | CCR5 | 1234 |
| ENSG00000216863 | 9.33 | -4.38 | 0.87 | -5.04 | 4.7e-07 | 1.8e-05 | LY86-AS1 | 285780 |
| ENSG00000185527 | 32.65 | -2.25 | 0.45 | -5.03 | 5.0e-07 | 1.9e-05 | PDE6G | 5148 |
| ENSG00000251301 | 60.41 | -3.07 | 0.61 | -5.02 | 5.2e-07 | 2.0e-05 | LINC02384 | 100507195 |
| ENSG00000189057 | 49.35 | -2.42 | 0.48 | -5.01 | 5.5e-07 | 2.1e-05 | FAM111B | 374393 |
| ENSG00000230937 | 81.15 | -3.59 | 0.72 | -5.00 | 5.8e-07 | 2.2e-05 | MIR205HG | 642587 |
| ENSG00000007968 | 145.96 | -2.63 | 0.53 | -5.00 | 5.9e-07 | 2.2e-05 | E2F2 | 1870 |
| ENSG00000093009 | 54.14 | -2.22 | 0.44 | -4.99 | 6.1e-07 | 2.3e-05 | CDC45 | 8318 |
| ENSG00000111537 | 30.77 | -3.82 | 0.77 | -4.95 | 7.4e-07 | 2.7e-05 | IFNG | 3458 |
| ENSG00000105255 | 36.63 | -2.41 | 0.49 | -4.94 | 7.9e-07 | 2.9e-05 | FSD1 | 79187 |
| ENSG00000121807 | 336.84 | -2.51 | 0.51 | -4.94 | 7.9e-07 | 2.9e-05 | CCR2 | 729230 |
| ENSG00000143228 | 67.52 | -2.11 | 0.43 | -4.92 | 8.7e-07 | 3.2e-05 | NUF2 | 83540 |
| ENSG00000012124 | 2713.50 | -3.07 | 0.63 | -4.90 | 9.6e-07 | 3.5e-05 | CD22 | 933 |
| ENSG00000248329 | 4.89 | -5.63 | 1.15 | -4.90 | 9.8e-07 | 3.5e-05 | APELA | 100506013 |
| ENSG00000168685 | 3193.54 | -2.95 | 0.60 | -4.89 | 9.9e-07 | 3.5e-05 | IL7R | 3575 |
| ENSG00000179813 | 11.06 | -4.76 | 0.97 | -4.89 | 9.9e-07 | 3.5e-05 | FAM216B | 144809 |
| ENSG00000143869 | 43.23 | -2.44 | 0.50 | -4.89 | 1.0e-06 | 3.6e-05 | GDF7 | 151449 |
| ENSG00000265148 | 43.22 | -2.03 | 0.42 | -4.87 | 1.1e-06 | 4.0e-05 | TSPOAP1-AS1 | 100506779 |
| ENSG00000120332 | 270.61 | 2.57 | 0.53 | 4.85 | 1.2e-06 | 4.3e-05 | TNN | 63923 |
| ENSG00000189238 | 34.07 | -2.45 | 0.50 | -4.85 | 1.2e-06 | 4.3e-05 | LINC00943 | 100507206 |
| ENSG00000223823 | 10.34 | -2.52 | 0.52 | -4.85 | 1.2e-06 | 4.3e-05 | LINC01342 | 254099 |
| ENSG00000131747 | 311.35 | -2.23 | 0.46 | -4.85 | 1.3e-06 | 4.4e-05 | TOP2A | 7153 |
| ENSG00000260101 | 25.35 | -2.34 | 0.48 | -4.84 | 1.3e-06 | 4.6e-05 | LOC101927402 | 101927402 |
| ENSG00000234965 | 7.21 | -5.43 | 1.12 | -4.83 | 1.3e-06 | 4.7e-05 | SHISA8 | 440829 |
| ENSG00000165480 | 25.08 | -2.45 | 0.51 | -4.83 | 1.4e-06 | 4.8e-05 | SKA3 | 221150 |
| ENSG00000230709 | 9.90 | -4.02 | 0.83 | -4.83 | 1.4e-06 | 4.8e-05 | LOC284191 | 284191 |
| ENSG00000109101 | 65.96 | -2.11 | 0.44 | -4.82 | 1.4e-06 | 5.0e-05 | FOXN1 | 8456 |
| ENSG00000189430 | 12.94 | -2.41 | 0.50 | -4.82 | 1.4e-06 | 5.0e-05 | NCR1 | 9437 |
| ENSG00000152495 | 392.69 | -2.65 | 0.55 | -4.80 | 1.6e-06 | 5.4e-05 | CAMK4 | 814 |
| ENSG00000214894 | 23.76 | -3.11 | 0.65 | -4.79 | 1.6e-06 | 5.6e-05 | LINC00243 | 401247 |
| ENSG00000158477 | 22.99 | -5.09 | 1.07 | -4.77 | 1.8e-06 | 6.2e-05 | CD1A | 909 |
| ENSG00000136492 | 40.74 | -2.25 | 0.47 | -4.77 | 1.8e-06 | 6.2e-05 | BRIP1 | 83990 |
| ENSG00000179583 | 3030.63 | -2.01 | 0.42 | -4.76 | 1.9e-06 | 6.5e-05 | CIITA | 4261 |
| ENSG00000173585 | 8.82 | -2.59 | 0.55 | -4.75 | 2.0e-06 | 6.7e-05 | CCR9 | 10803 |
| ENSG00000050730 | 19.32 | -3.12 | 0.66 | -4.74 | 2.1e-06 | 7.1e-05 | TNIP3 | 79931 |
| ENSG00000186891 | 184.16 | -2.75 | 0.58 | -4.74 | 2.1e-06 | 7.1e-05 | TNFRSF18 | 8784 |
| ENSG00000129204 | 428.14 | 2.09 | 0.44 | 4.74 | 2.1e-06 | 7.1e-05 | USP6 | 9098 |
| ENSG00000177272 | 229.31 | -2.08 | 0.44 | -4.73 | 2.2e-06 | 7.4e-05 | KCNA3 | 3738 |
| ENSG00000100985 | 292.17 | -2.80 | 0.59 | -4.71 | 2.4e-06 | 8.0e-05 | MMP9 | 4318 |
| ENSG00000166428 | 129.30 | -2.51 | 0.53 | -4.70 | 2.6e-06 | 8.5e-05 | PLD4 | 122618 |
| ENSG00000129810 | 25.65 | -2.46 | 0.52 | -4.69 | 2.7e-06 | 8.9e-05 | SGO1 | 151648 |
| ENSG00000006128 | 298.53 | 3.09 | 0.66 | 4.66 | 3.2e-06 | 1.0e-04 | TAC1 | 6863 |
| ENSG00000170486 | 52.53 | -3.42 | 0.74 | -4.65 | 3.4e-06 | 1.1e-04 | KRT72 | 140807 |
| ENSG00000246084 | 10.33 | -3.56 | 0.77 | -4.64 | 3.5e-06 | 1.1e-04 | LINC02325 | 101929241 |
| ENSG00000261448 | 8.99 | -2.89 | 0.62 | -4.64 | 3.5e-06 | 1.1e-04 | LOC102723692 | 102723692 |
| ENSG00000239961 | 14.34 | -2.52 | 0.54 | -4.64 | 3.5e-06 | 1.1e-04 | LILRA4 | 23547 |
| ENSG00000024526 | 36.20 | -2.30 | 0.50 | -4.63 | 3.6e-06 | 1.1e-04 | DEPDC1 | 55635 |
| ENSG00000105366 | 66.13 | -3.06 | 0.66 | -4.62 | 3.9e-06 | 1.2e-04 | SIGLEC8 | 27181 |
| ENSG00000255833 | 22.38 | -3.56 | 0.77 | -4.61 | 4.0e-06 | 1.3e-04 | TIFAB | 497189 |
| ENSG00000158488 | 77.18 | -3.71 | 0.81 | -4.59 | 4.5e-06 | 1.4e-04 | CD1E | 913 |
| ENSG00000164512 | 80.79 | -3.79 | 0.83 | -4.58 | 4.6e-06 | 1.4e-04 | ANKRD55 | 79722 |
| ENSG00000187808 | 29.04 | -2.47 | 0.54 | -4.58 | 4.7e-06 | 1.5e-04 | SOWAHD | 347454 |
| ENSG00000179873 | 8.88 | -3.97 | 0.87 | -4.57 | 4.8e-06 | 1.5e-04 | NLRP11 | 204801 |
| ENSG00000058335 | 38.67 | -2.00 | 0.44 | -4.56 | 5.1e-06 | 1.6e-04 | RASGRF1 | 5923 |
| ENSG00000166736 | 39.63 | -4.36 | 0.96 | -4.55 | 5.3e-06 | 1.6e-04 | HTR3A | 3359 |
| ENSG00000187510 | 24.64 | -6.05 | 1.33 | -4.55 | 5.3e-06 | 1.6e-04 | C12orf74 | 338809 |
| ENSG00000145850 | 134.79 | -3.00 | 0.66 | -4.55 | 5.5e-06 | 1.7e-04 | TIMD4 | 91937 |
| ENSG00000127564 | 80.30 | -2.07 | 0.46 | -4.54 | 5.7e-06 | 1.8e-04 | PKMYT1 | 9088 |
| ENSG00000166268 | 25.32 | -2.74 | 0.60 | -4.53 | 5.8e-06 | 1.8e-04 | MYRFL | 196446 |
| ENSG00000263413 | 2.00 | -4.97 | 1.10 | -4.53 | 5.8e-06 | 1.8e-04 | MIR4538 | 100616276 |
| ENSG00000185697 | 348.59 | -2.19 | 0.48 | -4.53 | 5.9e-06 | 1.8e-04 | MYBL1 | 4603 |
| ENSG00000172724 | 3885.91 | -3.60 | 0.80 | -4.52 | 6.1e-06 | 1.8e-04 | CCL19 | 6363 |
| ENSG00000236977 | 3.04 | -3.61 | 0.80 | -4.52 | 6.2e-06 | 1.9e-04 | ANKRD44-IT1 | 101927547 |
| ENSG00000090889 | 59.97 | -2.11 | 0.47 | -4.52 | 6.2e-06 | 1.9e-04 | KIF4A | 24137 |
| ENSG00000188886 | 10.63 | -3.67 | 0.81 | -4.52 | 6.2e-06 | 1.9e-04 | ASTL | 431705 |
| ENSG00000105639 | 3460.33 | -2.03 | 0.45 | -4.51 | 6.3e-06 | 1.9e-04 | JAK3 | 3718 |
| ENSG00000114013 | 222.88 | -2.00 | 0.44 | -4.51 | 6.4e-06 | 1.9e-04 | CD86 | 942 |
| ENSG00000107593 | 6.77 | -3.26 | 0.72 | -4.51 | 6.6e-06 | 2.0e-04 | PKD2L1 | 9033 |
| ENSG00000113249 | 13.23 | -3.53 | 0.79 | -4.49 | 7.0e-06 | 2.1e-04 | HAVCR1 | 26762 |
| ENSG00000159337 | 7.06 | -3.34 | 0.75 | -4.45 | 8.5e-06 | 2.5e-04 | PLA2G4D | 283748 |
| ENSG00000204277 | 7.23 | -3.32 | 0.75 | -4.41 | 1.0e-05 | 3.0e-04 | LINC01993 | 100996291 |
| ENSG00000253364 | 31.17 | -3.05 | 0.69 | -4.41 | 1.0e-05 | 3.0e-04 | COPDA1 | 115253418 |
| ENSG00000125084 | 13.22 | -2.19 | 0.50 | -4.40 | 1.1e-05 | 3.1e-04 | WNT1 | 7471 |
| ENSG00000233308 | 2.49 | -4.59 | 1.05 | -4.39 | 1.1e-05 | 3.2e-04 | OSTN-AS1 | 106480738 |
| ENSG00000148204 | 84.17 | -2.26 | 0.52 | -4.38 | 1.2e-05 | 3.4e-04 | CRB2 | 286204 |
| ENSG00000228590 | 6.43 | -4.14 | 0.95 | -4.37 | 1.2e-05 | 3.5e-04 | MIR4432HG | 106660609 |
| ENSG00000148600 | 177.71 | -2.24 | 0.51 | -4.37 | 1.3e-05 | 3.5e-04 | CDHR1 | 92211 |
| ENSG00000254211 | 7.61 | -3.15 | 0.72 | -4.35 | 1.3e-05 | 3.7e-04 | LINC01485 | 101928154 |
| ENSG00000142512 | 374.65 | -2.53 | 0.58 | -4.34 | 1.5e-05 | 4.0e-04 | SIGLEC10 | 89790 |
| ENSG00000124721 | 47.05 | -3.07 | 0.71 | -4.33 | 1.5e-05 | 4.0e-04 | DNAH8 | 1769 |
| ENSG00000161270 | 22.82 | -3.82 | 0.88 | -4.33 | 1.5e-05 | 4.1e-04 | NPHS1 | 4868 |
| ENSG00000186049 | 10.72 | -2.55 | 0.59 | -4.33 | 1.5e-05 | 4.1e-04 | KRT73 | 319101 |
| ENSG00000133105 | 15.25 | 3.92 | 0.91 | 4.33 | 1.5e-05 | 4.1e-04 | RXFP2 | 122042 |
| ENSG00000174885 | 60.33 | -2.53 | 0.59 | -4.31 | 1.6e-05 | 4.5e-04 | NLRP6 | 171389 |
| ENSG00000169575 | 2.94 | -5.01 | 1.16 | -4.30 | 1.7e-05 | 4.6e-04 | VPREB1 | 7441 |
| ENSG00000155307 | 398.08 | -2.10 | 0.49 | -4.28 | 1.9e-05 | 5.0e-04 | SAMSN1 | 64092 |
| ENSG00000162366 | 102.34 | -2.20 | 0.52 | -4.27 | 1.9e-05 | 5.2e-04 | PDZK1IP1 | 10158 |
| ENSG00000181143 | 385.07 | -3.51 | 0.82 | -4.26 | 2.0e-05 | 5.4e-04 | MUC16 | 94025 |
| ENSG00000214999 | 15.30 | -2.45 | 0.58 | -4.26 | 2.0e-05 | 5.4e-04 | LOC107985075 | 107985075 |
| ENSG00000260228 | 8.66 | -2.43 | 0.57 | -4.25 | 2.1e-05 | 5.6e-04 | LOC102724163 | 102724163 |
| ENSG00000236081 | 5.19 | -4.31 | 1.01 | -4.25 | 2.2e-05 | 5.7e-04 | ELFN1-AS1 | 101927125 |
| ENSG00000232629 | 334.74 | -2.64 | 0.62 | -4.24 | 2.3e-05 | 6.0e-04 | HLA-DQB2 | 3120 |
| ENSG00000253633 | 6.93 | -3.85 | 0.91 | -4.23 | 2.3e-05 | 6.0e-04 | LOC107986898 | 107986898 |
| ENSG00000122025 | 84.00 | -2.44 | 0.58 | -4.23 | 2.3e-05 | 6.1e-04 | FLT3 | 2322 |
| ENSG00000057294 | 126.29 | -2.08 | 0.49 | -4.23 | 2.3e-05 | 6.2e-04 | PKP2 | 5318 |
| ENSG00000170858 | 3.80 | -2.75 | 0.65 | -4.22 | 2.4e-05 | 6.3e-04 | LILRP2 | 79166 |
| ENSG00000164112 | 14.24 | -2.58 | 0.61 | -4.21 | 2.6e-05 | 6.8e-04 | TMEM155 | 132332 |
| ENSG00000105492 | 17.05 | -2.82 | 0.67 | -4.19 | 2.8e-05 | 7.2e-04 | SIGLEC6 | 946 |
| ENSG00000164485 | 3.88 | -5.83 | 1.39 | -4.19 | 2.8e-05 | 7.3e-04 | IL22RA2 | 116379 |
| ENSG00000167769 | 12.90 | -2.06 | 0.49 | -4.19 | 2.8e-05 | 7.3e-04 | ACER1 | 125981 |
| ENSG00000116147 | 42.65 | -2.58 | 0.62 | -4.18 | 2.9e-05 | 7.4e-04 | TNR | 7143 |
| ENSG00000131650 | 14.01 | -2.48 | 0.59 | -4.18 | 2.9e-05 | 7.5e-04 | KREMEN2 | 79412 |
| ENSG00000102245 | 114.28 | -2.46 | 0.59 | -4.18 | 2.9e-05 | 7.5e-04 | CD40LG | 959 |
| ENSG00000115163 | 29.30 | -2.17 | 0.52 | -4.17 | 3.0e-05 | 7.6e-04 | CENPA | 1058 |
| ENSG00000266913 | 2.98 | -3.73 | 0.90 | -4.14 | 3.4e-05 | 8.6e-04 | LINC01841 | 105372288 |
| ENSG00000213231 | 4.13 | -3.81 | 0.92 | -4.14 | 3.5e-05 | 8.8e-04 | TCL1B | 9623 |
| ENSG00000091181 | 12.89 | -2.50 | 0.61 | -4.12 | 3.8e-05 | 9.4e-04 | IL5RA | 3568 |
| ENSG00000181074 | 40.60 | -2.50 | 0.61 | -4.12 | 3.8e-05 | 9.5e-04 | OR52N4 | 390072 |
| ENSG00000144218 | 372.43 | -2.06 | 0.50 | -4.12 | 3.8e-05 | 9.5e-04 | AFF3 | 3899 |
| ENSG00000203721 | 5.53 | -2.01 | 0.49 | -4.12 | 3.8e-05 | 9.5e-04 | LINC00862 | 554279 |
| ENSG00000110848 | 1023.97 | -2.32 | 0.56 | -4.11 | 3.9e-05 | 9.6e-04 | CD69 | 969 |
| ENSG00000073734 | 8.92 | -2.50 | 0.61 | -4.11 | 4.0e-05 | 9.9e-04 | ABCB11 | 8647 |
| ENSG00000137673 | 23.60 | -3.21 | 0.78 | -4.11 | 4.0e-05 | 9.9e-04 | MMP7 | 4316 |
| ENSG00000158481 | 146.38 | -2.60 | 0.64 | -4.10 | 4.1e-05 | 1.0e-03 | CD1C | 911 |
| ENSG00000144460 | 7.44 | -3.97 | 0.97 | -4.10 | 4.1e-05 | 1.0e-03 | NYAP2 | 57624 |
| ENSG00000225362 | 35.25 | 2.21 | 0.54 | 4.10 | 4.1e-05 | 1.0e-03 | CT62 | 196993 |
| ENSG00000167634 | 6.51 | -2.55 | 0.63 | -4.08 | 4.5e-05 | 1.1e-03 | NLRP7 | 199713 |
| ENSG00000237484 | 15.36 | -2.06 | 0.51 | -4.07 | 4.7e-05 | 1.1e-03 | LINC01684 | 105372751 |
| ENSG00000231621 | 6.58 | -3.55 | 0.88 | -4.05 | 5.0e-05 | 1.2e-03 | ANKRD44-AS1 | 101927596 |
| ENSG00000143552 | 143.99 | 3.59 | 0.89 | 4.02 | 5.7e-05 | 1.3e-03 | NUP210L | 91181 |
| ENSG00000169413 | 401.36 | -2.04 | 0.51 | -4.02 | 5.7e-05 | 1.3e-03 | RNASE6 | 6039 |
| ENSG00000187997 | 6.49 | -4.09 | 1.03 | -3.98 | 6.8e-05 | 1.6e-03 | C17orf99 | 100141515 |
| ENSG00000090104 | 4596.00 | -2.42 | 0.61 | -3.98 | 7.0e-05 | 1.6e-03 | RGS1 | 5996 |
| ENSG00000227145 | 8.84 | -4.17 | 1.05 | -3.97 | 7.2e-05 | 1.7e-03 | IL21-AS1 | 100996941 |
| ENSG00000235295 | 2.39 | -4.13 | 1.04 | -3.96 | 7.6e-05 | 1.7e-03 | LINC01634 | 100192420 |
| ENSG00000093134 | 24.68 | -2.19 | 0.55 | -3.95 | 7.9e-05 | 1.8e-03 | VNN3 | 55350 |
| ENSG00000147614 | 11.31 | -2.55 | 0.65 | -3.94 | 8.2e-05 | 1.9e-03 | ATP6V0D2 | 245972 |
| ENSG00000179934 | 4.16 | -3.82 | 0.97 | -3.92 | 8.7e-05 | 2.0e-03 | CCR8 | 1237 |
| ENSG00000152192 | 6.95 | -2.69 | 0.69 | -3.92 | 8.9e-05 | 2.0e-03 | POU4F1 | 5457 |
| ENSG00000233673 | 24.19 | -2.52 | 0.65 | -3.90 | 9.6e-05 | 2.1e-03 | ANAPC1P1 | 100286979 |
| ENSG00000231752 | 6.93 | -2.43 | 0.62 | -3.90 | 9.6e-05 | 2.2e-03 | EMBP1 | 647121 |
| ENSG00000231682 | 2.83 | -4.82 | 1.24 | -3.90 | 9.8e-05 | 2.2e-03 | LINC01891 | 105373934 |
| ENSG00000238266 | 2.00 | -4.79 | 1.24 | -3.87 | 1.1e-04 | 2.4e-03 | LINC00707 | 100507127 |
| ENSG00000215644 | 24.88 | -2.69 | 0.70 | -3.86 | 1.1e-04 | 2.5e-03 | GCGR | 2642 |
| ENSG00000102970 | 22.77 | -3.52 | 0.91 | -3.86 | 1.2e-04 | 2.5e-03 | CCL17 | 6361 |
| ENSG00000169245 | 334.62 | -2.86 | 0.75 | -3.83 | 1.3e-04 | 2.7e-03 | CXCL10 | 3627 |
| ENSG00000260802 | 9.70 | -3.53 | 0.92 | -3.83 | 1.3e-04 | 2.8e-03 | SERTM2 | 401613 |
| ENSG00000179840 | 4.32 | -3.21 | 0.84 | -3.82 | 1.3e-04 | 2.9e-03 | PIK3CD-AS1 | 644997 |
| ENSG00000114455 | 9.48 | -2.13 | 0.56 | -3.81 | 1.4e-04 | 3.0e-03 | HHLA2 | 11148 |
| ENSG00000263080 | 5.94 | -2.61 | 0.69 | -3.81 | 1.4e-04 | 3.0e-03 | LOC105371083 | 105371083 |
| ENSG00000109674 | 10.31 | -2.27 | 0.60 | -3.80 | 1.5e-04 | 3.1e-03 | NEIL3 | 55247 |
| ENSG00000146049 | 11.35 | 2.42 | 0.64 | 3.79 | 1.5e-04 | 3.2e-03 | KAAG1 | 353219 |
| ENSG00000150556 | 18.44 | -2.40 | 0.63 | -3.79 | 1.5e-04 | 3.2e-03 | LYPD6B | 130576 |
| ENSG00000166603 | 2.76 | -5.30 | 1.40 | -3.79 | 1.5e-04 | 3.2e-03 | MC4R | 4160 |
| ENSG00000160505 | 15.67 | -3.76 | 1.00 | -3.78 | 1.6e-04 | 3.4e-03 | NLRP4 | 147945 |
| ENSG00000166211 | 3.85 | -4.64 | 1.23 | -3.77 | 1.6e-04 | 3.4e-03 | SPIC | 121599 |
| ENSG00000233093 | 25.46 | -2.39 | 0.64 | -3.75 | 1.8e-04 | 3.7e-03 | LINC00892 | 100128420 |
| ENSG00000231858 | 1.96 | -3.00 | 0.81 | -3.72 | 2.0e-04 | 4.1e-03 | LOC105373805 | 105373805 |
| ENSG00000255582 | 2.27 | -4.44 | 1.20 | -3.72 | 2.0e-04 | 4.1e-03 | OR10G2 | 26534 |
| ENSG00000181126 | 226.48 | -2.09 | 0.56 | -3.71 | 2.1e-04 | 4.2e-03 | HLA-V | 352962 |
| ENSG00000228495 | 12.87 | -2.59 | 0.70 | -3.71 | 2.1e-04 | 4.3e-03 | LINC01013 | 100507254 |
| ENSG00000255221 | 1.65 | -3.96 | 1.07 | -3.70 | 2.1e-04 | 4.3e-03 | CARD17 | 440068 |
| ENSG00000241163 | 47.41 | -2.79 | 0.75 | -3.70 | 2.2e-04 | 4.4e-03 | LINC00877 | 285286 |
| ENSG00000125726 | 34.17 | -2.72 | 0.74 | -3.69 | 2.2e-04 | 4.4e-03 | CD70 | 970 |
| ENSG00000185972 | 11.61 | 2.51 | 0.68 | 3.69 | 2.3e-04 | 4.5e-03 | CCIN | 881 |
| ENSG00000269720 | 9.15 | -2.25 | 0.61 | -3.69 | 2.3e-04 | 4.5e-03 | CCDC194 | 110806280 |
| ENSG00000272666 | 17.64 | -2.62 | 0.72 | -3.66 | 2.5e-04 | 4.9e-03 | LOC105373098 | 105373098 |
| ENSG00000179088 | 30.18 | -3.61 | 0.99 | -3.66 | 2.5e-04 | 5.0e-03 | C12orf42 | 374470 |
| ENSG00000226935 | 5.19 | -2.79 | 0.76 | -3.65 | 2.6e-04 | 5.0e-03 | LINC00161 | 118421 |
| ENSG00000152766 | 26.41 | -2.38 | 0.65 | -3.65 | 2.7e-04 | 5.2e-03 | ANKRD22 | 118932 |
| ENSG00000110680 | 74.69 | 3.45 | 0.95 | 3.64 | 2.8e-04 | 5.4e-03 | CALCA | 796 |
| ENSG00000261760 | 8.02 | 2.32 | 0.64 | 3.63 | 2.8e-04 | 5.5e-03 | LOC100507334 | 100507334 |
| ENSG00000054803 | 35.24 | 2.56 | 0.70 | 3.63 | 2.8e-04 | 5.5e-03 | CBLN4 | 140689 |
| ENSG00000188848 | 78.97 | -3.31 | 0.91 | -3.62 | 2.9e-04 | 5.6e-03 | BEND4 | 389206 |
| ENSG00000133063 | 151.67 | -2.04 | 0.56 | -3.62 | 3.0e-04 | 5.7e-03 | CHIT1 | 1118 |
| ENSG00000223914 | 9.48 | -4.56 | 1.26 | -3.62 | 3.0e-04 | 5.7e-03 | LINC02471 | 105369734 |
| ENSG00000167618 | 5.97 | -3.02 | 0.84 | -3.61 | 3.0e-04 | 5.8e-03 | LAIR2 | 3904 |
| ENSG00000170786 | 15.44 | -2.41 | 0.67 | -3.60 | 3.2e-04 | 6.1e-03 | SDR16C5 | 195814 |
| ENSG00000170128 | 11.45 | -2.14 | 0.60 | -3.59 | 3.3e-04 | 6.2e-03 | GPR25 | 2848 |
| ENSG00000105251 | 7.38 | -2.29 | 0.64 | -3.59 | 3.3e-04 | 6.2e-03 | SHD | 56961 |
| ENSG00000100079 | 38.13 | -2.31 | 0.64 | -3.59 | 3.3e-04 | 6.2e-03 | LGALS2 | 3957 |
| ENSG00000168078 | 36.21 | -2.07 | 0.58 | -3.59 | 3.4e-04 | 6.3e-03 | PBK | 55872 |
| ENSG00000164265 | 8.02 | -2.56 | 0.72 | -3.58 | 3.5e-04 | 6.5e-03 | SCGB3A2 | 117156 |
| ENSG00000137868 | 91.86 | -2.26 | 0.64 | -3.52 | 4.4e-04 | 7.9e-03 | STRA6 | 64220 |
| ENSG00000078081 | 359.38 | -2.11 | 0.60 | -3.50 | 4.6e-04 | 8.2e-03 | LAMP3 | 27074 |
| ENSG00000197721 | 7.85 | -2.56 | 0.73 | -3.50 | 4.6e-04 | 8.2e-03 | CR1L | 1379 |
| ENSG00000254126 | 5.04 | -3.46 | 0.99 | -3.49 | 4.8e-04 | 8.5e-03 | CD8B2 | 927 |
| ENSG00000224184 | 4.39 | -3.18 | 0.92 | -3.45 | 5.6e-04 | 9.6e-03 | MIR3681HG | 100506457 |
| ENSG00000258512 | 19.70 | -2.01 | 0.58 | -3.45 | 5.6e-04 | 9.7e-03 | LINC00239 | 145200 |
| ENSG00000158402 | 13.54 | -2.05 | 0.59 | -3.44 | 5.8e-04 | 9.9e-03 | CDC25C | 995 |
| ENSG00000141096 | 12.75 | -2.01 | 0.58 | -3.44 | 5.8e-04 | 9.9e-03 | DPEP3 | 64180 |
| ENSG00000104970 | 16.91 | -2.51 | 0.73 | -3.44 | 5.8e-04 | 1.0e-02 | KIR3DX1 | 90011 |
| ENSG00000267123 | 4.99 | -2.43 | 0.71 | -3.41 | 6.4e-04 | 1.1e-02 | SCAT1 | 101928710 |
| ENSG00000258525 | 8.96 | -2.09 | 0.61 | -3.41 | 6.5e-04 | 1.1e-02 | LOC100506071 | 100506071 |
| ENSG00000255772 | 2.18 | -3.11 | 0.91 | -3.41 | 6.6e-04 | 1.1e-02 | LINC01479 | 101927922 |
| ENSG00000104951 | 86.11 | -2.08 | 0.62 | -3.38 | 7.2e-04 | 1.2e-02 | IL4I1 | 259307 |
| ENSG00000121570 | 9.87 | -2.10 | 0.62 | -3.38 | 7.3e-04 | 1.2e-02 | DPPA4 | 55211 |
| ENSG00000212658 | 1.64 | -4.08 | 1.21 | -3.36 | 7.7e-04 | 1.3e-02 | KRTAP29-1 | 100533177 |
| ENSG00000165509 | 26.92 | 2.14 | 0.64 | 3.35 | 8.1e-04 | 1.3e-02 | MAGEC3 | 139081 |
| ENSG00000214336 | 1.32 | -3.50 | 1.05 | -3.34 | 8.4e-04 | 1.4e-02 | FOXI3 | 344167 |
| ENSG00000169035 | 24.78 | 2.23 | 0.67 | 3.33 | 8.7e-04 | 1.4e-02 | KLK7 | 5650 |
| ENSG00000124635 | 129.01 | -2.28 | 0.69 | -3.31 | 9.5e-04 | 1.5e-02 | H2BC11 | 8970 |
| ENSG00000230023 | 1.36 | -3.44 | 1.05 | -3.29 | 1.0e-03 | 1.6e-02 | LINC02800 | 284632 |
| ENSG00000144481 | 4.46 | -3.27 | 0.99 | -3.28 | 1.0e-03 | 1.6e-02 | TRPM8 | 79054 |
| ENSG00000258869 | 1.21 | -4.12 | 1.25 | -3.28 | 1.0e-03 | 1.6e-02 | LINC02312 | 100132612 |
| ENSG00000136244 | 352.73 | 2.50 | 0.77 | 3.27 | 1.1e-03 | 1.6e-02 | IL6 | 3569 |
| ENSG00000135248 | 11.80 | 2.25 | 0.69 | 3.27 | 1.1e-03 | 1.7e-02 | FAM71F1 | 84691 |
| ENSG00000187033 | 1.31 | -3.52 | 1.08 | -3.27 | 1.1e-03 | 1.7e-02 | SAMD7 | 344658 |
| ENSG00000237541 | 438.68 | -2.95 | 0.90 | -3.26 | 1.1e-03 | 1.7e-02 | HLA-DQA1 | 3117 |
| ENSG00000249993 | 5.95 | -2.93 | 0.90 | -3.24 | 1.2e-03 | 1.8e-02 | BFSP2-AS1 | 85003 |
| ENSG00000140835 | 20.12 | -2.01 | 0.62 | -3.24 | 1.2e-03 | 1.8e-02 | CHST4 | 10164 |
| ENSG00000158050 | 1402.26 | -2.46 | 0.76 | -3.24 | 1.2e-03 | 1.8e-02 | DUSP2 | 1844 |
| ENSG00000183395 | 3.02 | -3.14 | 0.97 | -3.23 | 1.2e-03 | 1.9e-02 | PMCH | 5367 |
| ENSG00000255151 | 2.16 | -4.92 | 1.53 | -3.23 | 1.3e-03 | 1.9e-02 | GLYATL1B | 100287520 |
| ENSG00000205057 | 2.70 | -5.30 | 1.65 | -3.21 | 1.3e-03 | 2.0e-02 | CLLU1OS | 574016 |
| ENSG00000254521 | 16.19 | -2.01 | 0.63 | -3.19 | 1.4e-03 | 2.1e-02 | SIGLEC12 | 89858 |
| ENSG00000237372 | 2.31 | -4.12 | 1.29 | -3.19 | 1.4e-03 | 2.1e-02 | UNQ6494 | 100129066 |
| ENSG00000168594 | 2.96 | -3.82 | 1.20 | -3.18 | 1.5e-03 | 2.1e-02 | ADAM29 | 11086 |
| ENSG00000159516 | 2.32 | 3.23 | 1.03 | 3.15 | 1.6e-03 | 2.3e-02 | SPRR2G | 6706 |
| ENSG00000111536 | 3.73 | -3.02 | 0.96 | -3.14 | 1.7e-03 | 2.3e-02 | IL26 | 55801 |
| ENSG00000233392 | 29.01 | -2.34 | 0.75 | -3.14 | 1.7e-03 | 2.4e-02 | LOC200772 | 200772 |
| ENSG00000116031 | 37.13 | -2.50 | 0.80 | -3.11 | 1.9e-03 | 2.6e-02 | CD207 | 50489 |
| ENSG00000124575 | 42.22 | -2.83 | 0.91 | -3.11 | 1.9e-03 | 2.6e-02 | H1-3 | 3007 |
| ENSG00000163501 | 96.72 | 2.65 | 0.85 | 3.10 | 1.9e-03 | 2.6e-02 | IHH | 3549 |
| ENSG00000249534 | 3.17 | 2.54 | 0.82 | 3.09 | 2.0e-03 | 2.7e-02 | LINC01258 | 101928776 |
| ENSG00000138684 | 1.57 | -4.14 | 1.34 | -3.08 | 2.1e-03 | 2.8e-02 | IL21 | 59067 |
| ENSG00000130957 | 5.14 | -2.27 | 0.74 | -3.07 | 2.1e-03 | 2.8e-02 | FBP2 | 8789 |
| ENSG00000249667 | 1.64 | -4.06 | 1.32 | -3.07 | 2.1e-03 | 2.8e-02 | LINC01259 | 106144599 |
| ENSG00000133980 | 4.43 | -3.23 | 1.05 | -3.07 | 2.1e-03 | 2.9e-02 | VRTN | 55237 |
| ENSG00000116014 | 6.12 | -2.44 | 0.79 | -3.07 | 2.2e-03 | 2.9e-02 | KISS1R | 84634 |
| ENSG00000267593 | 1.37 | -3.65 | 1.19 | -3.06 | 2.2e-03 | 2.9e-02 | LINC01926 | 105372147 |
| ENSG00000124391 | 4.71 | -2.37 | 0.77 | -3.06 | 2.2e-03 | 2.9e-02 | IL17C | 27189 |
| ENSG00000148123 | 1.49 | 3.28 | 1.07 | 3.06 | 2.2e-03 | 2.9e-02 | PLPPR1 | 54886 |
| ENSG00000185130 | 4.60 | -2.84 | 0.93 | -3.06 | 2.2e-03 | 2.9e-02 | H2BC13 | 8340 |
| ENSG00000267568 | 3.22 | -2.60 | 0.85 | -3.06 | 2.2e-03 | 2.9e-02 | LOC105371899 | 105371899 |
| ENSG00000173404 | 10.58 | -2.66 | 0.87 | -3.05 | 2.3e-03 | 3.0e-02 | INSM1 | 3642 |
| ENSG00000253214 | 2.27 | -3.11 | 1.02 | -3.05 | 2.3e-03 | 3.0e-02 | LOC105375924 | 105375924 |
| ENSG00000171643 | 10.08 | -2.09 | 0.69 | -3.05 | 2.3e-03 | 3.0e-02 | S100Z | 170591 |
| ENSG00000092758 | 3756.11 | 2.13 | 0.70 | 3.04 | 2.4e-03 | 3.1e-02 | COL9A3 | 1299 |
| ENSG00000196890 | 19.23 | -2.74 | 0.91 | -3.03 | 2.5e-03 | 3.2e-02 | H2BU1 | 128312 |
| ENSG00000154165 | 59.57 | -2.65 | 0.88 | -3.02 | 2.5e-03 | 3.2e-02 | GPR15 | 2838 |
| ENSG00000128322 | 10.47 | -2.10 | 0.70 | -3.00 | 2.7e-03 | 3.4e-02 | IGLL1 | 3543 |
| ENSG00000230943 | 3.19 | -3.58 | 1.20 | -3.00 | 2.7e-03 | 3.4e-02 | LINC02541 | 101927686 |
| ENSG00000150275 | 13.55 | -2.45 | 0.82 | -2.99 | 2.8e-03 | 3.5e-02 | PCDH15 | 65217 |
| ENSG00000187848 | 33.72 | -2.99 | 1.00 | -2.99 | 2.8e-03 | 3.5e-02 | P2RX2 | 22953 |
| ENSG00000265929 | 1.00 | -3.92 | 1.31 | -2.99 | 2.8e-03 | 3.5e-02 | MIR5195 | 100847062 |
| ENSG00000247151 | 2.16 | -2.90 | 0.97 | -2.99 | 2.8e-03 | 3.5e-02 | CSTF3-DT | 338739 |
| ENSG00000226397 | 2.11 | -3.58 | 1.20 | -2.98 | 2.9e-03 | 3.6e-02 | C12orf77 | 196415 |
| ENSG00000208024 | 2.71 | 2.06 | 0.69 | 2.97 | 3.0e-03 | 3.7e-02 | MIR199A2 | 406977 |
| ENSG00000197153 | 5.52 | -2.56 | 0.87 | -2.96 | 3.1e-03 | 3.7e-02 | H3C12 | 8356 |
| ENSG00000101292 | 2.26 | -3.86 | 1.31 | -2.96 | 3.1e-03 | 3.8e-02 | PROKR2 | 128674 |
| ENSG00000163121 | 5.59 | -2.34 | 0.79 | -2.95 | 3.1e-03 | 3.8e-02 | NEURL3 | 93082 |
| ENSG00000203814 | 172.27 | -2.37 | 0.80 | -2.95 | 3.2e-03 | 3.8e-02 | H2BC18 | 440689 |
| ENSG00000197888 | 9.89 | -2.58 | 0.88 | -2.94 | 3.3e-03 | 3.9e-02 | UGT2B17 | 7367 |
| ENSG00000164400 | 2.17 | -3.70 | 1.26 | -2.94 | 3.3e-03 | 4.0e-02 | CSF2 | 1437 |
| ENSG00000184357 | 4.57 | -3.23 | 1.11 | -2.91 | 3.6e-03 | 4.2e-02 | H1-5 | 3009 |
| ENSG00000105352 | 40.06 | -2.10 | 0.72 | -2.91 | 3.6e-03 | 4.2e-02 | CEACAM4 | 1089 |
| ENSG00000175514 | 3.17 | -2.31 | 0.80 | -2.89 | 3.9e-03 | 4.4e-02 | GPR152 | 390212 |
| ENSG00000185736 | 31.46 | -2.17 | 0.75 | -2.89 | 3.9e-03 | 4.4e-02 | ADARB2 | 105 |
| ENSG00000226807 | 7.26 | 2.29 | 0.79 | 2.89 | 3.9e-03 | 4.4e-02 | MROH5 | 389690 |
| ENSG00000231787 | 1.37 | -3.44 | 1.20 | -2.87 | 4.1e-03 | 4.6e-02 | H2BP9 | 115482691 |
| ENSG00000090402 | 1.65 | 4.03 | 1.41 | 2.87 | 4.1e-03 | 4.7e-02 | SI | 6476 |
| ENSG00000139151 | 1.34 | -2.97 | 1.04 | -2.86 | 4.2e-03 | 4.7e-02 | PLCZ1 | 89869 |
| ENSG00000016490 | 3.87 | 2.20 | 0.77 | 2.86 | 4.2e-03 | 4.8e-02 | CLCA1 | 1179 |
| ENSG00000169248 | 73.15 | -2.44 | 0.85 | -2.86 | 4.2e-03 | 4.8e-02 | CXCL11 | 6373 |
| ENSG00000132437 | 9.84 | 2.53 | 0.89 | 2.84 | 4.5e-03 | 5.0e-02 | DDC | 1644 |
| ENSG00000245928 | 1.96 | -2.53 | 0.89 | -2.83 | 4.6e-03 | 5.1e-02 | LOC101928809 | 101928809 |
| ENSG00000183822 | 3.41 | -2.28 | 0.81 | -2.83 | 4.7e-03 | 5.1e-02 | NCF4-AS1 | 107985578 |
| ENSG00000267522 | 1.81 | 2.63 | 0.93 | 2.81 | 4.9e-03 | 5.3e-02 | LINC01864 | 101928886 |
| ENSG00000135903 | 2.76 | 2.27 | 0.81 | 2.80 | 5.1e-03 | 5.4e-02 | PAX3 | 5077 |
| ENSG00000254415 | 110.45 | -2.15 | 0.77 | -2.80 | 5.1e-03 | 5.5e-02 | SIGLEC14 | 100049587 |
| ENSG00000138483 | 9.97 | 2.09 | 0.75 | 2.79 | 5.2e-03 | 5.6e-02 | CCDC54 | 84692 |
| ENSG00000207205 | 0.91 | -2.71 | 0.97 | -2.78 | 5.4e-03 | 5.7e-02 | RNVU1-15 | 101954267 |
| ENSG00000147256 | 4.77 | 2.12 | 0.76 | 2.78 | 5.4e-03 | 5.7e-02 | ARHGAP36 | 158763 |
| ENSG00000075461 | 19.72 | 2.12 | 0.77 | 2.77 | 5.5e-03 | 5.8e-02 | CACNG4 | 27092 |
| ENSG00000258483 | 2.19 | -3.44 | 1.24 | -2.77 | 5.6e-03 | 5.9e-02 | LINC02251 | 105371008 |
| ENSG00000176177 | 3.53 | -2.64 | 0.95 | -2.77 | 5.7e-03 | 5.9e-02 | ENTHD1 | 150350 |
| ENSG00000139223 | 1.35 | 3.42 | 1.24 | 2.76 | 5.9e-03 | 6.0e-02 | ANP32D | 23519 |
| ENSG00000131142 | 6.76 | -2.16 | 0.79 | -2.74 | 6.1e-03 | 6.3e-02 | CCL25 | 6370 |
| ENSG00000234224 | 5.03 | 2.81 | 1.03 | 2.73 | 6.2e-03 | 6.3e-02 | TMEM229A | 730130 |
| ENSG00000137270 | 5.81 | -2.58 | 0.95 | -2.73 | 6.4e-03 | 6.4e-02 | GCM1 | 8521 |
| ENSG00000251676 | 3.18 | 3.06 | 1.12 | 2.73 | 6.4e-03 | 6.4e-02 | SNHG27 | 101927305 |
| ENSG00000145451 | 4.39 | -2.86 | 1.05 | -2.72 | 6.6e-03 | 6.5e-02 | GLRA3 | 8001 |
| ENSG00000229921 | 2.58 | -2.32 | 0.86 | -2.70 | 6.8e-03 | 6.7e-02 | KIF25-AS1 | 100505879 |
| ENSG00000197978 | 3.23 | 2.52 | 0.93 | 2.70 | 6.9e-03 | 6.8e-02 | GOLGA6L9 | 440295 |
| ENSG00000196131 | 1.19 | 2.95 | 1.09 | 2.69 | 7.1e-03 | 6.9e-02 | VN1R2 | 317701 |
| ENSG00000189099 | 1.17 | 2.41 | 0.89 | 2.69 | 7.1e-03 | 6.9e-02 | PRSS48 | 345062 |
| ENSG00000147570 | 13.76 | -2.33 | 0.86 | -2.69 | 7.1e-03 | 6.9e-02 | DNAJC5B | 85479 |
| ENSG00000249550 | 1.89 | -3.38 | 1.26 | -2.69 | 7.2e-03 | 7.0e-02 | LINC01234 | 100506465 |
| ENSG00000186844 | 1.39 | 3.03 | 1.13 | 2.68 | 7.3e-03 | 7.1e-02 | LCE1A | 353131 |
| ENSG00000115602 | 1073.94 | 2.42 | 0.90 | 2.68 | 7.3e-03 | 7.1e-02 | IL1RL1 | 9173 |
| ENSG00000204033 | 2.20 | -2.46 | 0.92 | -2.68 | 7.4e-03 | 7.1e-02 | LRIT2 | 340745 |
| ENSG00000180613 | 1.49 | -3.93 | 1.47 | -2.68 | 7.4e-03 | 7.1e-02 | GSX2 | 170825 |
| ENSG00000137561 | 2.22 | -2.12 | 0.80 | -2.66 | 7.8e-03 | 7.4e-02 | TTPA | 7274 |
| ENSG00000198685 | 0.88 | 2.90 | 1.10 | 2.64 | 8.3e-03 | 7.8e-02 | LINC01565 | 23434 |
| ENSG00000254233 | 1.27 | -3.56 | 1.35 | -2.63 | 8.4e-03 | 7.8e-02 | LINC02365 | 105377586 |
| ENSG00000106302 | 6.53 | -2.51 | 0.95 | -2.63 | 8.4e-03 | 7.8e-02 | HYAL4 | 23553 |
| ENSG00000086967 | 152.58 | -2.00 | 0.77 | -2.62 | 8.8e-03 | 8.1e-02 | MYBPC2 | 4606 |
| ENSG00000215182 | 8.42 | 2.27 | 0.87 | 2.62 | 8.9e-03 | 8.2e-02 | MUC5AC | 4586 |
| ENSG00000226806 | 1.82 | -4.81 | 1.85 | -2.60 | 9.3e-03 | 8.4e-02 | LCT-AS1 | 100507600 |
| ENSG00000261645 | 1.22 | -2.76 | 1.08 | -2.57 | 1.0e-02 | 9.0e-02 | DISC1FP1 | 101929222 |
| ENSG00000218819 | 1.27 | -4.02 | 1.57 | -2.56 | 1.0e-02 | 9.0e-02 | TDRD15 | 100129278 |
| ENSG00000152592 | 4.89 | 2.01 | 0.79 | 2.55 | 1.1e-02 | 9.3e-02 | DMP1 | 1758 |
| ENSG00000173213 | 16.65 | -2.07 | 0.81 | -2.55 | 1.1e-02 | 9.3e-02 | TUBB8B | 260334 |
| ENSG00000258499 | 1.04 | -3.29 | 1.29 | -2.55 | 1.1e-02 | 9.4e-02 | LINC02287 | 101929002 |
| ENSG00000233922 | 1.78 | -2.15 | 0.84 | -2.55 | 1.1e-02 | 9.4e-02 | LINC01694 | 105372840 |
| ENSG00000167941 | 6.06 | 2.03 | 0.80 | 2.54 | 1.1e-02 | 9.4e-02 | SOST | 50964 |
| ENSG00000089225 | 237.40 | 2.36 | 0.93 | 2.54 | 1.1e-02 | 9.4e-02 | TBX5 | 6910 |
| ENSG00000152430 | 3.77 | 2.31 | 0.91 | 2.54 | 1.1e-02 | 9.5e-02 | BOLL | 66037 |
| ENSG00000240403 | 3.80 | -2.75 | 1.08 | -2.54 | 1.1e-02 | 9.6e-02 | KIR3DL2 | 3812 |
| ENSG00000229425 | 2.40 | -2.61 | 1.03 | -2.53 | 1.1e-02 | 9.7e-02 | LOC101927745 | 101927745 |
| ENSG00000228016 | 2.31 | -2.11 | 0.84 | -2.53 | 1.2e-02 | 9.8e-02 | RAPGEF4-AS1 | 91149 |
out of 46777 with nonzero total read count
adjusted p-value < 0.1
LFC > 0 (up) : 952, 2%
LFC < 0 (down) : 2862, 6.1%
outliers [1] : 0, 0%
low counts [2] : 14515, 31%
(mean count < 1)
[1] see 'cooksCutoff' argument of ?results
[2] see 'independentFiltering' argument of ?results
Tabla 8: toptable y tabla resumen que contienen tanto la lista como el resumen de los genes que presentan evidencia de estar diferencialmente expresados entre las condiciones NIT y ELI.
SFI vs ELI:
Finalmente, vamos a estudiar que diferencias existen entre la presencia de infilitraciones focales y la presencia de infiltraciones extensivas. Análogamente a las dos comparaciones anteriores, en la Tabla 9 podemos viusalizar la topTable con los genes diferencialmente expresados entre condiciones y la summaryTable con un resumen del número de genes sobrexpresados e infraexpresados. Observamos que -respecto a la aplcación de infiltraciones focales- la aplicación de infilitraciones extensivas en el tejido tiroideo (ELI) desencadena una respuesta que implica -por lo menos- la expresión diferencial de 3814 (8.1%). De estos genes, un 2% están sobrexpresados y un 6.1% infraexpresados.
| baseMean | log2FoldChange | lfcSE | stat | pvalue | padj | symbol | entrez | |
|---|---|---|---|---|---|---|---|---|
| ENSG00000105369 | 1948.87 | -4.90 | 0.80 | -6.14 | 8.4e-10 | 4.6e-07 | CD79A | 973 |
| ENSG00000170476 | 1628.40 | -4.15 | 0.74 | -5.61 | 2.0e-08 | 7.4e-06 | MZB1 | 51237 |
| ENSG00000156738 | 5112.78 | -4.50 | 0.81 | -5.54 | 3.0e-08 | 1.0e-05 | MS4A1 | 931 |
| ENSG00000181847 | 505.03 | -3.02 | 0.55 | -5.52 | 3.3e-08 | 1.1e-05 | TIGIT | 201633 |
| ENSG00000156234 | 561.78 | -4.44 | 0.83 | -5.32 | 1.0e-07 | 3.0e-05 | CXCL13 | 10563 |
| ENSG00000110777 | 1986.24 | -3.24 | 0.62 | -5.19 | 2.1e-07 | 5.7e-05 | POU2AF1 | 5450 |
| ENSG00000226777 | 416.84 | -3.91 | 0.76 | -5.13 | 2.8e-07 | 7.5e-05 | FAM30A | 9834 |
| ENSG00000132465 | 7603.68 | -3.78 | 0.74 | -5.09 | 3.6e-07 | 9.1e-05 | JCHAIN | 3512 |
| ENSG00000129204 | 428.14 | 2.15 | 0.44 | 4.89 | 1.0e-06 | 2.4e-04 | USP6 | 9098 |
| ENSG00000187862 | 90.87 | -2.94 | 0.60 | -4.86 | 1.2e-06 | 2.7e-04 | TTC24 | 164118 |
| ENSG00000235304 | 36.49 | -5.87 | 1.24 | -4.74 | 2.1e-06 | 4.8e-04 | LINC01281 | 286442 |
| ENSG00000048462 | 108.47 | -2.52 | 0.54 | -4.68 | 2.8e-06 | 6.3e-04 | TNFRSF17 | 608 |
| ENSG00000163534 | 804.39 | -3.53 | 0.76 | -4.63 | 3.7e-06 | 8.2e-04 | FCRL1 | 115350 |
| ENSG00000160856 | 926.56 | -3.03 | 0.66 | -4.57 | 4.8e-06 | 1.0e-03 | FCRL3 | 115352 |
| ENSG00000177455 | 1184.57 | -3.51 | 0.77 | -4.56 | 5.1e-06 | 1.1e-03 | CD19 | 930 |
| ENSG00000254709 | 101.05 | -4.44 | 0.98 | -4.54 | 5.6e-06 | 1.1e-03 | IGLL5 | 100423062 |
| ENSG00000122188 | 236.81 | -2.19 | 0.49 | -4.51 | 6.6e-06 | 1.3e-03 | LAX1 | 54900 |
| ENSG00000235532 | 73.30 | -4.17 | 0.93 | -4.51 | 6.6e-06 | 1.3e-03 | LINC00402 | 100507612 |
| ENSG00000026751 | 787.52 | -2.25 | 0.50 | -4.49 | 7.2e-06 | 1.4e-03 | SLAMF7 | 57823 |
| ENSG00000197057 | 177.97 | -2.42 | 0.54 | -4.45 | 8.5e-06 | 1.7e-03 | DTHD1 | 401124 |
| ENSG00000086967 | 152.58 | -3.35 | 0.76 | -4.38 | 1.2e-05 | 2.3e-03 | MYBPC2 | 4606 |
| ENSG00000136573 | 911.22 | -2.90 | 0.66 | -4.38 | 1.2e-05 | 2.3e-03 | BLK | 640 |
| ENSG00000083454 | 913.26 | -2.62 | 0.60 | -4.37 | 1.2e-05 | 2.3e-03 | P2RX5 | 5026 |
| ENSG00000140465 | 120.99 | -3.68 | 0.84 | -4.36 | 1.3e-05 | 2.4e-03 | CYP1A1 | 1543 |
| ENSG00000089012 | 258.32 | -2.24 | 0.51 | -4.36 | 1.3e-05 | 2.4e-03 | SIRPG | 55423 |
| ENSG00000121895 | 207.04 | -2.60 | 0.60 | -4.32 | 1.5e-05 | 2.8e-03 | TMEM156 | 80008 |
| ENSG00000196092 | 398.98 | -3.43 | 0.80 | -4.31 | 1.6e-05 | 2.8e-03 | PAX5 | 5079 |
| ENSG00000159958 | 162.27 | -3.54 | 0.82 | -4.30 | 1.7e-05 | 3.0e-03 | TNFRSF13C | 115650 |
| ENSG00000122224 | 497.02 | -2.47 | 0.58 | -4.28 | 1.8e-05 | 3.2e-03 | LY9 | 4063 |
| ENSG00000143297 | 1671.07 | -3.42 | 0.80 | -4.27 | 2.0e-05 | 3.4e-03 | FCRL5 | 83416 |
| ENSG00000113088 | 259.07 | -2.48 | 0.58 | -4.26 | 2.0e-05 | 3.4e-03 | GZMK | 3003 |
| ENSG00000116748 | 50.56 | -2.34 | 0.55 | -4.24 | 2.2e-05 | 3.7e-03 | AMPD1 | 270 |
| ENSG00000198576 | 199.58 | 2.48 | 0.59 | 4.18 | 2.9e-05 | 4.7e-03 | ARC | 23237 |
| ENSG00000086159 | 5.21 | 2.72 | 0.66 | 4.13 | 3.6e-05 | 5.6e-03 | AQP6 | 363 |
| ENSG00000138755 | 1841.40 | -2.50 | 0.61 | -4.13 | 3.6e-05 | 5.7e-03 | CXCL9 | 4283 |
| ENSG00000168081 | 68.51 | -2.60 | 0.64 | -4.07 | 4.7e-05 | 7.1e-03 | PNOC | 5368 |
| ENSG00000092345 | 4.26 | 4.26 | 1.07 | 3.97 | 7.0e-05 | 1.0e-02 | DAZL | 1618 |
| ENSG00000257242 | 72.86 | -2.07 | 0.52 | -3.96 | 7.5e-05 | 1.1e-02 | LINC01619 | 256021 |
| ENSG00000240505 | 194.19 | -4.25 | 1.08 | -3.92 | 8.7e-05 | 1.2e-02 | TNFRSF13B | 23495 |
| ENSG00000131096 | 18.83 | 2.26 | 0.58 | 3.91 | 9.2e-05 | 1.3e-02 | PYY | 5697 |
| ENSG00000165076 | 9.47 | 2.28 | 0.59 | 3.89 | 1.0e-04 | 1.4e-02 | PRSS37 | 136242 |
| ENSG00000225362 | 35.25 | 2.07 | 0.54 | 3.85 | 1.2e-04 | 1.6e-02 | CT62 | 196993 |
| ENSG00000183918 | 263.35 | -2.09 | 0.54 | -3.85 | 1.2e-04 | 1.6e-02 | SH2D1A | 4068 |
| ENSG00000255760 | 66.56 | -4.18 | 1.09 | -3.84 | 1.2e-04 | 1.6e-02 | LINC02422 | 105369723 |
| ENSG00000269404 | 416.45 | -2.45 | 0.64 | -3.82 | 1.3e-04 | 1.8e-02 | SPIB | 6689 |
| ENSG00000171903 | 519.64 | -2.20 | 0.58 | -3.80 | 1.5e-04 | 1.9e-02 | CYP4F11 | 57834 |
| ENSG00000234184 | 32.14 | -4.48 | 1.18 | -3.79 | 1.5e-04 | 2.0e-02 | LINC01781 | 101927412 |
| ENSG00000178562 | 397.88 | -2.24 | 0.60 | -3.76 | 1.7e-04 | 2.1e-02 | CD28 | 940 |
| ENSG00000136931 | 7.75 | 2.98 | 0.80 | 3.73 | 1.9e-04 | 2.4e-02 | NR5A1 | 2516 |
| ENSG00000158477 | 22.99 | -3.95 | 1.07 | -3.70 | 2.2e-04 | 2.7e-02 | CD1A | 909 |
| ENSG00000137673 | 23.60 | -2.89 | 0.78 | -3.69 | 2.2e-04 | 2.7e-02 | MMP7 | 4316 |
| ENSG00000135248 | 11.80 | 2.57 | 0.70 | 3.68 | 2.3e-04 | 2.8e-02 | FAM71F1 | 84691 |
| ENSG00000102970 | 22.77 | -3.33 | 0.91 | -3.65 | 2.6e-04 | 3.1e-02 | CCL17 | 6361 |
| ENSG00000049249 | 22.64 | -2.35 | 0.65 | -3.64 | 2.8e-04 | 3.3e-02 | TNFRSF9 | 3604 |
| ENSG00000249923 | 7.03 | 2.03 | 0.56 | 3.62 | 3.0e-04 | 3.5e-02 | LOC284865 | 284865 |
| ENSG00000255733 | 55.44 | -2.68 | 0.75 | -3.55 | 3.9e-04 | 4.4e-02 | IFNG-AS1 | 100885789 |
| ENSG00000185972 | 11.61 | 2.40 | 0.68 | 3.52 | 4.2e-04 | 4.7e-02 | CCIN | 881 |
| ENSG00000163599 | 420.70 | -2.19 | 0.63 | -3.49 | 4.9e-04 | 5.4e-02 | CTLA4 | 1493 |
| ENSG00000254211 | 7.61 | -2.54 | 0.73 | -3.47 | 5.2e-04 | 5.6e-02 | LINC01485 | 101928154 |
| ENSG00000078589 | 193.96 | -2.04 | 0.59 | -3.47 | 5.3e-04 | 5.7e-02 | P2RY10 | 27334 |
| ENSG00000234572 | 10.73 | -3.91 | 1.14 | -3.44 | 5.8e-04 | 6.0e-02 | LINC01800 | 101927438 |
| ENSG00000163508 | 258.50 | -2.01 | 0.58 | -3.44 | 5.9e-04 | 6.1e-02 | EOMES | 8320 |
| ENSG00000169245 | 334.62 | -2.56 | 0.75 | -3.43 | 6.1e-04 | 6.3e-02 | CXCL10 | 3627 |
| ENSG00000159556 | 10.15 | -2.90 | 0.85 | -3.40 | 6.7e-04 | 6.8e-02 | ISL2 | 64843 |
| ENSG00000256574 | 14.46 | -3.47 | 1.02 | -3.39 | 6.9e-04 | 6.9e-02 | OR13A1 | 79290 |
| ENSG00000231439 | 54.87 | 2.28 | 0.68 | 3.34 | 8.3e-04 | 8.0e-02 | WASIR2 | 100132169 |
| ENSG00000144460 | 7.44 | -3.25 | 0.98 | -3.33 | 8.6e-04 | 8.2e-02 | NYAP2 | 57624 |
| ENSG00000100721 | 310.88 | -3.08 | 0.93 | -3.30 | 9.6e-04 | 8.9e-02 | TCL1A | 8115 |
| ENSG00000204595 | 1.65 | 3.59 | 1.09 | 3.29 | 9.9e-04 | 9.2e-02 | DPRX | 503834 |
| ENSG00000185155 | 28.43 | -2.44 | 0.75 | -3.27 | 1.1e-03 | 9.9e-02 | MIXL1 | 83881 |
out of 46777 with nonzero total read count
adjusted p-value < 0.1
LFC > 0 (up) : 1292, 2.8%
LFC < 0 (down) : 2843, 6.1%
outliers [1] : 0, 0%
low counts [2] : 17235, 37%
(mean count < 2)
[1] see 'cooksCutoff' argument of ?results
[2] see 'independentFiltering' argument of ?results
Tabla 9: toptable y tabla resumen que contienen tanto la lista como el resumen de los genes que presentan evidencia de estar diferencialmente expresados entre las condiciones SFI y ELI.
Las tablas de genes diferencialmente expresados (conocidas también como topTables) tienen la misma debilidad y el mismo punto fuerte: contienen demasiada información. Una alternativa más visual para identificar cuan diferencialmente expresados están los genes de cada comparación es mediante el uso de volcano plots. A continuación se muestran los volcano plots para cada una de las 3 comparaciones (Figura 3). Para facilitar su interpretación se han añadido una línea horizontal con el fdr cutoff (FDR = 0.1), dos líneas verticales con los foldChange cutoffs (FC = -2, 2) y una leyenda de colores (NS = gris, log2FC = verde, p-value = azul, p-value & log2FC = rojo).
En línea con lo observado en las topTables y las summaryTables, los volcano plots parecen indicar que las comparaciones que presentan una mayor variación en su expresión son NITvsELI y SFIvsELI. Visto de otro modo, esto sugiere que la aplicación de infiltraciones focales no tiene un efecto demasiado significativo respecto al control. Estos resultados secundan el patrón que observamos en el PCA plot de los datos normalizados (Figura 1).
Figura 3: volcano plots resultantes de las comparaciones entre los grupos NIT, SFI (A), NIT y ELI (B) y SFI y ELI (C). Se consideran diferencialmente expresados los genes que corresponden a los puntos de color rojo.
Aunque ya conocemos que genes están sobrexpresados o infraexpresados en cada de las comparaciones, es difícil extraer conclusiones a partir de esta información. Con el objetivo de obtener una visión más general e identificar que vías metabólicas se ven modificadas por la presencia y grado de infiltraciones en el tejido tiroideo, podemos realizar un análisis de significación o de pathways. Este tipo de análisis permiten clasificar y agrupar los genes diferencialmente expresados dentro de las vías metabólicas en las que participan. A continuación se muestra, para cada dieta, una tabla que contiene los resultados de este análisis (Tablas 10-12).
NIT vs SFI:
| Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | |
|---|---|---|---|---|---|---|
| GO:0042113 | B cell activation | 12/54 | 310/18670 | 6.5e-11 | 6.6e-08 | 4.9e-08 |
| GO:0042100 | B cell proliferation | 8/54 | 95/18670 | 2.9e-10 | 1.4e-07 | 1.1e-07 |
| GO:0050853 | B cell receptor signaling pathway | 8/54 | 129/18670 | 3.3e-09 | 1.1e-06 | 8.4e-07 |
| GO:0006959 | humoral immune response | 11/54 | 356/18670 | 4.8e-09 | 1.2e-06 | 9.0e-07 |
| GO:0050851 | antigen receptor-mediated signaling pathway | 10/54 | 316/18670 | 2.1e-08 | 4.2e-06 | 3.1e-06 |
| GO:0050864 | regulation of B cell activation | 8/54 | 184/18670 | 5.4e-08 | 9.1e-06 | 6.8e-06 |
| GO:0046651 | lymphocyte proliferation | 9/54 | 272/18670 | 7.8e-08 | 1.0e-05 | 7.8e-06 |
| GO:0032943 | mononuclear cell proliferation | 9/54 | 274/18670 | 8.3e-08 | 1.0e-05 | 7.8e-06 |
| GO:0051249 | regulation of lymphocyte activation | 11/54 | 485/18670 | 1.1e-07 | 1.3e-05 | 9.5e-06 |
| GO:0070661 | leukocyte proliferation | 9/54 | 298/18670 | 1.7e-07 | 1.7e-05 | 1.3e-05 |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 10/54 | 473/18670 | 8.7e-07 | 7.4e-05 | 5.5e-05 |
| GO:0030888 | regulation of B cell proliferation | 5/54 | 61/18670 | 8.8e-07 | 7.4e-05 | 5.5e-05 |
| GO:0050855 | regulation of B cell receptor signaling pathway | 4/54 | 29/18670 | 1.4e-06 | 1.1e-04 | 8.2e-05 |
| GO:0030098 | lymphocyte differentiation | 8/54 | 353/18670 | 7.4e-06 | 5.3e-04 | 4.0e-04 |
| GO:0010524 | positive regulation of calcium ion transport into cytosol | 4/54 | 54/18670 | 1.8e-05 | 1.2e-03 | 8.9e-04 |
| GO:0050670 | regulation of lymphocyte proliferation | 6/54 | 208/18670 | 2.9e-05 | 1.8e-03 | 1.3e-03 |
| GO:0032944 | regulation of mononuclear cell proliferation | 6/54 | 209/18670 | 3.0e-05 | 1.8e-03 | 1.3e-03 |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | 7/54 | 319/18670 | 3.5e-05 | 2.0e-03 | 1.5e-03 |
| GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 4/54 | 65/18670 | 3.7e-05 | 2.0e-03 | 1.5e-03 |
| GO:0070663 | regulation of leukocyte proliferation | 6/54 | 222/18670 | 4.2e-05 | 2.1e-03 | 1.6e-03 |
| GO:0042110 | T cell activation | 8/54 | 464/18670 | 5.2e-05 | 2.5e-03 | 1.9e-03 |
| GO:0051480 | regulation of cytosolic calcium ion concentration | 7/54 | 357/18670 | 7.2e-05 | 3.3e-03 | 2.5e-03 |
| GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 7/54 | 361/18670 | 7.7e-05 | 3.4e-03 | 2.5e-03 |
| GO:0060402 | calcium ion transport into cytosol | 5/54 | 158/18670 | 9.2e-05 | 3.9e-03 | 2.9e-03 |
| GO:0070098 | chemokine-mediated signaling pathway | 4/54 | 88/18670 | 1.2e-04 | 4.9e-03 | 3.7e-03 |
| GO:0060401 | cytosolic calcium ion transport | 5/54 | 171/18670 | 1.3e-04 | 5.2e-03 | 3.9e-03 |
| GO:0022407 | regulation of cell-cell adhesion | 7/54 | 403/18670 | 1.5e-04 | 5.7e-03 | 4.3e-03 |
| GO:1990868 | response to chemokine | 4/54 | 97/18670 | 1.8e-04 | 6.2e-03 | 4.6e-03 |
| GO:1990869 | cellular response to chemokine | 4/54 | 97/18670 | 1.8e-04 | 6.2e-03 | 4.6e-03 |
| GO:0071356 | cellular response to tumor necrosis factor | 6/54 | 291/18670 | 1.9e-04 | 6.3e-03 | 4.7e-03 |
| GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 3/54 | 40/18670 | 2.1e-04 | 6.8e-03 | 5.1e-03 |
| GO:0010522 | regulation of calcium ion transport into cytosol | 4/54 | 102/18670 | 2.2e-04 | 6.8e-03 | 5.1e-03 |
| GO:0030593 | neutrophil chemotaxis | 4/54 | 104/18670 | 2.3e-04 | 7.1e-03 | 5.3e-03 |
| GO:1903037 | regulation of leukocyte cell-cell adhesion | 6/54 | 304/18670 | 2.4e-04 | 7.1e-03 | 5.3e-03 |
| GO:0034612 | response to tumor necrosis factor | 6/54 | 312/18670 | 2.7e-04 | 7.9e-03 | 5.9e-03 |
| GO:0050863 | regulation of T cell activation | 6/54 | 314/18670 | 2.8e-04 | 7.9e-03 | 5.9e-03 |
| GO:0006874 | cellular calcium ion homeostasis | 7/54 | 458/18670 | 3.3e-04 | 9.1e-03 | 6.8e-03 |
| GO:1990266 | neutrophil migration | 4/54 | 118/18670 | 3.8e-04 | 1.0e-02 | 7.4e-03 |
| GO:0051251 | positive regulation of lymphocyte activation | 6/54 | 334/18670 | 3.9e-04 | 1.0e-02 | 7.4e-03 |
| GO:0055074 | calcium ion homeostasis | 7/54 | 471/18670 | 4.0e-04 | 1.0e-02 | 7.4e-03 |
| GO:0007159 | leukocyte cell-cell adhesion | 6/54 | 337/18670 | 4.1e-04 | 1.0e-02 | 7.5e-03 |
| GO:0019730 | antimicrobial humoral response | 4/54 | 122/18670 | 4.3e-04 | 1.0e-02 | 7.5e-03 |
| GO:0051928 | positive regulation of calcium ion transport | 4/54 | 123/18670 | 4.4e-04 | 1.0e-02 | 7.5e-03 |
| GO:0071621 | granulocyte chemotaxis | 4/54 | 123/18670 | 4.4e-04 | 1.0e-02 | 7.5e-03 |
| GO:0045661 | regulation of myoblast differentiation | 3/54 | 53/18670 | 4.8e-04 | 1.1e-02 | 8.1e-03 |
| GO:0002449 | lymphocyte mediated immunity | 6/54 | 352/18670 | 5.2e-04 | 1.1e-02 | 8.3e-03 |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 7/54 | 493/18670 | 5.2e-04 | 1.1e-02 | 8.3e-03 |
| GO:0030183 | B cell differentiation | 4/54 | 131/18670 | 5.6e-04 | 1.2e-02 | 8.7e-03 |
| GO:0031295 | T cell costimulation | 3/54 | 56/18670 | 5.7e-04 | 1.2e-02 | 8.7e-03 |
| GO:0031294 | lymphocyte costimulation | 3/54 | 57/18670 | 6.0e-04 | 1.2e-02 | 9.0e-03 |
| GO:0097530 | granulocyte migration | 4/54 | 141/18670 | 7.4e-04 | 1.4e-02 | 1.0e-02 |
| GO:0050871 | positive regulation of B cell activation | 4/54 | 142/18670 | 7.6e-04 | 1.4e-02 | 1.0e-02 |
| GO:0002260 | lymphocyte homeostasis | 3/54 | 62/18670 | 7.7e-04 | 1.4e-02 | 1.0e-02 |
| GO:0002696 | positive regulation of leukocyte activation | 6/54 | 380/18670 | 7.7e-04 | 1.4e-02 | 1.0e-02 |
| GO:1904064 | positive regulation of cation transmembrane transport | 4/54 | 144/18670 | 8.0e-04 | 1.4e-02 | 1.0e-02 |
| GO:0002637 | regulation of immunoglobulin production | 3/54 | 63/18670 | 8.0e-04 | 1.4e-02 | 1.0e-02 |
| GO:0051924 | regulation of calcium ion transport | 5/54 | 254/18670 | 8.2e-04 | 1.4e-02 | 1.0e-02 |
| GO:0022409 | positive regulation of cell-cell adhesion | 5/54 | 255/18670 | 8.4e-04 | 1.4e-02 | 1.0e-02 |
| GO:0051250 | negative regulation of lymphocyte activation | 4/54 | 146/18670 | 8.4e-04 | 1.4e-02 | 1.0e-02 |
| GO:0048247 | lymphocyte chemotaxis | 3/54 | 64/18670 | 8.4e-04 | 1.4e-02 | 1.0e-02 |
| GO:0002467 | germinal center formation | 2/54 | 15/18670 | 8.4e-04 | 1.4e-02 | 1.0e-02 |
| GO:0050867 | positive regulation of cell activation | 6/54 | 394/18670 | 9.3e-04 | 1.5e-02 | 1.1e-02 |
| GO:0030889 | negative regulation of B cell proliferation | 2/54 | 16/18670 | 9.6e-04 | 1.5e-02 | 1.1e-02 |
| GO:2000243 | positive regulation of reproductive process | 3/54 | 69/18670 | 1.0e-03 | 1.7e-02 | 1.2e-02 |
| GO:0034767 | positive regulation of ion transmembrane transport | 4/54 | 156/18670 | 1.1e-03 | 1.7e-02 | 1.2e-02 |
| GO:0010819 | regulation of T cell chemotaxis | 2/54 | 17/18670 | 1.1e-03 | 1.7e-02 | 1.2e-02 |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 3/54 | 71/18670 | 1.1e-03 | 1.7e-02 | 1.3e-02 |
| GO:0043270 | positive regulation of ion transport | 5/54 | 275/18670 | 1.2e-03 | 1.7e-02 | 1.3e-02 |
| GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 3/54 | 73/18670 | 1.2e-03 | 1.8e-02 | 1.3e-02 |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | 4/54 | 167/18670 | 1.4e-03 | 2.0e-02 | 1.5e-02 |
| GO:0007492 | endoderm development | 3/54 | 76/18670 | 1.4e-03 | 2.0e-02 | 1.5e-02 |
| GO:0006816 | calcium ion transport | 6/54 | 434/18670 | 1.5e-03 | 2.2e-02 | 1.6e-02 |
| GO:0002695 | negative regulation of leukocyte activation | 4/54 | 175/18670 | 1.6e-03 | 2.2e-02 | 1.7e-02 |
| GO:0035590 | purinergic nucleotide receptor signaling pathway | 2/54 | 21/18670 | 1.7e-03 | 2.2e-02 | 1.7e-02 |
| GO:1901739 | regulation of myoblast fusion | 2/54 | 21/18670 | 1.7e-03 | 2.2e-02 | 1.7e-02 |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 3/54 | 82/18670 | 1.7e-03 | 2.3e-02 | 1.7e-02 |
| GO:0033622 | integrin activation | 2/54 | 22/18670 | 1.8e-03 | 2.4e-02 | 1.8e-02 |
| GO:0045445 | myoblast differentiation | 3/54 | 84/18670 | 1.8e-03 | 2.4e-02 | 1.8e-02 |
| GO:0002285 | lymphocyte activation involved in immune response | 4/54 | 181/18670 | 1.9e-03 | 2.4e-02 | 1.8e-02 |
| GO:0001776 | leukocyte homeostasis | 3/54 | 86/18670 | 2.0e-03 | 2.5e-02 | 1.9e-02 |
| GO:0002697 | regulation of immune effector process | 6/54 | 458/18670 | 2.0e-03 | 2.5e-02 | 1.9e-02 |
| GO:0002683 | negative regulation of immune system process | 6/54 | 463/18670 | 2.1e-03 | 2.6e-02 | 2.0e-02 |
| GO:0002377 | immunoglobulin production | 4/54 | 193/18670 | 2.3e-03 | 2.8e-02 | 2.1e-02 |
| GO:0032461 | positive regulation of protein oligomerization | 2/54 | 25/18670 | 2.4e-03 | 2.8e-02 | 2.1e-02 |
| GO:0045662 | negative regulation of myoblast differentiation | 2/54 | 25/18670 | 2.4e-03 | 2.8e-02 | 2.1e-02 |
| GO:0050866 | negative regulation of cell activation | 4/54 | 199/18670 | 2.6e-03 | 3.0e-02 | 2.3e-02 |
| GO:0070838 | divalent metal ion transport | 6/54 | 483/18670 | 2.6e-03 | 3.0e-02 | 2.3e-02 |
| GO:1901623 | regulation of lymphocyte chemotaxis | 2/54 | 27/18670 | 2.8e-03 | 3.1e-02 | 2.3e-02 |
| GO:0050870 | positive regulation of T cell activation | 4/54 | 202/18670 | 2.8e-03 | 3.1e-02 | 2.3e-02 |
| GO:0072511 | divalent inorganic cation transport | 6/54 | 489/18670 | 2.8e-03 | 3.1e-02 | 2.3e-02 |
| GO:0034764 | positive regulation of transmembrane transport | 4/54 | 204/18670 | 2.9e-03 | 3.2e-02 | 2.4e-02 |
| GO:0010818 | T cell chemotaxis | 2/54 | 28/18670 | 3.0e-03 | 3.3e-02 | 2.4e-02 |
| GO:0002824 | positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 3/54 | 100/18670 | 3.0e-03 | 3.3e-02 | 2.5e-02 |
| GO:0050900 | leukocyte migration | 6/54 | 499/18670 | 3.1e-03 | 3.3e-02 | 2.5e-02 |
| GO:0097529 | myeloid leukocyte migration | 4/54 | 210/18670 | 3.2e-03 | 3.3e-02 | 2.5e-02 |
| GO:0060142 | regulation of syncytium formation by plasma membrane fusion | 2/54 | 29/18670 | 3.2e-03 | 3.3e-02 | 2.5e-02 |
| GO:0001782 | B cell homeostasis | 2/54 | 30/18670 | 3.4e-03 | 3.5e-02 | 2.6e-02 |
| GO:0050869 | negative regulation of B cell activation | 2/54 | 30/18670 | 3.4e-03 | 3.5e-02 | 2.6e-02 |
| GO:0002708 | positive regulation of lymphocyte mediated immunity | 3/54 | 105/18670 | 3.5e-03 | 3.5e-02 | 2.6e-02 |
| GO:0002821 | positive regulation of adaptive immune response | 3/54 | 105/18670 | 3.5e-03 | 3.5e-02 | 2.6e-02 |
| GO:0002699 | positive regulation of immune effector process | 4/54 | 216/18670 | 3.5e-03 | 3.5e-02 | 2.6e-02 |
| GO:2000406 | positive regulation of T cell migration | 2/54 | 31/18670 | 3.6e-03 | 3.6e-02 | 2.7e-02 |
| GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 4/54 | 218/18670 | 3.6e-03 | 3.6e-02 | 2.7e-02 |
| GO:0001909 | leukocyte mediated cytotoxicity | 3/54 | 107/18670 | 3.7e-03 | 3.6e-02 | 2.7e-02 |
| GO:0035587 | purinergic receptor signaling pathway | 2/54 | 32/18670 | 3.9e-03 | 3.7e-02 | 2.7e-02 |
| GO:0045589 | regulation of regulatory T cell differentiation | 2/54 | 32/18670 | 3.9e-03 | 3.7e-02 | 2.7e-02 |
| GO:0030595 | leukocyte chemotaxis | 4/54 | 224/18670 | 4.0e-03 | 3.8e-02 | 2.8e-02 |
| GO:0072676 | lymphocyte migration | 3/54 | 111/18670 | 4.1e-03 | 3.8e-02 | 2.8e-02 |
| GO:0050868 | negative regulation of T cell activation | 3/54 | 112/18670 | 4.2e-03 | 3.9e-02 | 2.9e-02 |
| GO:0045066 | regulatory T cell differentiation | 2/54 | 34/18670 | 4.3e-03 | 4.0e-02 | 3.0e-02 |
| GO:0032733 | positive regulation of interleukin-10 production | 2/54 | 36/18670 | 4.9e-03 | 4.4e-02 | 3.3e-02 |
| GO:0030217 | T cell differentiation | 4/54 | 240/18670 | 5.1e-03 | 4.6e-02 | 3.4e-02 |
| GO:2000403 | positive regulation of lymphocyte migration | 2/54 | 37/18670 | 5.1e-03 | 4.6e-02 | 3.4e-02 |
| GO:0010959 | regulation of metal ion transport | 5/54 | 394/18670 | 5.5e-03 | 4.9e-02 | 3.6e-02 |
| GO:0051209 | release of sequestered calcium ion into cytosol | 3/54 | 124/18670 | 5.5e-03 | 4.9e-02 | 3.6e-02 |
Tabla 10: GOtable que contiene las vías metabólicas expresadas diferencialmente entre los grupos NIT y SFI.
NIT vs ELI:
| Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | |
|---|---|---|---|---|---|---|
| GO:0042110 | T cell activation | 94/547 | 464/18670 | 3.6e-52 | 1.4e-48 | 1.2e-48 |
| GO:0030098 | lymphocyte differentiation | 75/547 | 353/18670 | 4.9e-43 | 9.9e-40 | 8.1e-40 |
| GO:0030217 | T cell differentiation | 58/547 | 240/18670 | 1.2e-36 | 1.7e-33 | 1.4e-33 |
| GO:0051249 | regulation of lymphocyte activation | 78/547 | 485/18670 | 1.2e-35 | 1.1e-32 | 9.0e-33 |
| GO:0050863 | regulation of T cell activation | 64/547 | 314/18670 | 1.4e-35 | 1.1e-32 | 9.0e-33 |
| GO:0007159 | leukocyte cell-cell adhesion | 64/547 | 337/18670 | 1.1e-33 | 7.6e-31 | 6.3e-31 |
| GO:1903037 | regulation of leukocyte cell-cell adhesion | 59/547 | 304/18670 | 1.3e-31 | 7.4e-29 | 6.1e-29 |
| GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 49/547 | 218/18670 | 1.8e-29 | 8.9e-27 | 7.3e-27 |
| GO:0022407 | regulation of cell-cell adhesion | 63/547 | 403/18670 | 4.0e-28 | 1.8e-25 | 1.5e-25 |
| GO:0050870 | positive regulation of T cell activation | 46/547 | 202/18670 | 5.4e-28 | 2.2e-25 | 1.8e-25 |
| GO:0022409 | positive regulation of cell-cell adhesion | 50/547 | 255/18670 | 4.0e-27 | 1.5e-24 | 1.2e-24 |
| GO:0046651 | lymphocyte proliferation | 50/547 | 272/18670 | 9.1e-26 | 3.1e-23 | 2.5e-23 |
| GO:0070661 | leukocyte proliferation | 52/547 | 298/18670 | 1.2e-25 | 3.7e-23 | 3.1e-23 |
| GO:0032943 | mononuclear cell proliferation | 50/547 | 274/18670 | 1.3e-25 | 3.7e-23 | 3.1e-23 |
| GO:0002696 | positive regulation of leukocyte activation | 58/547 | 380/18670 | 2.1e-25 | 5.6e-23 | 4.6e-23 |
| GO:0050867 | positive regulation of cell activation | 59/547 | 394/18670 | 2.2e-25 | 5.6e-23 | 4.6e-23 |
| GO:0051251 | positive regulation of lymphocyte activation | 54/547 | 334/18670 | 6.2e-25 | 1.5e-22 | 1.2e-22 |
| GO:0002449 | lymphocyte mediated immunity | 54/547 | 352/18670 | 8.4e-24 | 1.9e-21 | 1.5e-21 |
| GO:0050670 | regulation of lymphocyte proliferation | 41/547 | 208/18670 | 1.7e-22 | 3.5e-20 | 2.9e-20 |
| GO:0032944 | regulation of mononuclear cell proliferation | 41/547 | 209/18670 | 2.0e-22 | 4.0e-20 | 3.3e-20 |
| GO:0070663 | regulation of leukocyte proliferation | 42/547 | 222/18670 | 2.6e-22 | 5.1e-20 | 4.2e-20 |
| GO:0046631 | alpha-beta T cell activation | 34/547 | 138/18670 | 3.6e-22 | 6.7e-20 | 5.5e-20 |
| GO:0045058 | T cell selection | 22/547 | 47/18670 | 9.2e-22 | 1.6e-19 | 1.3e-19 |
| GO:0042113 | B cell activation | 48/547 | 310/18670 | 2.0e-21 | 3.3e-19 | 2.7e-19 |
| GO:0045785 | positive regulation of cell adhesion | 54/547 | 403/18670 | 5.7e-21 | 9.1e-19 | 7.5e-19 |
| GO:0050851 | antigen receptor-mediated signaling pathway | 47/547 | 316/18670 | 2.9e-20 | 4.5e-18 | 3.7e-18 |
| GO:0045619 | regulation of lymphocyte differentiation | 35/547 | 169/18670 | 4.1e-20 | 5.9e-18 | 4.8e-18 |
| GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 50/547 | 361/18670 | 4.1e-20 | 5.9e-18 | 4.8e-18 |
| GO:0050900 | leukocyte migration | 59/547 | 499/18670 | 4.2e-20 | 5.9e-18 | 4.9e-18 |
| GO:0043368 | positive T cell selection | 18/547 | 34/18670 | 2.7e-19 | 3.7e-17 | 3.0e-17 |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 56/547 | 473/18670 | 3.8e-19 | 5.0e-17 | 4.1e-17 |
| GO:0002706 | regulation of lymphocyte mediated immunity | 32/547 | 149/18670 | 5.4e-19 | 6.8e-17 | 5.6e-17 |
| GO:0046632 | alpha-beta T cell differentiation | 27/547 | 101/18670 | 7.4e-19 | 9.1e-17 | 7.5e-17 |
| GO:0042129 | regulation of T cell proliferation | 32/547 | 156/18670 | 2.3e-18 | 2.7e-16 | 2.2e-16 |
| GO:0002699 | positive regulation of immune effector process | 37/547 | 216/18670 | 2.9e-18 | 3.3e-16 | 2.7e-16 |
| GO:1902105 | regulation of leukocyte differentiation | 41/547 | 272/18670 | 5.0e-18 | 5.6e-16 | 4.6e-16 |
| GO:0045580 | regulation of T cell differentiation | 30/547 | 139/18670 | 5.9e-18 | 6.5e-16 | 5.3e-16 |
| GO:0002697 | regulation of immune effector process | 53/547 | 458/18670 | 9.9e-18 | 1.1e-15 | 8.7e-16 |
| GO:0002703 | regulation of leukocyte mediated immunity | 35/547 | 201/18670 | 1.4e-17 | 1.4e-15 | 1.2e-15 |
| GO:0042102 | positive regulation of T cell proliferation | 25/547 | 95/18670 | 2.2e-17 | 2.3e-15 | 1.9e-15 |
| GO:0042098 | T cell proliferation | 33/547 | 184/18670 | 4.8e-17 | 4.7e-15 | 3.9e-15 |
| GO:0001819 | positive regulation of cytokine production | 52/547 | 464/18670 | 8.1e-17 | 7.8e-15 | 6.4e-15 |
| GO:0002285 | lymphocyte activation involved in immune response | 32/547 | 181/18670 | 2.2e-16 | 2.1e-14 | 1.7e-14 |
| GO:0002708 | positive regulation of lymphocyte mediated immunity | 25/547 | 105/18670 | 3.0e-16 | 2.7e-14 | 2.3e-14 |
| GO:0070665 | positive regulation of leukocyte proliferation | 28/547 | 139/18670 | 5.2e-16 | 4.6e-14 | 3.8e-14 |
| GO:0050671 | positive regulation of lymphocyte proliferation | 27/547 | 130/18670 | 7.7e-16 | 6.8e-14 | 5.6e-14 |
| GO:0031295 | T cell costimulation | 19/547 | 56/18670 | 8.4e-16 | 7.3e-14 | 6.0e-14 |
| GO:0032946 | positive regulation of mononuclear cell proliferation | 27/547 | 131/18670 | 9.5e-16 | 8.0e-14 | 6.5e-14 |
| GO:0031294 | lymphocyte costimulation | 19/547 | 57/18670 | 1.2e-15 | 1.0e-13 | 8.4e-14 |
| GO:0002683 | negative regulation of immune system process | 50/547 | 463/18670 | 1.5e-15 | 1.2e-13 | 9.9e-14 |
| GO:0042100 | B cell proliferation | 23/547 | 95/18670 | 3.2e-15 | 2.5e-13 | 2.1e-13 |
| GO:0033077 | T cell differentiation in thymus | 20/547 | 70/18670 | 6.4e-15 | 5.0e-13 | 4.1e-13 |
| GO:0032609 | interferon-gamma production | 24/547 | 113/18670 | 1.9e-14 | 1.4e-12 | 1.2e-12 |
| GO:0002819 | regulation of adaptive immune response | 28/547 | 160/18670 | 2.3e-14 | 1.7e-12 | 1.4e-12 |
| GO:0031341 | regulation of cell killing | 22/547 | 98/18670 | 6.9e-14 | 5.0e-12 | 4.2e-12 |
| GO:0002705 | positive regulation of leukocyte mediated immunity | 25/547 | 133/18670 | 1.0e-13 | 7.5e-12 | 6.1e-12 |
| GO:0072676 | lymphocyte migration | 23/547 | 111/18670 | 1.2e-13 | 8.2e-12 | 6.7e-12 |
| GO:0050852 | T cell receptor signaling pathway | 30/547 | 202/18670 | 2.4e-13 | 1.7e-11 | 1.4e-11 |
| GO:0043367 | CD4-positive, alpha-beta T cell differentiation | 19/547 | 74/18670 | 2.6e-13 | 1.8e-11 | 1.5e-11 |
| GO:0001909 | leukocyte mediated cytotoxicity | 22/547 | 107/18670 | 4.7e-13 | 3.2e-11 | 2.6e-11 |
| GO:0031343 | positive regulation of cell killing | 18/547 | 68/18670 | 6.3e-13 | 4.2e-11 | 3.4e-11 |
| GO:0001910 | regulation of leukocyte mediated cytotoxicity | 19/547 | 78/18670 | 7.3e-13 | 4.8e-11 | 3.9e-11 |
| GO:0002822 | regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 25/547 | 145/18670 | 8.0e-13 | 5.1e-11 | 4.2e-11 |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | 37/547 | 319/18670 | 9.6e-13 | 6.1e-11 | 5.0e-11 |
| GO:1903706 | regulation of hemopoiesis | 46/547 | 475/18670 | 1.1e-12 | 7.0e-11 | 5.7e-11 |
| GO:0032649 | regulation of interferon-gamma production | 21/547 | 101/18670 | 1.3e-12 | 7.8e-11 | 6.4e-11 |
| GO:0046634 | regulation of alpha-beta T cell activation | 20/547 | 93/18670 | 2.2e-12 | 1.4e-10 | 1.1e-10 |
| GO:0045061 | thymic T cell selection | 11/547 | 21/18670 | 3.3e-12 | 2.0e-10 | 1.6e-10 |
| GO:0001912 | positive regulation of leukocyte mediated cytotoxicity | 16/547 | 56/18670 | 3.3e-12 | 2.0e-10 | 1.6e-10 |
| GO:0001906 | cell killing | 26/547 | 168/18670 | 3.7e-12 | 2.1e-10 | 1.7e-10 |
| GO:0030595 | leukocyte chemotaxis | 30/547 | 224/18670 | 3.7e-12 | 2.1e-10 | 1.7e-10 |
| GO:1990868 | response to chemokine | 20/547 | 97/18670 | 5.2e-12 | 2.9e-10 | 2.3e-10 |
| GO:1990869 | cellular response to chemokine | 20/547 | 97/18670 | 5.2e-12 | 2.9e-10 | 2.3e-10 |
| GO:0051480 | regulation of cytosolic calcium ion concentration | 38/547 | 357/18670 | 6.7e-12 | 3.6e-10 | 3.0e-10 |
| GO:0070098 | chemokine-mediated signaling pathway | 19/547 | 88/18670 | 7.4e-12 | 4.0e-10 | 3.3e-10 |
| GO:0002695 | negative regulation of leukocyte activation | 26/547 | 175/18670 | 9.6e-12 | 5.1e-10 | 4.2e-10 |
| GO:0035710 | CD4-positive, alpha-beta T cell activation | 19/547 | 92/18670 | 1.7e-11 | 9.0e-10 | 7.4e-10 |
| GO:0046635 | positive regulation of alpha-beta T cell activation | 16/547 | 62/18670 | 1.9e-11 | 9.7e-10 | 7.9e-10 |
| GO:0002440 | production of molecular mediator of immune response | 33/547 | 286/18670 | 1.9e-11 | 9.9e-10 | 8.1e-10 |
| GO:0060326 | cell chemotaxis | 34/547 | 304/18670 | 2.3e-11 | 1.1e-09 | 9.4e-10 |
| GO:0002821 | positive regulation of adaptive immune response | 20/547 | 105/18670 | 2.4e-11 | 1.2e-09 | 9.8e-10 |
| GO:0045621 | positive regulation of lymphocyte differentiation | 19/547 | 94/18670 | 2.5e-11 | 1.3e-09 | 1.0e-09 |
| GO:0002286 | T cell activation involved in immune response | 20/547 | 106/18670 | 2.9e-11 | 1.4e-09 | 1.2e-09 |
| GO:1902107 | positive regulation of leukocyte differentiation | 23/547 | 144/18670 | 3.4e-11 | 1.6e-09 | 1.3e-09 |
| GO:0032729 | positive regulation of interferon-gamma production | 16/547 | 65/18670 | 4.1e-11 | 1.9e-09 | 1.6e-09 |
| GO:0042108 | positive regulation of cytokine biosynthetic process | 16/547 | 67/18670 | 6.7e-11 | 3.1e-09 | 2.6e-09 |
| GO:0002824 | positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 19/547 | 100/18670 | 7.9e-11 | 3.7e-09 | 3.0e-09 |
| GO:0002377 | immunoglobulin production | 26/547 | 193/18670 | 9.0e-11 | 4.2e-09 | 3.4e-09 |
| GO:0042035 | regulation of cytokine biosynthetic process | 20/547 | 114/18670 | 1.1e-10 | 5.2e-09 | 4.3e-09 |
| GO:0055074 | calcium ion homeostasis | 42/547 | 471/18670 | 1.5e-10 | 6.9e-09 | 5.7e-09 |
| GO:0050853 | B cell receptor signaling pathway | 21/547 | 129/18670 | 1.7e-10 | 7.4e-09 | 6.0e-09 |
| GO:0002287 | alpha-beta T cell activation involved in immune response | 15/547 | 61/18670 | 1.7e-10 | 7.4e-09 | 6.0e-09 |
| GO:0002293 | alpha-beta T cell differentiation involved in immune response | 15/547 | 61/18670 | 1.7e-10 | 7.4e-09 | 6.0e-09 |
| GO:0050866 | negative regulation of cell activation | 26/547 | 199/18670 | 1.8e-10 | 7.7e-09 | 6.4e-09 |
| GO:0002456 | T cell mediated immunity | 19/547 | 106/18670 | 2.3e-10 | 9.6e-09 | 7.9e-09 |
| GO:0006874 | cellular calcium ion homeostasis | 41/547 | 458/18670 | 2.3e-10 | 9.6e-09 | 7.9e-09 |
| GO:0043383 | negative T cell selection | 8/547 | 12/18670 | 2.3e-10 | 9.6e-09 | 7.9e-09 |
| GO:0043373 | CD4-positive, alpha-beta T cell lineage commitment | 9/547 | 17/18670 | 2.9e-10 | 1.2e-08 | 1.0e-08 |
| GO:0002228 | natural killer cell mediated immunity | 15/547 | 64/18670 | 3.5e-10 | 1.4e-08 | 1.2e-08 |
| GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 15/547 | 65/18670 | 4.5e-10 | 1.8e-08 | 1.5e-08 |
| GO:0072678 | T cell migration | 15/547 | 65/18670 | 4.5e-10 | 1.8e-08 | 1.5e-08 |
| GO:0042089 | cytokine biosynthetic process | 20/547 | 123/18670 | 4.7e-10 | 1.9e-08 | 1.5e-08 |
| GO:0042107 | cytokine metabolic process | 20/547 | 124/18670 | 5.5e-10 | 2.1e-08 | 1.8e-08 |
| GO:0002292 | T cell differentiation involved in immune response | 15/547 | 68/18670 | 8.8e-10 | 3.4e-08 | 2.8e-08 |
| GO:0050864 | regulation of B cell activation | 24/547 | 184/18670 | 9.4e-10 | 3.6e-08 | 3.0e-08 |
| GO:0002363 | alpha-beta T cell lineage commitment | 9/547 | 19/18670 | 1.1e-09 | 4.0e-08 | 3.3e-08 |
| GO:0002294 | CD4-positive, alpha-beta T cell differentiation involved in immune response | 14/547 | 60/18670 | 1.5e-09 | 5.5e-08 | 4.5e-08 |
| GO:0030183 | B cell differentiation | 20/547 | 131/18670 | 1.5e-09 | 5.5e-08 | 4.6e-08 |
| GO:0002360 | T cell lineage commitment | 10/547 | 26/18670 | 1.5e-09 | 5.5e-08 | 4.6e-08 |
| GO:0030888 | regulation of B cell proliferation | 14/547 | 61/18670 | 1.8e-09 | 6.8e-08 | 5.6e-08 |
| GO:0043369 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment | 9/547 | 20/18670 | 1.9e-09 | 6.8e-08 | 5.6e-08 |
| GO:0045582 | positive regulation of T cell differentiation | 16/547 | 83/18670 | 2.0e-09 | 7.2e-08 | 5.9e-08 |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 41/547 | 493/18670 | 2.1e-09 | 7.4e-08 | 6.1e-08 |
| GO:0002237 | response to molecule of bacterial origin | 33/547 | 343/18670 | 2.3e-09 | 8.1e-08 | 6.7e-08 |
| GO:0046637 | regulation of alpha-beta T cell differentiation | 14/547 | 63/18670 | 2.9e-09 | 1.0e-07 | 8.4e-08 |
| GO:0006968 | cellular defense response | 13/547 | 53/18670 | 2.9e-09 | 1.0e-07 | 8.4e-08 |
| GO:0032496 | response to lipopolysaccharide | 32/547 | 330/18670 | 3.3e-09 | 1.1e-07 | 9.4e-08 |
| GO:0071219 | cellular response to molecule of bacterial origin | 25/547 | 212/18670 | 3.5e-09 | 1.2e-07 | 9.9e-08 |
| GO:0002700 | regulation of production of molecular mediator of immune response | 20/547 | 139/18670 | 4.3e-09 | 1.5e-07 | 1.2e-07 |
| GO:0045060 | negative thymic T cell selection | 7/547 | 11/18670 | 5.3e-09 | 1.8e-07 | 1.5e-07 |
| GO:1903708 | positive regulation of hemopoiesis | 23/547 | 185/18670 | 5.4e-09 | 1.8e-07 | 1.5e-07 |
| GO:0002295 | T-helper cell lineage commitment | 8/547 | 16/18670 | 5.4e-09 | 1.8e-07 | 1.5e-07 |
| GO:0002715 | regulation of natural killer cell mediated immunity | 12/547 | 46/18670 | 5.6e-09 | 1.8e-07 | 1.5e-07 |
| GO:0002381 | immunoglobulin production involved in immunoglobulin mediated immune response | 13/547 | 56/18670 | 6.1e-09 | 2.0e-07 | 1.6e-07 |
| GO:0019722 | calcium-mediated signaling | 25/547 | 218/18670 | 6.3e-09 | 2.0e-07 | 1.7e-07 |
| GO:0043370 | regulation of CD4-positive, alpha-beta T cell differentiation | 12/547 | 47/18670 | 7.3e-09 | 2.3e-07 | 1.9e-07 |
| GO:0071216 | cellular response to biotic stimulus | 26/547 | 236/18670 | 7.3e-09 | 2.3e-07 | 1.9e-07 |
| GO:0019724 | B cell mediated immunity | 25/547 | 221/18670 | 8.3e-09 | 2.6e-07 | 2.2e-07 |
| GO:0071222 | cellular response to lipopolysaccharide | 24/547 | 205/18670 | 8.4e-09 | 2.6e-07 | 2.2e-07 |
| GO:0042093 | T-helper cell differentiation | 13/547 | 58/18670 | 9.6e-09 | 3.0e-07 | 2.5e-07 |
| GO:0051250 | negative regulation of lymphocyte activation | 20/547 | 146/18670 | 1.0e-08 | 3.1e-07 | 2.6e-07 |
| GO:0072540 | T-helper 17 cell lineage commitment | 7/547 | 12/18670 | 1.2e-08 | 3.8e-07 | 3.1e-07 |
| GO:0002709 | regulation of T cell mediated immunity | 14/547 | 70/18670 | 1.2e-08 | 3.8e-07 | 3.1e-07 |
| GO:0042267 | natural killer cell mediated cytotoxicity | 13/547 | 60/18670 | 1.5e-08 | 4.5e-07 | 3.7e-07 |
| GO:0002685 | regulation of leukocyte migration | 23/547 | 196/18670 | 1.6e-08 | 4.9e-07 | 4.0e-07 |
| GO:0006959 | humoral immune response | 32/547 | 356/18670 | 2.1e-08 | 6.2e-07 | 5.1e-07 |
| GO:0045059 | positive thymic T cell selection | 7/547 | 13/18670 | 2.6e-08 | 7.7e-07 | 6.4e-07 |
| GO:0032103 | positive regulation of response to external stimulus | 30/547 | 323/18670 | 2.8e-08 | 8.1e-07 | 6.7e-07 |
| GO:0045076 | regulation of interleukin-2 biosynthetic process | 8/547 | 19/18670 | 2.9e-08 | 8.5e-07 | 7.0e-07 |
| GO:0019932 | second-messenger-mediated signaling | 36/547 | 439/18670 | 2.9e-08 | 8.5e-07 | 7.0e-07 |
| GO:0042269 | regulation of natural killer cell mediated cytotoxicity | 11/547 | 44/18670 | 3.9e-08 | 1.1e-06 | 9.3e-07 |
| GO:0045088 | regulation of innate immune response | 36/547 | 452/18670 | 6.1e-08 | 1.7e-06 | 1.4e-06 |
| GO:0001773 | myeloid dendritic cell activation | 9/547 | 28/18670 | 6.3e-08 | 1.8e-06 | 1.5e-06 |
| GO:0046638 | positive regulation of alpha-beta T cell differentiation | 11/547 | 47/18670 | 8.3e-08 | 2.3e-06 | 1.9e-06 |
| GO:0042094 | interleukin-2 biosynthetic process | 8/547 | 22/18670 | 1.1e-07 | 3.2e-06 | 2.6e-06 |
| GO:0016064 | immunoglobulin mediated immune response | 23/547 | 218/18670 | 1.2e-07 | 3.3e-06 | 2.7e-06 |
| GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity | 9/547 | 30/18670 | 1.2e-07 | 3.4e-06 | 2.8e-06 |
| GO:2000514 | regulation of CD4-positive, alpha-beta T cell activation | 12/547 | 61/18670 | 1.7e-07 | 4.6e-06 | 3.7e-06 |
| GO:0002312 | B cell activation involved in immune response | 13/547 | 73/18670 | 1.8e-07 | 4.8e-06 | 3.9e-06 |
| GO:0001776 | leukocyte homeostasis | 14/547 | 86/18670 | 1.9e-07 | 5.1e-06 | 4.2e-06 |
| GO:0032623 | interleukin-2 production | 12/547 | 62/18670 | 2.0e-07 | 5.4e-06 | 4.4e-06 |
| GO:1903038 | negative regulation of leukocyte cell-cell adhesion | 17/547 | 129/18670 | 2.3e-07 | 6.1e-06 | 5.0e-06 |
| GO:0002637 | regulation of immunoglobulin production | 12/547 | 63/18670 | 2.4e-07 | 6.4e-06 | 5.3e-06 |
| GO:0050857 | positive regulation of antigen receptor-mediated signaling pathway | 8/547 | 24/18670 | 2.5e-07 | 6.6e-06 | 5.4e-06 |
| GO:0002717 | positive regulation of natural killer cell mediated immunity | 9/547 | 33/18670 | 3.1e-07 | 7.9e-06 | 6.5e-06 |
| GO:0032633 | interleukin-4 production | 9/547 | 33/18670 | 3.1e-07 | 7.9e-06 | 6.5e-06 |
| GO:0050727 | regulation of inflammatory response | 36/547 | 485/18670 | 3.5e-07 | 8.9e-06 | 7.4e-06 |
| GO:1990266 | neutrophil migration | 16/547 | 118/18670 | 3.5e-07 | 8.9e-06 | 7.4e-06 |
| GO:0030593 | neutrophil chemotaxis | 15/547 | 104/18670 | 3.6e-07 | 9.1e-06 | 7.5e-06 |
| GO:0050901 | leukocyte tethering or rolling | 8/547 | 25/18670 | 3.6e-07 | 9.1e-06 | 7.5e-06 |
| GO:0032655 | regulation of interleukin-12 production | 11/547 | 54/18670 | 3.8e-07 | 9.4e-06 | 7.7e-06 |
| GO:0032663 | regulation of interleukin-2 production | 11/547 | 54/18670 | 3.8e-07 | 9.4e-06 | 7.7e-06 |
| GO:0022408 | negative regulation of cell-cell adhesion | 20/547 | 181/18670 | 3.8e-07 | 9.4e-06 | 7.7e-06 |
| GO:0045066 | regulatory T cell differentiation | 9/547 | 34/18670 | 4.1e-07 | 1.0e-05 | 8.2e-06 |
| GO:0050777 | negative regulation of immune response | 18/547 | 150/18670 | 4.2e-07 | 1.0e-05 | 8.6e-06 |
| GO:0072539 | T-helper 17 cell differentiation | 8/547 | 26/18670 | 5.1e-07 | 1.2e-05 | 1.0e-05 |
| GO:0032615 | interleukin-12 production | 11/547 | 56/18670 | 5.6e-07 | 1.3e-05 | 1.1e-05 |
| GO:0045086 | positive regulation of interleukin-2 biosynthetic process | 6/547 | 13/18670 | 8.9e-07 | 2.1e-05 | 1.8e-05 |
| GO:0050868 | negative regulation of T cell activation | 15/547 | 112/18670 | 9.5e-07 | 2.3e-05 | 1.9e-05 |
| GO:0097529 | myeloid leukocyte migration | 21/547 | 210/18670 | 1.0e-06 | 2.4e-05 | 2.0e-05 |
| GO:0002687 | positive regulation of leukocyte migration | 16/547 | 128/18670 | 1.1e-06 | 2.5e-05 | 2.1e-05 |
| GO:0002688 | regulation of leukocyte chemotaxis | 15/547 | 114/18670 | 1.2e-06 | 2.8e-05 | 2.3e-05 |
| GO:0002704 | negative regulation of leukocyte mediated immunity | 10/547 | 49/18670 | 1.3e-06 | 2.9e-05 | 2.4e-05 |
| GO:0050855 | regulation of B cell receptor signaling pathway | 8/547 | 29/18670 | 1.3e-06 | 3.0e-05 | 2.4e-05 |
| GO:0072538 | T-helper 17 type immune response | 8/547 | 29/18670 | 1.3e-06 | 3.0e-05 | 2.4e-05 |
| GO:1903555 | regulation of tumor necrosis factor superfamily cytokine production | 18/547 | 163/18670 | 1.5e-06 | 3.3e-05 | 2.7e-05 |
| GO:0046629 | gamma-delta T cell activation | 6/547 | 14/18670 | 1.5e-06 | 3.5e-05 | 2.8e-05 |
| GO:0002260 | lymphocyte homeostasis | 11/547 | 62/18670 | 1.6e-06 | 3.6e-05 | 3.0e-05 |
| GO:0002562 | somatic diversification of immune receptors via germline recombination within a single locus | 11/547 | 62/18670 | 1.6e-06 | 3.6e-05 | 3.0e-05 |
| GO:0016444 | somatic cell DNA recombination | 11/547 | 62/18670 | 1.6e-06 | 3.6e-05 | 3.0e-05 |
| GO:0032743 | positive regulation of interleukin-2 production | 8/547 | 30/18670 | 1.7e-06 | 3.8e-05 | 3.1e-05 |
| GO:0043372 | positive regulation of CD4-positive, alpha-beta T cell differentiation | 8/547 | 30/18670 | 1.7e-06 | 3.8e-05 | 3.1e-05 |
| GO:0002200 | somatic diversification of immune receptors | 12/547 | 75/18670 | 1.7e-06 | 3.8e-05 | 3.1e-05 |
| GO:0002712 | regulation of B cell mediated immunity | 10/547 | 51/18670 | 1.9e-06 | 4.0e-05 | 3.3e-05 |
| GO:0002889 | regulation of immunoglobulin mediated immune response | 10/547 | 51/18670 | 1.9e-06 | 4.0e-05 | 3.3e-05 |
| GO:0034612 | response to tumor necrosis factor | 26/547 | 312/18670 | 1.9e-06 | 4.0e-05 | 3.3e-05 |
| GO:2000401 | regulation of lymphocyte migration | 11/547 | 63/18670 | 1.9e-06 | 4.1e-05 | 3.4e-05 |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | 18/547 | 167/18670 | 2.1e-06 | 4.5e-05 | 3.7e-05 |
| GO:0048247 | lymphocyte chemotaxis | 11/547 | 64/18670 | 2.2e-06 | 4.8e-05 | 3.9e-05 |
| GO:0071706 | tumor necrosis factor superfamily cytokine production | 18/547 | 168/18670 | 2.3e-06 | 4.8e-05 | 3.9e-05 |
| GO:0001818 | negative regulation of cytokine production | 25/547 | 296/18670 | 2.3e-06 | 4.9e-05 | 4.0e-05 |
| GO:0050663 | cytokine secretion | 22/547 | 240/18670 | 2.5e-06 | 5.2e-05 | 4.3e-05 |
| GO:0050729 | positive regulation of inflammatory response | 17/547 | 153/18670 | 2.6e-06 | 5.5e-05 | 4.5e-05 |
| GO:0097028 | dendritic cell differentiation | 9/547 | 42/18670 | 2.8e-06 | 5.8e-05 | 4.8e-05 |
| GO:0032753 | positive regulation of interleukin-4 production | 7/547 | 23/18670 | 2.9e-06 | 6.0e-05 | 5.0e-05 |
| GO:0045089 | positive regulation of innate immune response | 29/547 | 381/18670 | 3.0e-06 | 6.1e-05 | 5.0e-05 |
| GO:0000819 | sister chromatid segregation | 19/547 | 189/18670 | 3.1e-06 | 6.3e-05 | 5.2e-05 |
| GO:0007059 | chromosome segregation | 26/547 | 321/18670 | 3.1e-06 | 6.4e-05 | 5.3e-05 |
| GO:0071621 | granulocyte chemotaxis | 15/547 | 123/18670 | 3.2e-06 | 6.4e-05 | 5.3e-05 |
| GO:0140014 | mitotic nuclear division | 23/547 | 264/18670 | 3.5e-06 | 7.0e-05 | 5.8e-05 |
| GO:0001914 | regulation of T cell mediated cytotoxicity | 8/547 | 33/18670 | 3.8e-06 | 7.5e-05 | 6.2e-05 |
| GO:0000280 | nuclear division | 30/547 | 407/18670 | 3.8e-06 | 7.7e-05 | 6.3e-05 |
| GO:0097530 | granulocyte migration | 16/547 | 141/18670 | 3.9e-06 | 7.7e-05 | 6.4e-05 |
| GO:0033081 | regulation of T cell differentiation in thymus | 7/547 | 24/18670 | 4.0e-06 | 7.9e-05 | 6.5e-05 |
| GO:0060402 | calcium ion transport into cytosol | 17/547 | 158/18670 | 4.1e-06 | 8.0e-05 | 6.6e-05 |
| GO:2000404 | regulation of T cell migration | 9/547 | 44/18670 | 4.2e-06 | 8.3e-05 | 6.8e-05 |
| GO:0032680 | regulation of tumor necrosis factor production | 17/547 | 160/18670 | 4.8e-06 | 9.4e-05 | 7.7e-05 |
| GO:0006816 | calcium ion transport | 31/547 | 434/18670 | 5.0e-06 | 9.8e-05 | 8.1e-05 |
| GO:0002820 | negative regulation of adaptive immune response | 9/547 | 45/18670 | 5.2e-06 | 1.0e-04 | 8.2e-05 |
| GO:0071356 | cellular response to tumor necrosis factor | 24/547 | 291/18670 | 5.5e-06 | 1.1e-04 | 8.7e-05 |
| GO:0006310 | DNA recombination | 24/547 | 292/18670 | 5.9e-06 | 1.1e-04 | 9.2e-05 |
| GO:0002701 | negative regulation of production of molecular mediator of immune response | 8/547 | 35/18670 | 6.0e-06 | 1.1e-04 | 9.4e-05 |
| GO:0045622 | regulation of T-helper cell differentiation | 8/547 | 35/18670 | 6.0e-06 | 1.1e-04 | 9.4e-05 |
| GO:0032640 | tumor necrosis factor production | 17/547 | 163/18670 | 6.2e-06 | 1.2e-04 | 9.6e-05 |
| GO:0002437 | inflammatory response to antigenic stimulus | 9/547 | 46/18670 | 6.2e-06 | 1.2e-04 | 9.6e-05 |
| GO:0002204 | somatic recombination of immunoglobulin genes involved in immune response | 9/547 | 47/18670 | 7.5e-06 | 1.4e-04 | 1.1e-04 |
| GO:0002208 | somatic diversification of immunoglobulins involved in immune response | 9/547 | 47/18670 | 7.5e-06 | 1.4e-04 | 1.1e-04 |
| GO:0045190 | isotype switching | 9/547 | 47/18670 | 7.5e-06 | 1.4e-04 | 1.1e-04 |
| GO:0030101 | natural killer cell activation | 12/547 | 86/18670 | 7.5e-06 | 1.4e-04 | 1.1e-04 |
| GO:2000516 | positive regulation of CD4-positive, alpha-beta T cell activation | 8/547 | 36/18670 | 7.6e-06 | 1.4e-04 | 1.1e-04 |
| GO:0002923 | regulation of humoral immune response mediated by circulating immunoglobulin | 5/547 | 11/18670 | 8.5e-06 | 1.5e-04 | 1.3e-04 |
| GO:0033089 | positive regulation of T cell differentiation in thymus | 5/547 | 11/18670 | 8.5e-06 | 1.5e-04 | 1.3e-04 |
| GO:0002690 | positive regulation of leukocyte chemotaxis | 12/547 | 87/18670 | 8.5e-06 | 1.5e-04 | 1.3e-04 |
| GO:0002711 | positive regulation of T cell mediated immunity | 9/547 | 48/18670 | 9.0e-06 | 1.6e-04 | 1.3e-04 |
| GO:0002714 | positive regulation of B cell mediated immunity | 8/547 | 37/18670 | 9.4e-06 | 1.7e-04 | 1.4e-04 |
| GO:0002891 | positive regulation of immunoglobulin mediated immune response | 8/547 | 37/18670 | 9.4e-06 | 1.7e-04 | 1.4e-04 |
| GO:0000070 | mitotic sister chromatid segregation | 16/547 | 151/18670 | 9.5e-06 | 1.7e-04 | 1.4e-04 |
| GO:0032673 | regulation of interleukin-4 production | 7/547 | 27/18670 | 9.5e-06 | 1.7e-04 | 1.4e-04 |
| GO:0034113 | heterotypic cell-cell adhesion | 10/547 | 61/18670 | 1.0e-05 | 1.8e-04 | 1.5e-04 |
| GO:0045123 | cellular extravasation | 10/547 | 61/18670 | 1.0e-05 | 1.8e-04 | 1.5e-04 |
| GO:0001913 | T cell mediated cytotoxicity | 9/547 | 49/18670 | 1.1e-05 | 1.9e-04 | 1.5e-04 |
| GO:0071887 | leukocyte apoptotic process | 13/547 | 104/18670 | 1.1e-05 | 1.9e-04 | 1.6e-04 |
| GO:0060401 | cytosolic calcium ion transport | 17/547 | 171/18670 | 1.2e-05 | 2.0e-04 | 1.7e-04 |
| GO:0002922 | positive regulation of humoral immune response | 6/547 | 19/18670 | 1.2e-05 | 2.1e-04 | 1.7e-04 |
| GO:0046641 | positive regulation of alpha-beta T cell proliferation | 6/547 | 19/18670 | 1.2e-05 | 2.1e-04 | 1.7e-04 |
| GO:0071674 | mononuclear cell migration | 12/547 | 90/18670 | 1.2e-05 | 2.1e-04 | 1.7e-04 |
| GO:0045577 | regulation of B cell differentiation | 7/547 | 28/18670 | 1.2e-05 | 2.1e-04 | 1.7e-04 |
| GO:0048872 | homeostasis of number of cells | 21/547 | 246/18670 | 1.3e-05 | 2.1e-04 | 1.8e-04 |
| GO:0002863 | positive regulation of inflammatory response to antigenic stimulus | 5/547 | 12/18670 | 1.4e-05 | 2.4e-04 | 2.0e-04 |
| GO:0007162 | negative regulation of cell adhesion | 23/547 | 289/18670 | 1.5e-05 | 2.6e-04 | 2.1e-04 |
| GO:0016445 | somatic diversification of immunoglobulins | 10/547 | 64/18670 | 1.6e-05 | 2.6e-04 | 2.2e-04 |
| GO:0045165 | cell fate commitment | 22/547 | 270/18670 | 1.6e-05 | 2.7e-04 | 2.2e-04 |
| GO:0051209 | release of sequestered calcium ion into cytosol | 14/547 | 124/18670 | 1.6e-05 | 2.7e-04 | 2.2e-04 |
| GO:0070838 | divalent metal ion transport | 32/547 | 483/18670 | 1.6e-05 | 2.7e-04 | 2.2e-04 |
| GO:0002823 | negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 8/547 | 40/18670 | 1.7e-05 | 2.9e-04 | 2.4e-04 |
| GO:0016447 | somatic recombination of immunoglobulin gene segments | 9/547 | 52/18670 | 1.8e-05 | 2.9e-04 | 2.4e-04 |
| GO:0002548 | monocyte chemotaxis | 10/547 | 65/18670 | 1.8e-05 | 3.0e-04 | 2.4e-04 |
| GO:0050871 | positive regulation of B cell activation | 15/547 | 142/18670 | 1.9e-05 | 3.0e-04 | 2.5e-04 |
| GO:0051283 | negative regulation of sequestering of calcium ion | 14/547 | 126/18670 | 2.0e-05 | 3.2e-04 | 2.6e-04 |
| GO:0050869 | negative regulation of B cell activation | 7/547 | 30/18670 | 2.0e-05 | 3.3e-04 | 2.7e-04 |
| GO:0072511 | divalent inorganic cation transport | 32/547 | 489/18670 | 2.1e-05 | 3.4e-04 | 2.8e-04 |
| GO:0051282 | regulation of sequestering of calcium ion | 14/547 | 128/18670 | 2.4e-05 | 3.8e-04 | 3.1e-04 |
| GO:0048285 | organelle fission | 30/547 | 449/18670 | 2.6e-05 | 4.1e-04 | 3.4e-04 |
| GO:2000106 | regulation of leukocyte apoptotic process | 11/547 | 83/18670 | 3.0e-05 | 4.7e-04 | 3.9e-04 |
| GO:0051208 | sequestering of calcium ion | 14/547 | 131/18670 | 3.1e-05 | 4.9e-04 | 4.0e-04 |
| GO:0048305 | immunoglobulin secretion | 6/547 | 22/18670 | 3.1e-05 | 4.9e-04 | 4.0e-04 |
| GO:0045589 | regulation of regulatory T cell differentiation | 7/547 | 32/18670 | 3.2e-05 | 5.0e-04 | 4.1e-04 |
| GO:0098813 | nuclear chromosome segregation | 21/547 | 262/18670 | 3.2e-05 | 5.0e-04 | 4.2e-04 |
| GO:0002718 | regulation of cytokine production involved in immune response | 11/547 | 84/18670 | 3.3e-05 | 5.2e-04 | 4.3e-04 |
| GO:0043374 | CD8-positive, alpha-beta T cell differentiation | 5/547 | 14/18670 | 3.4e-05 | 5.3e-04 | 4.3e-04 |
| GO:0050862 | positive regulation of T cell receptor signaling pathway | 5/547 | 14/18670 | 3.4e-05 | 5.3e-04 | 4.3e-04 |
| GO:0061756 | leukocyte adhesion to vascular endothelial cell | 8/547 | 44/18670 | 3.6e-05 | 5.6e-04 | 4.6e-04 |
| GO:0046633 | alpha-beta T cell proliferation | 7/547 | 33/18670 | 3.9e-05 | 6.0e-04 | 5.0e-04 |
| GO:0036037 | CD8-positive, alpha-beta T cell activation | 6/547 | 23/18670 | 4.1e-05 | 6.2e-04 | 5.1e-04 |
| GO:0050921 | positive regulation of chemotaxis | 14/547 | 135/18670 | 4.3e-05 | 6.6e-04 | 5.4e-04 |
| GO:0002532 | production of molecular mediator involved in inflammatory response | 10/547 | 72/18670 | 4.5e-05 | 6.8e-04 | 5.6e-04 |
| GO:0032660 | regulation of interleukin-17 production | 7/547 | 34/18670 | 4.8e-05 | 7.3e-04 | 6.0e-04 |
| GO:0050707 | regulation of cytokine secretion | 18/547 | 210/18670 | 4.9e-05 | 7.4e-04 | 6.1e-04 |
| GO:0032945 | negative regulation of mononuclear cell proliferation | 10/547 | 73/18670 | 5.1e-05 | 7.6e-04 | 6.2e-04 |
| GO:0050672 | negative regulation of lymphocyte proliferation | 10/547 | 73/18670 | 5.1e-05 | 7.6e-04 | 6.2e-04 |
| GO:0002698 | negative regulation of immune effector process | 13/547 | 120/18670 | 5.1e-05 | 7.6e-04 | 6.2e-04 |
| GO:0002407 | dendritic cell chemotaxis | 6/547 | 24/18670 | 5.3e-05 | 7.8e-04 | 6.4e-04 |
| GO:0002861 | regulation of inflammatory response to antigenic stimulus | 6/547 | 24/18670 | 5.3e-05 | 7.8e-04 | 6.4e-04 |
| GO:2000107 | negative regulation of leukocyte apoptotic process | 8/547 | 47/18670 | 5.9e-05 | 8.7e-04 | 7.2e-04 |
| GO:0097553 | calcium ion transmembrane import into cytosol | 14/547 | 140/18670 | 6.4e-05 | 9.4e-04 | 7.8e-04 |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 18/547 | 215/18670 | 6.7e-05 | 9.7e-04 | 8.0e-04 |
| GO:0002507 | tolerance induction | 6/547 | 25/18670 | 6.8e-05 | 9.8e-04 | 8.1e-04 |
| GO:0002719 | negative regulation of cytokine production involved in immune response | 6/547 | 25/18670 | 6.8e-05 | 9.8e-04 | 8.1e-04 |
| GO:0032695 | negative regulation of interleukin-12 production | 5/547 | 16/18670 | 7.1e-05 | 1.0e-03 | 8.4e-04 |
| GO:0050920 | regulation of chemotaxis | 18/547 | 217/18670 | 7.5e-05 | 1.1e-03 | 8.9e-04 |
| GO:0045453 | bone resorption | 9/547 | 62/18670 | 7.6e-05 | 1.1e-03 | 9.0e-04 |
| GO:1904894 | positive regulation of STAT cascade | 11/547 | 92/18670 | 7.8e-05 | 1.1e-03 | 9.2e-04 |
| GO:0043029 | T cell homeostasis | 7/547 | 37/18670 | 8.6e-05 | 1.2e-03 | 1.0e-03 |
| GO:0045730 | respiratory burst | 7/547 | 37/18670 | 8.6e-05 | 1.2e-03 | 1.0e-03 |
| GO:0001916 | positive regulation of T cell mediated cytotoxicity | 6/547 | 26/18670 | 8.6e-05 | 1.2e-03 | 1.0e-03 |
| GO:0070664 | negative regulation of leukocyte proliferation | 10/547 | 78/18670 | 9.0e-05 | 1.3e-03 | 1.0e-03 |
| GO:0006909 | phagocytosis | 25/547 | 369/18670 | 9.7e-05 | 1.4e-03 | 1.1e-03 |
| GO:0048535 | lymph node development | 5/547 | 17/18670 | 9.8e-05 | 1.4e-03 | 1.1e-03 |
| GO:1904892 | regulation of STAT cascade | 14/547 | 146/18670 | 1.0e-04 | 1.4e-03 | 1.2e-03 |
| GO:0002707 | negative regulation of lymphocyte mediated immunity | 7/547 | 38/18670 | 1.0e-04 | 1.4e-03 | 1.2e-03 |
| GO:0032620 | interleukin-17 production | 7/547 | 38/18670 | 1.0e-04 | 1.4e-03 | 1.2e-03 |
| GO:0002702 | positive regulation of production of molecular mediator of immune response | 11/547 | 95/18670 | 1.0e-04 | 1.4e-03 | 1.2e-03 |
| GO:0036336 | dendritic cell migration | 6/547 | 27/18670 | 1.1e-04 | 1.5e-03 | 1.2e-03 |
| GO:0097696 | STAT cascade | 15/547 | 166/18670 | 1.1e-04 | 1.6e-03 | 1.3e-03 |
| GO:0050856 | regulation of T cell receptor signaling pathway | 7/547 | 39/18670 | 1.2e-04 | 1.7e-03 | 1.4e-03 |
| GO:0032653 | regulation of interleukin-10 production | 8/547 | 52/18670 | 1.2e-04 | 1.7e-03 | 1.4e-03 |
| GO:0043011 | myeloid dendritic cell differentiation | 5/547 | 18/18670 | 1.3e-04 | 1.8e-03 | 1.5e-03 |
| GO:0001768 | establishment of T cell polarity | 4/547 | 10/18670 | 1.3e-04 | 1.8e-03 | 1.5e-03 |
| GO:0010818 | T cell chemotaxis | 6/547 | 28/18670 | 1.3e-04 | 1.8e-03 | 1.5e-03 |
| GO:0006323 | DNA packaging | 17/547 | 210/18670 | 1.6e-04 | 2.1e-03 | 1.8e-03 |
| GO:0030890 | positive regulation of B cell proliferation | 7/547 | 41/18670 | 1.7e-04 | 2.3e-03 | 1.9e-03 |
| GO:0002710 | negative regulation of T cell mediated immunity | 5/547 | 19/18670 | 1.8e-04 | 2.3e-03 | 1.9e-03 |
| GO:0000018 | regulation of DNA recombination | 11/547 | 101/18670 | 1.8e-04 | 2.4e-03 | 2.0e-03 |
| GO:0032613 | interleukin-10 production | 8/547 | 55/18670 | 1.9e-04 | 2.5e-03 | 2.0e-03 |
| GO:0018108 | peptidyl-tyrosine phosphorylation | 24/547 | 363/18670 | 1.9e-04 | 2.5e-03 | 2.1e-03 |
| GO:0002639 | positive regulation of immunoglobulin production | 7/547 | 42/18670 | 2.0e-04 | 2.6e-03 | 2.1e-03 |
| GO:0050766 | positive regulation of phagocytosis | 9/547 | 70/18670 | 2.0e-04 | 2.6e-03 | 2.1e-03 |
| GO:0046425 | regulation of JAK-STAT cascade | 13/547 | 137/18670 | 2.0e-04 | 2.6e-03 | 2.1e-03 |
| GO:0002367 | cytokine production involved in immune response | 11/547 | 102/18670 | 2.0e-04 | 2.6e-03 | 2.1e-03 |
| GO:0046640 | regulation of alpha-beta T cell proliferation | 6/547 | 30/18670 | 2.0e-04 | 2.6e-03 | 2.1e-03 |
| GO:0001767 | establishment of lymphocyte polarity | 4/547 | 11/18670 | 2.0e-04 | 2.6e-03 | 2.2e-03 |
| GO:0002517 | T cell tolerance induction | 4/547 | 11/18670 | 2.0e-04 | 2.6e-03 | 2.2e-03 |
| GO:0007259 | JAK-STAT cascade | 14/547 | 156/18670 | 2.1e-04 | 2.6e-03 | 2.2e-03 |
| GO:0007260 | tyrosine phosphorylation of STAT protein | 10/547 | 86/18670 | 2.1e-04 | 2.7e-03 | 2.2e-03 |
| GO:0018212 | peptidyl-tyrosine modification | 24/547 | 366/18670 | 2.2e-04 | 2.8e-03 | 2.3e-03 |
| GO:0051897 | positive regulation of protein kinase B signaling | 15/547 | 176/18670 | 2.2e-04 | 2.8e-03 | 2.3e-03 |
| GO:0002577 | regulation of antigen processing and presentation | 5/547 | 20/18670 | 2.3e-04 | 2.9e-03 | 2.4e-03 |
| GO:0002675 | positive regulation of acute inflammatory response | 6/547 | 31/18670 | 2.4e-04 | 3.1e-03 | 2.5e-03 |
| GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway | 6/547 | 31/18670 | 2.4e-04 | 3.1e-03 | 2.5e-03 |
| GO:2000406 | positive regulation of T cell migration | 6/547 | 31/18670 | 2.4e-04 | 3.1e-03 | 2.5e-03 |
| GO:1903557 | positive regulation of tumor necrosis factor superfamily cytokine production | 10/547 | 88/18670 | 2.5e-04 | 3.1e-03 | 2.6e-03 |
| GO:0034341 | response to interferon-gamma | 16/547 | 199/18670 | 2.6e-04 | 3.3e-03 | 2.7e-03 |
| GO:0046427 | positive regulation of JAK-STAT cascade | 10/547 | 89/18670 | 2.7e-04 | 3.4e-03 | 2.8e-03 |
| GO:0071103 | DNA conformation change | 22/547 | 327/18670 | 2.7e-04 | 3.4e-03 | 2.8e-03 |
| GO:0071346 | cellular response to interferon-gamma | 15/547 | 180/18670 | 2.8e-04 | 3.5e-03 | 2.8e-03 |
| GO:0071353 | cellular response to interleukin-4 | 6/547 | 32/18670 | 2.9e-04 | 3.6e-03 | 3.0e-03 |
| GO:0035590 | purinergic nucleotide receptor signaling pathway | 5/547 | 21/18670 | 2.9e-04 | 3.6e-03 | 3.0e-03 |
| GO:0045579 | positive regulation of B cell differentiation | 4/547 | 12/18670 | 3.0e-04 | 3.7e-03 | 3.0e-03 |
| GO:0048302 | regulation of isotype switching to IgG isotypes | 4/547 | 12/18670 | 3.0e-04 | 3.7e-03 | 3.0e-03 |
| GO:0045581 | negative regulation of T cell differentiation | 7/547 | 45/18670 | 3.1e-04 | 3.8e-03 | 3.1e-03 |
| GO:0002573 | myeloid leukocyte differentiation | 16/547 | 204/18670 | 3.5e-04 | 4.3e-03 | 3.5e-03 |
| GO:0033622 | integrin activation | 5/547 | 22/18670 | 3.7e-04 | 4.5e-03 | 3.7e-03 |
| GO:0072643 | interferon-gamma secretion | 5/547 | 22/18670 | 3.7e-04 | 4.5e-03 | 3.7e-03 |
| GO:2001251 | negative regulation of chromosome organization | 13/547 | 146/18670 | 3.7e-04 | 4.5e-03 | 3.7e-03 |
| GO:0031334 | positive regulation of protein complex assembly | 19/547 | 268/18670 | 3.7e-04 | 4.5e-03 | 3.7e-03 |
| GO:0019882 | antigen processing and presentation | 17/547 | 226/18670 | 3.8e-04 | 4.5e-03 | 3.7e-03 |
| GO:0043547 | positive regulation of GTPase activity | 25/547 | 405/18670 | 4.0e-04 | 4.8e-03 | 4.0e-03 |
| GO:0030261 | chromosome condensation | 7/547 | 47/18670 | 4.1e-04 | 4.8e-03 | 4.0e-03 |
| GO:0070670 | response to interleukin-4 | 6/547 | 34/18670 | 4.1e-04 | 4.9e-03 | 4.0e-03 |
| GO:0033623 | regulation of integrin activation | 4/547 | 13/18670 | 4.2e-04 | 5.0e-03 | 4.1e-03 |
| GO:0048291 | isotype switching to IgG isotypes | 4/547 | 13/18670 | 4.2e-04 | 5.0e-03 | 4.1e-03 |
| GO:1902713 | regulation of interferon-gamma secretion | 4/547 | 13/18670 | 4.2e-04 | 5.0e-03 | 4.1e-03 |
| GO:0043087 | regulation of GTPase activity | 28/547 | 479/18670 | 4.4e-04 | 5.2e-03 | 4.3e-03 |
| GO:0001774 | microglial cell activation | 7/547 | 48/18670 | 4.6e-04 | 5.4e-03 | 4.5e-03 |
| GO:0002269 | leukocyte activation involved in inflammatory response | 7/547 | 48/18670 | 4.6e-04 | 5.4e-03 | 4.5e-03 |
| GO:0032735 | positive regulation of interleukin-12 production | 6/547 | 35/18670 | 4.8e-04 | 5.7e-03 | 4.7e-03 |
| GO:0002534 | cytokine production involved in inflammatory response | 7/547 | 49/18670 | 5.3e-04 | 6.1e-03 | 5.0e-03 |
| GO:0045670 | regulation of osteoclast differentiation | 8/547 | 64/18670 | 5.4e-04 | 6.2e-03 | 5.1e-03 |
| GO:0046579 | positive regulation of Ras protein signal transduction | 8/547 | 64/18670 | 5.4e-04 | 6.2e-03 | 5.1e-03 |
| GO:0042832 | defense response to protozoan | 5/547 | 24/18670 | 5.7e-04 | 6.5e-03 | 5.4e-03 |
| GO:0046639 | negative regulation of alpha-beta T cell differentiation | 5/547 | 24/18670 | 5.7e-04 | 6.5e-03 | 5.4e-03 |
| GO:0090023 | positive regulation of neutrophil chemotaxis | 5/547 | 24/18670 | 5.7e-04 | 6.5e-03 | 5.4e-03 |
| GO:0001771 | immunological synapse formation | 4/547 | 14/18670 | 5.8e-04 | 6.6e-03 | 5.4e-03 |
| GO:0050848 | regulation of calcium-mediated signaling | 10/547 | 98/18670 | 6.0e-04 | 6.8e-03 | 5.6e-03 |
| GO:2000403 | positive regulation of lymphocyte migration | 6/547 | 37/18670 | 6.6e-04 | 7.5e-03 | 6.2e-03 |
| GO:0009615 | response to virus | 21/547 | 326/18670 | 6.6e-04 | 7.5e-03 | 6.2e-03 |
| GO:0001562 | response to protozoan | 5/547 | 25/18670 | 6.9e-04 | 7.8e-03 | 6.4e-03 |
| GO:0042509 | regulation of tyrosine phosphorylation of STAT protein | 9/547 | 83/18670 | 7.1e-04 | 8.0e-03 | 6.6e-03 |
| GO:0051260 | protein homooligomerization | 22/547 | 351/18670 | 7.2e-04 | 8.1e-03 | 6.6e-03 |
| GO:0032611 | interleukin-1 beta production | 10/547 | 101/18670 | 7.6e-04 | 8.5e-03 | 7.0e-03 |
| GO:0046636 | negative regulation of alpha-beta T cell activation | 6/547 | 38/18670 | 7.6e-04 | 8.6e-03 | 7.0e-03 |
| GO:0050715 | positive regulation of cytokine secretion | 12/547 | 139/18670 | 8.1e-04 | 9.0e-03 | 7.4e-03 |
| GO:0071624 | positive regulation of granulocyte chemotaxis | 5/547 | 26/18670 | 8.4e-04 | 9.3e-03 | 7.7e-03 |
| GO:0032715 | negative regulation of interleukin-6 production | 7/547 | 53/18670 | 8.5e-04 | 9.4e-03 | 7.8e-03 |
| GO:0050702 | interleukin-1 beta secretion | 7/547 | 53/18670 | 8.5e-04 | 9.4e-03 | 7.8e-03 |
| GO:0070228 | regulation of lymphocyte apoptotic process | 7/547 | 53/18670 | 8.5e-04 | 9.4e-03 | 7.8e-03 |
| GO:0046330 | positive regulation of JNK cascade | 12/547 | 140/18670 | 8.6e-04 | 9.5e-03 | 7.8e-03 |
| GO:0007229 | integrin-mediated signaling pathway | 10/547 | 103/18670 | 8.8e-04 | 9.7e-03 | 7.9e-03 |
| GO:1902106 | negative regulation of leukocyte differentiation | 10/547 | 103/18670 | 8.8e-04 | 9.7e-03 | 7.9e-03 |
| GO:0070227 | lymphocyte apoptotic process | 8/547 | 69/18670 | 9.0e-04 | 9.8e-03 | 8.1e-03 |
| GO:0032760 | positive regulation of tumor necrosis factor production | 9/547 | 86/18670 | 9.2e-04 | 1.0e-02 | 8.3e-03 |
| GO:0032720 | negative regulation of tumor necrosis factor production | 8/547 | 70/18670 | 9.9e-04 | 1.1e-02 | 8.8e-03 |
| GO:0034121 | regulation of toll-like receptor signaling pathway | 8/547 | 70/18670 | 9.9e-04 | 1.1e-02 | 8.8e-03 |
| GO:0002475 | antigen processing and presentation via MHC class Ib | 4/547 | 16/18670 | 1.0e-03 | 1.1e-02 | 8.8e-03 |
| GO:0030889 | negative regulation of B cell proliferation | 4/547 | 16/18670 | 1.0e-03 | 1.1e-02 | 8.8e-03 |
| GO:0033631 | cell-cell adhesion mediated by integrin | 4/547 | 16/18670 | 1.0e-03 | 1.1e-02 | 8.8e-03 |
| GO:0002825 | regulation of T-helper 1 type immune response | 5/547 | 27/18670 | 1.0e-03 | 1.1e-02 | 8.8e-03 |
| GO:1901623 | regulation of lymphocyte chemotaxis | 5/547 | 27/18670 | 1.0e-03 | 1.1e-02 | 8.8e-03 |
| GO:0042036 | negative regulation of cytokine biosynthetic process | 6/547 | 40/18670 | 1.0e-03 | 1.1e-02 | 8.9e-03 |
| GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 18/547 | 269/18670 | 1.0e-03 | 1.1e-02 | 8.9e-03 |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 21/547 | 338/18670 | 1.0e-03 | 1.1e-02 | 9.2e-03 |
| GO:0045620 | negative regulation of lymphocyte differentiation | 7/547 | 55/18670 | 1.1e-03 | 1.1e-02 | 9.3e-03 |
| GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | 8/547 | 71/18670 | 1.1e-03 | 1.1e-02 | 9.4e-03 |
| GO:0051057 | positive regulation of small GTPase mediated signal transduction | 8/547 | 71/18670 | 1.1e-03 | 1.1e-02 | 9.4e-03 |
| GO:0007088 | regulation of mitotic nuclear division | 13/547 | 164/18670 | 1.1e-03 | 1.2e-02 | 9.6e-03 |
| GO:0051321 | meiotic cell cycle | 17/547 | 249/18670 | 1.1e-03 | 1.2e-02 | 9.7e-03 |
| GO:0007520 | myoblast fusion | 6/547 | 41/18670 | 1.2e-03 | 1.2e-02 | 9.9e-03 |
| GO:0150077 | regulation of neuroinflammatory response | 6/547 | 41/18670 | 1.2e-03 | 1.2e-02 | 9.9e-03 |
| GO:0006334 | nucleosome assembly | 12/547 | 145/18670 | 1.2e-03 | 1.2e-02 | 1.0e-02 |
| GO:1903556 | negative regulation of tumor necrosis factor superfamily cytokine production | 8/547 | 72/18670 | 1.2e-03 | 1.2e-02 | 1.0e-02 |
| GO:0000768 | syncytium formation by plasma membrane fusion | 7/547 | 56/18670 | 1.2e-03 | 1.2e-02 | 1.0e-02 |
| GO:0140253 | cell-cell fusion | 7/547 | 56/18670 | 1.2e-03 | 1.2e-02 | 1.0e-02 |
| GO:0007076 | mitotic chromosome condensation | 4/547 | 17/18670 | 1.3e-03 | 1.3e-02 | 1.1e-02 |
| GO:0010819 | regulation of T cell chemotaxis | 4/547 | 17/18670 | 1.3e-03 | 1.3e-02 | 1.1e-02 |
| GO:0032740 | positive regulation of interleukin-17 production | 4/547 | 17/18670 | 1.3e-03 | 1.3e-02 | 1.1e-02 |
| GO:0045072 | regulation of interferon-gamma biosynthetic process | 4/547 | 17/18670 | 1.3e-03 | 1.3e-02 | 1.1e-02 |
| GO:0045132 | meiotic chromosome segregation | 9/547 | 90/18670 | 1.3e-03 | 1.3e-02 | 1.1e-02 |
| GO:0046849 | bone remodeling | 9/547 | 90/18670 | 1.3e-03 | 1.3e-02 | 1.1e-02 |
| GO:1903046 | meiotic cell cycle process | 14/547 | 188/18670 | 1.3e-03 | 1.3e-02 | 1.1e-02 |
| GO:0035025 | positive regulation of Rho protein signal transduction | 5/547 | 29/18670 | 1.4e-03 | 1.4e-02 | 1.2e-02 |
| GO:0060142 | regulation of syncytium formation by plasma membrane fusion | 5/547 | 29/18670 | 1.4e-03 | 1.4e-02 | 1.2e-02 |
| GO:1902624 | positive regulation of neutrophil migration | 5/547 | 29/18670 | 1.4e-03 | 1.4e-02 | 1.2e-02 |
| GO:0043254 | regulation of protein complex assembly | 26/547 | 467/18670 | 1.4e-03 | 1.4e-02 | 1.2e-02 |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 19/547 | 300/18670 | 1.4e-03 | 1.4e-02 | 1.2e-02 |
| GO:0006949 | syncytium formation | 7/547 | 58/18670 | 1.5e-03 | 1.5e-02 | 1.2e-02 |
| GO:0061900 | glial cell activation | 7/547 | 58/18670 | 1.5e-03 | 1.5e-02 | 1.2e-02 |
| GO:0042088 | T-helper 1 type immune response | 6/547 | 43/18670 | 1.5e-03 | 1.5e-02 | 1.2e-02 |
| GO:0050850 | positive regulation of calcium-mediated signaling | 6/547 | 43/18670 | 1.5e-03 | 1.5e-02 | 1.2e-02 |
| GO:0150076 | neuroinflammatory response | 8/547 | 75/18670 | 1.6e-03 | 1.5e-02 | 1.3e-02 |
| GO:0042095 | interferon-gamma biosynthetic process | 4/547 | 18/18670 | 1.6e-03 | 1.6e-02 | 1.3e-02 |
| GO:0051023 | regulation of immunoglobulin secretion | 4/547 | 18/18670 | 1.6e-03 | 1.6e-02 | 1.3e-02 |
| GO:0051782 | negative regulation of cell division | 4/547 | 18/18670 | 1.6e-03 | 1.6e-02 | 1.3e-02 |
| GO:0042130 | negative regulation of T cell proliferation | 7/547 | 59/18670 | 1.6e-03 | 1.6e-02 | 1.3e-02 |
| GO:0001782 | B cell homeostasis | 5/547 | 30/18670 | 1.6e-03 | 1.6e-02 | 1.3e-02 |
| GO:0050690 | regulation of defense response to virus by virus | 5/547 | 30/18670 | 1.6e-03 | 1.6e-02 | 1.3e-02 |
| GO:0090022 | regulation of neutrophil chemotaxis | 5/547 | 30/18670 | 1.6e-03 | 1.6e-02 | 1.3e-02 |
| GO:0045910 | negative regulation of DNA recombination | 6/547 | 44/18670 | 1.7e-03 | 1.6e-02 | 1.3e-02 |
| GO:0032874 | positive regulation of stress-activated MAPK cascade | 13/547 | 172/18670 | 1.7e-03 | 1.6e-02 | 1.4e-02 |
| GO:0140013 | meiotic nuclear division | 13/547 | 172/18670 | 1.7e-03 | 1.6e-02 | 1.4e-02 |
| GO:0043122 | regulation of I-kappaB kinase/NF-kappaB signaling | 16/547 | 237/18670 | 1.7e-03 | 1.7e-02 | 1.4e-02 |
| GO:0070304 | positive regulation of stress-activated protein kinase signaling cascade | 13/547 | 173/18670 | 1.8e-03 | 1.7e-02 | 1.4e-02 |
| GO:0045576 | mast cell activation | 7/547 | 60/18670 | 1.8e-03 | 1.7e-02 | 1.4e-02 |
| GO:0042116 | macrophage activation | 9/547 | 95/18670 | 1.9e-03 | 1.8e-02 | 1.5e-02 |
| GO:0002724 | regulation of T cell cytokine production | 5/547 | 31/18670 | 1.9e-03 | 1.8e-02 | 1.5e-02 |
| GO:0007202 | activation of phospholipase C activity | 5/547 | 31/18670 | 1.9e-03 | 1.8e-02 | 1.5e-02 |
| GO:0002920 | regulation of humoral immune response | 11/547 | 134/18670 | 2.0e-03 | 1.9e-02 | 1.5e-02 |
| GO:0050701 | interleukin-1 secretion | 7/547 | 61/18670 | 2.0e-03 | 1.9e-02 | 1.5e-02 |
| GO:0002544 | chronic inflammatory response | 4/547 | 19/18670 | 2.0e-03 | 1.9e-02 | 1.5e-02 |
| GO:0060252 | positive regulation of glial cell proliferation | 4/547 | 19/18670 | 2.0e-03 | 1.9e-02 | 1.5e-02 |
| GO:0071800 | podosome assembly | 4/547 | 19/18670 | 2.0e-03 | 1.9e-02 | 1.5e-02 |
| GO:0032612 | interleukin-1 production | 10/547 | 115/18670 | 2.0e-03 | 1.9e-02 | 1.6e-02 |
| GO:1903707 | negative regulation of hemopoiesis | 12/547 | 155/18670 | 2.1e-03 | 1.9e-02 | 1.6e-02 |
| GO:1900015 | regulation of cytokine production involved in inflammatory response | 6/547 | 46/18670 | 2.1e-03 | 2.0e-02 | 1.6e-02 |
| GO:0035587 | purinergic receptor signaling pathway | 5/547 | 32/18670 | 2.2e-03 | 2.1e-02 | 1.7e-02 |
| GO:0050764 | regulation of phagocytosis | 9/547 | 98/18670 | 2.3e-03 | 2.2e-02 | 1.8e-02 |
| GO:0033045 | regulation of sister chromatid segregation | 8/547 | 80/18670 | 2.4e-03 | 2.2e-02 | 1.8e-02 |
| GO:0033630 | positive regulation of cell adhesion mediated by integrin | 4/547 | 20/18670 | 2.4e-03 | 2.2e-02 | 1.8e-02 |
| GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process | 4/547 | 20/18670 | 2.4e-03 | 2.2e-02 | 1.8e-02 |
| GO:0043371 | negative regulation of CD4-positive, alpha-beta T cell differentiation | 4/547 | 20/18670 | 2.4e-03 | 2.2e-02 | 1.8e-02 |
| GO:1900017 | positive regulation of cytokine production involved in inflammatory response | 4/547 | 20/18670 | 2.4e-03 | 2.2e-02 | 1.8e-02 |
| GO:1903978 | regulation of microglial cell activation | 4/547 | 20/18670 | 2.4e-03 | 2.2e-02 | 1.8e-02 |
| GO:0070588 | calcium ion transmembrane transport | 19/547 | 315/18670 | 2.5e-03 | 2.3e-02 | 1.9e-02 |
| GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell | 3/547 | 10/18670 | 2.6e-03 | 2.3e-02 | 1.9e-02 |
| GO:0048304 | positive regulation of isotype switching to IgG isotypes | 3/547 | 10/18670 | 2.6e-03 | 2.3e-02 | 1.9e-02 |
| GO:0072610 | interleukin-12 secretion | 3/547 | 10/18670 | 2.6e-03 | 2.3e-02 | 1.9e-02 |
| GO:0097048 | dendritic cell apoptotic process | 3/547 | 10/18670 | 2.6e-03 | 2.3e-02 | 1.9e-02 |
| GO:2000668 | regulation of dendritic cell apoptotic process | 3/547 | 10/18670 | 2.6e-03 | 2.3e-02 | 1.9e-02 |
| GO:0070371 | ERK1 and ERK2 cascade | 19/547 | 317/18670 | 2.7e-03 | 2.4e-02 | 2.0e-02 |
| GO:0033044 | regulation of chromosome organization | 20/547 | 342/18670 | 2.8e-03 | 2.5e-02 | 2.1e-02 |
| GO:0019884 | antigen processing and presentation of exogenous antigen | 13/547 | 182/18670 | 2.8e-03 | 2.5e-02 | 2.1e-02 |
| GO:0030099 | myeloid cell differentiation | 23/547 | 416/18670 | 2.8e-03 | 2.5e-02 | 2.1e-02 |
| GO:0042533 | tumor necrosis factor biosynthetic process | 5/547 | 34/18670 | 2.9e-03 | 2.6e-02 | 2.1e-02 |
| GO:0042534 | regulation of tumor necrosis factor biosynthetic process | 5/547 | 34/18670 | 2.9e-03 | 2.6e-02 | 2.1e-02 |
| GO:0051383 | kinetochore organization | 4/547 | 21/18670 | 2.9e-03 | 2.6e-02 | 2.1e-02 |
| GO:1901739 | regulation of myoblast fusion | 4/547 | 21/18670 | 2.9e-03 | 2.6e-02 | 2.1e-02 |
| GO:0001894 | tissue homeostasis | 15/547 | 227/18670 | 2.9e-03 | 2.6e-02 | 2.1e-02 |
| GO:0002686 | negative regulation of leukocyte migration | 6/547 | 49/18670 | 3.0e-03 | 2.6e-02 | 2.1e-02 |
| GO:0046718 | viral entry into host cell | 10/547 | 121/18670 | 3.0e-03 | 2.6e-02 | 2.2e-02 |
| GO:0046328 | regulation of JNK cascade | 13/547 | 185/18670 | 3.2e-03 | 2.8e-02 | 2.3e-02 |
| GO:0051983 | regulation of chromosome segregation | 9/547 | 103/18670 | 3.3e-03 | 2.9e-02 | 2.4e-02 |
| GO:0042092 | type 2 immune response | 5/547 | 35/18670 | 3.3e-03 | 2.9e-02 | 2.4e-02 |
| GO:0060251 | regulation of glial cell proliferation | 5/547 | 35/18670 | 3.3e-03 | 2.9e-02 | 2.4e-02 |
| GO:0002638 | negative regulation of immunoglobulin production | 3/547 | 11/18670 | 3.5e-03 | 3.0e-02 | 2.5e-02 |
| GO:0033632 | regulation of cell-cell adhesion mediated by integrin | 3/547 | 11/18670 | 3.5e-03 | 3.0e-02 | 2.5e-02 |
| GO:0071803 | positive regulation of podosome assembly | 3/547 | 11/18670 | 3.5e-03 | 3.0e-02 | 2.5e-02 |
| GO:0031497 | chromatin assembly | 12/547 | 165/18670 | 3.5e-03 | 3.0e-02 | 2.5e-02 |
| GO:0019883 | antigen processing and presentation of endogenous antigen | 4/547 | 22/18670 | 3.5e-03 | 3.0e-02 | 2.5e-02 |
| GO:0045624 | positive regulation of T-helper cell differentiation | 4/547 | 22/18670 | 3.5e-03 | 3.0e-02 | 2.5e-02 |
| GO:0002791 | regulation of peptide secretion | 26/547 | 500/18670 | 3.6e-03 | 3.1e-02 | 2.5e-02 |
| GO:0030071 | regulation of mitotic metaphase/anaphase transition | 6/547 | 51/18670 | 3.6e-03 | 3.1e-02 | 2.6e-02 |
| GO:0033627 | cell adhesion mediated by integrin | 7/547 | 68/18670 | 3.7e-03 | 3.2e-02 | 2.6e-02 |
| GO:0051783 | regulation of nuclear division | 13/547 | 188/18670 | 3.7e-03 | 3.2e-02 | 2.6e-02 |
| GO:0032733 | positive regulation of interleukin-10 production | 5/547 | 36/18670 | 3.8e-03 | 3.2e-02 | 2.6e-02 |
| GO:1902622 | regulation of neutrophil migration | 5/547 | 36/18670 | 3.8e-03 | 3.2e-02 | 2.6e-02 |
| GO:0002224 | toll-like receptor signaling pathway | 11/547 | 146/18670 | 3.9e-03 | 3.3e-02 | 2.7e-02 |
| GO:0032703 | negative regulation of interleukin-2 production | 4/547 | 23/18670 | 4.1e-03 | 3.5e-02 | 2.9e-02 |
| GO:0038083 | peptidyl-tyrosine autophosphorylation | 5/547 | 37/18670 | 4.3e-03 | 3.6e-02 | 3.0e-02 |
| GO:0007254 | JNK cascade | 14/547 | 214/18670 | 4.4e-03 | 3.7e-02 | 3.0e-02 |
| GO:0032872 | regulation of stress-activated MAPK cascade | 15/547 | 237/18670 | 4.4e-03 | 3.7e-02 | 3.0e-02 |
| GO:0045840 | positive regulation of mitotic nuclear division | 6/547 | 53/18670 | 4.4e-03 | 3.7e-02 | 3.0e-02 |
| GO:1902099 | regulation of metaphase/anaphase transition of cell cycle | 6/547 | 53/18670 | 4.4e-03 | 3.7e-02 | 3.0e-02 |
| GO:0038110 | interleukin-2-mediated signaling pathway | 3/547 | 12/18670 | 4.5e-03 | 3.7e-02 | 3.1e-02 |
| GO:0042368 | vitamin D biosynthetic process | 3/547 | 12/18670 | 4.5e-03 | 3.7e-02 | 3.1e-02 |
| GO:0046541 | saliva secretion | 3/547 | 12/18670 | 4.5e-03 | 3.7e-02 | 3.1e-02 |
| GO:0048934 | peripheral nervous system neuron differentiation | 3/547 | 12/18670 | 4.5e-03 | 3.7e-02 | 3.1e-02 |
| GO:0048935 | peripheral nervous system neuron development | 3/547 | 12/18670 | 4.5e-03 | 3.7e-02 | 3.1e-02 |
| GO:0070601 | centromeric sister chromatid cohesion | 3/547 | 12/18670 | 4.5e-03 | 3.7e-02 | 3.1e-02 |
| GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 15/547 | 239/18670 | 4.7e-03 | 3.9e-02 | 3.2e-02 |
| GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | 6/547 | 54/18670 | 4.8e-03 | 4.0e-02 | 3.3e-02 |
| GO:0010524 | positive regulation of calcium ion transport into cytosol | 6/547 | 54/18670 | 4.8e-03 | 4.0e-02 | 3.3e-02 |
| GO:0032651 | regulation of interleukin-1 beta production | 8/547 | 90/18670 | 4.9e-03 | 4.0e-02 | 3.3e-02 |
| GO:0051304 | chromosome separation | 8/547 | 90/18670 | 4.9e-03 | 4.0e-02 | 3.3e-02 |
| GO:0002793 | positive regulation of peptide secretion | 17/547 | 288/18670 | 5.1e-03 | 4.2e-02 | 3.4e-02 |
| GO:0043030 | regulation of macrophage activation | 6/547 | 55/18670 | 5.3e-03 | 4.3e-02 | 3.5e-02 |
| GO:0043551 | regulation of phosphatidylinositol 3-kinase activity | 6/547 | 55/18670 | 5.3e-03 | 4.3e-02 | 3.5e-02 |
| GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 7/547 | 73/18670 | 5.5e-03 | 4.5e-02 | 3.7e-02 |
| GO:0045807 | positive regulation of endocytosis | 11/547 | 153/18670 | 5.5e-03 | 4.5e-02 | 3.7e-02 |
| GO:0032461 | positive regulation of protein oligomerization | 4/547 | 25/18670 | 5.7e-03 | 4.6e-02 | 3.8e-02 |
| GO:0045672 | positive regulation of osteoclast differentiation | 4/547 | 25/18670 | 5.7e-03 | 4.6e-02 | 3.8e-02 |
| GO:2000482 | regulation of interleukin-8 secretion | 4/547 | 25/18670 | 5.7e-03 | 4.6e-02 | 3.8e-02 |
| GO:0051896 | regulation of protein kinase B signaling | 15/547 | 244/18670 | 5.7e-03 | 4.6e-02 | 3.8e-02 |
| GO:0030656 | regulation of vitamin metabolic process | 3/547 | 13/18670 | 5.7e-03 | 4.6e-02 | 3.8e-02 |
| GO:0035723 | interleukin-15-mediated signaling pathway | 3/547 | 13/18670 | 5.7e-03 | 4.6e-02 | 3.8e-02 |
| GO:0042635 | positive regulation of hair cycle | 3/547 | 13/18670 | 5.7e-03 | 4.6e-02 | 3.8e-02 |
| GO:0045779 | negative regulation of bone resorption | 3/547 | 13/18670 | 5.7e-03 | 4.6e-02 | 3.8e-02 |
| GO:0071350 | cellular response to interleukin-15 | 3/547 | 13/18670 | 5.7e-03 | 4.6e-02 | 3.8e-02 |
| GO:0071352 | cellular response to interleukin-2 | 3/547 | 13/18670 | 5.7e-03 | 4.6e-02 | 3.8e-02 |
| GO:1900225 | regulation of NLRP3 inflammasome complex assembly | 3/547 | 13/18670 | 5.7e-03 | 4.6e-02 | 3.8e-02 |
| GO:0044784 | metaphase/anaphase transition of cell cycle | 6/547 | 56/18670 | 5.8e-03 | 4.6e-02 | 3.8e-02 |
| GO:0014015 | positive regulation of gliogenesis | 7/547 | 74/18670 | 5.9e-03 | 4.7e-02 | 3.8e-02 |
| GO:0050710 | negative regulation of cytokine secretion | 7/547 | 74/18670 | 5.9e-03 | 4.7e-02 | 3.8e-02 |
| GO:0002369 | T cell cytokine production | 5/547 | 40/18670 | 6.0e-03 | 4.7e-02 | 3.9e-02 |
| GO:0045124 | regulation of bone resorption | 5/547 | 40/18670 | 6.0e-03 | 4.7e-02 | 3.9e-02 |
| GO:0098760 | response to interleukin-7 | 5/547 | 40/18670 | 6.0e-03 | 4.7e-02 | 3.9e-02 |
| GO:0098761 | cellular response to interleukin-7 | 5/547 | 40/18670 | 6.0e-03 | 4.7e-02 | 3.9e-02 |
| GO:0043491 | protein kinase B signaling | 16/547 | 269/18670 | 6.0e-03 | 4.7e-02 | 3.9e-02 |
| GO:0030260 | entry into host cell | 10/547 | 134/18670 | 6.1e-03 | 4.8e-02 | 3.9e-02 |
| GO:0044409 | entry into host | 10/547 | 134/18670 | 6.1e-03 | 4.8e-02 | 3.9e-02 |
| GO:0051806 | entry into cell of other organism involved in symbiotic interaction | 10/547 | 134/18670 | 6.1e-03 | 4.8e-02 | 3.9e-02 |
| GO:0051828 | entry into other organism involved in symbiotic interaction | 10/547 | 134/18670 | 6.1e-03 | 4.8e-02 | 3.9e-02 |
| GO:0030198 | extracellular matrix organization | 20/547 | 368/18670 | 6.2e-03 | 4.8e-02 | 4.0e-02 |
| GO:0010965 | regulation of mitotic sister chromatid separation | 6/547 | 57/18670 | 6.3e-03 | 4.9e-02 | 4.0e-02 |
| GO:0002218 | activation of innate immune response | 18/547 | 319/18670 | 6.3e-03 | 4.9e-02 | 4.0e-02 |
Tabla 11: GOtable que contiene las vías metabólicas expresadas diferencialmente entre los grupos NIT y ELI.
SFI vs ELI:
| Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | |
|---|---|---|---|---|---|---|
| GO:0042110 | T cell activation | 61/409 | 464/18670 | 4.5e-30 | 1.7e-26 | 1.5e-26 |
| GO:0051249 | regulation of lymphocyte activation | 57/409 | 485/18670 | 1.4e-25 | 2.6e-22 | 2.2e-22 |
| GO:0050863 | regulation of T cell activation | 46/409 | 314/18670 | 8.0e-25 | 1.0e-21 | 8.7e-22 |
| GO:0030098 | lymphocyte differentiation | 48/409 | 353/18670 | 2.1e-24 | 2.0e-21 | 1.7e-21 |
| GO:0022409 | positive regulation of cell-cell adhesion | 38/409 | 255/18670 | 6.4e-21 | 4.3e-18 | 3.7e-18 |
| GO:0007159 | leukocyte cell-cell adhesion | 43/409 | 337/18670 | 7.4e-21 | 4.3e-18 | 3.7e-18 |
| GO:0046651 | lymphocyte proliferation | 39/409 | 272/18670 | 7.8e-21 | 4.3e-18 | 3.7e-18 |
| GO:0032943 | mononuclear cell proliferation | 39/409 | 274/18670 | 1.0e-20 | 4.9e-18 | 4.2e-18 |
| GO:0050870 | positive regulation of T cell activation | 34/409 | 202/18670 | 1.5e-20 | 6.3e-18 | 5.3e-18 |
| GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 35/409 | 218/18670 | 2.0e-20 | 7.5e-18 | 6.4e-18 |
| GO:0070661 | leukocyte proliferation | 40/409 | 298/18670 | 2.8e-20 | 9.9e-18 | 8.4e-18 |
| GO:1903037 | regulation of leukocyte cell-cell adhesion | 40/409 | 304/18670 | 5.9e-20 | 1.9e-17 | 1.6e-17 |
| GO:0030217 | T cell differentiation | 34/409 | 240/18670 | 4.0e-18 | 1.2e-15 | 9.9e-16 |
| GO:0002696 | positive regulation of leukocyte activation | 42/409 | 380/18670 | 4.9e-18 | 1.3e-15 | 1.1e-15 |
| GO:0022407 | regulation of cell-cell adhesion | 43/409 | 403/18670 | 7.2e-18 | 1.8e-15 | 1.6e-15 |
| GO:0051251 | positive regulation of lymphocyte activation | 39/409 | 334/18670 | 1.2e-17 | 2.9e-15 | 2.5e-15 |
| GO:0050867 | positive regulation of cell activation | 42/409 | 394/18670 | 1.8e-17 | 4.1e-15 | 3.5e-15 |
| GO:0050670 | regulation of lymphocyte proliferation | 31/409 | 208/18670 | 2.9e-17 | 6.1e-15 | 5.2e-15 |
| GO:0032944 | regulation of mononuclear cell proliferation | 31/409 | 209/18670 | 3.3e-17 | 6.6e-15 | 5.6e-15 |
| GO:0070663 | regulation of leukocyte proliferation | 31/409 | 222/18670 | 1.9e-16 | 3.6e-14 | 3.1e-14 |
| GO:0042113 | B cell activation | 35/409 | 310/18670 | 1.7e-15 | 3.1e-13 | 2.7e-13 |
| GO:0045785 | positive regulation of cell adhesion | 38/409 | 403/18670 | 3.6e-14 | 6.3e-12 | 5.4e-12 |
| GO:0042129 | regulation of T cell proliferation | 24/409 | 156/18670 | 5.8e-14 | 9.7e-12 | 8.2e-12 |
| GO:0046631 | alpha-beta T cell activation | 22/409 | 138/18670 | 3.1e-13 | 4.8e-11 | 4.1e-11 |
| GO:0042098 | T cell proliferation | 25/409 | 184/18670 | 3.2e-13 | 4.8e-11 | 4.1e-11 |
| GO:0050851 | antigen receptor-mediated signaling pathway | 32/409 | 316/18670 | 6.0e-13 | 8.8e-11 | 7.5e-11 |
| GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 34/409 | 361/18670 | 8.9e-13 | 1.3e-10 | 1.1e-10 |
| GO:0042100 | B cell proliferation | 18/409 | 95/18670 | 2.2e-12 | 2.8e-10 | 2.4e-10 |
| GO:0042102 | positive regulation of T cell proliferation | 18/409 | 95/18670 | 2.2e-12 | 2.8e-10 | 2.4e-10 |
| GO:0002449 | lymphocyte mediated immunity | 33/409 | 352/18670 | 2.2e-12 | 2.8e-10 | 2.4e-10 |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 38/409 | 473/18670 | 5.2e-12 | 6.5e-10 | 5.5e-10 |
| GO:0050671 | positive regulation of lymphocyte proliferation | 20/409 | 130/18670 | 7.5e-12 | 9.0e-10 | 7.6e-10 |
| GO:0032946 | positive regulation of mononuclear cell proliferation | 20/409 | 131/18670 | 8.7e-12 | 1.0e-09 | 8.6e-10 |
| GO:0070665 | positive regulation of leukocyte proliferation | 20/409 | 139/18670 | 2.7e-11 | 3.0e-09 | 2.5e-09 |
| GO:0046632 | alpha-beta T cell differentiation | 17/409 | 101/18670 | 6.6e-11 | 7.2e-09 | 6.1e-09 |
| GO:0002285 | lymphocyte activation involved in immune response | 22/409 | 181/18670 | 8.0e-11 | 8.5e-09 | 7.2e-09 |
| GO:0043368 | positive T cell selection | 11/409 | 34/18670 | 8.9e-11 | 9.2e-09 | 7.8e-09 |
| GO:0045619 | regulation of lymphocyte differentiation | 21/409 | 169/18670 | 1.4e-10 | 1.4e-08 | 1.2e-08 |
| GO:0031295 | T cell costimulation | 13/409 | 56/18670 | 1.8e-10 | 1.7e-08 | 1.5e-08 |
| GO:0031294 | lymphocyte costimulation | 13/409 | 57/18670 | 2.3e-10 | 2.2e-08 | 1.8e-08 |
| GO:0045058 | T cell selection | 12/409 | 47/18670 | 2.7e-10 | 2.5e-08 | 2.2e-08 |
| GO:1902105 | regulation of leukocyte differentiation | 26/409 | 272/18670 | 3.4e-10 | 3.1e-08 | 2.6e-08 |
| GO:0007059 | chromosome segregation | 28/409 | 321/18670 | 5.8e-10 | 5.1e-08 | 4.4e-08 |
| GO:0032729 | positive regulation of interferon-gamma production | 13/409 | 65/18670 | 1.3e-09 | 1.1e-07 | 9.6e-08 |
| GO:0002377 | immunoglobulin production | 21/409 | 193/18670 | 1.7e-09 | 1.4e-07 | 1.2e-07 |
| GO:0001819 | positive regulation of cytokine production | 33/409 | 464/18670 | 3.2e-09 | 2.6e-07 | 2.2e-07 |
| GO:0050853 | B cell receptor signaling pathway | 17/409 | 129/18670 | 3.3e-09 | 2.7e-07 | 2.3e-07 |
| GO:0140014 | mitotic nuclear division | 24/409 | 264/18670 | 4.5e-09 | 3.5e-07 | 3.0e-07 |
| GO:0002706 | regulation of lymphocyte mediated immunity | 18/409 | 149/18670 | 4.7e-09 | 3.7e-07 | 3.1e-07 |
| GO:0050900 | leukocyte migration | 34/409 | 499/18670 | 5.4e-09 | 4.1e-07 | 3.5e-07 |
| GO:0045580 | regulation of T cell differentiation | 17/409 | 139/18670 | 1.1e-08 | 7.9e-07 | 6.7e-07 |
| GO:0042108 | positive regulation of cytokine biosynthetic process | 12/409 | 67/18670 | 2.1e-08 | 1.5e-06 | 1.3e-06 |
| GO:0032609 | interferon-gamma production | 15/409 | 113/18670 | 2.5e-08 | 1.8e-06 | 1.6e-06 |
| GO:0000280 | nuclear division | 29/409 | 407/18670 | 2.8e-08 | 2.0e-06 | 1.7e-06 |
| GO:0002697 | regulation of immune effector process | 31/409 | 458/18670 | 3.0e-08 | 2.1e-06 | 1.8e-06 |
| GO:0000070 | mitotic sister chromatid segregation | 17/409 | 151/18670 | 3.7e-08 | 2.5e-06 | 2.1e-06 |
| GO:0000819 | sister chromatid segregation | 19/409 | 189/18670 | 3.7e-08 | 2.5e-06 | 2.1e-06 |
| GO:0002683 | negative regulation of immune system process | 31/409 | 463/18670 | 3.9e-08 | 2.6e-06 | 2.2e-06 |
| GO:0043367 | CD4-positive, alpha-beta T cell differentiation | 12/409 | 74/18670 | 6.7e-08 | 4.3e-06 | 3.7e-06 |
| GO:0002708 | positive regulation of lymphocyte mediated immunity | 14/409 | 105/18670 | 7.0e-08 | 4.5e-06 | 3.8e-06 |
| GO:0002819 | regulation of adaptive immune response | 17/409 | 160/18670 | 8.7e-08 | 5.5e-06 | 4.6e-06 |
| GO:0046635 | positive regulation of alpha-beta T cell activation | 11/409 | 62/18670 | 9.1e-08 | 5.6e-06 | 4.8e-06 |
| GO:0002703 | regulation of leukocyte mediated immunity | 19/409 | 201/18670 | 1.0e-07 | 6.1e-06 | 5.2e-06 |
| GO:0030595 | leukocyte chemotaxis | 20/409 | 224/18670 | 1.2e-07 | 7.1e-06 | 6.0e-06 |
| GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 11/409 | 65/18670 | 1.5e-07 | 8.9e-06 | 7.6e-06 |
| GO:0048285 | organelle fission | 29/409 | 449/18670 | 2.3e-07 | 1.3e-05 | 1.1e-05 |
| GO:0002699 | positive regulation of immune effector process | 19/409 | 216/18670 | 3.1e-07 | 1.8e-05 | 1.5e-05 |
| GO:0032649 | regulation of interferon-gamma production | 13/409 | 101/18670 | 3.2e-07 | 1.8e-05 | 1.5e-05 |
| GO:0033077 | T cell differentiation in thymus | 11/409 | 70/18670 | 3.3e-07 | 1.8e-05 | 1.6e-05 |
| GO:0098813 | nuclear chromosome segregation | 21/409 | 262/18670 | 3.5e-07 | 1.9e-05 | 1.6e-05 |
| GO:0016064 | immunoglobulin mediated immune response | 19/409 | 218/18670 | 3.6e-07 | 1.9e-05 | 1.6e-05 |
| GO:0002440 | production of molecular mediator of immune response | 22/409 | 286/18670 | 3.8e-07 | 2.0e-05 | 1.7e-05 |
| GO:0019724 | B cell mediated immunity | 19/409 | 221/18670 | 4.4e-07 | 2.3e-05 | 2.0e-05 |
| GO:0002295 | T-helper cell lineage commitment | 6/409 | 16/18670 | 7.1e-07 | 3.6e-05 | 3.1e-05 |
| GO:0002822 | regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 15/409 | 145/18670 | 7.1e-07 | 3.6e-05 | 3.1e-05 |
| GO:1903706 | regulation of hemopoiesis | 29/409 | 475/18670 | 7.4e-07 | 3.7e-05 | 3.2e-05 |
| GO:0030888 | regulation of B cell proliferation | 10/409 | 61/18670 | 7.6e-07 | 3.8e-05 | 3.2e-05 |
| GO:0035710 | CD4-positive, alpha-beta T cell activation | 12/409 | 92/18670 | 7.8e-07 | 3.8e-05 | 3.2e-05 |
| GO:0046634 | regulation of alpha-beta T cell activation | 12/409 | 93/18670 | 8.7e-07 | 4.2e-05 | 3.6e-05 |
| GO:0043373 | CD4-positive, alpha-beta T cell lineage commitment | 6/409 | 17/18670 | 1.1e-06 | 5.1e-05 | 4.4e-05 |
| GO:0030183 | B cell differentiation | 14/409 | 131/18670 | 1.1e-06 | 5.3e-05 | 4.5e-05 |
| GO:0006959 | humoral immune response | 24/409 | 356/18670 | 1.2e-06 | 5.7e-05 | 4.8e-05 |
| GO:0042035 | regulation of cytokine biosynthetic process | 13/409 | 114/18670 | 1.3e-06 | 6.0e-05 | 5.1e-05 |
| GO:0002705 | positive regulation of leukocyte mediated immunity | 14/409 | 133/18670 | 1.3e-06 | 6.1e-05 | 5.2e-05 |
| GO:0001773 | myeloid dendritic cell activation | 7/409 | 28/18670 | 1.8e-06 | 8.2e-05 | 7.0e-05 |
| GO:0002824 | positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 12/409 | 100/18670 | 1.9e-06 | 8.5e-05 | 7.3e-05 |
| GO:0031343 | positive regulation of cell killing | 10/409 | 68/18670 | 2.1e-06 | 9.4e-05 | 8.0e-05 |
| GO:0002363 | alpha-beta T cell lineage commitment | 6/409 | 19/18670 | 2.3e-06 | 9.9e-05 | 8.4e-05 |
| GO:0050855 | regulation of B cell receptor signaling pathway | 7/409 | 29/18670 | 2.4e-06 | 1.0e-04 | 8.6e-05 |
| GO:0050852 | T cell receptor signaling pathway | 17/409 | 202/18670 | 2.4e-06 | 1.0e-04 | 8.6e-05 |
| GO:0001776 | leukocyte homeostasis | 11/409 | 86/18670 | 2.7e-06 | 1.1e-04 | 9.8e-05 |
| GO:0042089 | cytokine biosynthetic process | 13/409 | 123/18670 | 3.1e-06 | 1.3e-04 | 1.1e-04 |
| GO:0043369 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment | 6/409 | 20/18670 | 3.2e-06 | 1.3e-04 | 1.1e-04 |
| GO:0002821 | positive regulation of adaptive immune response | 12/409 | 105/18670 | 3.2e-06 | 1.3e-04 | 1.1e-04 |
| GO:0002381 | immunoglobulin production involved in immunoglobulin mediated immune response | 9/409 | 56/18670 | 3.2e-06 | 1.3e-04 | 1.1e-04 |
| GO:0042107 | cytokine metabolic process | 13/409 | 124/18670 | 3.4e-06 | 1.3e-04 | 1.1e-04 |
| GO:0072540 | T-helper 17 cell lineage commitment | 5/409 | 12/18670 | 3.4e-06 | 1.4e-04 | 1.2e-04 |
| GO:1902107 | positive regulation of leukocyte differentiation | 14/409 | 144/18670 | 3.5e-06 | 1.4e-04 | 1.2e-04 |
| GO:0002286 | T cell activation involved in immune response | 12/409 | 106/18670 | 3.6e-06 | 1.4e-04 | 1.2e-04 |
| GO:0060326 | cell chemotaxis | 21/409 | 304/18670 | 3.9e-06 | 1.5e-04 | 1.3e-04 |
| GO:0045061 | thymic T cell selection | 6/409 | 21/18670 | 4.4e-06 | 1.7e-04 | 1.4e-04 |
| GO:0045059 | positive thymic T cell selection | 5/409 | 13/18670 | 5.5e-06 | 2.1e-04 | 1.7e-04 |
| GO:0048305 | immunoglobulin secretion | 6/409 | 22/18670 | 5.9e-06 | 2.2e-04 | 1.9e-04 |
| GO:0045621 | positive regulation of lymphocyte differentiation | 11/409 | 94/18670 | 6.6e-06 | 2.4e-04 | 2.1e-04 |
| GO:0002287 | alpha-beta T cell activation involved in immune response | 9/409 | 61/18670 | 6.7e-06 | 2.4e-04 | 2.1e-04 |
| GO:0002293 | alpha-beta T cell differentiation involved in immune response | 9/409 | 61/18670 | 6.7e-06 | 2.4e-04 | 2.1e-04 |
| GO:0002688 | regulation of leukocyte chemotaxis | 12/409 | 114/18670 | 7.7e-06 | 2.7e-04 | 2.3e-04 |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | 21/409 | 319/18670 | 8.2e-06 | 2.9e-04 | 2.5e-04 |
| GO:0031341 | regulation of cell killing | 11/409 | 98/18670 | 9.9e-06 | 3.5e-04 | 3.0e-04 |
| GO:0045582 | positive regulation of T cell differentiation | 10/409 | 83/18670 | 1.3e-05 | 4.6e-04 | 3.9e-04 |
| GO:0050864 | regulation of B cell activation | 15/409 | 184/18670 | 1.4e-05 | 4.7e-04 | 4.0e-04 |
| GO:0007088 | regulation of mitotic nuclear division | 14/409 | 164/18670 | 1.6e-05 | 5.4e-04 | 4.6e-04 |
| GO:0002292 | T cell differentiation involved in immune response | 9/409 | 68/18670 | 1.7e-05 | 5.7e-04 | 4.8e-04 |
| GO:0002360 | T cell lineage commitment | 6/409 | 26/18670 | 1.7e-05 | 5.7e-04 | 4.8e-04 |
| GO:0051783 | regulation of nuclear division | 15/409 | 188/18670 | 1.8e-05 | 5.9e-04 | 5.0e-04 |
| GO:0001906 | cell killing | 14/409 | 168/18670 | 2.1e-05 | 6.8e-04 | 5.8e-04 |
| GO:0001909 | leukocyte mediated cytotoxicity | 11/409 | 107/18670 | 2.3e-05 | 7.5e-04 | 6.4e-04 |
| GO:0001912 | positive regulation of leukocyte mediated cytotoxicity | 8/409 | 56/18670 | 2.8e-05 | 9.1e-04 | 7.7e-04 |
| GO:0002685 | regulation of leukocyte migration | 15/409 | 196/18670 | 2.9e-05 | 9.3e-04 | 7.9e-04 |
| GO:0002312 | B cell activation involved in immune response | 9/409 | 73/18670 | 3.0e-05 | 9.5e-04 | 8.1e-04 |
| GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 12/409 | 131/18670 | 3.2e-05 | 1.0e-03 | 8.5e-04 |
| GO:0032103 | positive regulation of response to external stimulus | 20/409 | 323/18670 | 3.2e-05 | 1.0e-03 | 8.6e-04 |
| GO:0002695 | negative regulation of leukocyte activation | 14/409 | 175/18670 | 3.3e-05 | 1.0e-03 | 8.6e-04 |
| GO:0051480 | regulation of cytosolic calcium ion concentration | 21/409 | 357/18670 | 4.4e-05 | 1.3e-03 | 1.1e-03 |
| GO:0046641 | positive regulation of alpha-beta T cell proliferation | 5/409 | 19/18670 | 4.4e-05 | 1.4e-03 | 1.2e-03 |
| GO:0002294 | CD4-positive, alpha-beta T cell differentiation involved in immune response | 8/409 | 60/18670 | 4.7e-05 | 1.4e-03 | 1.2e-03 |
| GO:0001910 | regulation of leukocyte mediated cytotoxicity | 9/409 | 78/18670 | 5.1e-05 | 1.5e-03 | 1.3e-03 |
| GO:0002260 | lymphocyte homeostasis | 8/409 | 62/18670 | 6.0e-05 | 1.8e-03 | 1.5e-03 |
| GO:1903708 | positive regulation of hemopoiesis | 14/409 | 185/18670 | 6.0e-05 | 1.8e-03 | 1.5e-03 |
| GO:0002923 | regulation of humoral immune response mediated by circulating immunoglobulin | 4/409 | 11/18670 | 6.6e-05 | 1.9e-03 | 1.7e-03 |
| GO:0002637 | regulation of immunoglobulin production | 8/409 | 63/18670 | 6.7e-05 | 1.9e-03 | 1.7e-03 |
| GO:0046637 | regulation of alpha-beta T cell differentiation | 8/409 | 63/18670 | 6.7e-05 | 1.9e-03 | 1.7e-03 |
| GO:0046638 | positive regulation of alpha-beta T cell differentiation | 7/409 | 47/18670 | 6.8e-05 | 2.0e-03 | 1.7e-03 |
| GO:0046633 | alpha-beta T cell proliferation | 6/409 | 33/18670 | 7.1e-05 | 2.0e-03 | 1.7e-03 |
| GO:0072678 | T cell migration | 8/409 | 65/18670 | 8.4e-05 | 2.4e-03 | 2.0e-03 |
| GO:0019722 | calcium-mediated signaling | 15/409 | 218/18670 | 9.8e-05 | 2.7e-03 | 2.3e-03 |
| GO:0048872 | homeostasis of number of cells | 16/409 | 246/18670 | 1.1e-04 | 3.1e-03 | 2.7e-03 |
| GO:0002687 | positive regulation of leukocyte migration | 11/409 | 128/18670 | 1.2e-04 | 3.3e-03 | 2.8e-03 |
| GO:0002690 | positive regulation of leukocyte chemotaxis | 9/409 | 87/18670 | 1.2e-04 | 3.3e-03 | 2.8e-03 |
| GO:0055074 | calcium ion homeostasis | 24/409 | 471/18670 | 1.2e-04 | 3.3e-03 | 2.8e-03 |
| GO:0050866 | negative regulation of cell activation | 14/409 | 199/18670 | 1.3e-04 | 3.6e-03 | 3.0e-03 |
| GO:0050729 | positive regulation of inflammatory response | 12/409 | 153/18670 | 1.4e-04 | 3.8e-03 | 3.2e-03 |
| GO:0002709 | regulation of T cell mediated immunity | 8/409 | 70/18670 | 1.4e-04 | 3.8e-03 | 3.2e-03 |
| GO:0048469 | cell maturation | 13/409 | 177/18670 | 1.5e-04 | 3.9e-03 | 3.3e-03 |
| GO:0042832 | defense response to protozoan | 5/409 | 24/18670 | 1.5e-04 | 3.9e-03 | 3.3e-03 |
| GO:0050857 | positive regulation of antigen receptor-mediated signaling pathway | 5/409 | 24/18670 | 1.5e-04 | 3.9e-03 | 3.3e-03 |
| GO:0001562 | response to protozoan | 5/409 | 25/18670 | 1.8e-04 | 4.7e-03 | 4.0e-03 |
| GO:0021700 | developmental maturation | 17/409 | 284/18670 | 1.9e-04 | 4.8e-03 | 4.1e-03 |
| GO:0043374 | CD8-positive, alpha-beta T cell differentiation | 4/409 | 14/18670 | 1.9e-04 | 4.9e-03 | 4.2e-03 |
| GO:0006909 | phagocytosis | 20/409 | 369/18670 | 2.0e-04 | 5.1e-03 | 4.3e-03 |
| GO:1903532 | positive regulation of secretion by cell | 21/409 | 399/18670 | 2.1e-04 | 5.2e-03 | 4.5e-03 |
| GO:0006874 | cellular calcium ion homeostasis | 23/409 | 458/18670 | 2.1e-04 | 5.2e-03 | 4.5e-03 |
| GO:0072539 | T-helper 17 cell differentiation | 5/409 | 26/18670 | 2.2e-04 | 5.5e-03 | 4.7e-03 |
| GO:0071216 | cellular response to biotic stimulus | 15/409 | 236/18670 | 2.3e-04 | 5.8e-03 | 4.9e-03 |
| GO:0071219 | cellular response to molecule of bacterial origin | 14/409 | 212/18670 | 2.5e-04 | 6.2e-03 | 5.3e-03 |
| GO:0042093 | T-helper cell differentiation | 7/409 | 58/18670 | 2.6e-04 | 6.5e-03 | 5.5e-03 |
| GO:0045577 | regulation of B cell differentiation | 5/409 | 28/18670 | 3.2e-04 | 7.7e-03 | 6.6e-03 |
| GO:0045165 | cell fate commitment | 16/409 | 270/18670 | 3.2e-04 | 7.7e-03 | 6.6e-03 |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | 12/409 | 167/18670 | 3.2e-04 | 7.7e-03 | 6.6e-03 |
| GO:2000404 | regulation of T cell migration | 6/409 | 44/18670 | 3.7e-04 | 8.9e-03 | 7.6e-03 |
| GO:0072538 | T-helper 17 type immune response | 5/409 | 29/18670 | 3.8e-04 | 8.9e-03 | 7.6e-03 |
| GO:0051250 | negative regulation of lymphocyte activation | 11/409 | 146/18670 | 3.8e-04 | 8.9e-03 | 7.6e-03 |
| GO:0000910 | cytokinesis | 12/409 | 171/18670 | 4.0e-04 | 9.4e-03 | 8.0e-03 |
| GO:0051321 | meiotic cell cycle | 15/409 | 249/18670 | 4.1e-04 | 9.6e-03 | 8.2e-03 |
| GO:0048535 | lymph node development | 4/409 | 17/18670 | 4.3e-04 | 1.0e-02 | 8.5e-03 |
| GO:0051983 | regulation of chromosome segregation | 9/409 | 103/18670 | 4.3e-04 | 1.0e-02 | 8.5e-03 |
| GO:0032743 | positive regulation of interleukin-2 production | 5/409 | 30/18670 | 4.5e-04 | 1.0e-02 | 8.7e-03 |
| GO:0046640 | regulation of alpha-beta T cell proliferation | 5/409 | 30/18670 | 4.5e-04 | 1.0e-02 | 8.7e-03 |
| GO:0071887 | leukocyte apoptotic process | 9/409 | 104/18670 | 4.7e-04 | 1.1e-02 | 9.0e-03 |
| GO:0002675 | positive regulation of acute inflammatory response | 5/409 | 31/18670 | 5.2e-04 | 1.2e-02 | 1.0e-02 |
| GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway | 5/409 | 31/18670 | 5.2e-04 | 1.2e-02 | 1.0e-02 |
| GO:0051047 | positive regulation of secretion | 21/409 | 428/18670 | 5.3e-04 | 1.2e-02 | 1.0e-02 |
| GO:0043370 | regulation of CD4-positive, alpha-beta T cell differentiation | 6/409 | 47/18670 | 5.4e-04 | 1.2e-02 | 1.0e-02 |
| GO:0007052 | mitotic spindle organization | 9/409 | 106/18670 | 5.4e-04 | 1.2e-02 | 1.0e-02 |
| GO:0043011 | myeloid dendritic cell differentiation | 4/409 | 18/18670 | 5.4e-04 | 1.2e-02 | 1.0e-02 |
| GO:0051023 | regulation of immunoglobulin secretion | 4/409 | 18/18670 | 5.4e-04 | 1.2e-02 | 1.0e-02 |
| GO:0051782 | negative regulation of cell division | 4/409 | 18/18670 | 5.4e-04 | 1.2e-02 | 1.0e-02 |
| GO:0034612 | response to tumor necrosis factor | 17/409 | 312/18670 | 5.6e-04 | 1.2e-02 | 1.0e-02 |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 23/409 | 493/18670 | 5.9e-04 | 1.3e-02 | 1.1e-02 |
| GO:0051785 | positive regulation of nuclear division | 7/409 | 66/18670 | 5.9e-04 | 1.3e-02 | 1.1e-02 |
| GO:0002237 | response to molecule of bacterial origin | 18/409 | 343/18670 | 6.0e-04 | 1.3e-02 | 1.1e-02 |
| GO:0071222 | cellular response to lipopolysaccharide | 13/409 | 205/18670 | 6.1e-04 | 1.3e-02 | 1.1e-02 |
| GO:0002544 | chronic inflammatory response | 4/409 | 19/18670 | 6.8e-04 | 1.4e-02 | 1.2e-02 |
| GO:0060252 | positive regulation of glial cell proliferation | 4/409 | 19/18670 | 6.8e-04 | 1.4e-02 | 1.2e-02 |
| GO:0032633 | interleukin-4 production | 5/409 | 33/18670 | 7.0e-04 | 1.5e-02 | 1.2e-02 |
| GO:0071356 | cellular response to tumor necrosis factor | 16/409 | 291/18670 | 7.3e-04 | 1.5e-02 | 1.3e-02 |
| GO:0072676 | lymphocyte migration | 9/409 | 111/18670 | 7.5e-04 | 1.5e-02 | 1.3e-02 |
| GO:0097529 | myeloid leukocyte migration | 13/409 | 210/18670 | 7.7e-04 | 1.6e-02 | 1.3e-02 |
| GO:0070227 | lymphocyte apoptotic process | 7/409 | 69/18670 | 7.7e-04 | 1.6e-02 | 1.3e-02 |
| GO:0045132 | meiotic chromosome segregation | 8/409 | 90/18670 | 8.0e-04 | 1.6e-02 | 1.4e-02 |
| GO:0045066 | regulatory T cell differentiation | 5/409 | 34/18670 | 8.1e-04 | 1.6e-02 | 1.4e-02 |
| GO:0002712 | regulation of B cell mediated immunity | 6/409 | 51/18670 | 8.3e-04 | 1.6e-02 | 1.4e-02 |
| GO:0002889 | regulation of immunoglobulin mediated immune response | 6/409 | 51/18670 | 8.3e-04 | 1.6e-02 | 1.4e-02 |
| GO:0030071 | regulation of mitotic metaphase/anaphase transition | 6/409 | 51/18670 | 8.3e-04 | 1.6e-02 | 1.4e-02 |
| GO:0050766 | positive regulation of phagocytosis | 7/409 | 70/18670 | 8.4e-04 | 1.6e-02 | 1.4e-02 |
| GO:0060251 | regulation of glial cell proliferation | 5/409 | 35/18670 | 9.3e-04 | 1.8e-02 | 1.5e-02 |
| GO:0090068 | positive regulation of cell cycle process | 16/409 | 298/18670 | 9.4e-04 | 1.8e-02 | 1.5e-02 |
| GO:0002700 | regulation of production of molecular mediator of immune response | 10/409 | 139/18670 | 9.9e-04 | 1.9e-02 | 1.6e-02 |
| GO:0051383 | kinetochore organization | 4/409 | 21/18670 | 1.0e-03 | 1.9e-02 | 1.6e-02 |
| GO:0045787 | positive regulation of cell cycle | 19/409 | 389/18670 | 1.0e-03 | 1.9e-02 | 1.6e-02 |
| GO:0045840 | positive regulation of mitotic nuclear division | 6/409 | 53/18670 | 1.0e-03 | 1.9e-02 | 1.6e-02 |
| GO:0070228 | regulation of lymphocyte apoptotic process | 6/409 | 53/18670 | 1.0e-03 | 1.9e-02 | 1.6e-02 |
| GO:1902099 | regulation of metaphase/anaphase transition of cell cycle | 6/409 | 53/18670 | 1.0e-03 | 1.9e-02 | 1.6e-02 |
| GO:0032496 | response to lipopolysaccharide | 17/409 | 330/18670 | 1.0e-03 | 1.9e-02 | 1.7e-02 |
| GO:0050727 | regulation of inflammatory response | 22/409 | 485/18670 | 1.1e-03 | 2.1e-02 | 1.8e-02 |
| GO:0007135 | meiosis II | 3/409 | 10/18670 | 1.1e-03 | 2.1e-02 | 1.8e-02 |
| GO:0061983 | meiosis II cell cycle process | 3/409 | 10/18670 | 1.1e-03 | 2.1e-02 | 1.8e-02 |
| GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | 6/409 | 54/18670 | 1.1e-03 | 2.1e-02 | 1.8e-02 |
| GO:0002714 | positive regulation of B cell mediated immunity | 5/409 | 37/18670 | 1.2e-03 | 2.2e-02 | 1.9e-02 |
| GO:0002891 | positive regulation of immunoglobulin mediated immune response | 5/409 | 37/18670 | 1.2e-03 | 2.2e-02 | 1.9e-02 |
| GO:0045730 | respiratory burst | 5/409 | 37/18670 | 1.2e-03 | 2.2e-02 | 1.9e-02 |
| GO:0051302 | regulation of cell division | 11/409 | 168/18670 | 1.2e-03 | 2.2e-02 | 1.9e-02 |
| GO:0051303 | establishment of chromosome localization | 7/409 | 75/18670 | 1.3e-03 | 2.3e-02 | 1.9e-02 |
| GO:1990868 | response to chemokine | 8/409 | 97/18670 | 1.3e-03 | 2.3e-02 | 2.0e-02 |
| GO:1990869 | cellular response to chemokine | 8/409 | 97/18670 | 1.3e-03 | 2.3e-02 | 2.0e-02 |
| GO:0007051 | spindle organization | 11/409 | 170/18670 | 1.3e-03 | 2.4e-02 | 2.0e-02 |
| GO:0050000 | chromosome localization | 7/409 | 76/18670 | 1.4e-03 | 2.4e-02 | 2.0e-02 |
| GO:0044784 | metaphase/anaphase transition of cell cycle | 6/409 | 56/18670 | 1.4e-03 | 2.4e-02 | 2.0e-02 |
| GO:0090307 | mitotic spindle assembly | 6/409 | 56/18670 | 1.4e-03 | 2.4e-02 | 2.0e-02 |
| GO:0050764 | regulation of phagocytosis | 8/409 | 98/18670 | 1.4e-03 | 2.4e-02 | 2.1e-02 |
| GO:0032753 | positive regulation of interleukin-4 production | 4/409 | 23/18670 | 1.4e-03 | 2.5e-02 | 2.1e-02 |
| GO:0036037 | CD8-positive, alpha-beta T cell activation | 4/409 | 23/18670 | 1.4e-03 | 2.5e-02 | 2.1e-02 |
| GO:0010965 | regulation of mitotic sister chromatid separation | 6/409 | 57/18670 | 1.5e-03 | 2.6e-02 | 2.2e-02 |
| GO:0031652 | positive regulation of heat generation | 3/409 | 11/18670 | 1.5e-03 | 2.6e-02 | 2.2e-02 |
| GO:0033089 | positive regulation of T cell differentiation in thymus | 3/409 | 11/18670 | 1.5e-03 | 2.6e-02 | 2.2e-02 |
| GO:0045060 | negative thymic T cell selection | 3/409 | 11/18670 | 1.5e-03 | 2.6e-02 | 2.2e-02 |
| GO:0033081 | regulation of T cell differentiation in thymus | 4/409 | 24/18670 | 1.7e-03 | 2.9e-02 | 2.4e-02 |
| GO:0042104 | positive regulation of activated T cell proliferation | 4/409 | 24/18670 | 1.7e-03 | 2.9e-02 | 2.4e-02 |
| GO:0019932 | second-messenger-mediated signaling | 20/409 | 439/18670 | 1.7e-03 | 2.9e-02 | 2.5e-02 |
| GO:0002793 | positive regulation of peptide secretion | 15/409 | 288/18670 | 1.8e-03 | 3.0e-02 | 2.6e-02 |
| GO:0033045 | regulation of sister chromatid segregation | 7/409 | 80/18670 | 1.8e-03 | 3.1e-02 | 2.6e-02 |
| GO:0042267 | natural killer cell mediated cytotoxicity | 6/409 | 60/18670 | 2.0e-03 | 3.2e-02 | 2.7e-02 |
| GO:0051306 | mitotic sister chromatid separation | 6/409 | 60/18670 | 2.0e-03 | 3.2e-02 | 2.7e-02 |
| GO:0002863 | positive regulation of inflammatory response to antigenic stimulus | 3/409 | 12/18670 | 2.0e-03 | 3.2e-02 | 2.7e-02 |
| GO:0043383 | negative T cell selection | 3/409 | 12/18670 | 2.0e-03 | 3.2e-02 | 2.7e-02 |
| GO:0046541 | saliva secretion | 3/409 | 12/18670 | 2.0e-03 | 3.2e-02 | 2.7e-02 |
| GO:0070601 | centromeric sister chromatid cohesion | 3/409 | 12/18670 | 2.0e-03 | 3.2e-02 | 2.7e-02 |
| GO:0050901 | leukocyte tethering or rolling | 4/409 | 25/18670 | 2.0e-03 | 3.2e-02 | 2.7e-02 |
| GO:0007218 | neuropeptide signaling pathway | 8/409 | 104/18670 | 2.0e-03 | 3.3e-02 | 2.8e-02 |
| GO:2000514 | regulation of CD4-positive, alpha-beta T cell activation | 6/409 | 61/18670 | 2.1e-03 | 3.4e-02 | 2.9e-02 |
| GO:2000106 | regulation of leukocyte apoptotic process | 7/409 | 83/18670 | 2.3e-03 | 3.6e-02 | 3.1e-02 |
| GO:0002456 | T cell mediated immunity | 8/409 | 106/18670 | 2.3e-03 | 3.6e-02 | 3.1e-02 |
| GO:0032623 | interleukin-2 production | 6/409 | 62/18670 | 2.3e-03 | 3.6e-02 | 3.1e-02 |
| GO:0045453 | bone resorption | 6/409 | 62/18670 | 2.3e-03 | 3.6e-02 | 3.1e-02 |
| GO:1905818 | regulation of chromosome separation | 6/409 | 62/18670 | 2.3e-03 | 3.6e-02 | 3.1e-02 |
| GO:0006775 | fat-soluble vitamin metabolic process | 5/409 | 43/18670 | 2.4e-03 | 3.7e-02 | 3.2e-02 |
| GO:0050850 | positive regulation of calcium-mediated signaling | 5/409 | 43/18670 | 2.4e-03 | 3.7e-02 | 3.2e-02 |
| GO:0007062 | sister chromatid cohesion | 6/409 | 63/18670 | 2.5e-03 | 3.9e-02 | 3.3e-02 |
| GO:2000401 | regulation of lymphocyte migration | 6/409 | 63/18670 | 2.5e-03 | 3.9e-02 | 3.3e-02 |
| GO:0031650 | regulation of heat generation | 3/409 | 13/18670 | 2.5e-03 | 3.9e-02 | 3.3e-02 |
| GO:0045086 | positive regulation of interleukin-2 biosynthetic process | 3/409 | 13/18670 | 2.5e-03 | 3.9e-02 | 3.3e-02 |
| GO:0050663 | cytokine secretion | 13/409 | 240/18670 | 2.5e-03 | 3.9e-02 | 3.3e-02 |
| GO:0033046 | negative regulation of sister chromatid segregation | 5/409 | 44/18670 | 2.6e-03 | 4.0e-02 | 3.4e-02 |
| GO:0042742 | defense response to bacterium | 16/409 | 330/18670 | 2.7e-03 | 4.0e-02 | 3.4e-02 |
| GO:0032673 | regulation of interleukin-4 production | 4/409 | 27/18670 | 2.7e-03 | 4.0e-02 | 3.4e-02 |
| GO:0002228 | natural killer cell mediated immunity | 6/409 | 64/18670 | 2.7e-03 | 4.1e-02 | 3.5e-02 |
| GO:0016445 | somatic diversification of immunoglobulins | 6/409 | 64/18670 | 2.7e-03 | 4.1e-02 | 3.5e-02 |
| GO:0046579 | positive regulation of Ras protein signal transduction | 6/409 | 64/18670 | 2.7e-03 | 4.1e-02 | 3.5e-02 |
| GO:0051985 | negative regulation of chromosome segregation | 5/409 | 45/18670 | 2.9e-03 | 4.3e-02 | 3.7e-02 |
| GO:0050921 | positive regulation of chemotaxis | 9/409 | 135/18670 | 2.9e-03 | 4.3e-02 | 3.7e-02 |
| GO:0002548 | monocyte chemotaxis | 6/409 | 65/18670 | 3.0e-03 | 4.3e-02 | 3.7e-02 |
| GO:1903046 | meiotic cell cycle process | 11/409 | 188/18670 | 3.0e-03 | 4.3e-02 | 3.7e-02 |
| GO:0000075 | cell cycle checkpoint | 12/409 | 216/18670 | 3.0e-03 | 4.3e-02 | 3.7e-02 |
| GO:0010818 | T cell chemotaxis | 4/409 | 28/18670 | 3.1e-03 | 4.4e-02 | 3.8e-02 |
| GO:0032196 | transposition | 4/409 | 28/18670 | 3.1e-03 | 4.4e-02 | 3.8e-02 |
| GO:0032770 | positive regulation of monooxygenase activity | 4/409 | 28/18670 | 3.1e-03 | 4.4e-02 | 3.8e-02 |
| GO:0050920 | regulation of chemotaxis | 12/409 | 217/18670 | 3.1e-03 | 4.4e-02 | 3.8e-02 |
| GO:0050862 | positive regulation of T cell receptor signaling pathway | 3/409 | 14/18670 | 3.2e-03 | 4.5e-02 | 3.9e-02 |
| GO:0070098 | chemokine-mediated signaling pathway | 7/409 | 88/18670 | 3.2e-03 | 4.5e-02 | 3.9e-02 |
| GO:0045931 | positive regulation of mitotic cell cycle | 10/409 | 163/18670 | 3.2e-03 | 4.6e-02 | 3.9e-02 |
| GO:0050868 | negative regulation of T cell activation | 8/409 | 112/18670 | 3.2e-03 | 4.6e-02 | 3.9e-02 |
| GO:0032465 | regulation of cytokinesis | 7/409 | 89/18670 | 3.4e-03 | 4.8e-02 | 4.1e-02 |
| GO:0035025 | positive regulation of Rho protein signal transduction | 4/409 | 29/18670 | 3.5e-03 | 4.9e-02 | 4.1e-02 |
| GO:0007093 | mitotic cell cycle checkpoint | 10/409 | 165/18670 | 3.5e-03 | 4.9e-02 | 4.1e-02 |
| GO:0002204 | somatic recombination of immunoglobulin genes involved in immune response | 5/409 | 47/18670 | 3.5e-03 | 4.9e-02 | 4.1e-02 |
| GO:0002208 | somatic diversification of immunoglobulins involved in immune response | 5/409 | 47/18670 | 3.5e-03 | 4.9e-02 | 4.1e-02 |
| GO:0030261 | chromosome condensation | 5/409 | 47/18670 | 3.5e-03 | 4.9e-02 | 4.1e-02 |
| GO:0045190 | isotype switching | 5/409 | 47/18670 | 3.5e-03 | 4.9e-02 | 4.1e-02 |
| GO:0002791 | regulation of peptide secretion | 21/409 | 500/18670 | 3.5e-03 | 4.9e-02 | 4.1e-02 |
| GO:0051304 | chromosome separation | 7/409 | 90/18670 | 3.6e-03 | 4.9e-02 | 4.2e-02 |
| GO:0071674 | mononuclear cell migration | 7/409 | 90/18670 | 3.6e-03 | 4.9e-02 | 4.2e-02 |
Tabla 12: GOtable que contiene las vías metabólicas expresadas diferencialmente entre los grupos SFI y ELI.
De forma análoga a las toptables, las pathwaytables o GOtables también contienen demasiada información. Una solución mucho más visual consiste en construir un barplot y un cnetplot para cada una de las comparaciones. A continuación se muestran los barplots (Figura 4) y los cnetplots (Figura 5) corresondientes a cada una de las tablas que se acaban de presentar. En el caso de los barplots, las barras están ordenadas de mayor a menor evidencia de que esa vía este diferencialmente expresada.
Figura 4: barplots que muestran las 10 vías metabólicas con mayor evidencia de estar diferencialmente expresadas en las comparaciones NIT-SFI (A), NIT-ELI (B) y SFI-ELI (C).
Figura 5: cnetplots que muestran las 4 vías metabólicas con mayor evidencia de estar diferencialmente expresadas en las comparaciones NIT-SFI (A), NIT-ELI (B) y SFI-ELI (C).
Para comentar y analizar estos resultados obtenidos, lo haremos comparación a comparación. Empezaremos -pues- por la comparación NIT-SFI. Si nos fijamos en los outputs de la GOtable (Tabla 10), el barplot (Figura 4.A) y el cnetplot (Figura 5.A) podemos identificar que las 4 rutas metabólicas que tienen una mayor evidencia de estar parcialmente diferencialmente expresadas están relacionadas con la respuesta inmune. En concreto estas vías están implicadas en la activación, señalización y la proliferación de los limfocitos B y en la respuesta inmune de tipo humoral. Adicionalmente es importante remarcar que la cantidad de genes diferencialmente expresados entre conidiciones oscila alrededor de 10 por vía y que todos estos genes se encuentran infraexpresados para la condición SFI.
Sigamos con la comparación NIT-ELI (Tabla 11, Figura 4.B, Figura 5.B). Analizando los resultados generados, identificamos que las 4 rutas con una mayor evidencia de estar diferencialmente expresadas también están relacionadas con la respuesta inmune. Sin embargo, esta vez las vías están más ligadas a los limfocitos T que a los B. Concretamente, las vías afectadas tienen relación con la activación y diferenciación de los limfocitos T aunque también de otro tipo de limfocitos. Para cada una de estas vías el número de genes diferencialmente expresados oscila entre 58 y 94. Otro hecho que podemos observar y que es muy interesante, es que todos estos genes están infraexpresados en la condición EFI menos tres (TAC1, IHH, IL6).
Finalmente, para la comparación SFI-ELI (Tabla 12, Figura 4.C, Figura 5.C) vemos que 2 de las 4 rutas con una mayor evidencia de estar diferencialmente expresadas son las mismas que vimos para la comparación NIT-ELI. En cuanto a las otras dos, estas tienen una relación muy estrecha con las que se observaron para la comparación anterior. Las vías afectadas están relacionadas con la activación de los limfocitos T y con la activación y regulación de otros limfocitos. El número de genes afectados para cada una de estas vías se mueve dentro del intervalo [48, 61]. Además, si miramos el cnetplot podemos ver que -de nuevo- sólo tres genes están sobrexpresados (IGF1, IL6, TAC1), estando dos de ellos compartidos con la comparación anterior.
En cualquier proyecto de investigación, la discusión de los resultados y la extracción de conclusiones requieren de un conocimiento exhaustivo del contexto biológico del estudio. Sin embargo, obtener el grado adecuado de este conocimiento puede implicar meses o años realizando investigación en una misma dirección. Por ese motivo, con mucha frecuencia, el papel del bioinformático pasa a un segundo plano en esta parte del proceso de investigación. Su papel, pues, consiste básicamente en ofrecer soporte al resto del equipo, generar un informe con los resultados y, dentro de lo posible, comentarlos. Aunque en la sección de resultados ya hemos realizado una breve discusión de estos, hemos decidido presentar -a continuación- una valoración general.
A diferencia de la PEC 1, donde nos intentamos basar en los métodos propuestos por el personal docente, en este caso hemos intendado improvisar un poco y utilizar aquellas pruebas/análisis y aquellos paquetes/librerías que más nos han convenido. Aunque no es mi intención utilizar esto como excusa, debido a temas laborales que han implicado emigrar a otro país, para algunos de los análisis hemos utilizado paquetes que -a priori- pueden parecer relativamente antiguos. La velocidad con la que avanzan las diferentes ramas de la bioinformática y la aparición constante de nuevos paquetes sumada a la falta de tiempo ha hecho que hayamos intendado simplificar el workflow de análisis.
A pesar de todo lo comentado anteriormente, hemos obtenido unos resultados que podemos considerar -como mínimo- interesantes. A continuación pasamos a comentarlos. Según los datos obtenidos, la expresión diferencial entre las condiciones NIT (control) y SFI (infilitraciones focales) es poco significativa. La aplicación de infilitraciones focales en el tejido tiroide afecta solo a un 0.71% de los genes, estando un 0.11% de ellos sobrexpresados y un 0.6% infraexpresados (Tabla 7, Figura 3.A). En contraste, si nos fijamos en las dos otras comparaciones, observamos que la aplicación de infiltraciones extensivas provoca una expresión diferencial significativa. Respecto al control, esta aplicación afecta la expresión de un 8.1% de los genes, estando un 2% sobrexpresados y un 6.1% infraexpresados. En cambio, respecto al grupo con infiltraciones focales, vemos que esta aplicación afecta la expresión del 8.9% de los genes. En síntonia con lo observado para la comparación NIT vs SFI, la mayoría de estos genes están infraexpresados (6.1% frente a 2.8%). Los volcano plots secundan estas conclusiones y nos permiten asimilar estas ideas de forma más visual.
Aunque los resultados que acabamos de presentar son muy interesantes y válidos, para sacar conclusiones es más conveniente traducir estos resultados de genes a vías metabólicas diferencialmente expresadas. La generación de pathwaytables y -a partir de estas- de barplots y cnetplots revela que en cualquiera de las tres comparaciones las vías metabólicas afectadas tienen relación con la respuesta inmune. Más concretamente con la activación, proliferación y diferenciación de los limfocitos B y T. Es importante destacar que para la comparación NIT-SFI, la mayoría de genes afectados están más relacionados con los limfocitos B mientras que para las otras dos comparaciones lo están para los T. Adicionalmente, como ya hemos visto anteriormente, casi todos los genes están infraexpresados. Sin embargo, para las comparaciones NIT-ELI y SFI-ELI, tres genes están sobrexpresados. Estos son IL6 y TAC1 (compartidos) y IGF1 (SFI-ELI) o RUNX3 (NIT-ELI). En consecuencia, podría ser interesante ver que función tienen estos genes y porque están sobrexpresados.
En síntesi, la aplicación de infiltraciones focales en el tejido tiroideo tienen un efecto significativamente leve sobre la respuesta inmune, provocando la infraexpresión de un número pequeño de genes. Sin embargo, la aplicación de inflitraciones extensivas tiene un efecto mucho más potente, provocando la infraexpresión de un número mucho más considerable de genes relacionados también con la respuesta inmune. Finalmente, si comparamos el grupo con extensiones focales y extensivas obtenemos unos resultados muy parecidos a los obtenidos entre el control y el segundo grupo.
A continuación se muestra todo el código que hemos utilizado para este análisis. Este contenido es idéntico a aquel presente dentro del script Garcia_Marc_ADO_PEC2.R.
# PEC2: Análisis de Datos Ómicos
# ------------------------------------------------------------------------------------------------------------------------------------------------------
# Estableciendo el directorio de trabajo
setwd("C:/Users/USER/Documents/Màster Bioestadística i Bioinfo/Análisis de datos Ómicos/PECS/ADO_PEC2_Marc_Garcia/")
# -------------------------------------------------------------------------------------------------------------------------------------------------------
# Preparando el entorno de trabajo
dir.create("data")
dir.create("scripts")
dir.create("results")
dir.create("other")
dir.create("figures")
# -------------------------------------------------------------------------------------------------------------------------------------------------------
# Carga de paquetes
# 1) CRAN
library(readxl)
library(ggplot2)
library(ggrepel)
library(viridis)
library(magrittr)
library(cowplot)
library(cluster)
library(factoextra)
# 2) Bioconductor
library(Biobase)
library(DESeq2)
library(AnnotationDbi)
library(EnhancedVolcano)
library(org.Hs.eg.db)
library(clusterProfiler)
library(ReactomePA)
library(enrichplot)
# -----------------------------------------------------------------------------------------------------------------------------------------------------
# Cargando los datos
counts_raw <- read.csv(file = "data/counts.csv",
sep = ";",
header = T,
row.names = 1,
stringsAsFactors = F,
check.names = F)
targets_file <- read.csv(file = "data/targets.csv",
sep = ",")
# -----------------------------------------------------------------------------------------------------------------------------------------------------
# Exploración raw counts + targets file
# 1) Raw counts
dim(counts_raw)
View(counts_raw)
head(counts_raw[ , 1:4], 8)
# 2) Targets
dim(targets_file)
View(targets_file)
head(targets_file, 10)
# ----------------------------------------------------------------------------------------------------------------------------------------------------
# Preprocesado de los datos
# 1) Selección de las muestras
targets_file_nit <- targets_file[targets_file$Group == "NIT", ]
targets_file_sfi <- targets_file[targets_file$Group == "SFI", ]
targets_file_eli <- targets_file[targets_file$Group == "ELI", ]
sample_names_nit <- as.character(targets_file_nit$Sample_Name)
sample_names_sfi <- as.character(targets_file_sfi$Sample_Name)
sample_names_eli <- as.character(targets_file_eli$Sample_Name)
set.seed(65261)
nit_subset <- sample(x = sample_names_nit, size = 10, replace = F)
sfi_subset <- sample(x = sample_names_sfi, size = 10, replace = F)
eli_subset <- sample(x = sample_names_eli, size = 10, replace = F)
selected_samples <- c(nit_subset, sfi_subset, eli_subset)
# 2) Subsetting
# 2.1) Counts
counts_raw_sub <- counts_raw[ , selected_samples]
# 2.2) Targets
rownames(targets_file) <- targets_file$Sample_Name
targets_raw_sub <- targets_file[selected_samples, ]
# 3) Cambio de nombre de las muestras
colnames(counts_raw_sub)[1:10] <- paste0("NIT_", 1:10)
colnames(counts_raw_sub)[11:20] <- paste0("SFI_", 1:10)
colnames(counts_raw_sub)[21:30] <- paste0("ELI_", 1:10)
rownames(targets_raw_sub) <- colnames(counts_raw_sub)
targets_raw_sub$color <- c(rep("#238A8DFF", 10), rep("#DCE319FF", 10), rep("#481567FF", 10))
# 4) Comprobaciones
head(counts_raw_sub[1:17], 10)
colnames(counts_raw_sub)
rownames(targets_raw_sub)
# 5) Guardando los subsets
# 5.1) Counts
write.csv(x = counts_raw_sub,
file = "data/counts_sub.csv",
row.names = T)
# 5.2) Targets
write.csv(x = targets_raw_sub,
file = "data/targets_sub.csv",
row.names = T)
# ----------------------------------------------------------------------------------------------------------------------------------------------------
# Construcción de un objeto DESeq dataset
count_data <- read.csv("data/counts_sub.csv", row.names = 1)
col_data <- read.csv("data/targets_sub.csv", row.names = 1)
(dds_mat <- DESeqDataSetFromMatrix(countData = count_data,
colData = col_data,
design = ~ Group))
# --------------------------------------------------------------------------------------------------------------------------
# Eliminando genes no expresados
(dds_mat_filtered <- dds_mat[rowSums(counts(dds_mat)) >= 1, ])
filtered_out <- nrow(dds_mat) - nrow(dds_mat_filtered)
# --------------------------------------------------------------------------------------------------------------------------
# Transformación vst
vsd <- vst(object = dds_mat_filtered, blind = FALSE)
head(assay(vsd), 10)[ , 1:10]
# --------------------------------------------------------------------------------------------------------------------------
# Control de calidad
# 1) Boxplot
dir.create("figures/boxplots")
(g1 <- ggplot(stack(data.frame(assay(vsd))), aes(x = ind, y = values, fill = ind)) +
geom_boxplot() +
scale_fill_manual(values = targets_raw_sub$color) +
labs(title = "Boxplot transformed counts",
x = "muestra",
y = "pseudocounts") +
theme_classic() +
theme(legend.position = "none", axis.text.x = element_text(angle = 90, hjust = 1)) +
theme(axis.title.y = element_text(margin = margin(t = 0, r = 10, b = 0, l = 0)),
axis.title.x = element_text(margin = margin(t = 10, r = 0, b = 0, l = 0))))
tiff("figures/boxplots/pseudocount_raw.tiff",
res = 300,
width = 5.5,
height = 5.5,
units = 'in',
bg = NA)
print(g1)
dev.off()
# 2) PCA plot
plotPCA3 <- function (datos, labels, factor, title, scale, size = 1.5, glineas = 0.25) {
data <- prcomp(t(datos), scale = scale)
# plot adjustments
dataDf <- data.frame(data$x)
Group <- factor
loads <- round(data$sdev^2/sum(data$sdev^2) * 100, 1)
# main plot
p1 <- ggplot(data = dataDf, aes(x = PC1, y = PC2)) +
theme_classic() +
geom_hline(yintercept = 0, color = "gray70") +
geom_vline(xintercept = 0, color = "gray70") +
geom_point(aes(color = Group), size = 2) +
coord_cartesian(xlim = c(min(data$x[ , 1]) - 5, max(data$x[ , 1]) + 5)) +
scale_fill_discrete(name = "Group") +
theme(axis.title.y = element_text(size = 10,
margin = margin(t = 0, r = 10, b = 0, l = 0)),
axis.title.x = element_text(size = 10,
margin = margin(t = 10, r = 0, b = 0, l = 0)),
axis.text = element_text(size = 7),
legend.text = element_text(size = 8),
legend.title = element_text(size = 10),
legend.key.size = unit(0.4, "cm"),
legend.key.width = unit(0.5,"cm"))
# avoiding labels superposition
p1 + geom_text_repel(aes(y = PC2 + 0.25, label = labels), segment.size = 0.25, size = size) +
labs(x = c(paste("PC1", loads[1], "%")), y = c(paste("PC2", loads[2], "%"))) +
ggtitle(paste("PCA for: ", title, sep = " ")) +
scale_color_viridis(discrete = T)
}
dir.create("figures/PCA_plots")
tiff("figures/PCA_plots/PCA_raw.tiff",
res = 300,
width = 5.5,
height = 5.5,
units = 'in',
bg = NA)
print(plotPCA3(datos = assay(vsd),
labels = colnames(counts_raw_sub),
factor = targets_raw_sub$Group,
title = "transformed counts",
scale = F,
size = 2.5))
dev.off()
# 3) Dendrograma
sample_dist <- dist(t(assay(vsd)))
res <- hcut(sample_dist, k = 2, stand = T, method = "euclidean")
res$labels <- as.character(colnames(dds_mat_filtered))
dir.create("figures/dendrograms")
tiff("figures/dendrograms/dendrogram.tiff",
res = 300,
width = 10,
height = 5.5,
units = 'in',
bg = NA)
print(fviz_dend(res,
rect = T,
cex = 0.5,
lwd = 1,
k_colors = c("#440154FF", "#FDE725FF"),
label_cols = "black"))
dev.off()
# -------------------------------------------------------------------------------------------------------------------------
# Selección de genes diferencialmente expresados (DEG)
# 1) Construyendo DESeq2DataSet
dds_mat <- DESeqDataSetFromMatrix(countData = count_data,
colData = col_data,
design = ~ Group)
# 2) Filtrando genes que cierta expresión
dds_mat_filtered <- dds_mat[rowSums(counts(dds_mat)) >= 1, ]
# 3) Creación de objeto DESeq
dds <- DESeq(dds_mat_filtered, parallel = T)
# 4) Contrastes
# 4.1) NIT vs SFI
# 4.1.1) Generando resultados contraste
res_1 <- results(dds, contrast = c("Group","NIT","SFI"))
# 4.1.2) Modificando los ENSEMBL gene ids
rownames(res_1) <- gsub("\\..*","", rownames(res_1))
# 4.1.3) Consultando resumen de los resultados (padj < 0.1)
summary_1 <- summary(res_1, alpha = 0.1)
# 4.1.4) Anotando DEG (genesymbol + entrezid)
res_1$symbol <- mapIds(x = org.Hs.eg.db,
keys = rownames(res_1),
column = "SYMBOL",
keytype = "ENSEMBL",
multiVals = "first")
res_1$entrez <- mapIds(x = org.Hs.eg.db,
keys = rownames(res_1),
column = "ENTREZID",
keytype = "ENSEMBL",
multiVals="first")
# 4.1.5) Eliminando genes que no tienen anotación
res_1 <- na.omit(res_1)
# 4.1.6) Guardando el contenido de la toptable
dir.create("results/top_taples")
write.csv(x = res_1,
file = "results/top_taples/top_table_NITvsSFI.csv",
row.names = T)
# 4.1.7) Filtrando DEG (log2FC > 2 & padj < 0.1)
res_1_filtered <- as.data.frame(res_1)[which(res_1$padj < 0.1 & abs(res_1$log2FoldChange) > 2), ]
res_1_filtered <- res_1_filtered[order(res_1_filtered$padj), ]
View(res_1_filtered)
# 4.1.8) Guardando el contenido de la toptable filtrada
dir.create("results/top_tables_filtered")
write.csv(x = res_1_filtered,
file = "results/top_tables_filtered/top_table_NITvsSFI_filtered.csv",
row.names = T)
# 4.1.9) Volcano plot
dir.create("figures/volcano_plots")
tiff(filename = "figures/volcano_plots/volcano_plot_NITvsSFI.tiff",
width = 5.5,
height = 5.5,
res = 300,
units = "in")
print(EnhancedVolcano(toptable = res_1,
lab = res_1$symbol,
selectLab = res_1$symbol[order(res_1$padj)][1:5],
x = "log2FoldChange",
y = "padj",
pCutoff = 0.1,
FCcutoff = 1,
ylim = c(0, 7),
xlim = c(-7, 5),
pointSize = 1.7,
axisLabSize = 13,
labSize = 4,
subtitle = "",
caption = "",
title = "NIT vs SFI",
titleLabSize = 18,
legendVisible = F,
legendPosition = "bottom",
legendLabSize = 10,
legendIconSize = 3))
dev.off()
# 4.1.10) heatmap
dir.create("figures/heatmaps")
h_res_1 <- as.matrix(counts_raw_sub[rownames(res_1_filtered), 1:20])
rownames(h_res_1) <- res_1_filtered$symbol
tiff(filename = "figures/heatmaps/heatmap_NITvsSFI.tiff",
width = 5.5,
height = 5.5,
res = 300,
units = "in")
heatmap(h_res_1)
dev.off()
# 4.2) NIT vs ELI
# 4.2.1) Generando resultados contraste
res_2 <- results(dds, contrast = c("Group", "NIT", "ELI"))
# 4.2.2) Modificando los ENSEMBL gene ids
rownames(res_2) <- gsub("\\..*","", rownames(res_2))
# 4.2.3) Consultando resumen de los resultados (padj < 0.1)
summary_1 <- summary(res_2, alpha = 0.1)
# 4.2.4) Anotando DEG
res_2$symbol <- mapIds(x = org.Hs.eg.db,
keys = rownames(res_2),
column = "SYMBOL",
keytype = "ENSEMBL",
multiVals = "first")
res_2$entrez <- mapIds(x = org.Hs.eg.db,
keys = rownames(res_2),
column = "ENTREZID",
keytype = "ENSEMBL",
multiVals="first")
# 4.2.5) Eliminando genes que no tienen anotación
res_2 <- na.omit(res_2)
# 4.2.6) Guardando el contenido de la toptable
write.csv(x = res_2,
file = "results/top_taples/top_table_NITvsELI.csv",
row.names = T)
# 4.2.7) Filtrando DEG (log2FC > 2 & padj < 0.1)
res_2_filtered <- as.data.frame(res_2)[which(res_2$padj < 0.1 & abs(res_2$log2FoldChange) > 2), ]
res_2_filtered <- res_2_filtered[order(res_2_filtered$padj), ]
View(res_2_filtered)
# 4.2.8) Guardando contenido de la toptable filtrada
write.csv(x = res_2_filtered,
file = "results/top_tables_filtered/top_table_NITvsELI_filtered.csv",
row.names = T)
# 4.2.9) Volcano plot
tiff(filename = "figures/volcano_plots/volcano_plot_NITvsELI.tiff",
width = 5.5,
height = 5.5,
res = 300,
units = "in")
print(EnhancedVolcano(toptable = res_2,
lab = res_2$symbol,
selectLab = res_2$symbol[order(res_2$padj)][1:5],
x = "log2FoldChange",
y = "padj",
pCutoff = 0.1,
FCcutoff = 1,
ylim = c(0, 30),
xlim = c(-10, 5),
pointSize = 1.7,
axisLabSize = 13,
labSize = 4,
subtitle = "",
caption = "",
title = "NIT vs ELI",
titleLabSize = 18,
legendVisible = F,
legendPosition = "bottom",
legendLabSize = 10,
legendIconSize = 3))
dev.off()
# 4.2.10) heatmap
h_res_2 <- as.matrix(counts_raw_sub[rownames(res_2_filtered), 1:20])
rownames(h_res_2) <- res_2_filtered$symbol
tiff(filename = "figures/heatmaps/heatmap_NITvsSFI.tiff",
width = 5.5,
height = 5.5,
res = 300,
units = "in")
heatmap(h_res_2)
dev.off()
# 4.3) SFI vs ELI
# 4.3.1) Generando resultados contraste
res_3 <- results(dds, contrast = c("Group", "SFI", "ELI"))
# 4.3.2) Modificando los ENSEMBL gene ids
rownames(res_3) <- gsub("\\..*","", rownames(res_3))
# 4.3.3) Consultando resumen de los resultados (padj < 0.1)
summary_3 <- summary(res_3, alpha = 0.1)
# 4.3.4) Anotando DEG
res_3$symbol <- mapIds(x = org.Hs.eg.db,
keys = rownames(res_3),
column = "SYMBOL",
keytype = "ENSEMBL",
multiVals = "first")
res_3$entrez <- mapIds(x = org.Hs.eg.db,
keys = rownames(res_3),
column = "ENTREZID",
keytype = "ENSEMBL",
multiVals="first")
# 4.3.5) Eliminando genes que no tienen anotación
res_3 <- na.omit(res_3)
# 4.3.6) Guardando el contenido de la toptable
write.csv(x = res_3,
file = "results/top_taples/top_table_SFIvsELI.csv",
row.names = T)
# 4.3.7) Filtrando DEG (log2FC > 2 & padj < 0.1)
res_3_filtered <- as.data.frame(res_3)[which(res_3$padj < 0.1 & abs(res_3$log2FoldChange) > 2), ]
res_3_filtered <- res_3_filtered[order(res_3_filtered$padj), ]
View(res_filtered)
# 4.3.8) Guardando contenido de la toptable filtrada
write.csv(x = res_3_filtered,
file = "results/top_tables_filtered/top_table_SFIvsELI_filtered.csv",
row.names = T)
# 4.3.9) Volcano plot
tiff(filename = "figures/volcano_plots/volcano_plot_SFIvsELI.tiff",
width = 5.5,
height = 5.5,
res = 300,
units = "in")
print(EnhancedVolcano(toptable = res_3,
lab = res_3$symbol,
selectLab = res_3$symbol[order(res_3$padj)][1:5],
x = "log2FoldChange",
y = "padj",
pCutoff = 0.1,
FCcutoff = 1,
ylim = c(0, 15),
xlim = c(-10, 5),
pointSize = 1.7,
axisLabSize = 13,
labSize = 4,
subtitle = "",
caption = "",
title = "SFI vs ELI",
titleLabSize = 18,
legendVisible = F,
legendPosition = "bottom",
legendLabSize = 10,
legendIconSize = 3))
dev.off()
# 4.3.10) heatmap
h_res_3 <- as.matrix(counts_raw_sub[rownames(res_3_filtered), 1:20])
rownames(h_res_3) <- res_3_filtered$symbol
tiff(filename = "figures/heatmaps/heatmap_NITvsSFI.tiff",
width = 5.5,
height = 5.5,
res = 300,
units = "in")
heatmap(h_res_3)
legend("topright",
legend = c("NIT", "SFI"),
col = c("royalblue3","goldenrod"),
lty = 1,
lwd = 10)
dev.off()
# -------------------------------------------------------------------------------------------------------------------------
# Análisis de significación (gene enrichment analysis)
# 1) NIT vs SFI
dir.create("results/GO_tables")
dir.create("figures/cnet_plots")
dir.create("figures/bar_plots")
entrez_res_1 <- res_1_filtered$entrez
res_1_enriched <- enrichGO(gene = entrez_res_1,
OrgDb = org.Hs.eg.db,
ont = "BP",
pAdjustMethod = "BH",
pvalueCutoff = 0.05,
qvalueCutoff = 0.05,
readable = TRUE)
GO_table_res_1 <- as.data.frame(res_1_enriched@result)[ , 1:7]
GO_table_res_1 <- GO_table_res_1[GO_table_res_1$p.adjust < 0.05 & GO_table_res_1$qvalue < 0.05, ]
View(GO_table_res_1)
write.csv(x = GO_table_res_1,
file = "results/GO_tables/GO_table_NITvsSFI.csv",
row.names = T)
tiff(filename = "figures/bar_plots/bar_plot_NITvsSFI.tiff",
width = 15,
height = 8,
res = 300,
units = "in")
barplot(res_1_enriched, showCategory = 10)
dev.off()
logFC <- res_1_filtered$log2FoldChange[res_1_filtered$padj < 0.05]
names <- res_1_filtered$symbol[res_1_filtered$padj < 0.05]
vec <- setNames(logFC, names)
tiff(filename = "figures/cnet_plots/cnet_plot_NITvsSFI.tiff",
width = 7.5,
height = 7,
res = 300,
units = "in")
cnetplot(x = res_1_enriched,
node_label = "all",
showCategory = 5,
foldChange = vec,
layout = "kk",
circular = F)
dev.off()
# 2) NIT vs ELI
entrez_res_2 <- res_2_filtered$entrez
res_2_enriched <- enrichGO(gene = entrez_res_2,
OrgDb = org.Hs.eg.db,
ont = "BP",
pAdjustMethod = "BH",
pvalueCutoff = 0.05,
qvalueCutoff = 0.05,
readable = TRUE)
GO_table_res_2 <- as.data.frame(res_2_enriched@result)[ , 1:7]
GO_table_res_2 <- GO_table_res_2[GO_table_res_2$p.adjust < 0.05 & GO_table_res_2$qvalue < 0.05, ]
View(GO_table_res_2)
write.csv(x = GO_table_res_2,
file = "results/GO_tables/GO_table_NITvsELI.csv",
row.names = T)
tiff(filename = "figures/bar_plots/bar_plot_NITvsELI.tiff",
width = 15,
height = 8,
res = 300,
units = "in")
barplot(res_2_enriched, showCategory = 10)
dev.off()
logFC <- res_2_filtered$log2FoldChange[res_2_filtered$padj < 0.05]
names <- res_2_filtered$symbol[res_2_filtered$padj < 0.05]
vec <- setNames(logFC, names)
tiff(filename = "figures/cnet_plots/cnet_plot_NITvsELI.tiff",
width = 7.5,
height = 7,
res = 300,
units = "in")
cnetplot(x = res_2_enriched,
node_label = "all",
showCategory = 4,
foldChange = vec,
layout = "kk",
circular = F)
dev.off()
# 3) SFI vs ELI
entrez_res_3 <- res_3_filtered$entrez
res_3_enriched <- enrichGO(gene = entrez_res_3,
OrgDb = org.Hs.eg.db,
ont = "BP",
pAdjustMethod = "BH",
pvalueCutoff = 0.15,
readable = TRUE)
GO_table_res_3 <- as.data.frame(res_3_enriched@result)[ , 1:7]
GO_table_res_3 <- GO_table_res_3[GO_table_res_3$p.adjust < 0.05 & GO_table_res_3$qvalue < 0.05, ]
View(GO_table_res_3)
write.csv(x = GO_table_res_3,
file = "results/GO_tables/GO_table_SFIvsELI.csv",
row.names = T)
tiff(filename = "figures/bar_plots/bar_plot_SFIvsELI.tiff",
width = 15,
height = 8,
res = 300,
units = "in")
barplot(res_3_enriched, showCategory = 10)
dev.off()
logFC <- res_3_filtered$log2FoldChange[res_3_filtered$padj < 0.05]
names <- res_3_filtered$symbol[res_3_filtered$padj < 0.05]
vec <- setNames(logFC, names)
tiff(filename = "figures/cnet_plots/cnet_plot_SFIvsELI.tiff",
width = 7.5,
height = 7,
res = 300,
units = "in")
cnetplot(x = res_3_enriched,
node_label = "all",
showCategory = 4,
foldChange = vec,
layout = "kk",
circular = F)
dev.off()
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